P S Thomas

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. pmc Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma
    Kazuhiro Ito
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Am J Respir Cell Mol Biol 39:543-50. 2008
  2. doi request reprint Exhaled breath analysis: novel approach for early detection of lung cancer
    Hiang Ping Chan
    Faculty of Medicine, University of New South Wales, Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    Lung Cancer 63:164-8. 2009
  3. pmc Exhaled nitric oxide is decreased by exposure to the hyperbaric oxygen therapy environment
    Zudin A Puthucheary
    UNSW and Department of Respiratory Medicine, Faculty of Medicine, Prince of Wales Hospital, Randwick, NSW, Australia
    Mediators Inflamm 2006:72620. 2006
  4. pmc Diagnosing GORD in Respiratory Medicine
    Chris J Timms
    Faculty of Medicine, University of New South Wales Sydney, NSW, Australia
    Front Pharmacol 2:40. 2011
  5. doi request reprint Exhaled breath condensate in pediatric asthma: promising new advance or pouring cold water on a lot of hot air? a systematic review
    P S Thomas
    Inflammation and Infection Research Centre, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    Pediatr Pulmonol 48:419-42. 2013
  6. pmc Effects of cigarette smoke on degranulation and NO production by mast cells and epithelial cells
    Xiu M Wei
    School of Pathology, Faculty of Medicine, UNSW, Sydney, Australia
    Respir Res 6:108. 2005
  7. pmc Proteomics as a method for early detection of cancer: a review of proteomics, exhaled breath condensate, and lung cancer screening
    Dean H Conrad
    Inflammatory Diseases Research Unit, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    J Gen Intern Med 23:78-84. 2008
  8. ncbi request reprint Sputum induction as a method of analyzing pulmonary cells: reproducibility and acceptability
    P S Thomas
    Department of Thoracic Medicine, National Heart and Lung Institute, London, UK
    J Asthma 36:335-41. 1999
  9. ncbi request reprint The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children
    Paul S Thomas
    Faculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia
    J Asthma 42:291-5. 2005
  10. ncbi request reprint Effect of ecNOS polymorphisms and coronary artery disease upon exhaled nitric oxide
    S Thomas
    Faculty of Medicine, University of New South Wales, Sydney, Australia
    J Mol Med (Berl) 80:181-6. 2002

Collaborators

Detail Information

Publications50

  1. pmc Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma
    Kazuhiro Ito
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
    Am J Respir Cell Mol Biol 39:543-50. 2008
    ..We conclude that impaired nuclear recruitment of HDAC2 could be an important mechanism of steroid resistance of the neutrophilic inflammation in exacerbations of asthma. Oxidative stress may contribute to decreased HDAC2 activity...
  2. doi request reprint Exhaled breath analysis: novel approach for early detection of lung cancer
    Hiang Ping Chan
    Faculty of Medicine, University of New South Wales, Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    Lung Cancer 63:164-8. 2009
    ..However, since EBC is a simple, non-invasive technique that can be easily performed, even in ill patients, it has the potential to be validated for use in screening for the early diagnosis of lung cancer...
  3. pmc Exhaled nitric oxide is decreased by exposure to the hyperbaric oxygen therapy environment
    Zudin A Puthucheary
    UNSW and Department of Respiratory Medicine, Faculty of Medicine, Prince of Wales Hospital, Randwick, NSW, Australia
    Mediators Inflamm 2006:72620. 2006
    ..Exhaled nitric oxide (eNO) detects airway inflammation. Hyperbaric oxygen therapy (HBOT) is used for tissue hypoxia, but can cause lung damage. We measured eNO following inhalation of oxygen at different tensions and pressures...
  4. pmc Diagnosing GORD in Respiratory Medicine
    Chris J Timms
    Faculty of Medicine, University of New South Wales Sydney, NSW, Australia
    Front Pharmacol 2:40. 2011
    ..Novel methods such as exhaled breath condensate analysis and electronic nose technology have the potential to improve the accuracy of diagnosing GORD...
  5. doi request reprint Exhaled breath condensate in pediatric asthma: promising new advance or pouring cold water on a lot of hot air? a systematic review
    P S Thomas
    Inflammation and Infection Research Centre, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    Pediatr Pulmonol 48:419-42. 2013
    ..It has the potential to be used in both population-based studies and in the context of pediatric asthma it may prove useful in diagnosis and monitoring...
  6. pmc Effects of cigarette smoke on degranulation and NO production by mast cells and epithelial cells
    Xiu M Wei
    School of Pathology, Faculty of Medicine, UNSW, Sydney, Australia
    Respir Res 6:108. 2005
    ..Thus, some of the inhibitory effects of CSS appear to be via oxidative free radicals rather than a NOX-related negative feedback...
  7. pmc Proteomics as a method for early detection of cancer: a review of proteomics, exhaled breath condensate, and lung cancer screening
    Dean H Conrad
    Inflammatory Diseases Research Unit, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    J Gen Intern Med 23:78-84. 2008
    ..This perspective will explore the potential of applying proteomics to the EBC from lung cancer patients as an example of detecting potential biomarkers of disease and progression...
  8. ncbi request reprint Sputum induction as a method of analyzing pulmonary cells: reproducibility and acceptability
    P S Thomas
    Department of Thoracic Medicine, National Heart and Lung Institute, London, UK
    J Asthma 36:335-41. 1999
    ..This technique may be less valuable in a clinical than a research setting...
  9. ncbi request reprint The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children
    Paul S Thomas
    Faculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia
    J Asthma 42:291-5. 2005
    ..eNO appears to be a useful indicator of atopy and airway inflammation, but in this population it was not closely related to airway hyperresponsiveness...
  10. ncbi request reprint Effect of ecNOS polymorphisms and coronary artery disease upon exhaled nitric oxide
    S Thomas
    Faculty of Medicine, University of New South Wales, Sydney, Australia
    J Mol Med (Berl) 80:181-6. 2002
    ..1 ppb) than subjects without angiographic CAD (19.9 ppb). In this selected population low levels of eNO were thus associated with presence of the ecNOS4a allele and also with CAD...
  11. pmc Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma
    P S Thomas
    Inflammation Research Unit, School of Pathology, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Thorax 57:774-8. 2002
    ..It was hypothesised that a similar challenge would increase airway reactivity in those with mild asthma, but that the inflammatory profile may differ...
  12. ncbi request reprint Tumour necrosis factor-alpha: the role of this multifunctional cytokine in asthma
    P S Thomas
    Faculty of Medicine, University of New South Wales and Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, New South Wales, Australia
    Immunol Cell Biol 79:132-40. 2001
    ..Treatment directed specifically at a reduction in TNF-alpha activity may conceivably be useful as a glucocorticosteroid-sparing asthma therapy...
  13. ncbi request reprint Influenza vaccination: changes in exhaled nitric oxide levels and sputum cytology
    P S Thomas
    Faculty of Medicine, University of New South Wales, Sydney, Australia
    Respirology 4:355-8. 1999
    ..The use of simple, non-invasive methods of assessing changes in airway inflammation could potentially allow improved understanding of the cellular mechanisms underlying such changes...
  14. ncbi request reprint Peak expiratory flow at increased barometric pressure: comparison of peak flow meters and volumetric spirometer
    P S Thomas
    Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia
    Clin Sci (Lond) 98:121-4. 2000
    ..86+/-1.69% at 303 kPa with the mini PEF meter). Using these data points, a correction factor was derived which allows appropriate values to be calculated from the Wright's meter readings under these conditions...
  15. ncbi request reprint Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytes
    X M Wei
    Inflammation Research Unit, School of Pathology, Faculty of Medicine, UNSW and Department of Respiratory Medicine, Prince of Wales Hospital, NSW 2031, Randwick, Australia
    Int Immunopharmacol 3:1581-8. 2003
    ..The dual mechanism involved in the inhibition of this cytokines may represent a novel therapeutical approach in the modulation of inflammatory disease...
  16. ncbi request reprint Passive smoke inhalation decreases exhaled nitric oxide in normal subjects
    D H Yates
    Department of Respiratory Medicine, Concord Repatriation General Hospital, Concord, NSW, Australia
    Am J Respir Crit Care Med 164:1043-6. 2001
    ..01). This suggests that eNO can be used for the investigation of the mechanisms of cigarette-induced lung damage in the experimental setting, and may potentially be useful also for environmental assessment of ETS effects...
  17. ncbi request reprint AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil
    C T Bruce
    University of New South Wales, NSW, Australia
    Eur J Clin Invest 36:899-905. 2006
    ..The NO synthase (NOS) iso-enzyme involved was studied by the NOS inhibitor aminoguanidine...
  18. doi request reprint Oxidative stress in COPD and its measurement through exhaled breath condensate
    Wei Lee
    Faculty of Medicine, University of New South Wales, Randwick, New South Wales 2031, Australia
    Clin Transl Sci 2:150-5. 2009
    ....
  19. pmc Caffeine decreases exhaled nitric oxide
    C Bruce
    Faculty of Medicine, UNSW and Department of Respiratory Medicine, Prince of Wales Hospital, Sydney, NSW 2031, Australia
    Thorax 57:361-3. 2002
    ..It was therefore hypothesised that caffeine may alter exhaled NO (eNO) levels...
  20. ncbi request reprint Nasal and exhaled nitric oxide in response to occupational latex exposure
    K Tan
    Faculty of Medicine, University of New South Wales, Australia
    Allergy 56:627-32. 2001
    ..Neither nNO nor eNO showed a clear relationship to routine workplace exposure...
  21. doi request reprint Elevated levels of oxidative stress markers in exhaled breath condensate
    Hiang Ping Chan
    Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    J Thorac Oncol 4:172-8. 2009
    ..Therefore, lung cancer patients were hypothesized to have higher levels of oxidative stress markers in their exhaled breath compared with controls...
  22. ncbi request reprint Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavage
    Abigail S Jackson
    Department of Thoracic Medicine, St Vincent s Hospital, Victoria Street, Darlinghurst, Sydney, Australia
    Am J Respir Crit Care Med 175:222-7. 2007
    ..The exact site of origin of substances measured in EBC is unknown, as is the clinical applicability of the technique. Special techniques might be needed to measure EBC biomarkers...
  23. doi request reprint Fractional exhaled nitric oxide in asthma: an update
    Alessandra Sandrini
    Department of Thoracic Medicine, St Vincent s Hospital, Sydney, NSW 2010, Australia
    Respirology 15:57-70. 2010
    ..Fe(NO) reference values and the role of Fe(NO) in asthma assessment, diagnosis and management are also discussed...
  24. doi request reprint L-arginine reverses cigarette-induced reduction of fractional exhaled nitric oxide in asthmatic smokers
    C T Bruce
    Centre for Infection and Inflammation Research and POWH Clinical School, Faculty of Medicine, University of New South Wales, Randwick, NSW, Australia
    Inflammopharmacology 18:9-16. 2010
    ..Aminoguanidine, a relatively selective Type II NOS inhibitor, was used also to assess the role of NOS subtypes in these changes of FE(NO)...
  25. ncbi request reprint Exhaled breath condensate nitrite/nitrate and pH in relation to pediatric asthma control and exhaled nitric oxide
    - Ratnawati
    Inflammatory Diseases Research Unit, School of Medical Sciences, Faculty of Medicine, UNSW, Sydney, New South Wales, Australia
    Pediatr Pulmonol 41:929-36. 2006
    ..This cross-sectional study evaluated the relationship of both EBC nitrite/nitrate (NOx) and EBC pH with asthma control and eNO in asthmatic, normal, and atopic children...
  26. doi request reprint Current perspectives of oxidative stress and its measurement in chronic obstructive pulmonary disease
    Jiun Lih Lin
    University of New South Wales, Sydney, Australia
    COPD 7:291-306. 2010
    ....
  27. ncbi request reprint Exhaled breath condensate as a method of sampling airway nitric oxide and other markers of inflammation
    Jia Liu
    Faculty of Medicine, University of New South Wales and Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW, Australia
    Med Sci Monit 11:MT53-62. 2005
    ..EBC is becoming a technique which will allow repeated non-invasive sampling from the respiratory tract thus assisting pulmonary research and possibly the monitoring of lung diseases...
  28. ncbi request reprint Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma
    Rakesh K Kumar
    Department of Pathology, University of New South Wales, Sydney, Australia
    J Pharmacol Exp Ther 307:349-55. 2003
    ..Roflumilast did not diminish accumulation of transforming growth factor-beta1, suggesting that it might affect remodeling by mechanisms distinct from glucocorticoids...
  29. doi request reprint The potential of the immunological markers of sarcoidosis in exhaled breath and peripheral blood as future diagnostic and monitoring techniques
    Hasib Ahmadzai
    Inflammation and Infection Research Centre, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    Inflammopharmacology 19:55-68. 2011
    ..This review explores the literature on the cytokine profiles of blood and bronchoalveolar lavage lymphocytes following ex vivo stimulation, as well as disease markers measured using the medium of EBC...
  30. ncbi request reprint Eotaxin expression by epithelial cells and plasma cells in chronic asthma
    Rakesh K Kumar
    Inflammation Research Unit, Department of Pathology, University of New South Wales, Sydney, Australia
    Lab Invest 82:495-504. 2002
    ..Although high eotaxin levels alone are not sufficient to cause recruitment of eosinophils into the airways, recurrent exposure may generate or up-regulate additional signals required for eosinophil chemotaxis...
  31. doi request reprint Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma
    C Herbert
    Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Clin Exp Allergy 38:847-56. 2008
    ..In a mouse model of mild chronic asthma, both inflammation and remodelling can be suppressed by dexamethasone (a glucocorticoid) and roflumilast (a selective phosphodiesterase-4 inhibitor)...
  32. ncbi request reprint Nitric oxide and exhaled breath nitrite/nitrates in chronic obstructive pulmonary disease patients
    Jia Liu
    Prince of Wales Hospital Clinical School, Faculty of Medicine, University of New South Wales, Randwick, Australia
    Respiration 74:617-23. 2007
    ..COPD-associated airway inflammation may be affected by multiple factors, including cigarette smoking and glucocorticosteroid (GCS) treatment...
  33. doi request reprint Mediators in exhaled breath condensate after hypertonic saline challenge
    - Ratnawati
    Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, New South Wales, Australia
    J Asthma 46:1045-51. 2009
    ..Airway narrowing after hypertonic saline challenge (HSC) is postulated to be mediated by bronchoconstrictors and inflammatory mediators...
  34. ncbi request reprint Fractional exhaled nitric oxide concentration is increased in asbestosis and pleural plaques
    Alessandra Sandrini
    Department of Thoracic Medicine, St Vincent s Hospital, and Worker s Compensation Dust Diseases Board Education and Research Unit, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    Respirology 11:325-9. 2006
    ..The authors hypothesized that fractional exhaled nitric oxide concentration (FENO) would be increased in subjects with asbestos-related lung disorders...
  35. ncbi request reprint Teaching asthma management: an evidence-based educational approach
    D H Yates
    Department of Respiratory Medicine, Concord Repatriation General Hospital, Sydney, NSW
    Aust N Z J Med 30:33-7. 2000
    ..Thirty-five students attended the workshop, with 26 returning questionnaires on both of the two sessions...
  36. ncbi request reprint Laughter-associated asthma
    G Liangas
    Faculty of Medicine, University of New South Wales, Sydney, Australia
    J Asthma 41:217-21. 2004
    ..043). Laughter-induced asthma is strongly associated with exercise as a trigger; the mechanism remains uncertain, but better understanding of this problem may assist in controlling difficult asthma...
  37. ncbi request reprint Nicorandil inhibits degranulation and TNF-alpha release from RBL-2H3 cells
    G J Heywood
    Inflammation Research Unit, School of Pathology, Faculty of Medicine, UNSW, Australia
    Inflamm Res 51:176-81. 2002
    ..Nicorandil is a potassium channel opener and nitric oxide (NO) donor, and the hypothesis was tested that these modes of action may inhibit cellular degranulation and release of tumour necrosis factor-alpha (TNF-alpha)...
  38. ncbi request reprint Health and stress in Australian interns
    C Bruce
    Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    Intern Med J 33:392-5. 2003
    ..9, P=0.003 and chi2=20.4, P<0.001, respectively). Despite workplace reform for junior doctors, this study suggests that interns still feel overburdened with work expectations and this is having a negative effect on their health...
  39. ncbi request reprint Relationship between exhaled breath condensate volume and measurements of lung volumes
    Jia Liu
    Faculty of Medicine, University of New South Wales, and Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, Australia
    Respiration 74:142-5. 2007
    ..Exhaled breath condensate (EBC) is proving to be a technique which can sample markers of lung inflammation; however, many factors affect the collection process...
  40. ncbi request reprint Exhaled breath condensate biomarkers in asbestos-related lung disorders
    Sharron Chow
    Research and Education Unit, Workers Compensation Dust Diseases Board of New South Wales, Sydney, Australia
    Respir Med 103:1091-7. 2009
    ..Several such species can be measured non-invasively in humans in exhaled breath condensate (EBC) but few have been evaluated. This study aimed to assess oxidative stress and lung inflammation in vivo...
  41. doi request reprint Effect of hydrofluoroalkane-ethanol inhalers on estimated alcohol levels in asthmatic subjects
    Colleen Bruce
    Faculty of Medicine, University of New South Wales, Sydney, Australia
    Respirology 14:112-6. 2009
    ..It was hypothesized that HFA-ethanol MDI may contribute to raising BEC above the legal limit...
  42. ncbi request reprint An electronic nose in the discrimination of breath from smokers and non-smokers: a model for toxin exposure
    Z J Cheng
    Centre for Infection and Inflammation Research and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    J Breath Res 3:036003. 2009
    ..It may prove to be a useful, non-invasive tool for further breath assessment of exposure to other inhaled noxious substances as well as disease monitoring...
  43. ncbi request reprint Deleterious effect of nitric oxide inhibition in chronic hepatopulmonary syndrome
    John A Almeida
    Gastrointestinal and Liver Unit, The Prince of Wales Hospital and University of New South Wales, Sydney, Australia
    Eur J Gastroenterol Hepatol 19:341-6. 2007
    ....
  44. ncbi request reprint Occupational sensitization to lupin in the workplace: occupational asthma, rhinitis, and work-aggravated asthma
    Charlotte P Campbell
    Department of Thoracic Medicine, St Vincent s Hospital, Darlinghurst, Sydney, Australia
    J Allergy Clin Immunol 119:1133-9. 2007
    ..Lupin is a legume. Its seed can be ground into flour and incorporated into food as a protein source. Cases of rhinitis, urticaria, and anaphylaxis from ingestion of lupin have been reported as well as asthma...
  45. ncbi request reprint Proteomics in detection and monitoring of asthma and smoking-related lung diseases
    Jiun Lih Lin
    Faculty of Medicine, University of New South Wales, Sydney, Australia
    Expert Rev Proteomics 7:361-72. 2010
    ..With better study design standardization and the implementation of novel technologies to reach the optimal research standard, there is enough reason be optimistic about the future of proteomic research and its clinical implications...
  46. ncbi request reprint Control of rheumatoid arthritis by oral tolerance
    E H Choy
    Guy's Kings, Hospital School of Medicine, King's College, London, UK
    Arthritis Rheum 44:1993-7. 2001
    ..However, the therapeutic window is narrow. The difference between our results and those of other trials may relate to the dose, species, and formulation of the CII...
  47. ncbi request reprint The effect of marimastat, a metalloprotease inhibitor, on allergen-induced asthmatic hyper-reactivity
    Colleen Bruce
    Department of Respiratory Medicine, Faculty of Medicine, University of New South Wales, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    Toxicol Appl Pharmacol 205:126-32. 2005
    ..Marimastat did not modify eNO, FEV(1), asthma symptoms, or albuterol usage. In conclusion, airway responsiveness to allergen may be modified by a MMP inhibitor, perhaps via TNFalpha playing a role in airway inflammation and remodeling...
  48. ncbi request reprint Delta tryptase is expressed in multiple human tissues, and a recombinant form has proteolytic activity
    Hong Wei Wang
    Inflammation Research Units, Department of Pathology, University of New South Wales, Sydney, Australia
    J Immunol 169:5145-52. 2002
    ..These results suggest that the range of functional tryptases is larger than previously recognized. For simplicity, we suggest that the gene, transcripts, and corresponding protein product be named delta tryptase...
  49. ncbi request reprint Pulmonary dysanapsis and diving assessments
    Lin Min Ong
    Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, NSW 2031, Australia
    Undersea Hyperb Med 36:375-80. 2009
    ..While pulmonary dysanapsis may increase the risk of airway hyperresponsiveness, there is no evidence of an association with diving-related pulmonary barotrauma...
  50. ncbi request reprint TNF-alpha as a target for anti-asthma therapy
    Colleen T Bruce
    Clin Sci (Lond) 110:265. 2006