Research Topics
| Joseph TorresiSummaryAffiliation: University of Melbourne Country: Australia Publications
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Detail Information
Publications
A self-adjuvanting multiepitope immunogen that induces a broadly cross-reactive antibody to hepatitis C virusJoseph Torresi
Department of Medicine and Clinical Centre for Research Excellence, Royal Melbourne Hospital, The University of Melbourne, Parkville 3050, Victoria, Australia
Hepatology 45:911-20. 2007....- Hepatitis B antiviral resistance and vaccine escape: two sides of the same coinJoseph Torresi
Victorian Infectious Diseases Service, Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
Antivir Ther 13:337-40. 2008 - Neutralising antibody, CTL and dendritic cell responses to hepatitis C virus: a preventative vaccine strategyJoseph Torresi
Department of Medicine RMH WH, University of Melbourne, Centre for Medical Research, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
Curr Drug Targets 5:41-56. 2004..The problems are further compounded by difficulties in growing the virus in vitro and the lack of a suitable and economical animal model... 
Progress in the development of preventive and therapeutic vaccines for hepatitis C virusJoseph Torresi
Austin Centre for Infection Research, Department of Infectious Diseases Austin Hospital, Heidelberg, Victoria 3084, Australia
J Hepatol 54:1273-85. 2011..This paper will review the vaccines strategies employed, their success to date and future directions of vaccine design...- Immunogenicity, safety and tolerability in adults of a new single-dose, live-attenuated vaccine against Japanese encephalitis: Randomised controlled phase 3 trialsJoseph Torresi
Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia
Vaccine 28:7993-8000. 2010..A single dose of JE-CV elicited rapid seroconversion in a higher proportion of vaccinees than the current vaccine with fewer reactions. The safety profile of JE-CV is good... - Defining infections in international travellers through the GeoSentinel surveillance networkJoseph Torresi
Department of Infectious Diseases and the Department of Medicine, Austin Hospital, PO Box 5555, Heidelberg, Victoria 3084, Australia
Nat Rev Microbiol 7:895-901. 2009..This Science and Society article focuses on the valuable function served by the GeoSentinel surveillance network in defining the range of infections in travellers... - The virological and clinical significance of mutations in the overlapping envelope and polymerase genes of hepatitis B virusJoseph Torresi
Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Vic, Australia
J Clin Virol 25:97-106. 2002..The ability to change a viral protein by mutations in an overlapping but unrelated viral gene may produce HBV mutants with altered antigenicity and/or replication and a natural history that may be distinctly different to wild type HBV... - Restoration of replication phenotype of lamivudine-resistant hepatitis B virus mutants by compensatory changes in the "fingers" subdomain of the viral polymerase selected as a consequence of mutations in the overlapping S geneJoseph Torresi
Department of Medicine RMH WH, University of Melbourne, Melbourne, Victoria 3050, Australia
Virology 299:88-99. 2002..Since these viruses carry mutations in the a determinant of HBsAg that may potentially decrease the ability of anti-HBs antibody to neutralize these viruses, these HBV mutants also have the potential to behave as vaccine escape mutants... - Reduced antigenicity of the hepatitis B virus HBsAg protein arising as a consequence of sequence changes in the overlapping polymerase gene that are selected by lamivudine therapyJoseph Torresi
Department of Medicine RMH, University of Melbourne, Parkville, Victoria 3050, Australia
Virology 293:305-13. 2002..These findings raise the possibility of lamivudine-resistant mutants arising that possess antigenically distinct HBsAg proteins... - Hepatitis a and e infection in international travellersJoseph Torresi
Department of Infectious Diseases, Austin Center for Infection Research, Austin Hospital, Level 7, Harold Stokes Building, 145 Studley Road, Heidelberg, Victoria, 3084, Australia
Curr Infect Dis Rep 13:248-55. 2011..2%, although this is substantially higher in pregnant women. A vaccine for hepatitis E is not available, and therefore travellers must be made aware of preventative measures to reduce their risk of infection... - Neutralizing antibodies in patients with chronic hepatitis C infection treated with (Peg)-interferon/ribavirinIrene Boo
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Prahran, Victoria 3001, Australia
J Clin Virol 39:288-94. 2007..The role of neutralizing antibody (NAb) in determining response to antiviral therapy has not been established... - A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infectionBrendon Y Chua
Department of Microbiology and Immunology, The University of Melbourne, Royal Parade, Parkville, Victoria 3010, Australia
Vaccine 26:4866-75. 2008.... - Failure of lamivudine to reverse hepatitis B virus-associated changes in ERK, Akt and cell cycle regulatory proteinsRuth Chin
Department of Medicine, CCREID, Royal Melbourne Hospital, University of Melbourne, Australia
Antivir Ther 13:221-30. 2008..We recently reported that replication of HBV in a cell-culture system was associated with the upregulation of pERK, pAkt, pc-Myc, nuclear cyclin B1, p21(cip1) and p53 together with G2 cell cycle arrest... - Gastrointestinal infection among international travelers globallyZoe Greenwood
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Victoria, Australia
J Travel Med 15:221-8. 2008..The objective of this study was to analyze infections associated with oral ingestion of pathogens in international travelers in relation to place of exposure... - Maturation of dendritic cells with lipopeptides that represent vaccine candidates for hepatitis C virusBrendon Y Chua
Cooperative Research Centre for Vaccine Technology, Department of Microbiology and Immunology, The University of Melbourne, Victoria, Australia
Immunol Cell Biol 81:67-72. 2003.... - Exploiting information inherent in binding sites of virus-specific antibodies: design of an HCV vaccine candidate cross-reactive with multiple genotypesLara Grollo
Cooperative Research Centre for Vaccine Technology, Department of Microbiology Et Immunology, The University of Melbourne, Parkville, Vic, Australia
Antivir Ther 11:1005-14. 2006..CONCLUSIONS: This approach exploits the information inherent in the binding sites of virus-specific antibodies and represents a novel method for the design of synthetic epitope-based vaccines... 
Hepatitis C VLPs delivered to dendritic cells by a TLR2 targeting lipopeptide results in enhanced antibody and cell-mediated responsesBrendon Y Chua
Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
PLoS ONE 7:e47492. 2012....- Dysregulation of hepatocyte cell cycle and cell viability by hepatitis B virusRuth Chin
Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Victoria 3084, Australia
Virus Res 147:7-16. 2010..Hepatitis B virus (HBV) is associated with a significant risk of developing hepatocellular carcinoma but the effects of HBV on cell cycle regulation are not completely understood... - Global control of hepatitis B virus: does treatment-induced antigenic change affect immunization?C John Clements
Melbourne University, Vic, Australia
Bull World Health Organ 88:66-73. 2010..This paper examines the mechanism of antiviral drug-selected changes in the portion of the viral genome that also affects the surface antigen, and explores their potential impact on current hepatitis B immunization programmes... - Highly reproducible transient transfections for the study of hepatitis B virus replication based on an internal GFP reporter systemTheo Gouskos
Department of Medicine (RMH, University of Melbourne, Vic, Australia
J Virol Methods 121:65-72. 2004..The presence of an internal GFP reporter increased the efficiency of generating highly reproducible results and facilitated multiple forms of analysis from a single transfection accurately... - Induction of neutralizing antibody responses to hepatitis C virus with synthetic peptide constructs incorporating both antibody and T-helper epitopesJoseph Torresi
Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
Immunol Cell Biol 85:169-73. 2007..These results demonstrate the potential of synthetic peptide-based constructs in the delivery of potential neutralizing epitopes that are present within the viral envelope of HCV... - Low risk of Japanese encephalitis in short-term Australian travelers to AsiaIrani Ratnam
Victorian Infectious Disease Service, Royal Melbourne Hospital, Parkville, Victoria, Australia Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
J Travel Med 20:206-8. 2013..No travelers were infected with JE virus during travel, indicating a low risk of infection for short-term travelers... - TCD8 response in diverse outcomes of recurrent exposure to hepatitis C virusMandvi Bharadwaj
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
Immunol Cell Biol 87:464-72. 2009.... - The profile of health problems in African immigrants attending an infectious disease unit in Melbourne, AustraliaKatherine B Gibney
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Victoria, Australia
Am J Trop Med Hyg 80:805-11. 2009..Clinicians need to be aware of these conditions to meet the health needs of this group. Comprehensive health checks should be encouraged for new arrivals, particularly from high-risk areas... - Imported Plasmodium vivax malaria: demographic and clinical features in nonimmune travelersJulian H Elliott
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Victoria, Australia
J Travel Med 11:213-7. 2004..vivax malaria in travelers. P. vivax malaria is an important cause of morbidity in travelers, and relapse following primaquine treatment is especially problematic with P. vivax malaria acquired in PNG... - Illness in travelers visiting friends and relatives: a review of the GeoSentinel Surveillance NetworkKarin Leder
Victorian Infectious Diseases Service, Centre for Clinical Research Excellence, Royal Melbourne Hospital, Parkville, Victoria, 3052, Australia
Clin Infect Dis 43:1185-93. 2006..A greater proportion of immigrant VFRs presented with serious, potentially preventable travel-related illnesses than did tourist travelers... - Fiber-modified recombinant adenoviral constructs encoding hepatitis C virus proteins induce potent HCV-specific T cell responseDuangtawan Thammanichanond
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia
Clin Immunol 128:329-39. 2008..These findings provide an effective approach for the expansion of HCV-specific CTLs from PBMCs of HCV-infected patients and have potential for immunotherapeutic/vaccine development... - Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patientTheo Gouskos
Department of Medicine (RMH, University of Melbourne, Melbourne, Australia
AIDS 18:1734-7. 2004..However, a strong HBV-specific CD8 T-cell response was identified and may have resulted in the severe hepatitis... - Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressantsEu Jin Lim
Liver Transplant Unit, Austin Hospital, Heidelberg, Victoria 3084, Australia
World J Gastroenterol 18:2172-9. 2012..These findings suggest that modulation of apoptosis within the liver either by changing immunosuppressive therapy or the use of apoptosis inhibitors may help prevent fibrosis progression in patients with post-transplant HCV disease... - Illness in returned travelers and immigrants/refugees: the 6-year experience of two Australian infectious diseases unitsDaniel P O'Brien
Victorian Infectious Diseases Service, Centre for Clinical Research Excellence, Royal Melbourne Hospital, Victoria, Australia
J Travel Med 13:145-52. 2006..Data comparing returned travelers and immigrants/refugees managed in a hospital setting is lacking... - Impaired dendritic cell maturation in response to pandemic H1N109 influenza virusRuth Chin
Department of Medicine, Austin Hospital, The University of Melbourne, Heidelberg, Vic, Australia
J Clin Virol 56:226-31. 2013..Infection with pandemic A/H1N1/2009 influenza virus led to hospitalisation of patients not expected to be at risk of severe disease from seasonal influenza infection... - Malaria in travelers: a review of the GeoSentinel surveillance networkKarin Leder
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
Clin Infect Dis 39:1104-12. 2004..Malaria is a common and important infection in travelers... - Long-term follow-up of schistosomiasis serology post-treatment in Australian travelers and immigrantsMichelle K Yong
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
J Travel Med 17:89-93. 2010.... - GeoSentinel surveillance of illness in returned travelers, 2007-2011Karin Leder
Victorian Infectious Disease Service, Royal Melbourne Hospital, Monash University, Austin Hospital, Melbourne University
Ann Intern Med 158:456-68. 2013..International travel continues to increase, particularly to Asia and Africa. Clinicians are increasingly likely to be consulted for advice before travel or by ill returned travelers... - The incidence of HBV and HCV infection in Australian travelers to AsiaDouglas F Johnson
Department of Infectious Diseases and Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Victoria, Australia
J Travel Med 20:203-5. 2013..The incidence density in nonimmune travelers for HCV infection was calculated as 1.8 infections per 10,000 traveler-days and for HBV infection 2.19 per 10,000 traveler-days... - Incidence and risk factors for acute respiratory illnesses and influenza virus infections in Australian travellers to AsiaIrani Ratnam
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Australia
J Clin Virol 57:54-8. 2013..Respiratory infections including influenza are a common cause of acute short-term morbidity in travellers and yet the risk of these infections is poorly defined... - Impact of swine influenza and quarantine measures on patients and households during the H1N1/09 pandemicBenjamin Teh
Department of Infectious Diseases, Austin Hospital, Heidelberg, Victoria, Australia
Scand J Infect Dis 44:289-96. 2012..To assess the secondary attack rates (SAR) and impact of the 2009 H1N1 epidemic in Melbourne, Victoria, Australia, and the measures implemented to control household transmission... - Immune responses in hepatitis C virus infection: the role of dendritic cellsNina L Fowler
Macfarlane Burnet Institute for Medical Research and Public Health, Prahran, Victoria, Australia
Immunol Cell Biol 81:63-6. 2003..If dendritic cell immunotherapy for hepatitis C virus infection is to become a reality, the mechanism behind the defective allostimulatory capacity needs to be deciphered... - A comparative analysis of methodological approaches used for estimating risk in travel medicineKarin Leder
Victorian Infectious Diseases Service, Centre for Clinical Research Excellence, Royal Melbourne Hospital, Victoria, Australia
J Travel Med 15:263-72. 2008 - Modulation of MAPK pathways and cell cycle by replicating hepatitis B virus: factors contributing to hepatocarcinogenesisRuth Chin
Department of Medicine, CCREID, Royal Melbourne Hospital, University of Melbourne, Post Office, Parkville, VIC 3050, Australia
J Hepatol 47:325-37. 2007..Numerous studies have focused on the HBV X protein showing that it activates signal transduction pathways while few have investigated these changes in HBV-replicating hepatocytes... - Development and validation of an instrument to assess the risk of developing viral infections in Australian travelers during international travelIrani Ratnam
Victorian Infectious Diseases Service, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
J Travel Med 18:262-70. 2011..Our objective was to develop and validate a questionnaire to be used in a prospective study designed to estimate the risk of three viral infections in Australian travelers to Asia... - A phase I clinical trial of dendritic cell immunotherapy in HCV-infected individualsEric J Gowans
Virology Program, Burnet Institute, G P O Box 2284, Melbourne, VIC 3001, Australia
J Hepatol 53:599-607. 2010..The aim of the study was to investigate the safety and efficacy of vaccination with autologous dendritic cells loaded with HCV-specific cytotoxic T cell epitopes... - Diagnosing swine flu: the inaccuracy of case definitions during the 2009 pandemic, an attempt at refinement, and the implications for future planningAndrew A Mahony
Infectious Diseases Department, Austin Health Melbourne, Vic, Australia Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic, Australia Infectious Diseases Department, Alfred Health, Melbourne, Vic, Australia Infectious Diseases Department, Northern Health, Melbourne, Vic, Australia Nossal Institute for Global Health, Melbourne, Vic, Australia Department of Medicine, The University of Melbourne, Melbourne, Vic, Australia
Influenza Other Respi Viruses 7:403-9. 2013..Investment in more widespread availability of rapid and sensitive diagnostic tests should be considered in future pandemic planning... - Hepatitis B and C infection in international travelersDouglas F Johnson
Department of Infectious Diseases Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Victoria, Australia
J Travel Med 20:194-202. 2013..Hepatitis B and C virus (HBV and HCV) cause significant morbidity and mortality worldwide. With the rise in international travel over the last three decades, many travelers are at risk of HBV and HCV infection... - Two cases of Old World cutaneous leishmaniasis in Australian travelers visiting MoroccoAndrew J Stewardson
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
J Travel Med 17:278-80. 2010..The patients were treated with sodium stibogluconate and fluconazole. Optimal treatment is not established, particularly in returned travelers, but identification of Leishmania species can help with the selection of appropriate therapy... - Vitamin D deficiency is associated with tuberculosis and latent tuberculosis infection in immigrants from sub-Saharan AfricaKatherine B Gibney
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Clin Infect Dis 46:443-6. 2008..001). Higher vitamin D levels were associated with lower probability of any M. tuberculosis infection (P=.001) and lower probability of tuberculosis or past tuberculosis (compared with latent tuberculosis infection; P=.001)... - Respiratory tract infections in travelers: a review of the GeoSentinel surveillance networkKarin Leder
Victorian Infectious Disease Service, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
Clin Infect Dis 36:399-406. 2003..Knowledge of the respiratory tract infections that occur in specific groups of travelers allows for the development of targeted pretravel preventive strategies to high-risk groups... - Comparison of immunoglobulin G subclass concentrations in severe community-acquired pneumonia and severe pandemic 2009 influenza A (H1N1) infectionClaire L Gordon
Department of Infectious Diseases, Austin Health, Melbourne, Australia
Clin Vaccine Immunol 19:446-8. 2012..008] and 2.5 versus 1.2 g/liter [P < 0.001], respectively). Low IgG2 levels may be specifically linked to severe H1N1; however, it is not clear whether this association is related to H1N1 or to other features of severity... - Dengue Fever in travelers returning from southeast AsiaValerie Sung
Victorian Infectious Disease Service, Royal Melbourne Hospital, The University of Melbourne, Melbourne, Australia
J Travel Med 10:208-13. 2003..The prevalence appears to be increasing in travelers, and health care professionals need to be familiar with its presentation in travelers. The clinical presenting features provide important guides to establishing the diagnosis... - Crohn's disease or tuberculosis?Kiley W J Loh
Department of Medicine, The Northern Hospital, Epping, Victoria, Australia
J Travel Med 18:221-3. 2011.... - Co-infection of human parvovirus B19 in Vietnamese patients with hepatitis B virus infectionNguyen L Toan
Department of Molecular Pathology, Institute of Pathology, University Hospital of Tuebingen, Germany
J Hepatol 45:361-9. 2006..Further studies are required to determine the role of B19-infection on HBV-associated pathogenesis... - Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivudine treatment after liver transplantationC-Thomas Bock
Department of Gastroenterology and Hepatology, Medical School of Hannover, FRG
Gastroenterology 122:264-73. 2002..The lamivudine-enhanced replication shown by these mutants suggests that continuation of therapy with lamivudine could be deleterious in some patients... - Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in VietnamNguyen L Toan
Department of Molecular Pathology, Institute of Pathology, University Hospital of Tuebingen, Germany
Hepatology 43:1375-84. 2006..Differences in the replication-phenotype of single genotypes compared to genotype-mixtures suggest that co-infection with different HBV-genotypes is associated with altered pathogenesis and clinical outcome... - Rabies preexposure vaccination in travelersPhilippe Gautret
J Travel Med 14:136; author reply 136-7. 2007 - Human parvovirus B19 NS1 protein modulates inflammatory signaling by activation of STAT3/PIAS3 in human endothelial cellsAnja Duechting
Department of Molecular Pathology, Institute for Pathology, University of Tuebingen, 72076 Tuebingen, Germany
J Virol 82:7942-52. 2008..Thus, NS1 may play a critical role in the mechanism of viral pathogenesis in B19-associated iCMP...