Paul A Tooney

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. pmc Gene expression profiling of xeroderma pigmentosum
    Nikola A Bowden
    Hunter Medical Research Institute, John Hunter Hospital, Lookout Rd, New Lambton Heights, NSW, 2305, Australia
    Hered Cancer Clin Pract 4:103-10. 2006
  2. ncbi request reprint Tachykinin NK1 and NK3 receptors in the prefrontal cortex of the human brain
    P A Tooney
    Neuroscience Institute of Schizophrenia and Allied Disorders and School of Biomedical Sciences, Faculty of Medicine and Health Sciences, The University of Newcastle, Callaghan, New South Wales, Australia
    Clin Exp Pharmacol Physiol 27:947-9. 2000
  3. ncbi request reprint The effects of haloperidol treatment on the distribution of NK1 receptor immunoreactive neurons in guinea-pig brain
    Paul A Tooney
    NISAD, Neuroscience Institute of Schizophrenia and Allied Disorders NISAD, Sydney, Australia
    Neurosci Lett 383:155-9. 2005
  4. ncbi request reprint Neurons expressing calcium-binding proteins in the prefrontal cortex in schizophrenia
    Paul A Tooney
    Neuroscience Institute of Schizophrenia and Allied Disorders, Darlinghurst, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 28:273-8. 2004
  5. ncbi request reprint Immunohistochemical localisation of the NK1 receptor in the human amygdala: preliminary investigation in schizophrenia
    Judith Weidenhofer
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 30:1313-21. 2006
  6. pmc Altered gene expression in the superior temporal gyrus in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, NSW, Australia
    BMC Genomics 9:199. 2008
  7. ncbi request reprint Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells
    Erin J Gardiner
    Schizophrenia Research Institute, Sydney, NSW, Australia
    J Psychiatr Res 47:425-37. 2013
  8. doi request reprint Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia
    Danielle M Santarelli
    Schizophrenia Research Institute, Sydney, Australia
    Biol Psychiatry 69:180-7. 2011
  9. pmc Gene-microRNA interactions associated with antipsychotic mechanisms and the metabolic side effects of olanzapine
    Danielle M Santarelli
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia
    Psychopharmacology (Berl) 227:67-78. 2013
  10. ncbi request reprint Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Australia
    Schizophr Res 82:175-83. 2006

Detail Information

Publications23

  1. pmc Gene expression profiling of xeroderma pigmentosum
    Nikola A Bowden
    Hunter Medical Research Institute, John Hunter Hospital, Lookout Rd, New Lambton Heights, NSW, 2305, Australia
    Hered Cancer Clin Pract 4:103-10. 2006
    ..Therefore, this analysis has revealed distinct gene expression profiles for the XP complementation groups and the first step towards understanding the neurological symptoms of XP...
  2. ncbi request reprint Tachykinin NK1 and NK3 receptors in the prefrontal cortex of the human brain
    P A Tooney
    Neuroscience Institute of Schizophrenia and Allied Disorders and School of Biomedical Sciences, Faculty of Medicine and Health Sciences, The University of Newcastle, Callaghan, New South Wales, Australia
    Clin Exp Pharmacol Physiol 27:947-9. 2000
    ..Dots of NK3 receptor immunoreactivity were scattered across all cortical layers. In the white matter, astrocytes and beaded fibres displayed NK3 receptor immunoreactivity, particularly in areas surrounding blood vessels...
  3. ncbi request reprint The effects of haloperidol treatment on the distribution of NK1 receptor immunoreactive neurons in guinea-pig brain
    Paul A Tooney
    NISAD, Neuroscience Institute of Schizophrenia and Allied Disorders NISAD, Sydney, Australia
    Neurosci Lett 383:155-9. 2005
    ..Whether these changes are related to the therapeutic effects or to the side effects of haloperidol in individuals with schizophrenia, remains to be determined...
  4. ncbi request reprint Neurons expressing calcium-binding proteins in the prefrontal cortex in schizophrenia
    Paul A Tooney
    Neuroscience Institute of Schizophrenia and Allied Disorders, Darlinghurst, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 28:273-8. 2004
    ....
  5. ncbi request reprint Immunohistochemical localisation of the NK1 receptor in the human amygdala: preliminary investigation in schizophrenia
    Judith Weidenhofer
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 30:1313-21. 2006
    ....
  6. pmc Altered gene expression in the superior temporal gyrus in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, NSW, Australia
    BMC Genomics 9:199. 2008
    ..The STG connects to the limbic system (hippocampus and amygdala), the thalamus and neocortical association areas in the prefrontal cortex, all of which have been implicated in schizophrenia...
  7. ncbi request reprint Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells
    Erin J Gardiner
    Schizophrenia Research Institute, Sydney, NSW, Australia
    J Psychiatr Res 47:425-37. 2013
    ....
  8. doi request reprint Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia
    Danielle M Santarelli
    Schizophrenia Research Institute, Sydney, Australia
    Biol Psychiatry 69:180-7. 2011
    ..We hypothesize that abnormal miRNA levels contribute to the complex global changes in gene expression that underlie the pathophysiology of schizophrenia...
  9. pmc Gene-microRNA interactions associated with antipsychotic mechanisms and the metabolic side effects of olanzapine
    Danielle M Santarelli
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia
    Psychopharmacology (Berl) 227:67-78. 2013
    ..MicroRNA regulate numerous genes involved in brain development and function. It is therefore plausible to question whether miRNA expression is also altered and hence whether they take part in the neuroleptic mechanism of action...
  10. ncbi request reprint Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Australia
    Schizophr Res 82:175-83. 2006
    ..The validity of this approach may lead to better methods of defining this enigmatic disease...
  11. pmc Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia
    Jing Qin Wu
    Schizophrenia Research Institute, Sydney, Australia
    PLoS ONE 7:e36351. 2012
    ..By contrast, sequencing technology can provide un-biased analysis of transcription at nucleotide resolution. Here we use this approach to investigate schizophrenia-associated cortical gene expression...
  12. ncbi request reprint Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation
    Natalie J Beveridge
    Schizophrenia Research Institute, Sydney, NSW 2006, Australia
    Cell Signal 21:1837-45. 2009
    ..This suggests that the miR-17 family have an integral role in fine-tuning the pathways involved in the regulation of neuronal differentiation...
  13. doi request reprint Context-specific microRNA function in developmental complexity
    Adam P Carroll
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW, Australia
    J Mol Cell Biol 5:73-84. 2013
    ..Moreover, by establishing the timing, location, and mechanism of these regulatory events, we may ultimately understand the true biological function of a specific miRNA in a given cellular environment...
  14. pmc Alternative mRNA fates identified in microRNA-associated transcriptome analysis
    Adam P Carroll
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW, Australia
    BMC Genomics 13:561. 2012
    ....
  15. doi request reprint Dysregulation of miRNA 181b in the temporal cortex in schizophrenia
    Natalie J Beveridge
    Schizophrenia Research Institute, Sydney, NSW 2006, Australia
    Hum Mol Genet 17:1156-68. 2008
    ..This study suggests altered miRNA levels could be a significant factor in the dysregulation of cortical gene expression in schizophrenia...
  16. pmc Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression
    Natalie J Beveridge
    To whom correspondence should be addressed School of Biomedical Sciences and Pharmacy, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia tel 61 2 4921 8670, fax 61 2 4921 7903, E mail
    Schizophr Bull 40:399-409. 2014
    ....
  17. doi request reprint Finding the needle in the haystack: a review of microarray gene expression research into schizophrenia
    Nishantha Kumarasinghe
    Priority Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Callaghan, Australia
    Aust N Z J Psychiatry 46:598-610. 2012
    ..Hence, the expression of susceptibility genes in response to environmental factors in concert with other disease-promoting or protecting genes has increasingly attracted attention...
  18. ncbi request reprint Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, Australia
    Schizophr Res 89:165-8. 2007
    ..Altered expression of RGS4 in cortical regions previously implicated in schizophrenia, such as the STG further supports the notion of RGS4 as a potential genetic and functional biological marker of schizophrenia...
  19. doi request reprint Design and interpretation of microRNA-reporter gene activity
    Adam P Carroll
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia
    Anal Biochem 437:164-71. 2013
    ....
  20. doi request reprint Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia
    Melissa J Green
    School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia Schizophrenia Research Institute, Darlinghurst, NSW, Australia Electronic address
    J Psychiatr Res 49:43-50. 2014
    ....
  21. pmc Different forms of glycine- and GABA(A)-receptor mediated inhibitory synaptic transmission in mouse superficial and deep dorsal horn neurons
    Wayne B Anderson
    School of Biomedical Sciences and Pharmacy, The University of Newcastle and Hunter Medical Research Institute, University Drive, Callaghan, NSW 2308, Australia
    Mol Pain 5:65. 2009
    ..Recent work in mouse has discovered an additional type of GlyR, (containing alpha 3 subunits) in the SDH. The contribution of differing forms of the GlyR to sensory processing in SDH and DDH is not understood...
  22. ncbi request reprint Antipsychotic drug-associated gene-miRNA interaction in T-lymphocytes
    Erin Gardiner
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, NSW, Australia
    Int J Neuropsychopharmacol 17:929-43. 2014
    ..These results indicate that APDs have a significant effect on expression in peripheral tissue that relate to both known mechanisms as well as poorly characterized side effects...
  23. ncbi request reprint Altered gene expression in the amygdala in schizophrenia: up-regulation of genes located in the cytomatrix active zone
    Judith Weidenhofer
    Neuroscience Institute of Schizophrenia and Allied Disorders NISAD, NSW, Australia
    Mol Cell Neurosci 31:243-50. 2006
    ..These results implicate for the first time the dysfunction of the cytomatrix active zone of synapses in the amygdala in the pathophysiology of schizophrenia...