Affiliation: University of Queensland
- Ghaffar K, Marasini N, Giddam A, Batzloff M, Good M, Skwarczynski M, et al. Liposome-based intranasal delivery of lipopeptide vaccine candidates against group A streptococcus. Acta Biomater. 2016;41:161-8 pubmed publisher..Thus, the combination of lipopeptides and liposomes generates a very promising delivery system for intranasal vaccines. ..
- Giddam A, Reiman J, Zaman M, Skwarczynski M, Toth I, Good M. A semi-synthetic whole parasite vaccine designed to protect against blood stage malaria. Acta Biomater. 2016;44:295-303 pubmed publisher..This semi-synthetic delivery platform is an exciting strategy to accelerate the development of a licensed malaria vaccine. Moreover, this strategy can be potentially applied to a wide range of pathogens. ..
- Marasini N, Khalil Z, Giddam A, Ghaffar K, Hussein W, Capon R, et al. Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus. Int J Pharm. 2016;513:410-420 pubmed publisher..Our results show that PLGA-based lipopeptide delivery is a promising approach for rational design of a simple, effective and patient friendly intranasal GAS vaccine resulting in mucosal IgA response. ..
- Simerska P, Suksamran T, Ziora Z, Rivera F, Engwerda C, Toth I. Ovalbumin lipid core peptide vaccines and their CD4(+) and CD8(+) T cell responses. Vaccine. 2014;32:4743-50 pubmed publisher..Promising in vivo data in mice suggested that this LCP-ovalbumin vaccine system could act as a novel and potent vehicle for the stimulation of robust antigen-specific CD8(+) T cell responses. ..
- Ghaffar K, Giddam A, Zaman M, Skwarczynski M, Toth I. Liposomes as nanovaccine delivery systems. Curr Top Med Chem. 2014;14:1194-208 pubmed..Topics such as size-dependent uptake, processing and activation of antigen presenting cells, targeting liposomes and route of administration are discussed. ..
- Azmi F, Elliott A, Marasini N, Ramu S, Ziora Z, Kavanagh A, et al. Short cationic lipopeptides as effective antibacterial agents: Design, physicochemical properties and biological evaluation. Bioorg Med Chem. 2016;24:2235-41 pubmed publisher..With such properties in mind, these lipopeptides have the potential to be developed as new antibacterial agents against drug-resistant Gram-positive bacteria. ..
- Chan A, Hussein W, Ghaffar K, Marasini N, Mostafa A, Eskandari S, et al. Structure-activity relationship of lipid core peptide-based Group A Streptococcus vaccine candidates. Bioorg Med Chem. 2016;24:3095-101 pubmed publisher..These findings highlight the importance of LAA moieties in the development of intranasal peptide vaccines and confirmed that its side chain length has an effect on the immunogenicity of the structure. ..