Istvan Toth


Affiliation: University of Queensland
Country: Australia


  1. Moradi S, Hussein W, Varamini P, Simerska P, Toth I. Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides. Chem Sci. 2016;7:2492-2500 pubmed publisher
    ..Furthermore, the impacts of glycosylation in overcoming the existing barriers that restrict oral and brain delivery of peptides are described herein. ..
  2. Nevagi R, Khalil Z, Hussein W, Powell J, Batzloff M, Capon R, et al. Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus. Acta Biomater. 2018;80:278-287 pubmed publisher
    ..Additionally, nanoparticles provided protection to vaccinated mice against group A streptococcus infection. Thus, this concept should be particularly useful in developing nanoparticles for the delivery of peptide antigens. ..
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    Sedaghat B, Stephenson R, Toth I. Targeting the mannose receptor with mannosylated subunit vaccines. Curr Med Chem. 2014;21:3405-18 pubmed
    ..This review describes the structure of the MR and provides an overview of the use of mannosylated proteins and peptides for vaccine targeting. ..
  4. Stephenson R, You H, McManus D, Toth I. Schistosome Vaccine Adjuvants in Preclinical and Clinical Research. Vaccines (Basel). 2014;2:654-85 pubmed publisher
    ..This review summarises the status of adjuvants that have been or are being employed in schistosomiasis vaccine development focusing on immunisation outcomes at preclinical and clinical stages. ..
  5. Goodwin D, Varamini P, Simerska P, D Occhio M, Toth I. Design, synthesis and evaluation of a gonadotropin releasing hormone-based subunit vaccine in rams (Ovis aries). Vaccine. 2015;33:1453-8 pubmed publisher
    ..The latter rams showed a marked decrease in testicular size. The marked and sustained reduction in testicular size in rams treated with GnRH-LP+AdjuVacâ„¢ provides the basis for an effective immunocastration vaccine in rams. ..
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    Ghaffar K, Hussein W, Khalil Z, Capon R, Skwarczynski M, Toth I. Levofloxacin and indolicidin for combination antimicrobial therapy. Curr Drug Deliv. 2015;12:108-14 pubmed
    ..Interestingly, physical mixture of levofloxacin and indolicidin showed improvement in the activity against Gram-positive bacteria. ..
  7. Azmi F, Ahmad Fuaad A, Giddam A, Batzloff M, Good M, Skwarczynski M, et al. Self-adjuvanting vaccine against group A streptococcus: application of fibrillized peptide and immunostimulatory lipid as adjuvant. Bioorg Med Chem. 2014;22:6401-8 pubmed publisher
    ..These findings highlight the impact of lipoamino acids moiety as a promising immunostimulant carrier and its number of attachment to peptide epitope was found to have a profound effect on the vaccine immunogenicity. ..
  8. Ahmad Fuaad A, Roubille R, Pearson M, Pickering D, Loukas A, Skwarczynski M, et al. The use of a conformational cathepsin D-derived epitope for vaccine development against Schistosoma mansoni. Bioorg Med Chem. 2015;23:1307-12 pubmed publisher
    ..These findings are particularly encouraging for the development of efficient and immunogenic vaccine against schistosomiasis. ..
  9. Rosli N, Christie M, Moyle P, Toth I. Peptide based DNA nanocarriers incorporating a cell-penetrating peptide derived from neurturin protein and poly-L-lysine dendrons. Bioorg Med Chem. 2015;23:2470-9 pubmed publisher
    ..There was also no significant difference between NRTN-30 and NRTN-17 for pDNA uptake, indicating that the truncated peptide alone is sufficient as a CPP for pDNA delivery. ..

More Information


  1. Ghaffar K, Marasini N, Giddam A, Batzloff M, Good M, Skwarczynski M, et al. Liposome-based intranasal delivery of lipopeptide vaccine candidates against group A streptococcus. Acta Biomater. 2016;41:161-8 pubmed publisher
    ..Thus, the combination of lipopeptides and liposomes generates a very promising delivery system for intranasal vaccines. ..
  2. Giddam A, Reiman J, Zaman M, Skwarczynski M, Toth I, Good M. A semi-synthetic whole parasite vaccine designed to protect against blood stage malaria. Acta Biomater. 2016;44:295-303 pubmed publisher
    ..This semi-synthetic delivery platform is an exciting strategy to accelerate the development of a licensed malaria vaccine. Moreover, this strategy can be potentially applied to a wide range of pathogens. ..
  3. Marasini N, Khalil Z, Giddam A, Ghaffar K, Hussein W, Capon R, et al. Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus. Int J Pharm. 2016;513:410-420 pubmed publisher
    ..Our results show that PLGA-based lipopeptide delivery is a promising approach for rational design of a simple, effective and patient friendly intranasal GAS vaccine resulting in mucosal IgA response. ..
  4. Simerska P, Suksamran T, Ziora Z, Rivera F, Engwerda C, Toth I. Ovalbumin lipid core peptide vaccines and their CD4(+) and CD8(+) T cell responses. Vaccine. 2014;32:4743-50 pubmed publisher
    ..Promising in vivo data in mice suggested that this LCP-ovalbumin vaccine system could act as a novel and potent vehicle for the stimulation of robust antigen-specific CD8(+) T cell responses. ..
  5. Eskandari S, Guerin T, Toth I, Stephenson R. Recent advances in self-assembled peptides: Implications for targeted drug delivery and vaccine engineering. Adv Drug Deliv Rev. 2017;110-111:169-187 pubmed publisher
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    Ghaffar K, Giddam A, Zaman M, Skwarczynski M, Toth I. Liposomes as nanovaccine delivery systems. Curr Top Med Chem. 2014;14:1194-208 pubmed
    ..Topics such as size-dependent uptake, processing and activation of antigen presenting cells, targeting liposomes and route of administration are discussed. ..
  7. Azmi F, Elliott A, Marasini N, Ramu S, Ziora Z, Kavanagh A, et al. Short cationic lipopeptides as effective antibacterial agents: Design, physicochemical properties and biological evaluation. Bioorg Med Chem. 2016;24:2235-41 pubmed publisher
    ..With such properties in mind, these lipopeptides have the potential to be developed as new antibacterial agents against drug-resistant Gram-positive bacteria. ..
  8. Chan A, Hussein W, Ghaffar K, Marasini N, Mostafa A, Eskandari S, et al. Structure-activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates. Bioorg Med Chem. 2016;24:3095-101 pubmed publisher
    ..These findings highlight the importance of LAA moieties in the development of intranasal peptide vaccines and confirmed that its side chain length has an effect on the immunogenicity of the structure. ..