Research Topics
Genomes and Genes | Peter M VisscherSummaryAffiliation: University of Queensland Country: Australia Publications
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Publications
Five years of GWAS discoveryPeter M Visscher
University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Am J Hum Genet 90:7-24. 2012..We return to the perceived failure or disappointment about GWASs in the concluding section...- Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traitsJian Yang
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Nat Genet 44:369-75, S1-3. 2012..The method we present is computationally fast and is also applicable to case-control data, which we demonstrate in an example from meta-analysis of type 2 diabetes by the DIAGRAM Consortium... - The Brisbane Systems Genetics Study: genetical genomics meets complex trait geneticsJoseph E Powell
University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
PLoS ONE 7:e35430. 2012..These associations corresponded to a total of 2,081 expression quantitative trait loci (eQTL) involving 1,503 probes. The majority of identified eQTL (87%) were located within cis-regions... - Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independentJoseph E Powell
Queensland Institute of Medical Research, Herston, Brisbane, QLD 4006, Australia
Genome Res 22:456-66. 2012.... - Common SNPs explain a large proportion of the heritability for human heightJian Yang
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Nat Genet 42:565-9. 2010.... - Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in AustraliaManuel A R Ferreira
Queensland Institute of Medical Research, Brisbane, QLD, Australia
Eur J Hum Genet 19:458-64. 2011..In conclusion, we confirm the association between asthma risk and variants in ORMDL3 and identify a novel risk variant in IL1RL1. Follow-up of the 17q21 deletion in larger cohorts is warranted... - Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPsS Hong Lee
Queensland Brain Institute, University of Queensland, Brisbane, Australia
Nat Genet 44:247-50. 2012..6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases... - Identification of IL6R and chromosome 11q13.5 as risk loci for asthmaManuel A R Ferreira
The Queensland Institute of Medical Research, Brisbane, QLD, Australia
Lancet 378:1006-14. 2011..We aimed to identify novel genetic variants affecting asthma risk, since these might provide novel insights into molecular mechanisms underlying the disease... 
LPAR1 and ITGA4 regulate peripheral blood monocyte countsNarelle Maugeri
Queensland Institute of Medical Research, Brisbane, Australia
Hum Mutat 32:873-6. 2011..Further studies that investigate the downstream mechanism involved and the impact on immune function are warranted...- FTO genotype is associated with phenotypic variability of body mass indexJian Yang
University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia
Nature 490:267-72. 2012.... - A versatile gene-based test for genome-wide association studiesJimmy Z Liu
Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
Am J Hum Genet 87:139-45. 2010..We have implemented the approach in both an easy-to-use web interface, which only requires the uploading of markers with their association p-values, and a separate downloadable application... - Association of variants in MMEL1 and CTLA4 with rheumatoid arthritis in the Han Chinese populationPatrick Danoy
Human Genetics Group, The University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Ann Rheum Dis 70:1793-7. 2011..However, few studies have tried to dissect disease aetiopathogenesis in other ethnic populations... - A better coefficient of determination for genetic profile analysisSang Hong Lee
Queensland Institute of Medical Research, Brisbane, QLD 4072, Australia
Genet Epidemiol 36:214-24. 2012..Furthermore, even when using ascertained case-control studies that are typical in human disease studies, we can obtain an R(2) measure on the liability scale that can be compared directly to heritability... - Common variants in TMPRSS6 are associated with iron status and erythrocyte volumeBeben Benyamin
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Nat Genet 41:1173-5. 2009..1 x 10(-10)). We also find suggestive evidence of association with blood hemoglobin levels (combined P = 5.3 x 10(-7)). These findings demonstrate the involvement of TMPRSS6 in control of iron homeostasis and in normal erythropoiesis... - Genomic inflation factors under polygenic inheritanceJian Yang
Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Eur J Hum Genet 19:807-12. 2011..Our predictions are consistent with empirical observations on height in independent samples of ~4000 and ~133,000 individuals... - GCTA: a tool for genome-wide complex trait analysisJian Yang
Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia
Am J Hum Genet 88:76-82. 2011..The GCTA software is a versatile tool to estimate and partition complex trait variation with large GWAS data sets... - Using the realized relationship matrix to disentangle confounding factors for the estimation of genetic variance components of complex traitsSang Hong Lee
Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane, Australia
Genet Sel Evol 42:22. 2010..Dominance and epistatic effects are typically confounded with additive genetic and non-genetic effects. This confounding may cause the estimated genetic variance components to be inaccurate and biased... - Genome partitioning of genetic variation for complex traits using common SNPsJian Yang
Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
Nat Genet 43:519-25. 2011.... - Genome-wide association study identifies a locus at 7p15.2 associated with endometriosisJodie N Painter
Molecular Epidemiology, Queensland Institute of Medical Research, Herston, Queensland, Australia
Nat Genet 43:51-4. 2011..4 × 10⁻⁹ (OR = 1.20, 95% CI 1.13-1.27) for 'all' endometriosis in our combined datasets of 5,586 cases and 9,331 controls. rs12700667 is located in an intergenic region upstream of the plausible candidate genes NFE2L3 and HOXA10... - Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han ChineseStuart I Davidson
The University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
Ann Rheum Dis 70:289-92. 2011..A candidate gene study in a Han Chinese population was performed based on these findings to identify associated genes in this population... - Whole-genome genetic diversity in a sample of Australians with deep Aboriginal ancestryBrian P McEvoy
Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
Am J Hum Genet 87:297-305. 2010.... - Reconciling the analysis of IBD and IBS in complex trait studiesJoseph E Powell
Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia
Nat Rev Genet 11:800-5. 2010..Recognizing this aim leads to better methods to estimating IBD with benefits in mapping genes, estimating genetic variance and predicting inbreeding depression... - A commentary on 'common SNPs explain a large proportion of the heritability for human height' by Yang et al. (2010)Peter M Visscher
Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
Twin Res Hum Genet 13:517-24. 2010..We also report a number of additional results that show that the estimates of additive genetic variation are not driven by population structure... 
Cattle gain staturePeter M Visscher
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Nat Genet 43:397-8. 2011..A new study combines the advantages of gene mapping in livestock with elegant genetic and functional analyses to address these challenges and identifies candidate regulatory variants affecting stature in cattle...