Research Topics
Species | Natalie C WardSummaryAffiliation: University of Western Australia Country: Australia Publications
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Publications
20-Hydroxyeicosatetraenoic acid is not associated with circulating insulin in lean to overweight humansNatalie C Ward
School of Medicine and Pharmacology RPH, University of Western Australia, Level 4, Rear 50 Murray Street, Perth, WA 6000, Australia
Diabetes Res Clin Pract 74:197-200. 2006..The results of the present study suggest that the observed positive association between urinary 20-HETE excretion and BMI may not be related to circulating insulin levels or insulin resistance...- Hypertension and oxidative stressNatalie C Ward
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
Clin Exp Pharmacol Physiol 33:872-6. 2006..Further studies investigating this relationship are warranted... - Urinary 20-hydroxyeicosatetraenoic acid excretion is associated with oxidative stress in hypertensive subjectsNatalie C Ward
School of Medicine and Pharmachology, University of Western Ausralia, Perth, Australia
Free Radic Biol Med 38:1032-6. 2005..In conclusion, the study highlights the positive association observed between 20-HETE excretion and markers of oxidative damage. The study also provides evidence that gamma-GT may be a useful marker of oxidative stress... - The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trialNatalie C Ward
School of Medicine and Pharmacology, University of Western Australia and West Australian Institute for Medical Research WAIMR, Perth, Australia
J Hypertens 23:427-34. 2005..Thus, dietary antioxidants may beneficially influence blood pressure (BP) and endothelial function by reducing oxidative stress... - Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic Acid, an important metabolite of proanthocyanidins in humansNatalie C Ward
School of Medicine and Pharmacology, University of Western Australia, and Western Australian Institute for Medical Research, Perth, Australia
J Agric Food Chem 52:5545-9. 2004..002). The observed increase in 3-HPP is in line with the suggestion that this compound is a major phenolic acid breakdown product of proanthocyanidin metabolism in vivo... - The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trialNatalie C Ward
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
J Hypertens 25:227-34. 2007..Our aim was to investigate the effect of alpha-tocopherol and gamma-tocopherol supplementation on 24-h ambulatory blood pressure (BP) and heart rate, vascular function and oxidative stress in individuals with type 2 diabetes... - Brachial artery vasomotor function is inversely associated with 24-h ambulatory blood pressureNatalie C Ward
University of Western Australia School of Medicine and Pharmacology, GPO X2213, Western Australian Institute for Medical Research WAIMR and Royal Perth Hospital, Perth, WA 6847, Australia
J Hypertens 22:967-72. 2004..The extent to which such changes reflect the co-existence of other cardiovascular disease risk factors rather than an independent association with blood pressure remains uncertain... - Oxidative stress in human hypertension: association with antihypertensive treatment, gender, nutrition, and lifestyleNatalie C Ward
School of Medicine and Pharmacology, University of Western Australia, Western Australian Institute for Medical Research WAIMR, Perth, Australia
Free Radic Biol Med 36:226-32. 2004..The results do not support the hypothesis that treated or untreated hypertensive subjects are under increased oxidative stress compared with normotensive controls... - Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy womenCatherine P Bondonno
School of Medicine and Pharmacology, University of Western Australia, Medical Research Foundation, GPO Box X2213, Perth, Western Australia, WA 6000, Australia
Food Funct 3:522-7. 2012.... - Effects of alpha-tocopherol and mixed tocopherol supplementation on markers of oxidative stress and inflammation in type 2 diabetesJason H Y Wu
School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
Clin Chem 53:511-9. 2007.... - Supplementation with mixed tocopherols increases serum and blood cell gamma-tocopherol but does not alter biomarkers of platelet activation in subjects with type 2 diabetesMichael W Clarke
Department of Core Clinical Pathology and Biochemistry, Royal Perth Hospital, University of Western Australia, Perth, Australia
Am J Clin Nutr 83:95-102. 2006..Changes in serum tocopherol closely reflect changes in cellular concentrations of tocopherols after supplementation... - Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humansNatalie C Ward
School of Medicine and Pharmacology, University of Western Australia and West Australian Institute of Medical Research, Perth, Australia
Circulation 110:438-43. 2004..Given the negative modulatory role of nitric oxide on omega-hydroxylase, the present results suggest a potentially important role for 20-HETE in human vascular physiology... - Phenolic acid metabolites as biomarkers for tea- and coffee-derived polyphenol exposure in human subjectsJonathan M Hodgson
University of Western Australia School of Medicine and Pharmacology, Royal Perth Hospital, Perth, Western Australia, Australia
Br J Nutr 91:301-6. 2004.... - Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trialCatherine P Bondonno
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Free Radic Biol Med 52:95-102. 2012..In conclusion, flavonoid-rich apples and nitrate-rich spinach can independently augment nitric oxide status, enhance endothelial function, and lower blood pressure acutely, outcomes that may benefit cardiovascular health... - Nitration of gamma-tocopherol prevents its oxidative metabolism by HepG2 cellsJason H Y Wu
School of Medicine and Pharmacology, University of Western Australia, PO Box X2213, GPO Perth 6847, West Australia
Free Radic Biol Med 39:483-94. 2005..Whether 5-NO2-gammaT could be metabolised via other pathways in vivo requires further investigation... - Increased lean red meat intake does not elevate markers of oxidative stress and inflammation in humansJonathan M Hodgson
University of Western Australia, School of Medicine and Pharmacology at Royal Perth Hospital, Perth, Western Australia, Australia
J Nutr 137:363-7. 2007..4 (-3.4, 0.5) mg/L], and plasma fibrinogen concentrations [-0.08 (-0.40. 0.24) g/L]. Our results suggest that partial replacement of dietary carbohydrate with protein from lean red meat does not elevate oxidative stress or inflammation... - A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressureNatalie C Ward
Schools of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Hypertension 51:1393-8. 2008..The positive association between the CYP4F2 GA/AA genotype and both systolic blood pressure and 20-hydroxyeicosatetraenoic acid excretion strengthens a role for 20-hydroxyeicosatetraenoic acid in the modulation of blood pressure... - Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controlsNatalie C Ward
School of Medicine and Pharmacology, University of Western Australia, and Stroke Unit, Sir Charles Gairdner Hospital, Perth, WA, Australia
Clin Sci (Lond) 121:501-7. 2011..Further investigation of the effect this has on long-term clinical outcome or whether this can be modified by treatment is warranted... - Effects of tea and coffee on cardiovascular disease riskSiv K Bøhn
School of Medicine and Pharmacology, The University of Western Australia M570, 35 Stirling Highway, Crawley, WA 6009, Australia
Food Funct 3:575-91. 2012..Although many biologically active compounds have been identified with known biological effects, tea and coffee contain many unidentified compounds with potential bioactivity... 
Evidence for the nitration of gamma-tocopherol in vivo: 5-nitro-gamma-tocopherol is elevated in the plasma of subjects with coronary heart diseaseLincoln W Morton
Department of Medicine, University of Western Australia and Western Australian Institute for Medical Research, PO Box X2213, GPO Perth, Western Australia, 6001, Australia
Biochem J 364:625-8. 2002..In addition, we demonstrate in carotid-artery atherosclerotic plaque that nitration of gamma-tocopherol is also evident at levels similar to that seen in the plasma of subjects with coronary heart disease...