Bradley J Turner

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi ER stress and UPR in familial amyotrophic lateral sclerosis
    Bradley J Turner
    Howard Florey Institute, University of Melbourne, Victoria, Australia
    Curr Mol Med 6:79-86. 2006
  2. ncbi Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis
    Bradley J Turner
    Motor Neuron Disease Research Laboratory, Brain Injury and Repair Group, Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia
    J Neurosci 25:108-17. 2005
  3. ncbi Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1
    Julie D Atkin
    Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, USA
    J Biol Chem 281:30152-65. 2006
  4. ncbi Antisense peptide nucleic acid-mediated knockdown of the p75 neurotrophin receptor delays motor neuron disease in mutant SOD1 transgenic mice
    Bradley J Turner
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 87:752-63. 2003
  5. ncbi Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS
    Alan Rembach
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria, Australia
    J Neurosci Res 77:573-82. 2004
  6. ncbi Brain beta-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1
    Bradley J Turner
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia
    Neurochem Res 29:2281-6. 2004
  7. ncbi Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis
    Julie D Atkin
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Melbourne, Australia Department of Florey Neuroscience, University of Melbourne, Parkville, Melbourne, Australia
    J Neurochem 129:190-204. 2014
  8. pmc Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model
    Cynthia P W Soon
    Department of Pathology, Mental Health Research Institute, School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia
    J Biol Chem 286:44035-44. 2011
  9. ncbi Effect of p75 neurotrophin receptor antagonist on disease progression in transgenic amyotrophic lateral sclerosis mice
    Bradley J Turner
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne, Victoria, Australia
    J Neurosci Res 78:193-9. 2004
  10. ncbi Inducible superoxide dismutase 1 aggregation in transgenic amyotrophic lateral sclerosis mouse fibroblasts
    Bradley J Turner
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria, Australia
    J Cell Biochem 91:1074-84. 2004

Collaborators

Detail Information

Publications19

  1. ncbi ER stress and UPR in familial amyotrophic lateral sclerosis
    Bradley J Turner
    Howard Florey Institute, University of Melbourne, Victoria, Australia
    Curr Mol Med 6:79-86. 2006
    ..We propose that ER stress and UPR may be coupled to GA dysfunction in mutant SOD1-mediated toxicity, promoting ER-initiated cell death signalling in FALS...
  2. ncbi Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis
    Bradley J Turner
    Motor Neuron Disease Research Laboratory, Brain Injury and Repair Group, Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia
    J Neurosci 25:108-17. 2005
    ..Collectively, these results suggest novel extracellular roles for SOD1 in ALS and support a causal relationship between mutant SOD1 secretion and intraneuronal toxicity...
  3. ncbi Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1
    Julie D Atkin
    Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, USA
    J Biol Chem 281:30152-65. 2006
    ..The possibility that PDI may be a therapeutic target to prevent SOD1 aggregation is also raised by this study...
  4. ncbi Antisense peptide nucleic acid-mediated knockdown of the p75 neurotrophin receptor delays motor neuron disease in mutant SOD1 transgenic mice
    Bradley J Turner
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 87:752-63. 2003
    ..The uptake of fluorescent-labelled antisense PNA in the nervous system of transgenic mice was also confirmed. This study suggests that p75NTR may be a promising antisense target in the treatment of ALS...
  5. ncbi Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS
    Alan Rembach
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria, Australia
    J Neurosci Res 77:573-82. 2004
    ....
  6. ncbi Brain beta-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1
    Bradley J Turner
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria 3010, Australia
    Neurochem Res 29:2281-6. 2004
    ..We therefore conclude that mutant SOD1 overexpression promotes neither Abeta toxicity nor brain accumulation in these ALS models...
  7. ncbi Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis
    Julie D Atkin
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Melbourne, Australia Department of Florey Neuroscience, University of Melbourne, Parkville, Melbourne, Australia
    J Neurochem 129:190-204. 2014
    ..These findings thus link several cellular events in amyotrophic lateral sclerosis into a single mechanism occurring early in mSOD1 expressing cells...
  8. pmc Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model
    Cynthia P W Soon
    Department of Pathology, Mental Health Research Institute, School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia
    J Biol Chem 286:44035-44. 2011
    ..CuII(atsm) therefore represents a potential new class of neuroprotective agents targeting multiple major disease pathways of motor neurons with therapeutic potential for ALS...
  9. ncbi Effect of p75 neurotrophin receptor antagonist on disease progression in transgenic amyotrophic lateral sclerosis mice
    Bradley J Turner
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne, Victoria, Australia
    J Neurosci Res 78:193-9. 2004
    ..Thus, alternate ligand-independent pathways of p75(NTR) activation or additional NGF receptor targets may contribute to motor neuron degeneration in ALS mice...
  10. ncbi Inducible superoxide dismutase 1 aggregation in transgenic amyotrophic lateral sclerosis mouse fibroblasts
    Bradley J Turner
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Victoria, Australia
    J Cell Biochem 91:1074-84. 2004
    ..We propose that non-neural cultures such as these transgenic fibroblasts with inducible SOD1 aggregation may be useful for rapid screening of compounds with anti-aggregation potential in FALS...
  11. ncbi Neuromuscular accumulation of mutant superoxide dismutase 1 aggregates in a transgenic mouse model of familial amyotrophic lateral sclerosis
    Bradley J Turner
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne, Victoria 3010, Australia
    Neurosci Lett 350:132-6. 2003
    ....
  12. ncbi The beta-amyloid peptide of Alzheimer's disease decreases adhesion of vascular smooth muscle cells to the basement membrane
    Su San Mok
    Department of Pathology, University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 96:53-64. 2006
    ..An inhibitor of ERK1/2 phosphorylation enhanced the effect of Abeta on cell adhesion. The studies suggest that Abeta can decrease VSMC viability by disrupting VSMC-extracellular matrix (ECM) adhesion...
  13. pmc Mutant TDP-43 Deregulates AMPK activation by PP2A in ALS models
    Nirma D Perera
    Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Melbourne, Victoria, Australia Centre for Neuroscience, University of Melbourne, Parkville, Melbourne, Victoria, Australia
    PLoS ONE 9:e90449. 2014
    ..While AMPK activation in motor neurons correlateswith progressionin mutant SOD1-mediated disease, AMPK inactivation mediated by PP2Ais associated withmutant TDP-43-linked ALS. ..
  14. pmc ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation
    Adam K Walker
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 8:e81170. 2013
    ..This study provides evidence for ER stress as a pathogenic pathway in TDP-43-mediated disease. ..
  15. pmc Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice
    Bradley J Turner
    Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia Centre for Neuroscience, University of Melbourne, Parkville, Victoria, Australia Electronic address
    Neurobiol Aging 35:906-15. 2014
    ..Studies in emerging mouse models of ALS are therefore warranted to further explore the potential of SMN as a modifier of ALS. ..
  16. ncbi Design and application of a peptide nucleic acid sequence targeting the p75 neurotrophin receptor
    Irwin K Cheah
    School of Chemistry, Monash University, 3800, Victoria, Australia
    Bioorg Med Chem Lett 13:2377-80. 2003
    ..The 19-mer PS-ODN sequences also failed to confer any activity against p75NTR but, unlike the PNA sequences, were toxic in vitro at comparable doses...
  17. ncbi Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine
    Su San Mok
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    Eur J Biochem 269:3014-22. 2002
    ..Our studies also suggest that homocysteine, a known risk factor for other cardiovascular diseases, could also be a risk factor for hemorrhagic stroke associated with CAA...
  18. doi Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS
    Bradley J Turner
    MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
    Prog Neurobiol 85:94-134. 2008
    ..This review summarises the wealth of known genetic and therapeutic modifiers in rodent models with SOD1 mutations and discusses these in the wider context of ALS pathoetiology and treatment...
  19. ncbi Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A G1H) mouse model of familial amyotrophic lateral sclerosis
    Michael F Azari
    Department of Anatomy and Cell Biology, Faculty of Medicine, P O Box 13C, Monash University, 3800 Victoria, Australia
    Brain Res 982:92-7. 2003
    ..However, we found no significant rescue of motoneurons or prolongation of survival as a result of this systemic dose of LIF in these mice...