Robyn L Ward

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. pmc The role of MYH and microsatellite instability in the development of sporadic colorectal cancer
    A Colebatch
    Department of Medical Oncology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    Br J Cancer 95:1239-43. 2006
  2. pmc Oesophagectomy rates and post-resection outcomes in patients with cancer of the oesophagus and gastro-oesophageal junction: a population-based study using linked health administrative linked data
    Efty P Stavrou
    Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia
    BMC Health Serv Res 12:384. 2012
  3. ncbi request reprint Population-based molecular screening for Lynch syndrome: implications for personalized medicine
    Robyn L Ward
    Lowy Cancer Research Centre, Prince of Wales Hospital, Randwick NSW 2031, Australia
    J Clin Oncol 31:2554-62. 2013
  4. pmc Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry
    Robyn L Ward
    Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Kensington, Australia
    Genet Med 15:25-35. 2013
  5. pmc A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines
    Luke B Hesson
    Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia
    Biol Proced Online 14:5. 2012
  6. pmc Identification of 5 novel genes methylated in breast and other epithelial cancers
    Victoria K Hill
    Department of Medical and Molecular Genetics, University of Birmingham, UK
    Mol Cancer 9:51. 2010
  7. ncbi request reprint MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa
    Nicholas J Hawkins
    School of Medical Sciences, University of NSW, Sydney, Australia
    Mod Pathol 22:1588-99. 2009
  8. ncbi request reprint Germline epimutation of MLH1 in individuals with multiple cancers
    Catherine M Suter
    Department of Medical Oncology, St Vincent s Hospital, Sydney, New South Wales, Australia
    Nat Genet 36:497-501. 2004
  9. ncbi request reprint Inheritance of a cancer-associated MLH1 germ-line epimutation
    Megan P Hitchins
    Department of Medical Oncology, St Vincent s Hospital, Sydney, Australia
    N Engl J Med 356:697-705. 2007
  10. doi request reprint Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer
    Justin J L Wong
    School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    Mod Pathol 24:396-411. 2011

Collaborators

Detail Information

Publications48

  1. pmc The role of MYH and microsatellite instability in the development of sporadic colorectal cancer
    A Colebatch
    Department of Medical Oncology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    Br J Cancer 95:1239-43. 2006
    ..Tumours arising in the setting of BER or mismatch repair deficiency may share a biological characteristic, which promotes lymphocytic infiltration...
  2. pmc Oesophagectomy rates and post-resection outcomes in patients with cancer of the oesophagus and gastro-oesophageal junction: a population-based study using linked health administrative linked data
    Efty P Stavrou
    Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia
    BMC Health Serv Res 12:384. 2012
    ....
  3. ncbi request reprint Population-based molecular screening for Lynch syndrome: implications for personalized medicine
    Robyn L Ward
    Lowy Cancer Research Centre, Prince of Wales Hospital, Randwick NSW 2031, Australia
    J Clin Oncol 31:2554-62. 2013
    ..We aimed to determine whether decisions of patients or clinicians reduced detection of Lynch syndrome...
  4. pmc Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry
    Robyn L Ward
    Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Kensington, Australia
    Genet Med 15:25-35. 2013
    ..Constitutional MLH1 epimutations manifest as promoter methylation and silencing of the affected allele in normal tissues, predisposing to Lynch syndrome-associated cancers. This study investigated their frequency and inheritance...
  5. pmc A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines
    Luke B Hesson
    Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia
    Biol Proced Online 14:5. 2012
    ..abstract:..
  6. pmc Identification of 5 novel genes methylated in breast and other epithelial cancers
    Victoria K Hill
    Department of Medical and Molecular Genetics, University of Birmingham, UK
    Mol Cancer 9:51. 2010
    ..We utilized one such recently developed approach, MIRA (methylated-CpG island recovery assay) combined with CpG island arrays to identify novel genes that are epigenetically inactivated in breast cancer...
  7. ncbi request reprint MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa
    Nicholas J Hawkins
    School of Medical Sciences, University of NSW, Sydney, Australia
    Mod Pathol 22:1588-99. 2009
    ....
  8. ncbi request reprint Germline epimutation of MLH1 in individuals with multiple cancers
    Catherine M Suter
    Department of Medical Oncology, St Vincent s Hospital, Sydney, New South Wales, Australia
    Nat Genet 36:497-501. 2004
    ..The mosaicism and nonmendelian inheritance that are characteristic of epigenetic states could produce patterns of disease risk that resemble those of polygenic or complex traits...
  9. ncbi request reprint Inheritance of a cancer-associated MLH1 germ-line epimutation
    Megan P Hitchins
    Department of Medical Oncology, St Vincent s Hospital, Sydney, Australia
    N Engl J Med 356:697-705. 2007
    ..These findings demonstrate a novel pattern of inheritance of cancer susceptibility and are consistent with transgenerational epigenetic inheritance...
  10. doi request reprint Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer
    Justin J L Wong
    School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    Mod Pathol 24:396-411. 2011
    ....
  11. ncbi request reprint Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer
    Mark W A Norrie
    Department of Medical Oncology, Schools of Medicine and Medical Science, St Vincent s Hospital, Darlinghurst, Australia
    J Surg Oncol 84:143-50. 2003
    ..Therefore, the aim of this study was to analyze loss of p16 expression and its relationship to hypermethylation in sporadic colorectal cancer...
  12. doi request reprint A correlation of the endoscopic characteristics of colonic laterally spreading tumours with genetic alterations
    Andrew J Metz
    Department of Gastroenterology, Westmead Hospital, Sydney, New South Wales, Australia
    Eur J Gastroenterol Hepatol 25:319-26. 2013
    ..It is currently unclear whether different molecular alterations determine their morphologies. We aimed to assess this relationship in LSTs using strict morphological classifications...
  13. doi request reprint Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome
    Chau To Kwok
    Medical Epigenetics Laboratory, Integrated Cancer Research Group, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia
    Fam Cancer 9:345-56. 2010
    ..Our findings illustrate that the study of allelic behaviour can complement conventional molecular analyses by providing new insight into the genetic or epigenetic mechanisms underlying disease...
  14. ncbi request reprint Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer
    Megan P Hitchins
    Department of Medical Oncology, St Vincent s Hospital, Victoria Street, Darlinghurst, New South Wales 2010, Australia
    Cancer Res 67:9107-16. 2007
    ..Simultaneous epigenetic silencing of this cluster of 3p22 genes may contribute to the development or progression of this type of cancer...
  15. doi request reprint Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa
    Jia Liu
    Lowy Cancer Research Centre and Prince of Wales Clinical School, Australia
    Cancer Prev Res (Phila) 5:921-9. 2012
    ..There was no evidence that mucosal global DNA methylation or folate distribution was related to the presence of cancer per se, suggesting that if abnormalities exist, they are confined to individual cells rather than the entire colon...
  16. pmc Reassembly of nucleosomes at the MLH1 promoter initiates resilencing following decitabine exposure
    Luke B Hesson
    Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    PLoS Genet 9:e1003636. 2013
    ....
  17. ncbi request reprint Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5'UTR
    Megan P Hitchins
    Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, Faculty of Medicine at the University of New South Wales, NSW 2052, Australia
    Cancer Cell 20:200-13. 2011
    ..27C > A located near the transcription initiation site and c.85G > T. The c.-27C > A variant significantly reduced transcriptional activity in reporter assays and is the probable cause of this epimutation...
  18. ncbi request reprint Histopathological and clinical evaluation of serrated adenomas of the colon and rectum
    Carolyn Bariol
    Schools of Medicine, University of New South Wales, Sydney, Australia
    Mod Pathol 16:417-23. 2003
    ..The optimum model for the histological identification of the serrated adenoma includes the presence of a serrated architecture in >/=20% of crypts in association with surface epithelial dysplasia...
  19. ncbi request reprint Epimutations and cancer predisposition: importance and mechanisms
    Luke B Hesson
    Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Kensington, New South Wales, Australia
    Curr Opin Genet Dev 20:290-8. 2010
    ..Understanding the origin of epimutations will inform cancer risk assessment and will also aid the design and application of new therapies that target the epigenome...
  20. doi request reprint Favoritism in DNA methylation
    Megan P Hitchins
    Level 1, EBB POW Hospital, High Street, Randwick, 2031, Sydney, Australia
    Cancer Prev Res (Phila) 2:847-9. 2009
    ..Aberrant MGMT methylation may identify individuals who could be targeted for cancer screening and chemoprevention strategies...
  21. doi request reprint A systematic review and meta-analysis of KRAS status as the determinant of response to anti-EGFR antibodies and the impact of partner chemotherapy in metastatic colorectal cancer
    Barbara Ann Adelstein
    Lowy Cancer Centre and Prince of Wales Clinical School, Faculty of Medicine, University of NSW, NSW 2052, Australia
    Eur J Cancer 47:1343-54. 2011
    ..This study systematically reviewed the evidence for KRAS mutation status as a treatment effect modifier of response to anti-EGFR antibodies and the influence of partner chemotherapy...
  22. doi request reprint Implementation of novel pyrosequencing assays to screen for common mutations of BRAF and KRAS in a cohort of sporadic colorectal cancers
    Deborah Packham
    Medical Oncology Department, St Vincent s Hospital Sydney, Darlinghurst, Australia
    Diagn Mol Pathol 18:62-71. 2009
    ..These assays would serve as a suitable platform for large-scale mutation detection in cancer specimens where the facility for pyrosequencing is available...
  23. ncbi request reprint Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue
    Catherine M Suter
    Medical Oncology Department, St Vincent s Hospital, Darlinghurst, 2010 Sydney, Australia
    Int J Colorectal Dis 19:95-101. 2004
    ..The bulk of cytosine methylation in the mammalian genome occurs on repetitive elements. This study analysed the methylation status of L1 retrotransposons in colorectal cancer...
  24. ncbi request reprint The role of hMLH1 methylation in the development of synchronous sporadic colorectal carcinomas
    Mark W A Norrie
    Department of Medical Oncology, St Vincent s Hospital, Darlinghurst, Australia
    Dis Colon Rectum 45:674-80. 2002
    ..We hypothesized that in the setting of sporadic microsatellite instability cancers, synchronicity may reflect a global predisposition of colorectal epithelium toward tumor development because of gene hypermethylation...
  25. ncbi request reprint Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33
    Lucy R Webster
    Sydney Medical School Westmead, University of Sydney, Westmead Westmead Institute for Cancer Research, Westmead Westmead Millennium Institute, Westmead Tissue Pathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead Translational Oncology, Sydney West Cancer Network, Western Sydney and Nepean Blue Mountains Local Health Districts, Westmead Anatomical Pathology, St Vincent s Hospital, Darlinghurst Prince of Wales Clinical School, University of New South Wales, Randwick School of Medical Sciences University of New South Wales, Randwick School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia Genetics Branch, National Cancer Institute, Bethesda MD USA these authors contributed equally to this work
    Pathology 45:629-36. 2013
    ..33 that were over-expressed in high grade cases, and showed a correlation between expression and gene copy number. The aim of this study was to investigate potential drivers of genomic amplification at 17q21.33...
  26. ncbi request reprint An audit of cancer of unknown primary notifications: A cautionary tale for population health research using cancer registry data
    Claire M Vajdic
    Adult Cancer Program, Prince of Wales Clinical School, University of New South Wales, Australia Electronic address
    Cancer Epidemiol 38:460-4. 2014
    ..Future population-based CUP research should take this into account, and consider stratification by basis of diagnosis due to differences in patient and tumour characteristics. ..
  27. ncbi request reprint Structural analysis of the ErbB-2 receptor using monoclonal antibodies: Implications for receptor signalling
    Yum L Yip
    School of Medicine, University of New South Wales, Sydney, Australia
    Int J Cancer 104:303-9. 2003
    ....
  28. ncbi request reprint Trastuzumab and metastatic breast cancer: trastuzumab use in Australia--monitoring the effect of an expensive medicine access program
    Sallie Anne Pearson
    School of Medicine, University of New South Wales, Australia
    J Clin Oncol 25:3688-93. 2007
    ..This study examines the extent to which the clinical practice use of trastuzumab for the treatment of metastatic breast cancer differs from its use under trial conditions...
  29. pmc Uptake of a web-based oncology protocol system: how do cancer clinicians use eviQ cancer treatments online?
    Julia M Langton
    Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia
    BMC Cancer 13:112. 2013
    ..Our objective was to examine the uptake of a web-based oncology protocol system (http://www.eviq.org.au) by Australian cancer clinicians...
  30. pmc Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries
    Viola A Heinzelmann-Schwarz
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    J Clin Pathol 60:622-6. 2007
    ....
  31. ncbi request reprint Standardizing care in medical oncology: are Web-based systems the answer?
    Isla M Hains
    University of New South Wales Cancer Research Centre, University of New South Wales, Sydney, Australia
    Cancer 115:5579-88. 2009
    ..The authors' aim was to determine the factors affecting the uptake and use of a Web-based protocol system for medical oncology in the Australian setting...
  32. pmc The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer
    Yan Ni Loh
    Adult Cancer Program, Level 2, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, New South Wales 2052, Australia
    BMC Cancer 13:174. 2013
    ..Here, our aim was to investigate if this key pathway was involved in acquired Tamoxifen resistance, and could be targeted therapeutically...
  33. doi request reprint Quantitative analysis of tissue folate using ultra high-performance liquid chromatography tandem mass spectrometry
    Jia Liu
    Prince of Wales Clinical School and Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
    Anal Biochem 411:210-7. 2011
    ..This assay would be useful in characterizing folate distribution in human and animal tissues as well as the role of deregulated folate homeostasis on disease pathogenesis...
  34. pmc The MLH1 c.-27C>A and c.85G>T variants are linked to dominantly inherited MLH1 epimutation and are borne on a European ancestral haplotype
    Chau To Kwok
    Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia
    Eur J Hum Genet 22:617-24. 2014
    ..Additional descendants bearing this founder haplotype may exist who are also at high risk of developing Lynch syndrome-related cancers. ..
  35. ncbi request reprint The serrated neoplasia pathway
    Nicholas J Hawkins
    Department of Pathology, School of Medical Sciences, University of NSW, Sydney, Australia
    Pathology 34:548-55. 2002
    ..Most notably, it requires pathologists to recognise the entity of the serrated adenoma, and also to recognise those features of hyperplastic polyps that may be associated with a potential for neoplastic progression...
  36. ncbi request reprint Clinicopathological correlates of GpIbalpha expression in human breast cancers
    Catherine M Suter
    Department of Medical Oncology, St Vincent s Hospital, Victoria St, Darlinghurst, NSW, Australia
    Anticancer Res 22:1251-5. 2002
    ..The current study examines the clinicopathological correlates of GPIbalpha expression in human breast cancer. Materials and..
  37. pmc The Wnt gatekeeper SFRP4 modulates EMT, cell migration and downstream Wnt signalling in serous ovarian cancer cells
    Caroline E Ford
    Wnt Signalling and Metastasis Group, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 8:e54362. 2013
    ..This raises the possibility that SFRP4 may be used both diagnostically and therapeutically in epithelial ovarian cancer...
  38. doi request reprint Establishing the clinical utility of epigenetic markers in cancer: many challenges ahead
    Peter Zarzour
    Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia
    Epigenomics 5:513-23. 2013
    ..In this special report, we will describe the challenges associated with developing epigenetic assays and the practical issues that must be overcome before they can be used in the clinic. ..
  39. doi request reprint The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis
    Caroline E Ford
    Wnt Signaling and Metastasis Group, Lowy Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Australia
    Int J Cancer 133:779-87. 2013
    ..This review will explore the dual role of ROR2 in tumorigenesis and provide an up to date analysis of current literature in this rapidly expanding field...
  40. ncbi request reprint Human papillomavirus (HPV) genotypes in an Australian sample of anal cancers
    Richard J Hillman
    Western Sydney Sexual Health Centre, University of Sydney, Westmead Hospital, Sydney, Australia
    Int J Cancer 135:996-1001. 2014
    ..However, given the mean age of onset of this condition, the vaccine is unlikely to have a significant impact for several decades. Further research is necessary to prove additional protective effects of the nHPV vaccine...
  41. ncbi request reprint C-kit mutations in gastrointestinal stromal tumours
    Adrienne L Morey
    Department of Anatomical Pathology, St Vincent s Hospital, Darlinghurst, NSW Australia
    Pathology 34:315-9. 2002
    ..In this study, the frequency of c-kit exon 11 mutations has been determined in a series of 18 gut stromal tumours...
  42. ncbi request reprint Current evidence does not support routine adjuvant radiotherapy for rectal cancer
    Alan P Meagher
    Department of Colorectal Surgery, St Vincents Hospital, Darlinghurst, New South Wales, Australia
    ANZ J Surg 72:835-40. 2002
    ..There is widespread support in the published literature for routine adjuvant radiotherapy for rectal cancer...
  43. ncbi request reprint Discrimination of pseudogene and parental gene DNA methylation using allelic bisulfite sequencing
    Luke B Hesson
    Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Kensington, Sydney, NSW, 2227, Australia
    Methods Mol Biol 1167:265-74. 2014
    ..Here, we discuss important points that should be considered when investigating pseudogene and parental gene methylation status and we describe the method of allelic bisulfite sequencing, including assay design. ..
  44. pmc Introducing research initiatives into healthcare: what do doctors think?
    Lucy Wyld
    1 Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
    Biopreserv Biobank 12:91-8. 2014
    ..This research project aims to explore doctors' views on the concept of institutional biobanking and to gain insight into the factors which impact the development of research initiatives within healthcare systems...
  45. ncbi request reprint Medical oncology
    Robyn L Ward
    St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010
    Med J Aust 176:25. 2002
  46. ncbi request reprint Analysis of IgE antibodies from a patient with atopic dermatitis: biased V gene usage and evidence for polyreactive IgE heavy chain complementarity-determining region 3
    Michael R Edwards
    School of Microbiology and Immunology, University of New South Wales, Kensington, Australia
    J Immunol 168:6305-13. 2002
    ..These results suggest that some IgE Abs may bind more than one Ag, which would have important implications for understanding the multiple sensitivities seen in conditions such as atopic dermatitis...
  47. ncbi request reprint Off-label use of medicines: consensus recommendations for evaluating appropriateness
    Madlen Gazarian
    University of New South Wales, Sydney, NSW, Australia
    Med J Aust 185:544-8. 2006
    ..This will reduce inappropriate use, enhance patient safety by reducing exposure to unnecessary risk, and may stimulate more clinically relevant medicines research...
  48. doi request reprint Minimal excess risk of cancer and reduced risk of death from cancer in Australian Department of Veterans' Affairs clients: a record linkage study
    Claire M Vajdic
    Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales
    Aust N Z J Public Health 38:30-4. 2014
    ..To quantify the risk of incident cancer and cancer-related mortality in Australian Government Department of Veterans' Affairs (DVA) clients...