Grant W Waterer

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Medium-term survival after hospitalization with community-acquired pneumonia
    Grant W Waterer
    Department of Medicine, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia
    Am J Respir Crit Care Med 169:910-4. 2004
  2. ncbi request reprint Monotherapy versus combination antimicrobial therapy for pneumococcal pneumonia
    Grant W Waterer
    Department of Medicine, University of Western Australia, Perth, Western Australia, Australia
    Curr Opin Infect Dis 18:157-63. 2005
  3. pmc Choosing the right combination therapy in severe community-acquired pneumonia
    Grant W Waterer
    School of Medicine and Pharmacology, University of Western Australia, MRF Building, Royal Perth Hospital, GPO Box X2213, Perth 6847, Australia
    Crit Care 10:115. 2006
  4. ncbi request reprint Delayed administration of antibiotics and atypical presentation in community-acquired pneumonia
    Grant W Waterer
    University of Western Australia, School of Medicine and Pharmacology, 4th Floor MRF Building, Royal Perth Hospital, GPO Box X2213, Perth, WA, Australia 6847
    Chest 130:11-5. 2006
  5. ncbi request reprint Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia
    Grant W Waterer
    Department of Medicine, University of Western Australia
    Crit Care Med 31:1367-72. 2003
  6. doi request reprint Feasibility of real-time polymerase chain reaction in whole blood to identify Streptococcus pneumoniae in patients with community-acquired pneumonia
    Cordelia Kee
    School of Medicine and Pharmacology, University of Western Australia, Perth 6009, Western Australia
    Diagn Microbiol Infect Dis 61:72-5. 2008
  7. ncbi request reprint The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B
    Suzanna E L Temple
    School of Medicine and Pharmacology, University of Western Australia, GPO Box X2213, 6847 Perth, Western Australia, Australia
    Intensive Care Med 30:1761-7. 2004
  8. doi request reprint Endotoxin induced TNF and IL-10 mRNA production is higher in male than female donors: correlation with elevated expression of TLR4
    Suzanna E L Temple
    School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
    Cell Immunol 251:69-71. 2008
  9. doi request reprint Pathogenic bacteria and TNF do not induce production of macrophage migration inhibitory factor (MIF) by human monocytes
    Suzanna E L Temple
    School of Medicine and Pharmacology, RPH Unit M570, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Cytokine 46:316-8. 2009
  10. doi request reprint Genetic risk of acute pulmonary infections and sepsis
    Grant W Waterer
    School of Medicine and Pharmacology, University of Western Australia, Level 4 MRF Building, Royal Perth Hospital, GPO Box X2213, Perth 6847, Australia
    Expert Rev Respir Med 4:229-38. 2010

Detail Information

Publications37

  1. ncbi request reprint Medium-term survival after hospitalization with community-acquired pneumonia
    Grant W Waterer
    Department of Medicine, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia
    Am J Respir Crit Care Med 169:910-4. 2004
    ....
  2. ncbi request reprint Monotherapy versus combination antimicrobial therapy for pneumococcal pneumonia
    Grant W Waterer
    Department of Medicine, University of Western Australia, Perth, Western Australia, Australia
    Curr Opin Infect Dis 18:157-63. 2005
    ..In the past 5 years a number of studies have suggested that combination antibiotic therapy may be superior to monotherapy for pneumococcal pneumonia. This review outlines the major findings for and against combination therapy...
  3. pmc Choosing the right combination therapy in severe community-acquired pneumonia
    Grant W Waterer
    School of Medicine and Pharmacology, University of Western Australia, MRF Building, Royal Perth Hospital, GPO Box X2213, Perth 6847, Australia
    Crit Care 10:115. 2006
    ..Several mechanisms exist by which quinolones could be inferior to macrolides in combination therapy, so if these findings are confirmed by other groups they have significant implications for physicians treating patients with severe CAP...
  4. ncbi request reprint Delayed administration of antibiotics and atypical presentation in community-acquired pneumonia
    Grant W Waterer
    University of Western Australia, School of Medicine and Pharmacology, 4th Floor MRF Building, Royal Perth Hospital, GPO Box X2213, Perth, WA, Australia 6847
    Chest 130:11-5. 2006
    ..We investigated the factors that predict a prolonged TFAD and their association with mortality...
  5. ncbi request reprint Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia
    Grant W Waterer
    Department of Medicine, University of Western Australia
    Crit Care Med 31:1367-72. 2003
    ....
  6. doi request reprint Feasibility of real-time polymerase chain reaction in whole blood to identify Streptococcus pneumoniae in patients with community-acquired pneumonia
    Cordelia Kee
    School of Medicine and Pharmacology, University of Western Australia, Perth 6009, Western Australia
    Diagn Microbiol Infect Dis 61:72-5. 2008
    ..Our findings suggest the lytA PCR is more sensitive, and the quantitative aspect of the assay shows promise as an aid to clinical judgment...
  7. ncbi request reprint The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B
    Suzanna E L Temple
    School of Medicine and Pharmacology, University of Western Australia, GPO Box X2213, 6847 Perth, Western Australia, Australia
    Intensive Care Med 30:1761-7. 2004
    ..To identify a functional polymorphic site(s) within HSPA1A and/or HSPA1B which is in linkage disequilibrium with the silent mutation HSPA1B1267A>G and explains its association with septic shock...
  8. doi request reprint Endotoxin induced TNF and IL-10 mRNA production is higher in male than female donors: correlation with elevated expression of TLR4
    Suzanna E L Temple
    School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
    Cell Immunol 251:69-71. 2008
    ..TLR4 expression was also significantly higher in cells from men. These gender differences in the immune response may help to elucidate the sexual dimorphism observed in infectious diseases...
  9. doi request reprint Pathogenic bacteria and TNF do not induce production of macrophage migration inhibitory factor (MIF) by human monocytes
    Suzanna E L Temple
    School of Medicine and Pharmacology, RPH Unit M570, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Cytokine 46:316-8. 2009
    ..Exposure of leukocytes to TNF did not induce MIF. Hence elevated levels of serum MIF observed in sepsis may not reflect MIF produced by blood leukocytes stimulated directly by bacteria or TNF...
  10. doi request reprint Genetic risk of acute pulmonary infections and sepsis
    Grant W Waterer
    School of Medicine and Pharmacology, University of Western Australia, Level 4 MRF Building, Royal Perth Hospital, GPO Box X2213, Perth 6847, Australia
    Expert Rev Respir Med 4:229-38. 2010
    ..Finally, our approach to reporting genetic studies needs to change to minimize the number of publications of spurious findings...
  11. ncbi request reprint Quantitative rt-PCR holds promise as a screening tool for patients with severe sepsis
    Shelley Kirkbright
    Emergency Medicine, Royal Perth Hospital, University of Western Australia and Centre for Clinical Research in Emergency Medicine, Western Australian Institute for Medical Research, Perth, Perth, Western Australia, Australia
    Emerg Med Australas 23:502-6. 2011
    ..The aim of the present study was to determine if the quantification of bacterial 16S rDNA could be clinically useful in predicting patients at increased risk of developing septic shock...
  12. pmc Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells
    Julius F Varano Della Vergiliana
    Pleural Disease Unit, Lung Institute of Western Australia, Centre for Asthma, Allergy and Respiratory Research, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
    PLoS ONE 8:e63873. 2013
    ..05). The data establish that pleural mesothelial cells can release Hsp72 in response to bacterial infection and levels are raised in infectious pleural effusions. The biological role of HSP70 in pleural infection warrants exploration...
  13. ncbi request reprint Genetic susceptibility to pneumonia
    Grant W Waterer
    School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, GP0 Box X2213, Perth, Western Australia
    Clin Chest Med 26:29-38. 2005
    ..IL-10 and IL-1 receptor antagonist polymorphisms have an important role in the anti-inflammatory response. Specific organ dysfunction, such as ARDS or DIC, may be related to polymorphisms in specific effector genes...
  14. doi request reprint Bioterrorism for the respiratory physician
    Grant W Waterer
    Centre for Asthma, Allergy and Respiratory Research and Lung Institute of Western Australia, The University of Western Australia, Perth, Australia
    Respirology 14:5-11. 2009
    ..The pathogenesis, clinical manifestations and treatment of these agents will be discussed as well as historical examples of their use. Other potential bioterrorism agents with respiratory manifestations will also be discussed briefly...
  15. doi request reprint Genetic predisposition to respiratory infection and sepsis
    Li Ping Chung
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
    Crit Rev Clin Lab Sci 48:250-68. 2011
    ..In addition, a summary of the expanding research in the field of epigenetics and post-sepsis immunosuppression will be discussed...
  16. ncbi request reprint Alleles carried at positions -819 and -592 of the IL10 promoter affect transcription following stimulation of peripheral blood cells with Streptococcus pneumoniae
    Suzanna E L Temple
    School of Medicine and Pharmacology, Royal Perth Hospital, University of Western Australia, GPO Box X2213, WA 6847, Perth, Australia
    Immunogenetics 55:629-32. 2003
    ..The results suggest that the -819 and/or -592 alleles affect transcription...
  17. ncbi request reprint Decreasing beta-lactam resistance in Pneumococci from the Memphis region: analysis of 2,152 isolates From 1996 to 2001
    Grant W Waterer
    Department of Medicine, University of Western Australia, Crawley, Australia
    Chest 124:519-25. 2003
    ..In recent years, we have seen a significant shift in antibiotic use away from beta-lactams toward the newer quinolones and macrolides. We hypothesized that these changes would cause a shift in pneumococcal antibiotic resistance patterns...
  18. doi request reprint Management of community-acquired pneumonia in adults
    Grant W Waterer
    University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 183:157-64. 2011
    ....
  19. doi request reprint Community-acquired pneumonia: genomics, epigenomics, transcriptomics, proteomics, and metabolomics
    Grant W Waterer
    Department of Medicine, University of Western Australia, Perth, Australia
    Semin Respir Crit Care Med 33:257-65. 2012
    ..Current and potential future uses of these platforms are discussed, and both key findings and key barriers to further progress are highlighted...
  20. pmc Science review: Genetic variability in the systemic inflammatory response
    Grant W Waterer
    Department of Medicine, University of Western Australia, Australia
    Crit Care 7:308-14. 2003
    ..However, large, phenotypically detailed studies are required to address all of the other potential polymorphisms in inflammatory molecule genes and their interactions...
  21. ncbi request reprint A quantitative LightCycler PCR to detect Streptococcus pneumoniae in blood and CSF
    Robert van Haeften
    Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Perth, Australia
    Diagn Microbiol Infect Dis 47:407-14. 2003
    ..pneumoniae infections, while bacterial load quantitation has opened up exciting possibilities for patient management...
  22. doi request reprint Public health management of pandemic (H1N1) 2009 infection in Australia: a failure!
    Grant W Waterer
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Respirology 15:51-6. 2010
    ..In this paper, two senior academics discuss the management of pandemic (H1N1) 2009 infection in Australia from the public health perspective...
  23. ncbi request reprint The diagnostic dilemma in suspected ventilator-associated pneumonia: one size will never fit all
    Grant W Waterer
    Chest 123:335-7. 2003
  24. ncbi request reprint Pharmaceutical industry research and cost savings in community-acquired pneumonia
    Lori A Kessler
    Physicians Research Network, Methodist Le Bonheur Healthcare Foundation, Memphis, Tenn 38104, USA
    Am J Manag Care 8:798-800. 2002
    ..To provide financial justification for continuing pharmaceutical research in an environment that has met with increasing resistance from insurance carriers to paying for the care of patients enrolled in research studies...
  25. ncbi request reprint Intracellular adhesion molecule Gly241Arg polymorphism has no impact on ARDS or septic shock in community-acquired pneumonia
    Michael W Quasney
    Department of Pediatrics, Crippled Children s Foundation Research Center, University of Tennessee, Memphis, 38103, USA
    Chest 121:85S-86S. 2002
  26. ncbi request reprint Tumor necrosis factor gene polymorphisms and the variable presentation and outcome of community-acquired pneumonia
    Richard G Wunderink
    Methodist Le Bonheur Healthcare Foundation, University of Tennessee, Memphis, TN, USA
    Chest 121:87S. 2002
  27. doi request reprint SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia
    Patrick G P Charles
    Departments of 1Infectious Diseases and 2Respiratory and Sleep Medicine, Austin Health, Heidelberg, VIC 3084, Australia
    Clin Infect Dis 47:375-84. 2008
    ....
  28. ncbi request reprint Genetics of community-acquired pneumonia
    Richard G Wunderink
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Respir Crit Care Med 26:553-62. 2005
    ..The real value of these genetic studies in CAP and other severe infections will be when the management of an individual patient can be optimized by therapy based on the individual's genotype for molecules important in outcome...
  29. doi request reprint The etiology of community-acquired pneumonia in Australia: why penicillin plus doxycycline or a macrolide is the most appropriate therapy
    Patrick G P Charles
    Department of Infectious Diseases, Austin Health, Heidelberg, Vic, Australia
    Clin Infect Dis 46:1513-21. 2008
    ..Local treatment guidelines promote the use of combination therapy with agents such as penicillin or amoxycillin combined with either doxycycline or a macrolide...
  30. ncbi request reprint Combination antibiotic therapy with macrolides in community-acquired pneumonia: more smoke but is there any fire?
    Grant W Waterer
    Chest 123:1328-9. 2003
  31. ncbi request reprint Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia
    Michael W Quasney
    Division of Critical Care, Department of Pediatrics, University of Tennessee, Memphis, Children s Foundation Research Center of Memphis, Le Bonheur Children s Medical Center, 50 N Dunlap, Memphis, TN 38103, USA
    Crit Care Med 32:1115-9. 2004
    ..The objective was to determine whether the SP-B + 1580 CC genotype is associated with an increased risk of respiratory failure and ARDS in adults with community-acquired pneumonia...
  32. ncbi request reprint Community-acquired pneumonia: pathophysiology and host factors with focus on possible new approaches to management of lower respiratory tract infections
    Richard G Wunderink
    Northwestern University Feinberg School of Medicine, 676 North St Clair, Suite 14 044, Chicago, IL 60611, USA
    Infect Dis Clin North Am 18:743-59, vii. 2004
    ..This article reviews genetic variation in the molecules involved in the known patho-genic mechanisms of CAP, including cough, bacterial recognition, inflammation and the compensatory anti-inflammatory response,and organ dysfunction...
  33. ncbi request reprint Genetics of sepsis and pneumonia
    Richard G Wunderink
    Research Department, Methodist LeBonheur Healthcare, Memphis, Tennessee, USA
    Curr Opin Crit Care 9:384-9. 2003
    ..Recent association studies in pneumonia and sepsis will be reviewed...
  34. ncbi request reprint The impact of estrogen and progesterone on asthma
    Catherine L Haggerty
    Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Ann Allergy Asthma Immunol 90:284-91; quiz 291-3, 347. 2003
    ..This paper describes evidence of a positive effect of both endogenous and exogenous estrogen and progesterone on lung function across the life span in women...
  35. ncbi request reprint High-mobility group box 1 (HMGB1) as a potential therapeutic target in sepsis--more questions than answers
    Grant W Waterer
    Crit Care Med 35:1205-6. 2007
  36. ncbi request reprint Polymorphism studies in critical illness--we have to raise the bar
    Grant W Waterer
    Crit Care Med 35:1424-5. 2007
  37. ncbi request reprint Pleurodesis practice for malignant pleural effusions in five English-speaking countries: survey of pulmonologists
    Y C Gary Lee
    University of Oxford and Osler Chest Unit, Churchill Hospital, Oxford OX3 7BN, UK
    Chest 124:2229-38. 2003
    ..Pleurodesis is important in the management of malignant pleural effusions, but no consensus exists on the optimal agent or methods of pleurodesis. How pleurodesis is practiced worldwide has not been studied...