Robyn Lynne Ward

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Medical oncology
    Robyn L Ward
    St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010
    Med J Aust 176:25. 2002
  2. pmc Microsatellite instability and the clinicopathological features of sporadic colorectal cancer
    R Ward
    Department of Medical Oncology, St Vincent s Hospital, Victoria St, Darlinghurst, NSW, 2010, Australia
    Gut 48:821-9. 2001
  3. ncbi request reprint Impact of microsatellite testing and mismatch repair protein expression on the clinical interpretation of genetic testing in hereditary non-polyposis colorectal cancer
    Robyn Ward
    School of Medical Science, University of NSW, Sydney, Australia
    J Cancer Res Clin Oncol 128:403-11. 2002
  4. pmc The relationship between hypomethylation and CpG island methylation in colorectal neoplasia
    Carolyn Bariol
    Department of Medical Oncology, Saint Vincent s Hospital, Darlinghurst and School of Medicine, University of New South Wales, Sydney, Australia
    Am J Pathol 162:1361-71. 2003
  5. ncbi request reprint MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer
    Megan Hitchins
    Department of Medical Oncology, St Vincent s Hospital, Sydney, New South Wales, Australia
    Gastroenterology 129:1392-9. 2005
  6. pmc Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer
    N J Hawkins
    School of Pathology, University of NSW, Sydney, Australia
    Br J Cancer 84:232-6. 2001
  7. pmc Evaluation of models to predict BRCA germline mutations
    H H Kang
    Department of Medical Oncology, St Vincent s Hospital, Sydney, New South Wales, and Familial Cancer Service Westmead Institute for Cancer Research at Westmead Millenium Institute, University of Sydney, Australia
    Br J Cancer 95:914-20. 2006
  8. pmc CpG island methylation is a common finding in colorectal cancer cell lines
    C M Suter
    Department of Medical Oncology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Br J Cancer 88:413-9. 2003
  9. pmc Off-trial evaluation of bisphosphonates in patients with metastatic breast cancer
    Winston Liauw
    Department of Medical Oncology, St Vincent s Hospital, Sydney, Australia
    BMC Cancer 5:89. 2005
  10. pmc Restriction endonuclease-mediated selective polymerase chain reaction: a novel assay for the detection of K-ras mutations in clinical samples
    R Ward
    Department of Medical Oncology, St Vincent s Hospital, Sydney, New South Wales, Australia
    Am J Pathol 153:373-9. 1998

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Medical oncology
    Robyn L Ward
    St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010
    Med J Aust 176:25. 2002
  2. pmc Microsatellite instability and the clinicopathological features of sporadic colorectal cancer
    R Ward
    Department of Medical Oncology, St Vincent s Hospital, Victoria St, Darlinghurst, NSW, 2010, Australia
    Gut 48:821-9. 2001
    ....
  3. ncbi request reprint Impact of microsatellite testing and mismatch repair protein expression on the clinical interpretation of genetic testing in hereditary non-polyposis colorectal cancer
    Robyn Ward
    School of Medical Science, University of NSW, Sydney, Australia
    J Cancer Res Clin Oncol 128:403-11. 2002
    ..The aim of this study was to retrospectively assess the clinical utility of immunostaining and microsatellite instability testing in a group of individuals in whom germline testing of hMSH2 and hMLH1 had already been performed...
  4. pmc The relationship between hypomethylation and CpG island methylation in colorectal neoplasia
    Carolyn Bariol
    Department of Medical Oncology, Saint Vincent s Hospital, Darlinghurst and School of Medicine, University of New South Wales, Sydney, Australia
    Am J Pathol 162:1361-71. 2003
    ..Some hyperplastic colorectal polyps have a propensity to develop dense CpG island methylation. Hypermethylation and hypomethylation contribute separately to the process of carcinogenesis...
  5. ncbi request reprint MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer
    Megan Hitchins
    Department of Medical Oncology, St Vincent s Hospital, Sydney, New South Wales, Australia
    Gastroenterology 129:1392-9. 2005
    ..In this study, we determined the frequency and role of germline epimutations of MLH1 in HNPCC...
  6. pmc Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer
    N J Hawkins
    School of Pathology, University of NSW, Sydney, Australia
    Br J Cancer 84:232-6. 2001
    ..These findings may have important implications for treatment options in this disease subset...
  7. pmc Evaluation of models to predict BRCA germline mutations
    H H Kang
    Department of Medical Oncology, St Vincent s Hospital, Sydney, New South Wales, and Familial Cancer Service Westmead Institute for Cancer Research at Westmead Millenium Institute, University of Sydney, Australia
    Br J Cancer 95:914-20. 2006
    ..Use of models for predicting BRCA mutation status is not currently justified for populations such as that evaluated in the current study...
  8. pmc CpG island methylation is a common finding in colorectal cancer cell lines
    C M Suter
    Department of Medical Oncology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Br J Cancer 88:413-9. 2003
    ..We suggest that CRC cell lines may be only representative of a small subset of real tumours, and this should be taken into account in the use of CRC cell lines for epigenetic studies...
  9. pmc Off-trial evaluation of bisphosphonates in patients with metastatic breast cancer
    Winston Liauw
    Department of Medical Oncology, St Vincent s Hospital, Sydney, Australia
    BMC Cancer 5:89. 2005
    ..In this study we determined whether the proportion of patients experiencing a skeletal related event (SRE) in a clinical practice population was similar to that observed in phase III randomized controlled studies...
  10. pmc Restriction endonuclease-mediated selective polymerase chain reaction: a novel assay for the detection of K-ras mutations in clinical samples
    R Ward
    Department of Medical Oncology, St Vincent s Hospital, Sydney, New South Wales, Australia
    Am J Pathol 153:373-9. 1998
    ..In contrast to previous assays, restriction endonuclease-mediated selective PCR is not labor intensive, and its format is suitable for use in routine diagnostic laboratory...
  11. ncbi request reprint Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified
    Robyn Lynne Ward
    Department of Medical Oncology, St Vincent s Hospital, Victoria St, Darlinghurst, NSW 2010, Australia
    J Pathol 207:377-84. 2005
    ..Abnormal immunohistochemistry should be confirmed by microsatellite testing to ensure that false-positive results do not adversely impact on treatment decisions...
  12. ncbi request reprint The CpG island methylator phenotype is not associated with a personal or family history of cancer
    Robyn Lynne Ward
    Department of Medical Oncology, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    Cancer Res 64:7618-21. 2004
    ..There is no justification for altering the personal or family cancer screening recommendations on the basis of tumor CpG island methylator phenotype status...
  13. ncbi request reprint Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability
    Robyn Lynne Ward
    Department of Medical Oncology and Colorectal Surgery, St Vincent s Hospital, Darlinghurst, Australia
    J Clin Oncol 21:3729-36. 2003
    ..In this study, we sought to determine the prognostic significance of DNA methylation, both in univariate analysis and in concert with other clinicopathologic factors known to influence outcome...
  14. ncbi request reprint Checking the scoreboard: the impact of cancer genetics on clinical practice
    R L Ward
    Department of Medical Oncology, St Vincent s Hospital and School of Medicine, University of New South Wales, Sydney, Australia
    Intern Med J 31:249-53. 2001
    ..It considers some of the issues that may have served to lessen this impact, as well as some of the reasons for this apparent imbalance between action and outcome...
  15. ncbi request reprint Phase I clinical trial of the chimeric monoclonal antibody (c30.6) in patients with metastatic colorectal cancer
    R L Ward
    Cooperative Research Centre for Biopharmaceutical Research Ltd, Darlinghurst, New South Wales, Australia
    Clin Cancer Res 6:4674-83. 2000
    ..The chimerized c30.6 antibody is not immunogenic in humans and appears worthy of further study. It does, however, produce a unique profile of side effects that can be well controlled with premedication...
  16. ncbi request reprint Randomized trial of a decision aid for individuals considering genetic testing for hereditary nonpolyposis colorectal cancer risk
    Claire E Wakefield
    Department of Psychology, Macquarie University, New South Wales, Australia
    Cancer 113:956-65. 2008
    ..The goal of the current study was to measure the effectiveness of a tailored decision aid designed specifically to assist individuals to make informed decisions regarding genetic testing for HNPCC risk...
  17. ncbi request reprint Germline epimutation: A basis for epigenetic disease in humans
    David I K Martin
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    Ann N Y Acad Sci 1054:68-77. 2005
    ..The application of this principle to the thalassemias is discussed...
  18. doi request reprint Folate and one-carbon metabolism and its impact on aberrant DNA methylation in cancer
    Jia Jenny Liu
    Lowy Cancer Research Centre, University of New South Wales, Kensington, New South Wales, Australia
    Adv Genet 71:79-121. 2010
    ..While there remain numerous technical challenges in this important field of research, changes to folate intake appear to be capable of modulating DNA methylation levels in the human colonic mucosa and this may potentially alter CRC risk...
  19. ncbi request reprint CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability
    Nicholas Hawkins
    Department of Medical Oncology and Colorectal Surgery, St Vincent s Hospital, Darlinghurst, Australia
    Gastroenterology 122:1376-87. 2002
    ..We evaluated the extent of CpG island methylation in 426 sporadic colorectal cancers to define its relationship to microsatellite instability and to describe its clinicopathologic and genetic features...