Robyn L Ward

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. pmc Oesophagectomy rates and post-resection outcomes in patients with cancer of the oesophagus and gastro-oesophageal junction: a population-based study using linked health administrative linked data
    Efty P Stavrou
    Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia
    BMC Health Serv Res 12:384. 2012
  2. doi request reprint Population-based molecular screening for Lynch syndrome: implications for personalized medicine
    Robyn L Ward
    Lowy Cancer Research Centre, Prince of Wales Hospital, Randwick NSW 2031, Australia
    J Clin Oncol 31:2554-62. 2013
  3. doi request reprint Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry
    Robyn L Ward
    Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Kensington, Australia
    Genet Med 15:25-35. 2013
  4. pmc A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines
    Luke B Hesson
    Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia
    Biol Proced Online 14:5. 2012
  5. pmc Identification of 5 novel genes methylated in breast and other epithelial cancers
    Victoria K Hill
    Department of Medical and Molecular Genetics, University of Birmingham, UK
    Mol Cancer 9:51. 2010
  6. ncbi request reprint Inheritance of a cancer-associated MLH1 germ-line epimutation
    Megan P Hitchins
    Department of Medical Oncology, St Vincent s Hospital, Sydney, Australia
    N Engl J Med 356:697-705. 2007
  7. doi request reprint MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa
    Nicholas J Hawkins
    School of Medical Sciences, University of NSW, Sydney, Australia
    Mod Pathol 22:1588-99. 2009
  8. doi request reprint A correlation of the endoscopic characteristics of colonic laterally spreading tumours with genetic alterations
    Andrew J Metz
    Department of Gastroenterology, Westmead Hospital, Sydney, New South Wales, Australia
    Eur J Gastroenterol Hepatol 25:319-26. 2013
  9. doi request reprint Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome
    Chau To Kwok
    Medical Epigenetics Laboratory, Integrated Cancer Research Group, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia
    Fam Cancer 9:345-56. 2010
  10. doi request reprint Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer
    Justin J L Wong
    School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    Mod Pathol 24:396-411. 2011

Collaborators

Detail Information

Publications27

  1. pmc Oesophagectomy rates and post-resection outcomes in patients with cancer of the oesophagus and gastro-oesophageal junction: a population-based study using linked health administrative linked data
    Efty P Stavrou
    Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia
    BMC Health Serv Res 12:384. 2012
    ....
  2. doi request reprint Population-based molecular screening for Lynch syndrome: implications for personalized medicine
    Robyn L Ward
    Lowy Cancer Research Centre, Prince of Wales Hospital, Randwick NSW 2031, Australia
    J Clin Oncol 31:2554-62. 2013
    ..We aimed to determine whether decisions of patients or clinicians reduced detection of Lynch syndrome...
  3. doi request reprint Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry
    Robyn L Ward
    Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Kensington, Australia
    Genet Med 15:25-35. 2013
    ..Screening for these changes is warranted in individuals who have a negative germline sequence screen of MLH1 and loss of MLH1 expression in their tumor.Genet Med 2013:15(1):25-35...
  4. pmc A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines
    Luke B Hesson
    Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia
    Biol Proced Online 14:5. 2012
    ..abstract:..
  5. pmc Identification of 5 novel genes methylated in breast and other epithelial cancers
    Victoria K Hill
    Department of Medical and Molecular Genetics, University of Birmingham, UK
    Mol Cancer 9:51. 2010
    ..We utilized one such recently developed approach, MIRA (methylated-CpG island recovery assay) combined with CpG island arrays to identify novel genes that are epigenetically inactivated in breast cancer...
  6. ncbi request reprint Inheritance of a cancer-associated MLH1 germ-line epimutation
    Megan P Hitchins
    Department of Medical Oncology, St Vincent s Hospital, Sydney, Australia
    N Engl J Med 356:697-705. 2007
    ..These findings demonstrate a novel pattern of inheritance of cancer susceptibility and are consistent with transgenerational epigenetic inheritance...
  7. doi request reprint MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa
    Nicholas J Hawkins
    School of Medical Sciences, University of NSW, Sydney, Australia
    Mod Pathol 22:1588-99. 2009
    ....
  8. doi request reprint A correlation of the endoscopic characteristics of colonic laterally spreading tumours with genetic alterations
    Andrew J Metz
    Department of Gastroenterology, Westmead Hospital, Sydney, New South Wales, Australia
    Eur J Gastroenterol Hepatol 25:319-26. 2013
    ..It is currently unclear whether different molecular alterations determine their morphologies. We aimed to assess this relationship in LSTs using strict morphological classifications...
  9. doi request reprint Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome
    Chau To Kwok
    Medical Epigenetics Laboratory, Integrated Cancer Research Group, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, 2052, Australia
    Fam Cancer 9:345-56. 2010
    ..Our findings illustrate that the study of allelic behaviour can complement conventional molecular analyses by providing new insight into the genetic or epigenetic mechanisms underlying disease...
  10. doi request reprint Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer
    Justin J L Wong
    School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    Mod Pathol 24:396-411. 2011
    ....
  11. pmc Reassembly of nucleosomes at the MLH1 promoter initiates resilencing following decitabine exposure
    Luke B Hesson
    Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia
    PLoS Genet 9:e1003636. 2013
    ....
  12. doi request reprint Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5'UTR
    Megan P Hitchins
    Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, Faculty of Medicine at the University of New South Wales, NSW 2052, Australia
    Cancer Cell 20:200-13. 2011
    ..27C > A located near the transcription initiation site and c.85G > T. The c.-27C > A variant significantly reduced transcriptional activity in reporter assays and is the probable cause of this epimutation...
  13. doi request reprint Epimutations and cancer predisposition: importance and mechanisms
    Luke B Hesson
    Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Kensington, New South Wales, Australia
    Curr Opin Genet Dev 20:290-8. 2010
    ..Understanding the origin of epimutations will inform cancer risk assessment and will also aid the design and application of new therapies that target the epigenome...
  14. doi request reprint Favoritism in DNA methylation
    Megan P Hitchins
    Level 1, EBB POW Hospital, High Street, Randwick, 2031, Sydney, Australia
    Cancer Prev Res (Phila) 2:847-9. 2009
    ..Aberrant MGMT methylation may identify individuals who could be targeted for cancer screening and chemoprevention strategies...
  15. doi request reprint Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa
    Jia Liu
    Lowy Cancer Research Centre and Prince of Wales Clinical School, Australia
    Cancer Prev Res (Phila) 5:921-9. 2012
    ..There was no evidence that mucosal global DNA methylation or folate distribution was related to the presence of cancer per se, suggesting that if abnormalities exist, they are confined to individual cells rather than the entire colon...
  16. ncbi request reprint Histopathological and clinical evaluation of serrated adenomas of the colon and rectum
    Carolyn Bariol
    Schools of Medicine, University of New South Wales, Sydney, Australia
    Mod Pathol 16:417-23. 2003
    ..The optimum model for the histological identification of the serrated adenoma includes the presence of a serrated architecture in >/=20% of crypts in association with surface epithelial dysplasia...
  17. doi request reprint A systematic review and meta-analysis of KRAS status as the determinant of response to anti-EGFR antibodies and the impact of partner chemotherapy in metastatic colorectal cancer
    Barbara Ann Adelstein
    Lowy Cancer Centre and Prince of Wales Clinical School, Faculty of Medicine, University of NSW, NSW 2052, Australia
    Eur J Cancer 47:1343-54. 2011
    ..This study systematically reviewed the evidence for KRAS mutation status as a treatment effect modifier of response to anti-EGFR antibodies and the influence of partner chemotherapy...
  18. pmc Uptake of a web-based oncology protocol system: how do cancer clinicians use eviQ cancer treatments online?
    Julia M Langton
    Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia
    BMC Cancer 13:112. 2013
    ..Our objective was to examine the uptake of a web-based oncology protocol system (http://www.eviq.org.au) by Australian cancer clinicians...
  19. ncbi request reprint Germline epimutation of MLH1 in individuals with multiple cancers
    Catherine M Suter
    Department of Medical Oncology, St Vincent s Hospital, Sydney, New South Wales, Australia
    Nat Genet 36:497-501. 2004
    ..The mosaicism and nonmendelian inheritance that are characteristic of epigenetic states could produce patterns of disease risk that resemble those of polygenic or complex traits...
  20. doi request reprint Quantitative analysis of tissue folate using ultra high-performance liquid chromatography tandem mass spectrometry
    Jia Liu
    Prince of Wales Clinical School and Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
    Anal Biochem 411:210-7. 2011
    ..This assay would be useful in characterizing folate distribution in human and animal tissues as well as the role of deregulated folate homeostasis on disease pathogenesis...
  21. doi request reprint Establishing the clinical utility of epigenetic markers in cancer: many challenges ahead
    Peter Zarzour
    Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia
    Epigenomics 5:513-23. 2013
    ..In this special report, we will describe the challenges associated with developing epigenetic assays and the practical issues that must be overcome before they can be used in the clinic. ..
  22. doi request reprint The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis
    Caroline E Ford
    Wnt Signaling and Metastasis Group, Lowy Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Australia
    Int J Cancer 133:779-87. 2013
    ..This review will explore the dual role of ROR2 in tumorigenesis and provide an up to date analysis of current literature in this rapidly expanding field...
  23. doi request reprint Standardizing care in medical oncology: are Web-based systems the answer?
    Isla M Hains
    University of New South Wales Cancer Research Centre, University of New South Wales, Sydney, Australia
    Cancer 115:5579-88. 2009
    ..The authors' aim was to determine the factors affecting the uptake and use of a Web-based protocol system for medical oncology in the Australian setting...
  24. doi request reprint Minimal excess risk of cancer and reduced risk of death from cancer in Australian Department of Veterans' Affairs clients: a record linkage study
    Claire M Vajdic
    Adult Cancer Program, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales
    Aust N Z J Public Health 38:30-4. 2014
    ..To quantify the risk of incident cancer and cancer-related mortality in Australian Government Department of Veterans' Affairs (DVA) clients...
  25. pmc The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer
    Yan Ni Loh
    Adult Cancer Program, Level 2, Lowy Cancer Research Centre and Prince of Wales Clinical School, University of New South Wales, New South Wales 2052, Australia
    BMC Cancer 13:174. 2013
    ..Here, our aim was to investigate if this key pathway was involved in acquired Tamoxifen resistance, and could be targeted therapeutically...
  26. ncbi request reprint The serrated neoplasia pathway
    Nicholas J Hawkins
    Department of Pathology, School of Medical Sciences, University of NSW, Sydney, Australia
    Pathology 34:548-55. 2002
    ..Most notably, it requires pathologists to recognise the entity of the serrated adenoma, and also to recognise those features of hyperplastic polyps that may be associated with a potential for neoplastic progression...
  27. ncbi request reprint Trastuzumab and metastatic breast cancer: trastuzumab use in Australia--monitoring the effect of an expensive medicine access program
    Sallie Anne Pearson
    School of Medicine, University of New South Wales, Australia
    J Clin Oncol 25:3688-93. 2007
    ..This study examines the extent to which the clinical practice use of trastuzumab for the treatment of metastatic breast cancer differs from its use under trial conditions...