Natalie C Ward

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    J Hypertens 25:227-34. 2007
  2. ncbi request reprint Hypertension and oxidative stress
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Clin Exp Pharmacol Physiol 33:872-6. 2006
  3. ncbi request reprint 20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans
    Natalie C Ward
    School of Medicine and Pharmacology RPH, University of Western Australia, Level 4, Rear 50 Murray Street, Perth, WA 6000, Australia
    Diabetes Res Clin Pract 74:197-200. 2006
  4. ncbi request reprint Urinary 20-hydroxyeicosatetraenoic acid excretion is associated with oxidative stress in hypertensive subjects
    Natalie C Ward
    School of Medicine and Pharmachology, University of Western Ausralia, Perth, Australia
    Free Radic Biol Med 38:1032-6. 2005
  5. ncbi request reprint The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia and West Australian Institute for Medical Research WAIMR, Perth, Australia
    J Hypertens 23:427-34. 2005
  6. ncbi request reprint Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic Acid, an important metabolite of proanthocyanidins in humans
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia, and Western Australian Institute for Medical Research, Perth, Australia
    J Agric Food Chem 52:5545-9. 2004
  7. ncbi request reprint Brachial artery vasomotor function is inversely associated with 24-h ambulatory blood pressure
    Natalie C Ward
    University of Western Australia School of Medicine and Pharmacology, GPO X2213, Western Australian Institute for Medical Research WAIMR and Royal Perth Hospital, Perth, WA 6847, Australia
    J Hypertens 22:967-72. 2004
  8. ncbi request reprint Oxidative stress in human hypertension: association with antihypertensive treatment, gender, nutrition, and lifestyle
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia, Western Australian Institute for Medical Research WAIMR, Perth, Australia
    Free Radic Biol Med 36:226-32. 2004
  9. ncbi request reprint Effects of a nitrate-rich meal on arterial stiffness and blood pressure in healthy volunteers
    Alex H Liu
    School of Medicine and Pharmacology, University of Western Australia, Perth, GPO Box X2213, Perth, Western Australia 6847, Australia
    Nitric Oxide 35:123-30. 2013
  10. doi request reprint Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy women
    Catherine P Bondonno
    School of Medicine and Pharmacology, University of Western Australia, Medical Research Foundation, GPO Box X2213, Perth, Western Australia, WA 6000, Australia
    Food Funct 3:522-7. 2012

Detail Information

Publications25

  1. ncbi request reprint The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    J Hypertens 25:227-34. 2007
    ..Our aim was to investigate the effect of alpha-tocopherol and gamma-tocopherol supplementation on 24-h ambulatory blood pressure (BP) and heart rate, vascular function and oxidative stress in individuals with type 2 diabetes...
  2. ncbi request reprint Hypertension and oxidative stress
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Clin Exp Pharmacol Physiol 33:872-6. 2006
    ..Further studies investigating this relationship are warranted...
  3. ncbi request reprint 20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humans
    Natalie C Ward
    School of Medicine and Pharmacology RPH, University of Western Australia, Level 4, Rear 50 Murray Street, Perth, WA 6000, Australia
    Diabetes Res Clin Pract 74:197-200. 2006
    ..The results of the present study suggest that the observed positive association between urinary 20-HETE excretion and BMI may not be related to circulating insulin levels or insulin resistance...
  4. ncbi request reprint Urinary 20-hydroxyeicosatetraenoic acid excretion is associated with oxidative stress in hypertensive subjects
    Natalie C Ward
    School of Medicine and Pharmachology, University of Western Ausralia, Perth, Australia
    Free Radic Biol Med 38:1032-6. 2005
    ..In conclusion, the study highlights the positive association observed between 20-HETE excretion and markers of oxidative damage. The study also provides evidence that gamma-GT may be a useful marker of oxidative stress...
  5. ncbi request reprint The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia and West Australian Institute for Medical Research WAIMR, Perth, Australia
    J Hypertens 23:427-34. 2005
    ..Thus, dietary antioxidants may beneficially influence blood pressure (BP) and endothelial function by reducing oxidative stress...
  6. ncbi request reprint Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic Acid, an important metabolite of proanthocyanidins in humans
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia, and Western Australian Institute for Medical Research, Perth, Australia
    J Agric Food Chem 52:5545-9. 2004
    ..002). The observed increase in 3-HPP is in line with the suggestion that this compound is a major phenolic acid breakdown product of proanthocyanidin metabolism in vivo...
  7. ncbi request reprint Brachial artery vasomotor function is inversely associated with 24-h ambulatory blood pressure
    Natalie C Ward
    University of Western Australia School of Medicine and Pharmacology, GPO X2213, Western Australian Institute for Medical Research WAIMR and Royal Perth Hospital, Perth, WA 6847, Australia
    J Hypertens 22:967-72. 2004
    ..The extent to which such changes reflect the co-existence of other cardiovascular disease risk factors rather than an independent association with blood pressure remains uncertain...
  8. ncbi request reprint Oxidative stress in human hypertension: association with antihypertensive treatment, gender, nutrition, and lifestyle
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia, Western Australian Institute for Medical Research WAIMR, Perth, Australia
    Free Radic Biol Med 36:226-32. 2004
    ..The results do not support the hypothesis that treated or untreated hypertensive subjects are under increased oxidative stress compared with normotensive controls...
  9. ncbi request reprint Effects of a nitrate-rich meal on arterial stiffness and blood pressure in healthy volunteers
    Alex H Liu
    School of Medicine and Pharmacology, University of Western Australia, Perth, GPO Box X2213, Perth, Western Australia 6847, Australia
    Nitric Oxide 35:123-30. 2013
    ..If sustained, these effects could contribute to better cardiovascular health. ..
  10. doi request reprint Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy women
    Catherine P Bondonno
    School of Medicine and Pharmacology, University of Western Australia, Medical Research Foundation, GPO Box X2213, Perth, Western Australia, WA 6000, Australia
    Food Funct 3:522-7. 2012
    ....
  11. ncbi request reprint Effects of alpha-tocopherol and mixed tocopherol supplementation on markers of oxidative stress and inflammation in type 2 diabetes
    Jason H Y Wu
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
    Clin Chem 53:511-9. 2007
    ....
  12. ncbi request reprint Supplementation with mixed tocopherols increases serum and blood cell gamma-tocopherol but does not alter biomarkers of platelet activation in subjects with type 2 diabetes
    Michael W Clarke
    Department of Core Clinical Pathology and Biochemistry, Royal Perth Hospital, University of Western Australia, Perth, Australia
    Am J Clin Nutr 83:95-102. 2006
    ..Gamma-tocopherol, a major dietary form of vitamin E, may have protective properties different from those of alpha-tocopherol...
  13. ncbi request reprint Phenolic acid metabolites as biomarkers for tea- and coffee-derived polyphenol exposure in human subjects
    Jonathan M Hodgson
    University of Western Australia School of Medicine and Pharmacology, Royal Perth Hospital, Perth, Western Australia, Australia
    Br J Nutr 91:301-6. 2004
    ....
  14. ncbi request reprint Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia and West Australian Institute of Medical Research, Perth, Australia
    Circulation 110:438-43. 2004
    ..In humans, there are few data relating 20-HETE to vascular pathophysiology. This study aimed to determine whether urinary 20-HETE excretion is related to blood pressure or vascular endothelial function in humans...
  15. ncbi request reprint Nitration of gamma-tocopherol prevents its oxidative metabolism by HepG2 cells
    Jason H Y Wu
    School of Medicine and Pharmacology, University of Western Australia, PO Box X2213, GPO Perth 6847, West Australia
    Free Radic Biol Med 39:483-94. 2005
    ..Whether 5-NO2-gammaT could be metabolised via other pathways in vivo requires further investigation...
  16. doi request reprint Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trial
    Catherine P Bondonno
    School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
    Free Radic Biol Med 52:95-102. 2012
    ..In conclusion, flavonoid-rich apples and nitrate-rich spinach can independently augment nitric oxide status, enhance endothelial function, and lower blood pressure acutely, outcomes that may benefit cardiovascular health...
  17. ncbi request reprint Increased lean red meat intake does not elevate markers of oxidative stress and inflammation in humans
    Jonathan M Hodgson
    University of Western Australia, School of Medicine and Pharmacology at Royal Perth Hospital, Perth, Western Australia, Australia
    J Nutr 137:363-7. 2007
    ..4 (-3.4, 0.5) mg/L], and plasma fibrinogen concentrations [-0.08 (-0.40. 0.24) g/L]. Our results suggest that partial replacement of dietary carbohydrate with protein from lean red meat does not elevate oxidative stress or inflammation...
  18. doi request reprint A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure
    Natalie C Ward
    Schools of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Hypertension 51:1393-8. 2008
    ..The positive association between the CYP4F2 GA/AA genotype and both systolic blood pressure and 20-hydroxyeicosatetraenoic acid excretion strengthens a role for 20-hydroxyeicosatetraenoic acid in the modulation of blood pressure...
  19. ncbi request reprint The acute effect of flavonoid-rich apples and nitrate-rich spinach on cognitive performance and mood in healthy men and women
    Catherine P Bondonno
    School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
    Food Funct 5:849-58. 2014
    ..In conclusion, flavonoid-rich apples and nitrate-rich spinach augmented NO status acutely with no concomitant improvements or deterioration in cognitive function and mood. ..
  20. ncbi request reprint Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls
    Natalie C Ward
    School of Medicine and Pharmacology, University of Western Australia, and Stroke Unit, Sir Charles Gairdner Hospital, Perth, WA, Australia
    Clin Sci (Lond) 121:501-7. 2011
    ..Further investigation of the effect this has on long-term clinical outcome or whether this can be modified by treatment is warranted...
  21. ncbi request reprint Relationships of vascular function with measures of ambulatory blood pressure variation
    Jonathan M Hodgson
    School of Medicine and Pharmacology, University of Western Australia, GPO Box X2213 Perth, Western Australia 6847, Australia Electronic address
    Atherosclerosis 233:48-54. 2014
    ..Characteristics of short-term blood pressure (BP) variation may influence cardiovascular disease risk via effects on vascular function...
  22. ncbi request reprint Effects of tea and coffee on cardiovascular disease risk
    Siv K Bøhn
    School of Medicine and Pharmacology, The University of Western Australia M570, 35 Stirling Highway, Crawley, WA 6009, Australia
    Food Funct 3:575-91. 2012
    ..Although many biologically active compounds have been identified with known biological effects, tea and coffee contain many unidentified compounds with potential bioactivity...
  23. pmc Evidence for the nitration of gamma-tocopherol in vivo: 5-nitro-gamma-tocopherol is elevated in the plasma of subjects with coronary heart disease
    Lincoln W Morton
    Department of Medicine, University of Western Australia and Western Australian Institute for Medical Research, PO Box X2213, GPO Perth, Western Australia, 6001, Australia
    Biochem J 364:625-8. 2002
    ..In addition, we demonstrate in carotid-artery atherosclerotic plaque that nitration of gamma-tocopherol is also evident at levels similar to that seen in the plasma of subjects with coronary heart disease...
  24. ncbi request reprint The effect of a single nucleotide polymorphism of the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acid excretion after weight loss
    Natalie C Ward
    aUniversity of Western Australia, School of Medicine and Pharmacology, Royal Perth Hospital bSchool of Surgery and Pathology cWestern Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia
    J Hypertens 32:1495-502. 2014
    ..Gene variants of CYP4F2 and CYP4A11 associate with hypertension and stroke. We showed that a gene variant of CYP4F2 but not CYP4A11 was associated with increased 20-HETE excretion and BP...
  25. doi request reprint Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1
    Yu Shen
    Medical School, Department of Cardiology, Drum Tower Hospital, Nanjing University, Nanjing, China School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Free Radic Biol Med 65:908-15. 2013
    ..These effects are associated with improvements in nitric oxide bioavailability and are critically related to arterial induction of HO-1. ..