Research Topics
| P S ThomasSummaryAffiliation: University of New South Wales Country: Australia Publications
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Detail Information
Publications
Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthmaKazuhiro Ito
Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
Am J Respir Cell Mol Biol 39:543-50. 2008..We conclude that impaired nuclear recruitment of HDAC2 could be an important mechanism of steroid resistance of the neutrophilic inflammation in exacerbations of asthma. Oxidative stress may contribute to decreased HDAC2 activity...
Exhaled breath analysis: novel approach for early detection of lung cancerHiang Ping Chan
Faculty of Medicine, University of New South Wales, Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW 2031, Australia
Lung Cancer 63:164-8. 2009..However, since EBC is a simple, non-invasive technique that can be easily performed, even in ill patients, it has the potential to be validated for use in screening for the early diagnosis of lung cancer...
Effects of cigarette smoke on degranulation and NO production by mast cells and epithelial cellsXiu M Wei
School of Pathology, Faculty of Medicine, UNSW, Sydney, Australia
Respir Res 6:108. 2005..Thus, some of the inhibitory effects of CSS appear to be via oxidative free radicals rather than a NOX-related negative feedback...- Proteomics as a method for early detection of cancer: a review of proteomics, exhaled breath condensate, and lung cancer screeningDean H Conrad
Inflammatory Diseases Research Unit, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
J Gen Intern Med 23:78-84. 2008..This perspective will explore the potential of applying proteomics to the EBC from lung cancer patients as an example of detecting potential biomarkers of disease and progression... 
Sputum induction as a method of analyzing pulmonary cells: reproducibility and acceptabilityP S Thomas
Department of Thoracic Medicine, National Heart and Lung Institute, London, UK
J Asthma 36:335-41. 1999..This technique may be less valuable in a clinical than a research setting...- The relationship of exhaled nitric oxide to airway inflammation and responsiveness in childrenPaul S Thomas
Faculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia
J Asthma 42:291-5. 2005..eNO appears to be a useful indicator of atopy and airway inflammation, but in this population it was not closely related to airway hyperresponsiveness... - Effect of ecNOS polymorphisms and coronary artery disease upon exhaled nitric oxideS Thomas
Faculty of Medicine, University of New South Wales, Sydney, Australia
J Mol Med (Berl) 80:181-6. 2002..1 ppb) than subjects without angiographic CAD (19.9 ppb). In this selected population low levels of eNO were thus associated with presence of the ecNOS4a allele and also with CAD... - Effects of inhaled tumour necrosis factor alpha in subjects with mild asthmaP S Thomas
Inflammation Research Unit, School of Pathology, Faculty of Medicine, University of New South Wales, Sydney, Australia
Thorax 57:774-8. 2002..It was hypothesised that a similar challenge would increase airway reactivity in those with mild asthma, but that the inflammatory profile may differ... - Peak expiratory flow at increased barometric pressure: comparison of peak flow meters and volumetric spirometerP S Thomas
Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia
Clin Sci (Lond) 98:121-4. 2000..86+/-1.69% at 303 kPa with the mini PEF meter). Using these data points, a correction factor was derived which allows appropriate values to be calculated from the Wright's meter readings under these conditions... - Tumour necrosis factor-alpha: the role of this multifunctional cytokine in asthmaP S Thomas
Faculty of Medicine, University of New South Wales and Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, New South Wales, Australia
Immunol Cell Biol 79:132-40. 2001..Treatment directed specifically at a reduction in TNF-alpha activity may conceivably be useful as a glucocorticosteroid-sparing asthma therapy... - Influenza vaccination: changes in exhaled nitric oxide levels and sputum cytologyP S Thomas
Faculty of Medicine, University of New South Wales, Sydney, Australia
Respirology 4:355-8. 1999..The use of simple, non-invasive methods of assessing changes in airway inflammation could potentially allow improved understanding of the cellular mechanisms underlying such changes... - Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytesX M Wei
Inflammation Research Unit, School of Pathology, Faculty of Medicine, UNSW and Department of Respiratory Medicine, Prince of Wales Hospital, NSW 2031, Randwick, Australia
Int Immunopharmacol 3:1581-8. 2003..The dual mechanism involved in the inhibition of this cytokines may represent a novel therapeutical approach in the modulation of inflammatory disease... - Passive smoke inhalation decreases exhaled nitric oxide in normal subjectsD H Yates
Department of Respiratory Medicine, Concord Repatriation General Hospital, Concord, NSW, Australia
Am J Respir Crit Care Med 164:1043-6. 2001..01). This suggests that eNO can be used for the investigation of the mechanisms of cigarette-induced lung damage in the experimental setting, and may potentially be useful also for environmental assessment of ETS effects... - AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromilC T Bruce
University of New South Wales, NSW, Australia
Eur J Clin Invest 36:899-905. 2006..Aminoguanidine abolished the nedocromil-induced protection on the late reduction in FE(NO), but not on AMP PC(20). Inducible NOS was implicated in the late FE(NO) decrease after the AMP challenge... - Oxidative stress in COPD and its measurement through exhaled breath condensateWei Lee
Faculty of Medicine, University of New South Wales, Randwick, New South Wales 2031, Australia
Clin Transl Sci 2:150-5. 2009.... - Nasal and exhaled nitric oxide in response to occupational latex exposureK Tan
Faculty of Medicine, University of New South Wales, Australia
Allergy 56:627-32. 2001..Neither nNO nor eNO showed a clear relationship to routine workplace exposure... - Caffeine decreases exhaled nitric oxideC Bruce
Faculty of Medicine, UNSW and Department of Respiratory Medicine, Prince of Wales Hospital, Sydney, NSW 2031, Australia
Thorax 57:361-3. 2002..CONCLUSION: Caffeine causes a significant decrease in eNO which will need to be considered when designing trials to measure eNO levels. The mechanism may be via adenosine receptor antagonism or by altering levels of cGMP... - Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavageAbigail S Jackson
Department of Thoracic Medicine, St Vincent s Hospital, Victoria Street, Darlinghurst, Sydney, Australia
Am J Respir Crit Care Med 175:222-7. 2007..The exact site of origin of substances measured in EBC is unknown, as is the clinical applicability of the technique. Special techniques might be needed to measure EBC biomarkers... - Exhaled breath condensate as a method of sampling airway nitric oxide and other markers of inflammationJia Liu
Faculty of Medicine, University of New South Wales and Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW, Australia
Med Sci Monit 11:MT53-62. 2005..EBC is becoming a technique which will allow repeated non-invasive sampling from the respiratory tract thus assisting pulmonary research and possibly the monitoring of lung diseases... - Exhaled breath condensate nitrite/nitrate and pH in relation to pediatric asthma control and exhaled nitric oxideJohn Morton
Inflammatory Diseases Research Unit, School of Medical Sciences, Faculty of Medicine, UNSW, Sydney, New South Wales, Australia
Pediatr Pulmonol 41:929-36. 2006..CONCLUSIONS: Mean EBC NOx levels differ between children with asthma, atopy, and those who are normal, but it is not interchangeable with eNO. EBC pH may be an additional marker of asthma control... - Exhaled nitric oxide is decreased by exposure to the hyperbaric oxygen therapy environmentZudin A Puthucheary
UNSW and Department of Respiratory Medicine, Faculty of Medicine, Prince of Wales Hospital, Randwick, NSW, Australia
Mediators Inflamm 2006:72620. 2006..CONCLUSION: HBO exposure causes a fall in eNO. Inducible nitric oxide synthase (iNOS) may cause elevated eNO in patients secondary to inflammation, and inhibition of iNOS may be the mechanism of the reduction of eNO seen with HBOT... - The potential of the immunological markers of sarcoidosis in exhaled breath and peripheral blood as future diagnostic and monitoring techniquesHasib Ahmadzai
Inflammation and Infection Research Centre, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
Inflammopharmacology 19:55-68. 2011..This review explores the literature on the cytokine profiles of blood and bronchoalveolar lavage lymphocytes following ex vivo stimulation, as well as disease markers measured using the medium of EBC... - Current perspectives of oxidative stress and its measurement in chronic obstructive pulmonary diseaseJiun Lih Lin
University of New South Wales, Sydney, Australia
COPD 7:291-306. 2010.... - Eotaxin expression by epithelial cells and plasma cells in chronic asthmaRakesh K Kumar
Inflammation Research Unit, Department of Pathology, University of New South Wales, Sydney, Australia
Lab Invest 82:495-504. 2002..Although high eotaxin levels alone are not sufficient to cause recruitment of eosinophils into the airways, recurrent exposure may generate or up-regulate additional signals required for eosinophil chemotaxis... - L-arginine reverses cigarette-induced reduction of fractional exhaled nitric oxide in asthmatic smokersC T Bruce
Centre for Infection and Inflammation Research and POWH Clinical School, Faculty of Medicine, University of New South Wales, Randwick, NSW, Australia
Inflammopharmacology 18:9-16. 2010..Aminoguanidine, a relatively selective Type II NOS inhibitor, was used also to assess the role of NOS subtypes in these changes of FE(NO)... - Fractional exhaled nitric oxide in asthma: an updateAlessandra Sandrini
Department of Thoracic Medicine, St Vincent s Hospital, Sydney, NSW 2010, Australia
Respirology 15:57-70. 2010..Fe(NO) reference values and the role of Fe(NO) in asthma assessment, diagnosis and management are also discussed... - Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthmaRakesh K Kumar
Department of Pathology, University of New South Wales, Sydney, Australia
J Pharmacol Exp Ther 307:349-55. 2003..Roflumilast did not diminish accumulation of transforming growth factor-beta1, suggesting that it might affect remodeling by mechanisms distinct from glucocorticoids... - Elevated levels of oxidative stress markers in exhaled breath condensateHiang Ping Chan
Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
J Thorac Oncol 4:172-8. 2009..Therefore, lung cancer patients were hypothesized to have higher levels of oxidative stress markers in their exhaled breath compared with controls... - Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthmaC Herbert
Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, Australia
Clin Exp Allergy 38:847-56. 2008..In a mouse model of mild chronic asthma, both inflammation and remodelling can be suppressed by dexamethasone (a glucocorticoid) and roflumilast (a selective phosphodiesterase-4 inhibitor)... - Nitric oxide and exhaled breath nitrite/nitrates in chronic obstructive pulmonary disease patientsJia Liu
Prince of Wales Hospital Clinical School, Faculty of Medicine, University of New South Wales, Randwick, Australia
Respiration 74:617-23. 2007..COPD-associated airway inflammation may be affected by multiple factors, including cigarette smoking and glucocorticosteroid (GCS) treatment... - Mediators in exhaled breath condensate after hypertonic saline challenge- Ratnawati
Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, New South Wales, Australia
J Asthma 46:1045-51. 2009..Airway narrowing after hypertonic saline challenge (HSC) is postulated to be mediated by bronchoconstrictors and inflammatory mediators... - Fractional exhaled nitric oxide concentration is increased in asbestosis and pleural plaquesAlessandra Sandrini
Department of Thoracic Medicine, St Vincent's Hospital, and Worker's Compensation (Dust Diseases) Board Education and Research Unit, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
Respirology 11:325-9. 2006..3+/-0.3 p.p.m.), pleural plaques (1.2+/-0.3 p.p.m.) or diffuse pleural thickening (1.1+/-0.3 p.p.m.). CONCLUSIONS: FENO is raised in asbestosis consistent with lung inflammation, and also in pleural plaques... - Teaching asthma management: an evidence-based educational approachD H Yates
Department of Respiratory Medicine, Concord Repatriation General Hospital, Sydney, NSW
Aust N Z J Med 30:33-7. 2000..Thirty-five students attended the workshop, with 26 returning questionnaires on both of the two sessions... - Health and stress in Australian internsC Bruce
Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
Intern Med J 33:392-5. 2003..9, P=0.003 and chi2=20.4, P<0.001, respectively). Despite workplace reform for junior doctors, this study suggests that interns still feel overburdened with work expectations and this is having a negative effect on their health... - Nicorandil inhibits degranulation and TNF-alpha release from RBL-2H3 cellsG J Heywood
Inflammation Research Unit, School of Pathology, Faculty of Medicine, UNSW, Australia
Inflamm Res 51:176-81. 2002.... - Laughter-associated asthmaG Liangas
Faculty of Medicine, University of New South Wales, Sydney, Australia
J Asthma 41:217-21. 2004..043). Laughter-induced asthma is strongly associated with exercise as a trigger; the mechanism remains uncertain, but better understanding of this problem may assist in controlling difficult asthma... - Relationship between exhaled breath condensate volume and measurements of lung volumesJia Liu
Faculty of Medicine, University of New South Wales, and Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, Australia
Respiration 74:142-5. 2007..Exhaled breath condensate (EBC) is proving to be a technique which can sample markers of lung inflammation; however, many factors affect the collection process... - Effect of hydrofluoroalkane-ethanol inhalers on estimated alcohol levels in asthmatic subjectsColleen Bruce
Faculty of Medicine, University of New South Wales, Sydney, Australia
Respirology 14:112-6. 2009..It was hypothesized that HFA-ethanol MDI may contribute to raising BEC above the legal limit... - Exhaled breath condensate biomarkers in asbestos-related lung disordersSharron Chow
Research and Education Unit, Workers Compensation Dust Diseases Board of New South Wales, Sydney, Australia
Respir Med 103:1091-7. 2009..Several such species can be measured non-invasively in humans in exhaled breath condensate (EBC) but few have been evaluated. This study aimed to assess oxidative stress and lung inflammation in vivo... - An electronic nose in the discrimination of breath from smokers and non-smokers: a model for toxin exposureZ J Cheng
Centre for Infection and Inflammation Research and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW 2031, Australia
J Breath Res 3:036003. 2009..It may prove to be a useful, non-invasive tool for further breath assessment of exposure to other inhaled noxious substances as well as disease monitoring... - Deleterious effect of nitric oxide inhibition in chronic hepatopulmonary syndromeJohn A Almeida
Gastrointestinal and Liver Unit, The Prince of Wales Hospital and University of New South Wales, Sydney, Australia
Eur J Gastroenterol Hepatol 19:341-6. 2007.... - Proteomics in detection and monitoring of asthma and smoking-related lung diseasesJiun Lih Lin
Faculty of Medicine, University of New South Wales, Sydney, Australia
Expert Rev Proteomics 7:361-72. 2010..With better study design standardization and the implementation of novel technologies to reach the optimal research standard, there is enough reason be optimistic about the future of proteomic research and its clinical implications... - Occupational sensitization to lupin in the workplace: occupational asthma, rhinitis, and work-aggravated asthmaCharlotte P Campbell
Department of Thoracic Medicine, St Vincent s Hospital, Darlinghurst, Sydney, Australia
J Allergy Clin Immunol 119:1133-9. 2007..Lupin is a legume. Its seed can be ground into flour and incorporated into food as a protein source. Cases of rhinitis, urticaria, and anaphylaxis from ingestion of lupin have been reported as well as asthma... - Control of rheumatoid arthritis by oral toleranceE H Choy
Guy's Kings, Hospital School of Medicine, King's College, London, UK
Arthritis Rheum 44:1993-7. 2001..However, the therapeutic window is narrow. The difference between our results and those of other trials may relate to the dose, species, and formulation of the CII... - Delta tryptase is expressed in multiple human tissues, and a recombinant form has proteolytic activityHong Wei Wang
Inflammation Research Units, Department of Pathology, University of New South Wales, Sydney, Australia
J Immunol 169:5145-52. 2002..These results suggest that the range of functional tryptases is larger than previously recognized. For simplicity, we suggest that the gene, transcripts, and corresponding protein product be named delta tryptase... - Pulmonary dysanapsis and diving assessmentsLin Min Ong
Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, NSW 2031, Australia
Undersea Hyperb Med 36:375-80. 2009..While pulmonary dysanapsis may increase the risk of airway hyperresponsiveness, there is no evidence of an association with diving-related pulmonary barotrauma... - The effect of marimastat, a metalloprotease inhibitor, on allergen-induced asthmatic hyper-reactivityColleen Bruce
Department of Respiratory Medicine, Faculty of Medicine, University of New South Wales, Prince of Wales Hospital, Randwick, NSW 2031, Australia
Toxicol Appl Pharmacol 205:126-32. 2005..Marimastat did not modify eNO, FEV(1), asthma symptoms, or albuterol usage. In conclusion, airway responsiveness to allergen may be modified by a MMP inhibitor, perhaps via TNFalpha playing a role in airway inflammation and remodeling... - TNF-alpha as a target for anti-asthma therapyColleen T Bruce
Clin Sci (Lond) 110:265. 2006