Istvan Toth

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi request reprint Development of conformational mimetics of conserved Streptococcus pyogenes minimal epitope as vaccine candidates
    Wei Zhong
    The School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia
    Curr Drug Deliv 6:520-7. 2009
  2. doi request reprint Peptide conjugation via CuAAC 'click' chemistry
    Abdullah A H Ahmad Fuaad
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia
    Molecules 18:13148-74. 2013
  3. ncbi request reprint Peptides as therapeutics with enhanced bioactivity
    D Goodwin
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    Curr Med Chem 19:4451-61. 2012
  4. ncbi request reprint Synthetic polyacrylate polymers as particulate intranasal vaccine delivery systems for the induction of mucosal immune response
    Mehfuz Zaman
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia
    Curr Drug Deliv 7:118-24. 2010
  5. doi request reprint Development of a liposaccharide-based delivery system and its application to the design of group A streptococcal vaccines
    Pavla Simerska
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 51:1447-52. 2008
  6. ncbi request reprint Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein
    Colleen Olive
    Cooperative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    J Infect Dis 194:316-24. 2006
  7. doi request reprint Synthesis and in vivo studies of carbohydrate-based vaccines against group A streptococcus
    Pavla Simerska
    School of Molecular and Microbial Sciences SMMS, The University of Queensland, St Lucia, Queensland 4072, Australia
    Biopolymers 90:611-6. 2008
  8. pmc Potential of lipid core peptide technology as a novel self-adjuvanting vaccine delivery system for multiple different synthetic peptide immunogens
    Colleen Olive
    Cooperative Research Centre for Vaccine Technology, Division of Infectious Diseases and Immunology, The Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Infect Immun 71:2373-83. 2003
  9. doi request reprint In vitro and in vivo evaluation of positively charged liposaccharide derivatives as oral absorption enhancers for the delivery of anionic drugs
    Julie A Bergeon
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia
    J Pharm Sci 99:2333-42. 2010
  10. ncbi request reprint Immunization with a tetraepitopic lipid core peptide vaccine construct induces broadly protective immune responses against group A streptococcus
    Colleen Olive
    Cooperative Research Centre for Vaccine Technology, Queensland Institute of Medical Research, Brisbane, Australia
    J Infect Dis 193:1666-76. 2006

Collaborators

Detail Information

Publications99

  1. ncbi request reprint Development of conformational mimetics of conserved Streptococcus pyogenes minimal epitope as vaccine candidates
    Wei Zhong
    The School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia
    Curr Drug Deliv 6:520-7. 2009
    ..Circular dichroism studies indicated that the template-assembled peptides formed alpha-helix bundles. This atom-economic strategy also reduces the complexity and cost of vaccine production by simply reducing the peptide epitope size...
  2. doi request reprint Peptide conjugation via CuAAC 'click' chemistry
    Abdullah A H Ahmad Fuaad
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia
    Molecules 18:13148-74. 2013
    ....
  3. ncbi request reprint Peptides as therapeutics with enhanced bioactivity
    D Goodwin
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    Curr Med Chem 19:4451-61. 2012
    ..This review describes the established and experimental approaches for manufacturing peptide drugs and highlights the techniques currently used for improving their drug like properties...
  4. ncbi request reprint Synthetic polyacrylate polymers as particulate intranasal vaccine delivery systems for the induction of mucosal immune response
    Mehfuz Zaman
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia
    Curr Drug Deliv 7:118-24. 2010
    ....
  5. doi request reprint Development of a liposaccharide-based delivery system and its application to the design of group A streptococcal vaccines
    Pavla Simerska
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 51:1447-52. 2008
    ..High serum IgG antibody titers against each of the incorporated peptide epitopes were detected following subcutaneous immunization of B10.BR (H-2 (k)) mice with the liposaccharide vaccine candidates...
  6. ncbi request reprint Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein
    Colleen Olive
    Cooperative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    J Infect Dis 194:316-24. 2006
    ..We investigated the lipid core peptide (LCP) system for mucosal vaccine delivery against infection with group A streptococcus (GAS)--the causative pathogen of rheumatic fever and rheumatic heart disease...
  7. doi request reprint Synthesis and in vivo studies of carbohydrate-based vaccines against group A streptococcus
    Pavla Simerska
    School of Molecular and Microbial Sciences SMMS, The University of Queensland, St Lucia, Queensland 4072, Australia
    Biopolymers 90:611-6. 2008
    ..In vivo experiments showed high serum IgG antibody titers against each of the incorporated peptide epitopes, J8 or J14...
  8. pmc Potential of lipid core peptide technology as a novel self-adjuvanting vaccine delivery system for multiple different synthetic peptide immunogens
    Colleen Olive
    Cooperative Research Centre for Vaccine Technology, Division of Infectious Diseases and Immunology, The Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Infect Immun 71:2373-83. 2003
    ....
  9. doi request reprint In vitro and in vivo evaluation of positively charged liposaccharide derivatives as oral absorption enhancers for the delivery of anionic drugs
    Julie A Bergeon
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia
    J Pharm Sci 99:2333-42. 2010
    ....
  10. ncbi request reprint Immunization with a tetraepitopic lipid core peptide vaccine construct induces broadly protective immune responses against group A streptococcus
    Colleen Olive
    Cooperative Research Centre for Vaccine Technology, Queensland Institute of Medical Research, Brisbane, Australia
    J Infect Dis 193:1666-76. 2006
    ....
  11. doi request reprint Development and characterization of anionic liposaccharides for enhanced oral drug delivery
    Adel S Abdelrahim
    The University of Queensland, School of Chemistry and Molecular Biosciences, Brisbane, Queensland 4072, Australia
    Int J Pharm 430:120-8. 2012
    ..The results suggested that the studied liposaccharide with two lipids was safe to apply biologically and may have an absorption enhancing activity on hydrophilic, orally poorly available drugs...
  12. ncbi request reprint Synthesis of a highly pure lipid core peptide based self-adjuvanting triepitopic group A streptococcal vaccine, and subsequent immunological evaluation
    Peter M Moyle
    School of Pharmacy, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 49:6364-70. 2006
    ..Subcutaneous immunization of B10.BR (H-2(k)) mice with the synthesized vaccine, with or without the addition of complete Freund's adjuvant, elicited high serum IgG antibody titers against each of the incorporated peptide epitopes...
  13. doi request reprint Design of three-component vaccines against group A streptococcal infections: importance of spatial arrangement of vaccine components
    Abu Baker M Abdel-Aal
    School of Chemistry and Molecular Biosciences SCMB, The University of Queensland, QLD 4072, Queensland, Australia
    J Med Chem 53:8041-6. 2010
    ..Our results highlight the importance of epitope orientation and lipid position in the design of three-component synthetic vaccines...
  14. ncbi request reprint Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group a streptococcal vaccine candidates
    Abu Baker M Abdel-Aal
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 51:167-72. 2008
    ..Overall, the best vaccines featured a C-terminal lipid moiety, conjugated through a lysine residue to P25 at the N-terminus, and J14 on the lysine side chain...
  15. doi request reprint Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates
    Yoshio Fujita
    School of Molecular and Microbial Sciences SMMS, The University of Queensland, St Lucia 4072, QLD, Australia
    Bioorg Med Chem 16:8907-13. 2008
    ....
  16. doi request reprint Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes
    Mehfuz Zaman
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia
    J Med Chem 55:8515-23. 2012
    ..These preclinical experiments show that this lipopeptide could form the basis of an optimal needle-free mucosal GAS vaccine...
  17. doi request reprint Self-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccine
    Mehfuz Zaman
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
    Nanomedicine 7:168-73. 2011
    ....
  18. ncbi request reprint Method for the synthesis of highly pure vaccines using the lipid core peptide system
    Peter M Moyle
    School of Molecular and Microbial Biosciences, The University of Queensland, St Lucia, Queensland, Australia
    J Pept Sci 12:800-7. 2006
    ..Subcutaneous immunization of B10.BR (H-2(k)) mice with one of these vaccines, without the addition of any adjuvant, elicited high levels of systemic IgG antibodies against each of the incorporated peptides...
  19. ncbi request reprint Method for the synthesis of multi-epitopic Streptococcus pyogenes lipopeptide vaccines using native chemical ligation
    Peter M Moyle
    School of Pharmacy and School of Molecular and Microbial Sciences SMMS, University of Queensland, St Lucia, QLD, Australia
    J Org Chem 71:6846-50. 2006
    ..Intranasal immunization of the described tri-epitopic GAS lipopeptide with the mucosal adjuvant cholera toxin B subunit induced high serum IgG antibody titers specific for each of the incorporated peptide epitopes...
  20. doi request reprint Cellular transport pathways of polymer coated gold nanoparticles
    I Chun Lin
    School of Chemistry and Molecular Bioscience, University of Queensland, Brisbane, Australia
    Nanomedicine 8:8-11. 2012
    ..This knowledge will aid in the future of the design of nanoparticles as potential oral drug carriers...
  21. doi request reprint Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope
    Pavla Simerska
    The University of Queensland, School of Molecular and Microbial Sciences, Chemistry Building 68, St Lucia, Brisbane, QLD 4072, Australia
    Bioorg Med Chem Lett 19:821-4. 2009
    ..The successful synthesis and characterisation of the vaccine candidate may contribute to the discovery of a therapeutically and clinically viable vaccine against group A streptococcus...
  22. pmc Synthesis and in vitro evaluation of a library of modified endomorphin 1 peptides
    Yasuko Koda
    School of Pharmacy, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia
    Bioorg Med Chem 16:6286-96. 2008
    ..Dmt provided a promising lead compound: [C8Laa-Dmt[1]]-Endo-1 is nine times more stable (t(1/2)=43.5min), >8-fold more permeable in Caco-2 cell monolayers, and exhibits 140-fold greater mu-opioid receptor affinity (K(imu)=0.08nM)...
  23. doi request reprint Structure-activity relationship of lipopeptide Group A streptococcus (GAS) vaccine candidates on toll-like receptor 2
    Mehfuz Zaman
    The University of Queensland, School of Chemistry and Molecular Biosciences SCMB, St Lucia 4072, Queensland, Australia
    Vaccine 28:2243-8. 2010
    ..Lipopeptides containing different copies of LAA 3 were synthesized and the di-lipidated analogue was the most effective in NFkappaB activation...
  24. pmc Lipo-endomorphin-1 derivatives with systemic activity against neuropathic pain without producing constipation
    Pegah Varamini
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
    PLoS ONE 7:e41909. 2012
    ..v. administration of compound 3 at 16 µmol/kg. Furthermore, following chronic administration of equi-potent doses of compound 3 and morphine to rats, there was less antinociceptive tolerance for compound 3 compared with morphine...
  25. ncbi request reprint Lipid core peptide technology and group A streptococcal vaccine delivery
    Colleen Olive
    Co operative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Expert Rev Vaccines 3:43-58. 2004
    ..This review aims to cover the various strategies and technologies that have been investigated with regard to group A streptococcus vaccine design and development...
  26. pmc Immunological evaluation of lipopeptide group A streptococcus (GAS) vaccine: structure-activity relationship
    Mehfuz Zaman
    The University of Queensland, School of Chemistry and Molecular Biosciences SCMB, St Lucia, Queensland, Australia
    PLoS ONE 7:e30146. 2012
    ..These findings have considerable relevance to the development of a broad spectrum J14-based GAS vaccine and in particular provided a rational basis for peptide vaccine design based on this self-adjuvanting lipopeptide technology...
  27. doi request reprint Molecular interaction of poly(acrylic acid) gold nanoparticles with human fibrinogen
    Zhou J Deng
    School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    ACS Nano 6:8962-9. 2012
    ..Taken together, these results demonstrate that subtle changes in nanoparticle size can influence protein binding both with the surface of the nanoparticle and within the protein corona...
  28. ncbi request reprint Oral vaccine delivery--new strategies and technologies
    Pavla Simerska
    The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, 4072, Queensland, Australia
    Curr Drug Deliv 6:347-58. 2009
    ..Approaches to overcome these obstacles aim to provide new vaccines and delivery systems that are capable of eliciting protective immune responses, and are making an impact on current vaccine development...
  29. doi request reprint Investigation toward multi-epitope vaccine candidates using native chemical ligation
    Yoshio Fujita
    School of Molecular and Microbial Sciences SMMS, The University of Queensland, Brisbane QLD 4072, Australia
    Biopolymers 90:624-32. 2008
    ..It was found that the difficulty in NCL of first two peptide antigen was associated with the steric hindrance. Using Thz instead of Cys(Acm) and Msc-Cys was important to reduce the steric hindrance and improve NCL yield...
  30. doi request reprint Oral absorption enhancement of dipeptide L-Glu-L-Trp-OH by lipid and glycosyl conjugation
    Julie A Bergeon
    School of Molecular and Microbial Sciences, The University of Queensland, Brisbane QLD 4072, Australia
    Biopolymers 90:633-43. 2008
    ..An initial in vivo experiment was then carried out in male Wistar rats to examine the effect of conjugation on the absorption rate and bioavailability...
  31. doi request reprint Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses
    Zhou J Deng
    School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    Nanotoxicology 7:314-22. 2013
    ..While common proteins can bind to different nanoparticles, the biological outcome may not be the same. Consequently, knowledge about the composition of the protein corona is not sufficient to predict biological effects of nanoparticles...
  32. ncbi request reprint Toward the development of prophylactic and therapeutic human papillomavirus type-16 lipopeptide vaccines
    Peter M Moyle
    School of Pharmacy, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 50:4721-7. 2007
    ....
  33. doi request reprint Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery
    Zyta M Ziora
    The University of Queensland, School of Chemistry and Molecular Biosciences, Brisbane, QLD 4072, Australia
    Carbohydr Res 346:1439-44. 2011
    ....
  34. doi request reprint In vitro stability and permeability studies of liposomal delivery systems for a novel lipophilic endomorphin 1 analogue
    Yasuko Koda
    School of Pharmacy, The University of Queensland, St Lucia, QLD 4072, Australia
    Int J Pharm 356:37-43. 2008
    ..These results suggest that the combination of chemical modification and liposome formulation has great potentials in improving the bioavailability of neuroactive peptides...
  35. doi request reprint Effect of polymer grafting density on silica nanoparticle toxicity
    I Chun Lin
    School of Chemistry and Molecular Bioscience, The University of Queensland, Chemistry Building 68, Brisbane QLD, Australia
    Bioorg Med Chem 20:6862-9. 2012
    ..These findings are important indicators for the future evaluation of the toxicological profile of polymer-coated nanoparticles...
  36. ncbi request reprint Self-adjuvanting lipopeptide vaccines
    Peter M Moyle
    School of Molecular and Microbial Sciences and School of Pharmacy, The University of Queensland, St Lucia 4072, QLD, Australia
    Curr Med Chem 15:506-16. 2008
    ..g. monophosphoryl lipid A). The review also discusses the potential mechanisms of action for lipopeptide and glycolipopeptide vaccines, as well as structure activity relationships, and provides examples of studies utilising each system...
  37. doi request reprint The characterization of a novel dendritic system for gene delivery by isothermal titration calorimetry
    Daniel J Coles
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia, QLD 4072, Australia
    Biopolymers 90:651-4. 2008
    ..The binding affinity was stronger at the lower pH but precipitation of the complex was more prominent at pH 7.2 which was shown by large enthalpies. The results indicate that our dendrimers are forming stable complexes with DNA...
  38. ncbi request reprint Enhancement of oral drug absorption-effect of lipid conjugation on the enzymatic stability and intestinal permeability of l-Glu-l-Trp-NH(2)
    Julie A Bergeon
    School of Molecular and Microbial Sciences SMMS, The University of Queensland, St Lucia, QLD 4072, Australia
    Bioorg Med Chem 15:7048-57. 2007
    ....
  39. doi request reprint Thymine, adenine and lipoamino acid based gene delivery systems
    Mariusz Skwarczynski
    The University of Queensland, School of Chemistry and Molecular Biosciences, QLD 4072, Brisbane, Australia
    Chem Commun (Camb) 46:3140-2. 2010
    ..Their ability to bind to DNA by hydrogen bonding was confirmed by NMR diffusion, isothermal titration calorimetry and transmission electron microscopy experiments...
  40. doi request reprint Polymer-peptide hybrids as a highly immunogenic single-dose nanovaccine
    Abdullah Ah Ahmad Fuaad
    The University of Queensland St Lucia, School of Chemistry and Molecular Biosciences, Brisbane, Queensland 4072, Australia
    Nanomedicine (Lond) 9:35-43. 2014
    ..Conclusion: PtBA analogs have the potential to be developed as potent carrier systems for single-dose synthetic vaccines. Original submitted 29 August 2012; Revised submitted 6 December 2012; Published online 23 April 2013. ..
  41. doi request reprint Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation
    Pegah Varamini
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Bioorg Med Chem 21:1898-904. 2013
    ..This finding revealed the lack of respiratory depression effect at antinociceptive dose...
  42. ncbi request reprint M-protein-derived conformational peptide epitope vaccine candidate against Group A Streptococcus
    Mariusz Skwarczynski
    The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, QLD 4072, Australia
    Curr Drug Deliv 10:39-45. 2013
    ..Moreover, the antibodies produced against this epitope were able to recognize the native p145 sequence from M-protein...
  43. doi request reprint Interaction of densely polymer-coated gold nanoparticles with epithelial Caco-2 monolayers
    I Chun Lin
    School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Biomacromolecules 12:1339-48. 2011
    ..The library of polymer-coated AuNPs showed no apparent signs of hemolysis to erythrocytes at physiological pH. Our investigation has provided insight on the influence of polymer coatings on the epithelial barrier...
  44. doi request reprint In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modification of biliverdin
    Andrew C Bulmer
    School of Human Movement Studies, Blair Drive, University of Queensland, St Lucia, QLD, 4067, Australia
    Bioorg Med Chem 16:3616-25. 2008
    ..In summary, exogenous bilirubin and biliverdin supplements could be absorbed across the intestinal epithelium in vivo and potentially increase circulating concentrations of these antioxidant compounds...
  45. doi request reprint Modern lipid-, carbohydrate-, and peptide-based delivery systems for peptide, vaccine, and gene products
    Pavla Simerska
    School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Australia
    Med Res Rev 31:520-47. 2011
    ..The synthetic methods for preparation of the systems are also described...
  46. doi request reprint Cellular uptake of densely packed polymer coatings on gold nanoparticles
    Mingtao Liang
    School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia
    ACS Nano 4:403-13. 2010
    ..We believe that this was due to the interplay between the hydrophobic nature of the NPs and their increased size...
  47. pmc A novel synthetic adjuvant enhances dendritic cell function
    Karen S M Phillipps
    School of Molecular and Microbial Sciences SMMS, The University of Queensland, St Lucia, Queensland, Australia
    Immunology 128:e582-8. 2009
    ..Here we show that LCP targets vaccines to DCs and induces their activation...
  48. ncbi request reprint Toward the development of a synthetic group a streptococcal vaccine of high purity and broad protective coverage
    Aniko Horvath
    School of Pharmacy and School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia
    J Med Chem 47:4100-4. 2004
    ..The LCP construct, however, elicited excellent antibody responses to all three epitopes without the need for any additional adjuvant or carrier. We have synthesized the LCP synthetic vaccine system with good reproducibility...
  49. ncbi request reprint Lipoamino acids as major components of absorption promoters in drug delivery
    Zyta M Ziora
    Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Curr Top Med Chem 12:1562-80. 2012
    ..This review discusses the potential of absorption promoters possessing lipoamino acids for improving drug bioavailability...
  50. doi request reprint Simple synthetic toll-like receptor 2 ligands
    Abu Baker M Abdel-Aal
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia
    Bioorg Med Chem Lett 21:5863-5. 2011
    ..The current study reports synthesis and TLR2 activity of two simple TLR2 ligands, which feature minimal structural requirement for TLR2 activity (two long lipid chains) and stimulate agonistic activity at nanomolar concentration...
  51. doi request reprint Design of fully synthetic, self-adjuvanting vaccine incorporating the tumor-associated carbohydrate Tn antigen and lipoamino acid-based Toll-like receptor 2 ligand
    Abu Baker M Abdel-Aal
    School of Chemistry and Molecular Biosciences SCMB, The University of Queensland, QLD 4072, Queensland, Australia
    J Med Chem 55:6968-74. 2012
    ..g., liposomes). Vaccine constructs were assembled either in a linear or in a branched architecture, which demonstrated the intervening effects of the incorporation and arrangement of T-cell epitopes on antibody recognition...
  52. ncbi request reprint Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide
    Yasuko Koda
    School of Pharmacy, University of Queensland, St Lucia, QLD 4072, Australia
    Bioorg Med Chem Lett 17:2043-6. 2007
    ..114 nM) exhibited the highest permeability suggesting that this may be the better lead compound despite the lower binding affinity than that of compound 2 or 3...
  53. doi request reprint Increasing entrapment of peptides within poly(alkyl cyanoacrylate) nanoparticles prepared from water-in-oil microemulsions by copolymerization
    Mingtao Liang
    School of Pharmacy, The University of Queensland, St Lucia, Brisbane 4072, Australia
    Int J Pharm 362:141-6. 2008
    ....
  54. doi request reprint Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer
    Tzu Yu Liu
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
    Biomacromolecules 14:2798-806. 2013
    ..These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant...
  55. doi request reprint Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives
    Pegah Varamini
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Bioorg Med Chem 20:6335-43. 2012
    ..The more active LAA-modified hybrid peptide showed a lower total interaction energy and higher negative value of MolDock score...
  56. ncbi request reprint Particulate systems as adjuvants and carriers for peptide and protein antigens
    Ming Tao Liang
    School of Pharmacy, University of Queensland, Australia
    Curr Drug Deliv 3:379-88. 2006
    ....
  57. doi request reprint Cellular uptake of self-assembled cationic peptide-DNA complexes: multifunctional role of the enhancer chloroquine
    Shu Yang
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    J Control Release 135:159-65. 2009
    ..The actions of lysosomotropic agents such as chloroquine reveal the multifactorial properties required for carriers used in non-viral gene delivery...
  58. doi request reprint The influence of incorporating lipids or liposaccharides on the particle size of peptide therapeutics
    Daniel J Coles
    The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, QLD 4072, Australia
    Biopolymers 96:172-6. 2011
    ..These experiments provided information which can be applied when formulating these peptides as drugs...
  59. ncbi request reprint Modification of peptides and other drugs using lipoamino acids and sugars
    Joanne T Blanchfield
    School of Molecular and Microbial Sciences, University of Queensland, St Lucia, Australia
    Methods Mol Biol 298:45-61. 2005
    ....
  60. doi request reprint Liposome-based delivery system for vaccine candidates: constructing an effective formulation
    Ashwini Kumar Giddam
    The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, QLD 4072, Australia
    Nanomedicine (Lond) 7:1877-93. 2012
    ..In particular, the effects of vesicle size, surface charge, bilayer composition, lamellarity, pegylation and targeting of liposomes are described...
  61. doi request reprint Lipophilic derivatives of leu-enkephalinamide: in vitro permeability, stability and in vivo nasal delivery
    Cécile D Cros
    School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane 4072, Australia
    Bioorg Med Chem 19:1528-34. 2011
    ..9±1.84×10(-2) μM in the olfactory bulbs, 1.35±1.01×10(-2) μM in the brain and 6.53±1.87×10(-3) μM in the blood 10 min after administration...
  62. doi request reprint Synthesis and in vitro evaluation of glycosyl derivatives of luteinizing hormone-releasing hormone (LHRH)
    Shayli Varasteh Moradi
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia
    Bioorg Med Chem 21:4259-65. 2013
    ..Our findings show that conjugating sugar moieties to the N-terminus of the LHRH peptide significantly increased both permeability and metabolic stability of most of the modified LHRH derivatives...
  63. doi request reprint Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method
    Waleed M Hussein
    The University of Queensland, School of Chemistry and Molecular Biosciences, Brisbane, QLD 4072, Australia
    Org Biomol Chem 11:2370-6. 2013
    ..Both methods produced the desired peptide in high yield and purity, while classical SPPS did not result in the desired product...
  64. doi request reprint Nanovaccines and their mode of action
    Mehfuz Zaman
    School of Chemistry and Molecular Biosciences SCMB, The University of Queensland, St Lucia 4072, Queensland, Australia
    Methods 60:226-31. 2013
    ..Examples of various nanoparticles currently being developed as vaccines are also provided...
  65. ncbi request reprint Investigation of the route of absorption of lipid and sugar modified leu-enkephalin analogues and their enzymatic stability using the caco-2 cell monolayer system
    Sherry Wu
    School of Pharmacy, The University of Queensland, St Lucia 4072, Australia
    Med Chem 2:203-11. 2006
    ..In contrast, N-terminus conjugation of both lipids and sugars appeared to provide the greatest protection against enzymatic degradation...
  66. ncbi request reprint Caco-2 cell permeability and stability of two d-glucopyranuronamide conjugates of thyrotropin-releasing hormone
    Susanne T Wessling
    School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Bioorg Med Chem 15:4946-50. 2007
    ....
  67. ncbi request reprint Peptide-based subunit nanovaccines
    Mariusz Skwarczynski
    The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, QLD 4072, Australia
    Curr Drug Deliv 8:282-9. 2011
    ..Here, we review a number of peptide vaccine delivery strategies based on nanoparticles composed of polymers, peptides, lipids, and inorganic materials...
  68. ncbi request reprint Optimized LC-MS/MS quantification method for the detection of piperacillin and application to the development of charged liposaccharides as oral penetration enhancers
    Aude Violette
    School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Australia
    Int J Pharm 351:152-7. 2008
    ..The same method was then successfully applied to assess the in vitro apparent permeability values of the charged liposaccharide complexes in Caco-2 monolayers...
  69. doi request reprint A novel method for preparing immune stimulating complexes (ISCOMs) by hydration of freeze-dried lipid matrix
    Mingtao Liang
    School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia
    Eur J Pharm Biopharm 68:840-5. 2008
    ..Entrapment efficiency was noted to decrease dramatically on increasing amount of lipopeptide in the ISCOMs from 5% to 10% of total lipid, decreasing to around 40%. All lipopeptide-loaded ISCOMs were observed to aggregate upon storage...
  70. doi request reprint Expression of maturation markers on murine dendritic cells in response to group A streptococcal lipopeptide vaccines
    Michelle Yong
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Vaccine 27:3313-8. 2009
    ..Our results indicate that an LCP-GAS vaccine induced phenotypic maturation of BM-Flt3-DC but not BM-GMCSF-DC...
  71. doi request reprint Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues
    Mark P Del Borgo
    School of Molecular and Microbial Sciences, University of Queensland, St Lucia, 4072 QLD, Australia
    Bioorg Med Chem 16:4341-6. 2008
    ....
  72. ncbi request reprint Gastrointestinal absorption of heparin by lipidization or coadministration with penetration enhancers
    Benjamin P Ross
    School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland 4072 Australia
    Curr Drug Deliv 2:277-87. 2005
    ..Overall, progress has been made in the quest for an oral heparin formulation...
  73. ncbi request reprint Chemo-enzymatic synthesis of a trisaccharide-linked peptide aimed at improved drug-delivery
    Ken D Johnstone
    School of Molecular and Microbial Sciences, University of Queensland, St Lucia 4072, QLD, Australia
    Curr Drug Deliv 2:215-22. 2005
    ..The glycosyltransferase enzyme LgtA, derived from the bacterial pathogen Neisseria meningitidis, was utilised in the chemo-enzymatic synthesis of a trisaccharide-linked endomorphin peptide drug candidate...
  74. doi request reprint Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation
    Zhou J Deng
    School of Biomedical Sciences, University of Queensland, Brisbane 4072, Australia
    Nat Nanotechnol 6:39-44. 2011
    ..Our results show that the binding of certain nanoparticles to fibrinogen in plasma offers an alternative mechanism to the more commonly described role of oxidative stress in the inflammatory response to nanomaterials...
  75. ncbi request reprint Lipoamino acid-based adjuvant carrier system: enhanced immunogenicity of group a streptococcal peptide epitopes
    Aniko Horvath
    School of Pharmacy, The University of Queensland, Brisbane QLD 4072, Australia
    J Med Chem 45:1387-90. 2002
    ..Furthermore, the peptides incorporated into the LCP system generated epitope-specific antibodies without the use of any conventional adjuvant...
  76. ncbi request reprint The stability of lipidic analogues of GnRH in plasma and kidney preparations: the stereoselective release of the parent peptide
    Joanne T Blanchfield
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia, QLD 4072, Australia
    Bioorg Med Chem Lett 15:1609-12. 2005
    ..The Laa-Glu linkage appears to act as a two phase prodrug system...
  77. ncbi request reprint Improved resistance to serum oxidation in Gilbert's syndrome: a mechanism for cardiovascular protection
    Andrew C Bulmer
    School of Human Movement Studies, University of Queensland, St Lucia, Queensland 4067, Australia
    Atherosclerosis 199:390-6. 2008
    ..96+/-0.31; control: 0.73+/-0.21; P=0.072). In summary, individuals with GS have an increased circulating antioxidant status and an improved resistance to serum oxidation which may partially explain their reduced prevalence of CVD...
  78. ncbi request reprint Biological properties and therapeutic potential of bilirubin
    Ross P McGeary
    The School of Pharmacy, The University of Queensland, Brisbane QLD 4072, Australia
    Mini Rev Med Chem 3:253-6. 2003
    ..This review summarises that work, as well as more recent investigations into the potential therapeutic uses of bilirubin...
  79. ncbi request reprint Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII
    Joanne T Blanchfield
    School of Pharmacy, Institute for Molecular Bioscience, and School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia
    J Med Chem 46:1266-72. 2003
    ..The active LaaMII analogue was found to exhibit significantly improved permeability across Caco-2 cell monolayers compared to the native MII, and both peptides showed negligible toxicity...
  80. ncbi request reprint Urotensin-II-converting enzyme activity of furin and trypsin in human cells in vitro
    Fraser D Russell
    Department of Medicine, University of Queensland, The Prince Charles Hospital, Chermside, Queensland, Australia
    J Pharmacol Exp Ther 310:209-14. 2004
    ..Aprotinin-sensitive UCE activity was detected in blood, suggesting that an endogenous serine protease such as trypsin may also contribute to proteolysis of hU-II prohormone, if the prohormone is secreted into the circulation...
  81. ncbi request reprint Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure
    Fraser D Russell
    Department of Medicine, University of Queensland, Prince Charles Hospital, Rode Road, Chermside, Queensland 4032, Australia
    Am J Physiol Heart Circ Physiol 285:H1576-81. 2003
    ..The findings indicated that hU-II-ir is elevated in the aortic root of CHF patients and that hU-II-ir is cleared at least in part from the microcirculation...
  82. doi request reprint Modern subunit vaccines: development, components, and research opportunities
    Peter Michael Moyle
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia
    ChemMedChem 8:360-76. 2013
    ..Herein we review the current state of the art and future direction in subunit vaccine development, with a focus on the described components and their potential to steer the immune response toward a desired response...
  83. doi request reprint Synthesis and biological evaluation of an orally active glycosylated endomorphin-1
    Pegah Varamini
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia
    J Med Chem 55:5859-67. 2012
    ..In contrast to morphine, no significant constipation was produced by compound 2 after oral administration...
  84. pmc Peptide-based subunit vaccine against hookworm infection
    Mariusz Skwarczynski
    The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, Queensland, Australia
    PLoS ONE 7:e46870. 2012
    ..This approach offers promise for the development of vaccines against helminth parasites of humans and their livestock and companion animals...
  85. ncbi request reprint Advances in peptide-based human papillomavirus therapeutic vaccines
    Tzu Yu Liu
    The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, QLD 4072, Australia
    Curr Top Med Chem 12:1581-92. 2012
    ..We address the challenges that scientists currently face for developing peptide-based vaccines and explore feasible strategies for improving the potency of the induced immune response with the aim of treating established HPV infections...
  86. ncbi request reprint Micellar aggregation and membrane partitioning of bile salts, fatty acids, sodium dodecyl sulfate, and sugar-conjugated fatty acids: correlation with hemolytic potency and implications for drug delivery
    Benjamin P Ross
    School of Molecular and Microbial Sciences and School of Pharmacy, University of Queensland, Brisbane, Queensland 4072, Australia
    Mol Pharm 1:233-45. 2004
    ..It was concluded that the biocompatibility of liposaccharides can be modulated by minor alterations in nc...
  87. ncbi request reprint Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition
    Harendra S Parekh
    School of Pharmacy, The University of Queensland, St Lucia, QLD 4072, Australia
    Bioorg Med Chem 14:4775-80. 2006
    ..At 48 h, hVEGF titres had returned to that of the untransfected control for Cytofectin GSV however, a number of dendriplexes continued to exhibit a marked reduction in hVEGF titres...
  88. ncbi request reprint Polycationic lipophilic-core dendrons as penetration enhancers for the oral administration of low molecular weight heparin
    Patricia Y Hayes
    Discipline of Chemistry, School of Molecular and Microbial Sciences, and School of Pharmacy, The University of Queensland, Brisbane, Queensland 4072, Australia
    Bioorg Med Chem 14:143-52. 2006
    ..Better results were obtained with dendrons containing terminal lysine residues than terminal arginine. A significant anti-factor Xa activity was obtained when low molecular weight heparin was coadministered with dendron 5...
  89. doi request reprint Lipidated analogues of luteinizing hormone-releasing hormone (LHRH) reduce serum levels of follicle-stimulating hormone (FSH) after oral administration
    Friederike M Mansfeld
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia
    Int J Pharm 439:216-22. 2012
    ..However, some of the lipidic peptides (3, 8 and 9) were able to reduce serum levels of follicle-stimulating hormone (FSH), an important finding towards the development of orally available LHRH agonists...
  90. ncbi request reprint Endomorphin derivatives with improved pharmacological properties
    Pegah Varamini
    School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia
    Curr Med Chem 20:2741-58. 2013
    ....
  91. doi request reprint Chemical methods for peptide and protein production
    Saranya Chandrudu
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia
    Molecules 18:4373-88. 2013
    ..This review describes the advances in peptide chemistry including the variety of synthetic peptide methods currently available and the broad application of peptides in medicinal chemistry...
  92. pmc Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model
    Simon H Apte
    Infectious Diseases Programme, Queensland Institute of Medical Research, Herston, Queensland, Australia
    PLoS ONE 7:e40928. 2012
    ....
  93. ncbi request reprint Lipid and carbohydrate based adjuvant/carriers in immunology
    Ross P McGeary
    School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland, Australia
    J Pept Sci 9:405-18. 2003
    ..There has been a recent increase of interest in the use of lipids and carbohydrates as adjuvants, and so a particular emphasis is placed on adjuvants derived from lipids or carbohydrates, or from both...
  94. ncbi request reprint Determination of transport in the Caco-2 cell assay of compounds varying in lipophilicity using LC-MS: enhanced transport of Leu-enkephalin analogues
    Allan K Wong
    School of Pharmacy, The University of Queensland, 4072, St Lucia, Australia
    Eur J Pharm Sci 16:113-8. 2002
    ..To synthesize a number of analogues of Leu-enkephalin with different lipophilicities and to develop an LC-MS method for determining the Caco-2 cell permeability values of these compounds...
  95. ncbi request reprint Dendritic peptide-based carriers for gene delivery
    Daniel J Coles
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia
    Curr Drug Deliv 6:338-42. 2009
    ..We will discuss some recent approaches to gene delivery using modified dendrimers. We also discuss our work to deliver oligonucleotides and genes using dendritic peptide-based carriers...
  96. ncbi request reprint Encapsulation of lipopeptides within liposomes: effect of number of lipid chains, chain length and method of liposome preparation
    Ming T Liang
    School of Pharmacy, The University of Queensland, St Lucia, Brisbane 4072, QLD, Australia
    Int J Pharm 301:247-54. 2005
    ..Consequently, upon hydration, the lipopeptide is more efficiently intercalated within the phospholipid bilayers...
  97. ncbi request reprint Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides
    Norbert Wimmer
    School of Pharmacy, The University of Queensland, Steele Building, St Lucia, QLD 4072, Australia
    Bioorg Med Chem Lett 12:2635-7. 2002
    ..The level of transfection was indirectly measured by the decreased production of the protein hVEGF (human vascular endothelial growth factor) in comparison to the transfection agent cytofectin GSV...
  98. ncbi request reprint Design, synthesis, and evaluation of a liposaccharide drug delivery agent: application to the gastrointestinal absorption of gentamicin
    Benjamin P Ross
    School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Med Chem 47:1251-8. 2004
    ..No morphological changes were found in either the esophagi or duodena of the rats examined. One rat dosed with 11 (100 mg/kg) and 1 (60 mg/kg) exhibited slight gastric erosion, which could be attributed to 11...
  99. ncbi request reprint Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue
    Joanne T Blanchfield
    School of Molecular and Microbial Sciences, The University of Queensland, Brisbane 4072, Australia
    Biochem Biophys Res Commun 361:97-102. 2007
    ..Neither peptide crossed the blood-brain barrier to any significant extent. This is the first study of the in vivo biodistribution of an alpha-conotoxin after oral administration...