J P Whitehead

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi request reprint Adiponectin--a key adipokine in the metabolic syndrome
    J P Whitehead
    Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Diabetes Obes Metab 8:264-80. 2006
  2. ncbi request reprint The role of Ca2+ in insulin-stimulated glucose transport in 3T3-L1 cells
    J P Whitehead
    Institute for Molecular Bioscience and the Department of Physiology and Pharmacology, University of Queensland, St Lucia, Queensland 4072, Australia
    J Biol Chem 276:27816-24. 2001
  3. ncbi request reprint Insulin and oleate promote translocation of inosine-5' monophosphate dehydrogenase to lipid bodies
    Jonathan P Whitehead
    Department of Diabetes and Obesity, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Traffic 5:739-49. 2004
  4. doi request reprint Distinct adiponectin profiles might contribute to differences in susceptibility to type 2 diabetes in dogs and humans
    K R Verkest
    Centre for Companion Animal Health, The University of Queensland, Brisbane, QLD, Australia
    Domest Anim Endocrinol 41:67-73. 2011
  5. doi request reprint Postprandial total and HMW adiponectin following a high-fat meal in lean, obese and diabetic men
    L K Phillips
    Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia
    Eur J Clin Nutr 67:377-84. 2013
  6. ncbi request reprint Nocodazole inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes via a microtubule-independent mechanism
    J C Molero
    Institute for Molecular Biosciences and the Department of Physiology and Pharmacology, University of Queensland, St Lucia, Queensland 4072, Australia
    J Biol Chem 276:43829-35. 2001
  7. pmc Contraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity, but not protein kinase B activation or glucose uptake, in rat muscle
    J P Whitehead
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QR, U K
    Biochem J 349:775-81. 2000
  8. ncbi request reprint Raised alanine transaminase and decreased adiponectin are features of the metabolic syndrome in patients with type 2 diabetes
    Ingrid J Hickman
    Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Diabetes Obes Metab 9:438-40. 2007
  9. doi request reprint Adiposity and adiponectin in dogs: investigation of causes of discrepant results between two studies
    K R Verkest
    Centre for Companion Animal Health, School of Veterinary Science, The University of Queensland, Brisbane, Australia
    Domest Anim Endocrinol 41:35-41. 2011
  10. doi request reprint Synergistic effects of ascorbic acid and thiazolidinedione on secretion of high molecular weight adiponectin from human adipocytes
    F J Rose
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Diabetes Obes Metab 12:1084-9. 2010

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Adiponectin--a key adipokine in the metabolic syndrome
    J P Whitehead
    Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Diabetes Obes Metab 8:264-80. 2006
    ....
  2. ncbi request reprint The role of Ca2+ in insulin-stimulated glucose transport in 3T3-L1 cells
    J P Whitehead
    Institute for Molecular Bioscience and the Department of Physiology and Pharmacology, University of Queensland, St Lucia, Queensland 4072, Australia
    J Biol Chem 276:27816-24. 2001
    ..Finally, BAPTA-AM may inhibit the activity of the facilitative transporters by binding directly to the transporter itself...
  3. ncbi request reprint Insulin and oleate promote translocation of inosine-5' monophosphate dehydrogenase to lipid bodies
    Jonathan P Whitehead
    Department of Diabetes and Obesity, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Traffic 5:739-49. 2004
    ..These data support a role for IMPDH in the dynamic regulation of lipid bodies and fatty acid metabolism and regulation of its activity by subcellular redistribution in response to extracellular factors that modify lipid metabolism...
  4. doi request reprint Distinct adiponectin profiles might contribute to differences in susceptibility to type 2 diabetes in dogs and humans
    K R Verkest
    Centre for Companion Animal Health, The University of Queensland, Brisbane, QLD, Australia
    Domest Anim Endocrinol 41:67-73. 2011
    ..Dogs with chronic, naturally occurring obesity do not have selectively reduced HMW adiponectin, and adiponectin does not appear to be important in the development of canine obesity-associated insulin resistance...
  5. doi request reprint Postprandial total and HMW adiponectin following a high-fat meal in lean, obese and diabetic men
    L K Phillips
    Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia
    Eur J Clin Nutr 67:377-84. 2013
    ..Findings from the water control suggest differential basal regulation of total adiponectin in T2DM compared with lean controls...
  6. ncbi request reprint Nocodazole inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes via a microtubule-independent mechanism
    J C Molero
    Institute for Molecular Biosciences and the Department of Physiology and Pharmacology, University of Queensland, St Lucia, Queensland 4072, Australia
    J Biol Chem 276:43829-35. 2001
    ..These studies reveal a new and unexpected effect of nocodazole in mammalian cells which appears to occur independently of its microtubule-depolymerizing effects...
  7. pmc Contraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity, but not protein kinase B activation or glucose uptake, in rat muscle
    J P Whitehead
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QR, U K
    Biochem J 349:775-81. 2000
    ..Thus, in contracting skeletal muscle, insulin stimulates glucose uptake and activates PKB, but not p70(S6K), by a PI 3-kinase-dependent mechanism that is independent of changes in IRS-1- and IRS-2-associated PI 3-kinase activity...
  8. ncbi request reprint Raised alanine transaminase and decreased adiponectin are features of the metabolic syndrome in patients with type 2 diabetes
    Ingrid J Hickman
    Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Diabetes Obes Metab 9:438-40. 2007
    ..The aim of the study was to investigate the relationship between the metabolic syndrome (MS), adiponectin and abnormal liver enzymes in patients with type 2 diabetes...
  9. doi request reprint Adiposity and adiponectin in dogs: investigation of causes of discrepant results between two studies
    K R Verkest
    Centre for Companion Animal Health, School of Veterinary Science, The University of Queensland, Brisbane, Australia
    Domest Anim Endocrinol 41:35-41. 2011
    ..Obesity might decrease adiponectin concentrations in intact but not in neutered dogs...
  10. doi request reprint Synergistic effects of ascorbic acid and thiazolidinedione on secretion of high molecular weight adiponectin from human adipocytes
    F J Rose
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Diabetes Obes Metab 12:1084-9. 2010
    ..To test the hypothesis that ascorbic acid (AA) and thiazolidinedione (TZD) would have additive effects on HMW adiponectin secretion by virtue of different modes of action...
  11. doi request reprint The effect of a high-fat meal on postprandial arterial stiffness in men with obesity and type 2 diabetes
    L K Phillips
    Diamantina Institute for Cancer, Immunology, and Metabolic Medicine, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
    J Clin Endocrinol Metab 95:4455-9. 2010
    ..Postprandial dysmetabolism is emerging as an important cardiovascular risk factor. Augmentation index (AIx) is a measure of systemic arterial stiffness and independently predicts cardiovascular outcome...
  12. doi request reprint Reduced phosphorylation of AS160 contributes to glucocorticoid-mediated inhibition of glucose uptake in human and murine adipocytes
    Sherry Ngo
    Metabolic Medicine Program, Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Brisbane, Queensland 4102, Australia
    Mol Cell Endocrinol 302:33-40. 2009
    ..These data suggest Dex inhibits glucose uptake in adipocytes, at least in part, by reducing AS160 phosphorylation and interaction with 14-3-3...
  13. ncbi request reprint Signalling through the insulin receptor
    J P Whitehead
    The Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, 4072, Australia
    Curr Opin Cell Biol 12:222-8. 2000
    ..When inappropriately dissociated from this matrix the signalling network collapses concomitant with loss of insulin sensitivity...
  14. doi request reprint Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes
    C H Widberg
    Diamantina Institute for Cancer, Immunology, and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Am J Physiol Endocrinol Metab 296:E121-31. 2009
    ..Together these data highlight the unique nature of the role of FGF-1 during the earliest stages of adipogenesis and establish a role for FGFR1 in human adipogenesis, identifying FGFR1 as a potential therapeutic target to reduce obesity...
  15. ncbi request reprint IRS-1 regulation in health and disease
    Carsten Schmitz-Peiffer
    Cell Signalling Group, Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    IUBMB Life 55:367-74. 2003
    ....
  16. doi request reprint Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms
    Jennifer H Gunter
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD 4102, Brisbane, Australia
    Int J Biochem Cell Biol 40:1716-28. 2008
    ....
  17. ncbi request reprint Structure, signalling and physiologic role of adiponectin-dietary and exercise- related variations
    I J Hickman
    Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, Australia 2Mater Medical Research Institute, Brisbane, Australia
    Curr Med Chem 19:5427-43. 2012
    ..We will also review studies into the effects of diet or exercise on circulating adiponectin levels focusing largely on reports from human trials...
  18. ncbi request reprint GLUT4--at the cross roads between membrane trafficking and signal transduction
    F Simpson
    Institute for Molecular Biosciences and the Department of Physiology and Pharmacology, University of Queensland, Brisbane, Australia
    Traffic 2:2-11. 2001
    ..Below we discuss some of these complexities and highlight new data that are bringing us closer to the resolution of these questions...
  19. doi request reprint Inhibition of inosine monophosphate dehydrogenase reduces adipogenesis and diet-induced obesity
    Hua Su
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Biochem Biophys Res Commun 386:351-5. 2009
    ..002) and adipocyte size (p=0.03) and number. These data suggest that inhibition of IMPDH may represent a novel strategy to reduce adipose tissue mass...
  20. ncbi request reprint The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity
    Elaine C Thomas
    Centre for Diabetes and Endocrine Research, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD 4102, Australia
    Int J Biochem Cell Biol 38:1686-99. 2006
    ....
  21. ncbi request reprint Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signaling
    Jørgen Jensen
    Department of Physiology, National Institute of Occupational Health, Oslo, Norway
    Am J Physiol Endocrinol Metab 290:E154-E162. 2006
    ..quot;Insulin resistance" is observed at the level of glycogen synthase, and the reduced glycogen synthesis leads to increased levels of glucose 6-phosphate, glycolytic flux, and accumulation of nonphosphorylated 2-deoxyglucose...
  22. ncbi request reprint High molecular weight adiponectin correlates with insulin sensitivity in patients with hepatitis C genotype 3, but not genotype 1 infection
    Amy Y H Wang
    Centre for Diabetes and Endocrine Research, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Am J Gastroenterol 100:2717-23. 2005
    ..Adiponectin is an anti-inflammatory adipokine that is present in serum in a range of multimeric forms that appear to have different metabolic functions...
  23. doi request reprint Adrenaline potentiates insulin-stimulated PKB activation in the rat fast-twitch epitrochlearis muscle without affecting IRS-1-associated PI 3-kinase activity
    Jørgen Jensen
    Department of Physiology, National Institute of Occupational Health, P O Box 8149 Dep, Oslo, 0033, Norway
    Pflugers Arch 456:969-78. 2008
    ..These results indicate that the combination of adrenaline and insulin may activate novel signalling molecules rather than just summing up their effects on linear pathways...
  24. doi request reprint Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation
    Ayanthi A Richards
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Brisbane, Queensland, Australia
    Mol Endocrinol 24:229-39. 2010
    ..These data suggest an important role for sialic acid content in the regulation of circulating adiponectin levels and highlight the importance of understanding mechanisms regulating adiponectin sialylation/desialylation...
  25. ncbi request reprint TNF and TNF receptor expression and insulin sensitivity in human omental and subcutaneous adipose tissue--influence of BMI and adipose distribution
    Manuela Good
    Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland, Australia 4102
    Diab Vasc Dis Res 3:26-33. 2006
    ..Furthermore, adipose tissue from obese subjects already appears insulin 'resistant' and this may be a result of the increased TNF levels...
  26. ncbi request reprint Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications
    Ayanthi A Richards
    Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
    Mol Endocrinol 20:1673-87. 2006
    ..Collectively, these data suggest that adiponectin multimer composition is affected by changes in PTM in response to physiological factors...
  27. doi request reprint Adiponectin--it's all about the modifications
    Fiona Simpson
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Int J Biochem Cell Biol 42:785-8. 2010
    ..Strategies that modulate processes governing PTM of adiponectin represent attractive therapeutic approaches...
  28. ncbi request reprint Olanzapine treatment is associated with reduced high molecular weight adiponectin in serum: a potential mechanism for olanzapine-induced insulin resistance in patients with schizophrenia
    Ayanthi A Richards
    Centre for Diabetes and Endocrine Research, The University of Queensland, Brisbane, Queensland, Australia
    J Clin Psychopharmacol 26:232-7. 2006
    ..This may not be a direct effect of olanzapine on adipocyte expression or secretion of adiponectin. These observations provide insights into possible mechanisms for the association between olanzapine treatment and insulin resistance...