Research Topics
Species | Meri K TulicSummaryAffiliation: University of Western Australia Country: Australia Publications
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Detail Information
Publications
Changes in thymic regulatory T-cell maturation from birth to puberty: differences in atopic childrenMeri K Tulic
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 129:199-206.e1-4. 2012..Characterization of regulatory immune pathways is a research priority for both the pathogenesis of allergic disease and potential therapeutic strategies...
Differences in innate immune function between allergic and nonallergic children: new insights into immune ontogenyMeri K Tulic
Childhood Allergy and Immunology Research, School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 127:470-478.e1. 2011..Microbial products are of central interest in the modulation of allergic propensity...
Associations between maternal antioxidant intakes in pregnancy and infant allergic outcomesChristina E West
School of Paediatrics and Child Health Research, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth WA 6001, Australia
Nutrients 4:1747-58. 2012..In summary, this study suggests that maternal diet of fresh foods rich in vitamin C is associated with reduced risk of infant wheeze, and that copper intake is associated with reduced risk of several allergic outcomes...
Presymptomatic differences in Toll-like receptor function in infants who have allergySusan L Prescott
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 122:391-9, 399.e1-5. 2008..Microbial exposure might play a key role in allergy development, but little is known about the role of Toll-like receptors (TLRs)...
Thymic indoleamine 2,3-dioxygenase-positive eosinophils in young children: potential role in maturation of the naive immune systemMeri K Tulic
Centre for Child Health Research, University of Western Australia, Perth, Australia
Am J Pathol 175:2043-52. 2009..57, P = 0.02) and toll-like receptor 4 expression (r = -0.74, P = 0.002). Taken together, these results suggest that functional thymic IDO+ eosinophils during human infant life may have an immunomodulatory role in Th2 immune responses...
Progress in understanding postnatal immune dysregulation in allergic diseaseSusan L Prescott
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia
World Allergy Organ J 3:162-6. 2010..To further understand the pathogenesis of these altered patterns of immune response, future research needs to encompass the complexity of gene-environmental interactions, which confer individual susceptibility to environmental exposures...
IFN-λ and IgE-mediated allergic disease: a potential future role?Silvana Gaudieri
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
Biomark Med 6:151-7. 2012..More recently, a genetic variation flanking IL28B encoding IFN-λ3 has been associated with allergic disease. Here, we examine this family and suggest how IFN-λ may be an important player in allergic disease...
Neonatal innate cytokine responses to BCG controlling T-cell development vary between populationsAnita H J van den Biggelaar
Telethon Institute for Child Health Research, Center for Child Health Research, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 124:544-50, 550.e1-2. 2009..The protective effect of Mycobacterium bovis BCG vaccination against infection and atopy varies between populations...
Role of toll-like receptor 4 in protection by bacterial lipopolysaccharide in the nasal mucosa of atopic children but not adultsMeri K Tulic
Meakins Christie Laboratories, Notre Dame Hospital and Institut ORL de Montréal, Montreal, Quebec, Canada
Lancet 363:1689-97. 2004..We examined the effect of bacterial lipopolysaccharide on allergic inflammation and expression of cytokines and lipopolysaccharide receptor (toll-like receptor 4 TLR4) in nasal mucosa of 15 atopic children and ten atopic adults...
Algorithmic models to predict allergic disease using multiple neonatal markersMegan Hodder
School of Pediatrics and Child Health Research, University of Western Australia Perth Western Australia P O Box D184, Princess Margaret Hospital, Perth WA 6001, Australia
Indian Pediatr 46:291-2. 2009....
Evidence for age-related and individual-specific changes in DNA methylation profile of mononuclear cells during early immune development in humansDavid J Martino
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
Epigenetics 6:1085-94. 2011..Further studies are now needed to examine evolving epigenetic variations in specific cell populations in relation to environmental exposures, immune phenotype and subsequent disease susceptibility...
Vitamin D and allergic disease: sunlight at the end of the tunnel?Anderson P Jones
School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia 6008, Australia
Nutrients 4:13-28. 2012..This review explores the findings of epidemiological, clinical and laboratory research, and the potential role of vitamin D in promoting the inappropriate immune responses which underpin the rise in a broad range of immune diseases...
Genetic variations in IL28B and allergic disease in childrenSilvana Gaudieri
School of Anatomy and Human Biology, University of Western Australia, Nedlands, Australia
PLoS ONE 7:e30607. 2012..In the context of rising rates of disease, these immunologic differences already present at birth imply very early interaction between genetic predisposition and prenatal environmental influences...
Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell functionMiranda Smith
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
J Allergy Clin Immunol 121:1460-6, 1466.e1-7. 2008..The role of regulatory T (Treg) cells in allergic predisposition is not known...
Local induction of a specific Th1 immune response by allergen linked immunostimulatory DNA in the nasal explants of ragweed-allergic subjectsMeri K Tulic
School of Pediatrics and Child Health, University of Western Australia, Australia
Allergol Int 58:565-72. 2009..In addition, we set out to determine whether AIC is more effective compared to stimulation with unlinked Amb a 1 and ISS...
TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharideMeri K Tulic
Division of Cell Biology, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, West Perth, WA 6872, Australia
J Immunol 179:132-40. 2007..Compromised first-line defense against RSV at the airway-epithelial surface of children expressing these TLR4 variants may thus confer increased susceptibility to severe infections with this virus...
