Affiliation: University of Queensland
Rehaume L, Matigian N, Mehdi A, Lachner N, Bowerman K, Daly J, et al
. IL-23 favours outgrowth of spondyloarthritis-associated pathobionts and suppresses host support for homeostatic microbiota. Ann Rheum Dis. 2019;: pubmed publisher
..In genetically susceptible hosts, IL-23p19 favours outgrowth of SpA-associated pathobionts and reduces support for homeostatic-inducing microbiota. The relative abundance of specific pathobionts is associated with disease severity. ..
Rahman M, Thomas R. The SKG model of spondyloarthritis. Best Pract Res Clin Rheumatol. 2017;31:895-909 pubmed publisher
Thomas R. The balancing act of autoimmunity: central and peripheral tolerance versus infection control. Int Rev Immunol. 2010;29:211-33 pubmed publisher
Law S, Benham H, Reid H, Rossjohn J, Thomas R. Identification of self-antigen-specific T cells reflecting loss of tolerance in autoimmune disease underpins preventative immunotherapeutic strategies in rheumatoid arthritis. Rheum Dis Clin North Am. 2014;40:735-52 pubmed publisher
Benham H, Nel H, Law S, Mehdi A, Street S, Ramnoruth N, et al
. Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients. Sci Transl Med. 2015;7:290ra87 pubmed publisher
Benham H, Robinson P, Baillet A, Rehaume L, Thomas R. Role of genetics in infection-associated arthritis. Best Pract Res Clin Rheumatol. 2015;29:213-25 pubmed publisher
..We go on to consider the evidence for a relationship between HLA-B27, infection and arthritis, and then emerging evidence for an interaction between microbiota and rheumatoid arthritis. ..
Maradana M, Yekollu S, Zeng B, Ellis J, Clouston A, Miller G, et al
. Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis. Metabolism. 2018;78:80-94 pubmed publisher
..Liposomes are a new strategy to target lipid rich inflammatory dendritic cells and have potential to deliver immunomodulatory compounds to treat NASH. ..
Nair P, Starkey M, Haw T, Ruscher R, Liu G, Maradana M, et al
. RelB-Deficient Dendritic Cells Promote the Development of Spontaneous Allergic Airway Inflammation. Am J Respir Cell Mol Biol. 2018;58:352-365 pubmed publisher
..These data indicate that RelB deficiency may be a key pathway underlying AAI, and that DC-encoded RelB is sufficient to restore control of this inflammation. ..