Jason White

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi Evaluation of levo-alpha-acetylmethdol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: a pharmacokinetic and pharmacodynamic analysis
    David A L Newcombe
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide 5005, Australia
    Drug Alcohol Depend 76:63-72. 2004
  2. ncbi Relationship between LAAM-methadone preference and treatment outcomes
    Jason M White
    Department of Clinical and Experimental Pharmacology, Adelaide University, SA 5005, Australia
    Drug Alcohol Depend 66:295-301. 2002
  3. doi Open-label dose-finding trial of buprenorphine implants (Probuphine) for treatment of heroin dependence
    Jason White
    Discipline of Pharmacology, University of Adelaide, Adelaide, SA 5005, Australia
    Drug Alcohol Depend 103:37-43. 2009
  4. ncbi Pleasure into pain: the consequences of long-term opioid use
    Jason M White
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, South Australia 5005, Australia
    Addict Behav 29:1311-24. 2004
  5. ncbi Opioid maintenance: a comparative review of pharmacological strategies
    Jason M White
    Discipline of Pharmacology, University of Adelaide, SA 5005, Australia
    Expert Opin Pharmacother 8:1-11. 2007
  6. pmc Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure
    Timothy B Mitchell
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, SA 5005, Australia
    Br J Clin Pharmacol 58:609-17. 2004
  7. ncbi Slow-release oral morphine versus methadone: a crossover comparison of patient outcomes and acceptability as maintenance pharmacotherapies for opioid dependence
    Timothy B Mitchell
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, South Australia, 5005, Australia
    Addiction 99:940-5. 2004
  8. ncbi Methadone maintenance patients are cross-tolerant to the antinociceptive effects of very high plasma morphine concentrations
    Peter Athanasos
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, SA 5005, Australia
    Pain 120:267-75. 2006
  9. ncbi Comparative pharmacodynamics and pharmacokinetics of methadone and slow-release oral morphine for maintenance treatment of opioid dependence
    Timothy B Mitchell
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, SA 5005, Australia
    Drug Alcohol Depend 72:85-94. 2003
  10. ncbi Inter- and intra-subject variability in ethanol pharmacokinetic parameters: effects of testing interval and dose
    Lisa N Yelland
    Discipline of Public Health, School of Population Health and Clinical Practice, The University of Adelaide, Adelaide 5005, Australia
    Forensic Sci Int 175:65-72. 2008

Detail Information

Publications34

  1. ncbi Evaluation of levo-alpha-acetylmethdol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: a pharmacokinetic and pharmacodynamic analysis
    David A L Newcombe
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide 5005, Australia
    Drug Alcohol Depend 76:63-72. 2004
    ..LAAM converted methadone non-holders into LAAM holders. LAAM may therefore be useful in selected MMT non-holders and improve retention in opioid treatment programs...
  2. ncbi Relationship between LAAM-methadone preference and treatment outcomes
    Jason M White
    Department of Clinical and Experimental Pharmacology, Adelaide University, SA 5005, Australia
    Drug Alcohol Depend 66:295-301. 2002
    ..For those who chose methadone, there were no differences in outcomes between the LAAM and methadone maintenance periods. Preference for LAAM is associated with treatment outcomes as good or better than those with methadone...
  3. doi Open-label dose-finding trial of buprenorphine implants (Probuphine) for treatment of heroin dependence
    Jason White
    Discipline of Pharmacology, University of Adelaide, Adelaide, SA 5005, Australia
    Drug Alcohol Depend 103:37-43. 2009
    ..No safety concerns were evident. These results suggest that Probuphine implants offer significant promise for enhancing delivery of effective opioid substitution treatment while minimizing risk for abuse of medication...
  4. ncbi Pleasure into pain: the consequences of long-term opioid use
    Jason M White
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, South Australia 5005, Australia
    Addict Behav 29:1311-24. 2004
    ..These aversive pain and mood states may contribute to the motivation for continued drug use and the dysfunction associated with drug dependence...
  5. ncbi Opioid maintenance: a comparative review of pharmacological strategies
    Jason M White
    Discipline of Pharmacology, University of Adelaide, SA 5005, Australia
    Expert Opin Pharmacother 8:1-11. 2007
    ..This review examines the existing strategies, highlights problems associated with their use and discusses the opportunities for new treatment approaches, particularly the use of long-acting formulations...
  6. pmc Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure
    Timothy B Mitchell
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, SA 5005, Australia
    Br J Clin Pharmacol 58:609-17. 2004
    ..R)-methadone...
  7. ncbi Slow-release oral morphine versus methadone: a crossover comparison of patient outcomes and acceptability as maintenance pharmacotherapies for opioid dependence
    Timothy B Mitchell
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, South Australia, 5005, Australia
    Addiction 99:940-5. 2004
    ..To evaluate slow-release oral morphine (SROM) as an alternative maintenance pharmacotherapy to methadone for treatment of opioid dependence...
  8. ncbi Methadone maintenance patients are cross-tolerant to the antinociceptive effects of very high plasma morphine concentrations
    Peter Athanasos
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, SA 5005, Australia
    Pain 120:267-75. 2006
    ..While even higher morphine doses may achieve some pain relief, this may be at the cost of unacceptable respiratory depression...
  9. ncbi Comparative pharmacodynamics and pharmacokinetics of methadone and slow-release oral morphine for maintenance treatment of opioid dependence
    Timothy B Mitchell
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, SA 5005, Australia
    Drug Alcohol Depend 72:85-94. 2003
    ..However, the pharmacodynamics and pharmacokinetics of SROM have not been previously assessed in a methadone maintenance population...
  10. ncbi Inter- and intra-subject variability in ethanol pharmacokinetic parameters: effects of testing interval and dose
    Lisa N Yelland
    Discipline of Public Health, School of Population Health and Clinical Practice, The University of Adelaide, Adelaide 5005, Australia
    Forensic Sci Int 175:65-72. 2008
    ..Forensically important differences in pharmacokinetic parameters were observed within individuals between occasions. These findings could have an important impact on medico-legal issues related to ethanol pharmacokinetics...
  11. doi Antinociceptive effects of high-dose remifentanil in male methadone-maintained patients
    Justin L Hay
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, SA 5005, Australia
    Eur J Pain 12:926-33. 2008
    ..Methadone-maintained patients demonstrate significant tolerance to remifentanil and may require opioid doses 20-30 higher than required for the treatment of acute pain in opioid-naïve patients...
  12. ncbi Plasma drug concentrations and physiological measures in 'dance party' participants
    Rodney J Irvine
    Department of Clinical and Experimental Pharmacology, University of Adelaide, SA, Australia
    Neuropsychopharmacology 31:424-30. 2006
    ....
  13. pmc Within- and between- subject variability in methadone pharmacokinetics and pharmacodynamics in methadone maintenance subjects
    Julia Hanna
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, Australia
    Br J Clin Pharmacol 60:404-13. 2005
    ..To investigate within- and between-subject variability of the pharmacodynamics and pharmacokinetics of (R)- and (S)-methadone in methadone maintenance subjects at steady-state...
  14. pmc Flexible dosing of tincture of opium in the management of opioid withdrawal: pharmacokinetics and pharmacodynamics
    Andrew A Somogyi
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, Australia
    Br J Clin Pharmacol 66:640-7. 2008
    ..The aim was to evaluate the clinical effectiveness, pharmacodynamics and pharmacokinetics of a range of Tincture of Opium (TOP) doses in the management of opioid withdrawal...
  15. doi Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients
    Justin L Hay
    Discipline of Pharmacology, Medical School North, University of Adelaide, SA, Australia
    J Pain 10:316-22. 2009
    ..These results add to the growing body of evidence that chronic opioid exposure increases sensitivity to some types of pain. They also demonstrate that in humans, this hyperalgesia is not associated with allodynia...
  16. doi The effects of prenatal exposure to buprenorphine or methadone on infant visual evoked potentials
    Justine N Whitham
    Discipline of Paediatrics, School of Paediatrics and Reproductive Health, The University of Adelaide, Australia
    Neurotoxicol Teratol 32:280-8. 2010
    ..Data from this controlled, non-randomised study suggest that buprenorphine may confer an advantage over methadone as a maintenance drug during pregnancy in terms of infant neural development at 4 months of age...
  17. doi Model of methadone-induced hyperalgesia in rats and effect of memantine
    Justin L Hay
    Discipline of Pharmacology, Level 5, Medical School North, University of Adelaide, SA 5005, Australia
    Eur J Pharmacol 626:229-33. 2010
    ..Furthermore, memantine does not alter the development of methadone-induced hyperalgesia...
  18. ncbi Opioid effects and opioid withdrawal during a 24 h dosing interval in patients maintained on buprenorphine
    Olga V Lopatko
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide 5005, SA, Australia
    Drug Alcohol Depend 69:317-22. 2003
    ....
  19. ncbi In vivo and in vitro potency studies of 6beta-naltrexol, the major human metabolite of naltrexone
    Susan J Porter
    Department of Clinical and Experimental Pharmacology, Adelaide University, Adelaide 5005, Australia
    Addict Biol 7:219-25. 2002
    ..Therefore, 6beta-naltrexol is likely to contribute to the efficacy of naltrexone in humans...
  20. ncbi Use of radiotelemetry to evaluate respiratory depression produced by chronic methadone administration
    Tanya Lewanowitsch
    Department of Clinical and Experimental Pharmacology, 5th Floor Medical School North, University of Adelaide, Adelaide, South Australia 5005, Australia
    Eur J Pharmacol 484:303-10. 2004
    ..Radiotelemetry offers a means of evaluating drug effects on respiratory rate continually in ambulatory, unstressed animals...
  21. pmc Population pharmacokinetics of (R)-, (S)- and rac-methadone in methadone maintenance patients
    David J R Foster
    Department of Clinical and Experimental Pharmacology, The University of Adelaide, Adelaide 5005, Australia
    Br J Clin Pharmacol 57:742-55. 2004
    ..To construct a population pharmacokinetic model for methadone enantiomers in the setting of methadone maintenance treatment for opioid dependence...
  22. ncbi Antagonist-precipitated heroin withdrawal under anaesthetic prior to maintenance naltrexone treatment: determinants of withdrawal severity
    Robert Ali
    Department of Clinical and Experimental Pharmacology, University of Adelaide, South Australia
    Drug Alcohol Rev 22:425-31. 2003
    ..Ali R, Thomas P, White J, McGregor C, Danz,C, Gowing L, Stegink A, Athanasos P. Antagonist-precipitated heroin withdrawal under anaesthetic prior to maintenance naltrexone treatment: determinants of withdrawal severity...
  23. doi Pregnancy-related changes in tobacco, alcohol and cannabis use reported by antenatal patients at two public hospitals in South Australia
    Elizabeth Hotham
    WHO Collaborating Centre, University of Adelaide, Adelaide, South Australia, Australia
    Aust N Z J Obstet Gynaecol 48:248-54. 2008
    ..Australian substance use data do not demonstrate pregnancy-related changes or distinguish between pregnant and lactating women...
  24. ncbi Baclofen prevents MDMA-induced rise in core body temperature in rats
    Sotiria Bexis
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, SA 5005, Australia
    Drug Alcohol Depend 74:89-96. 2004
    ..001), but also reduced the percentage of rats attaining a core body temperature of 40 degrees C. These data suggest that stimulation of GABA(B) receptors may provide a mechanism for the treatment of MDMA-induced hyperthermia...
  25. doi Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence
    Liang Liu
    Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia
    Pharmacogenet Genomics 19:869-76. 2009
    ..To confirm a previous study, we also examined the association between the IL-1B genetic polymorphism and alcohol dependence...
  26. ncbi The nature, time course and severity of methamphetamine withdrawal
    Catherine McGregor
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia
    Addiction 100:1320-9. 2005
    ..To characterize the natural history of methamphetamine withdrawal during the first 3 weeks of abstinence...
  27. ncbi Which substitution pharmacotherapy is most effective in treating opioid dependence?
    Linda R Gowing
    Evidence Based Practice Unit, Drug and Alcohol Services Council, Parkside, SA
    Med J Aust 176:493-4. 2002
  28. ncbi A comparison of antagonist-precipitated withdrawal under anesthesia to standard inpatient withdrawal as a precursor to maintenance naltrexone treatment in heroin users: outcomes at 6 and 12 months
    Catherine McGregor
    Clinical Policy and Research, Drug and Alcohol Services Council of South Australia, 161 Greenhill Road, Parkside, SA 5063, Australia
    Drug Alcohol Depend 68:5-14. 2002
    ..Long-term follow-up is crucial in assessing the effects of treatment interventions for heroin dependence...
  29. pmc Comparison of tincture of opium and methadone to control opioid withdrawal in a Thai treatment centre
    Jaroon Jittiwutikarn
    Northern Drug Dependence Centre, Chiang Mai Province, Thailand
    Br J Clin Pharmacol 58:536-41. 2004
    ..To evaluate the effectiveness of oral tincture of opium (TOP) and methadone to control opioid withdrawal in patients in northern Thailand...
  30. ncbi Buprenorphine versus methadone maintenance therapy: a randomized double-blind trial with 405 opioid-dependent patients
    Richard P Mattick
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia
    Addiction 98:441-52. 2003
    ..To assess the efficacy of buprenorphine compared with methadone maintenance therapy for opioid dependence in a large sample using a flexible dosing regime and the marketed buprenorphine tablet...
  31. ncbi Alpha2-adrenergic agonists in opioid withdrawal
    Linda R Gowing
    Evidence Based Practice Unit, Drug and Alcohol Services Council, Parkside, SA, Australia
    Addiction 97:49-58. 2002
    ..This paper presents the main findings of a systematic (Cochrane) review of the effectiveness of alpha2-adrenergic agonists in managing opioid withdrawal...
  32. ncbi Switching between methadone and morphine for maintenance treatment of opioid dependence: impact on pain sensitivity and mood status
    Timothy B Mitchell
    National Addiction Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Addict 15:311-5. 2006
    ..Hyperalgesia and mood disturbance cannot be resolved by changing from methadone to morphine maintenance...
  33. ncbi Fluctuations in (R,S)-methadone pharmacokinetics and response among long-term methadone maintenance patients
    Timothy B Mitchell
    National Addiction Centre, Institute of Psychiatry, King s College London, UK
    Addict Biol 11:170-4. 2006
    ..The pronounced and variable fluctuations in methadone disposition evident in these patients highlight the need for an individualized approach to patient dosing and monitoring...
  34. ncbi In-patient benzodiazepine withdrawal: comparison of fixed and symptom-triggered taper methods
    Catherina McGregor
    Drug and Alcohol Services Council, South Australia, Australia
    Drug Alcohol Rev 22:175-80. 2003
    ....