P Q Thomas

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia
    P Q Thomas
    Gene Discovery Unit, The Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, VIC 3052, Australia
    Hum Mol Genet 10:39-45. 2001
  2. ncbi request reprint Identification and enrichment of colony-forming cells from the adult murine pituitary
    D A Lepore
    Pituitary Research Unit, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Exp Cell Res 308:166-76. 2005
  3. ncbi request reprint Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary
    L D Wilson
    Murdoch Childrens Research Institute, Royal Childrens Hospital, Melbourne, VIC 3052, Australia
    Gene Expr Patterns 5:305-11. 2005
  4. pmc Array comparative genomic hybridisation analysis of boys with X linked hypopituitarism identifies a 3.9 Mb duplicated critical region at Xq27 containing SOX3
    N M Solomon
    Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Vic, 3052, Australia
    J Med Genet 41:669-78. 2004
  5. ncbi request reprint HESX1: a novel gene implicated in a familial form of septo-optic dysplasia
    M T Dattani
    London Centre for Paediatric Endocrinology and Metabolism, Institute of Child Health, UK
    Acta Paediatr Suppl 88:49-54. 1999
  6. ncbi request reprint Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse
    M T Dattani
    London Centre for Paediatric Endocrinology and Metabolism, Institute of Child Health, UK
    Nat Genet 19:125-33. 1998
  7. ncbi request reprint An anterior signalling centre in Xenopus revealed by the homeobox gene XHex
    C M Jones
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, UK
    Curr Biol 9:946-54. 1999
  8. ncbi request reprint Adrenocorticotropin deficiency in combined pituitary hormone deficiency patients homozygous for a novel PROP1 deletion
    G Agarwal
    Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226014 Lucknow, India
    J Clin Endocrinol Metab 85:4556-61. 2000
  9. ncbi request reprint Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
    P Q Thomas
    MRC National Institute for Medical Research, London, UK
    Development 125:85-94. 1998
  10. ncbi request reprint Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression
    L T Raetzman
    Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Dev Biol 265:329-40. 2004

Collaborators

  • J M Penninger
  • J M Brickman
  • M L Dattani
  • F A Hol
  • S A Ross
  • D A Lepore
  • L D Wilson
  • N M Solomon
  • L T Raetzman
  • S Cook
  • G Agarwal
  • C M Jones
  • J Wagner
  • K Bauer
  • T Wada
  • K Roeszler
  • N J Hopwood
  • S A Camper
  • A S Tan
  • S E Myers
  • S L Dunwoodie
  • G L Warne
  • T Morgan
  • J L Belsky
  • S M Forrest
  • P S Karnes
  • V Bhatia
  • J C Smith
  • R S Beddington
  • J Broadbent
  • G C Webb
  • J H Ford
  • P D Rathjen

Detail Information

Publications13

  1. ncbi request reprint Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia
    P Q Thomas
    Gene Discovery Unit, The Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, VIC 3052, Australia
    Hum Mol Genet 10:39-45. 2001
    ..These results demonstrate that some sporadic cases of the more common mild forms of pituitary hypoplasia have a genetic basis, resulting from heterozygous mutation of the HESX1 gene...
  2. ncbi request reprint Identification and enrichment of colony-forming cells from the adult murine pituitary
    D A Lepore
    Pituitary Research Unit, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Exp Cell Res 308:166-76. 2005
    ..Together, these data show that the pituitary contains a rare clonogenic population which may correspond to the somatotrope/lactotrope progenitors suggested by previous experiments...
  3. ncbi request reprint Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary
    L D Wilson
    Murdoch Childrens Research Institute, Royal Childrens Hospital, Melbourne, VIC 3052, Australia
    Gene Expr Patterns 5:305-11. 2005
    ..Pituitary cell differentiation and morphology appeared normal in the Rgs2 mutant animals, suggesting that other Rgs family members with similar activities may be present in the developing pituitary...
  4. pmc Array comparative genomic hybridisation analysis of boys with X linked hypopituitarism identifies a 3.9 Mb duplicated critical region at Xq27 containing SOX3
    N M Solomon
    Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Vic, 3052, Australia
    J Med Genet 41:669-78. 2004
    ..However, its ability to detect disease causing duplications in constitutional genomic DNA has not been shown. We developed an array CGH assay for X linked hypopituitarism, which is associated with duplication of Xq26-q27...
  5. ncbi request reprint HESX1: a novel gene implicated in a familial form of septo-optic dysplasia
    M T Dattani
    London Centre for Paediatric Endocrinology and Metabolism, Institute of Child Health, UK
    Acta Paediatr Suppl 88:49-54. 1999
    ..Hence, a vital role for Hesx1/HESX1 in forebrain and pituitary development in mice and humans is suggested...
  6. ncbi request reprint Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse
    M T Dattani
    London Centre for Paediatric Endocrinology and Metabolism, Institute of Child Health, UK
    Nat Genet 19:125-33. 1998
    ..These data suggest an important role for Hesx1/HESX1 in forebrain, midline and pituitary development in mouse and human...
  7. ncbi request reprint An anterior signalling centre in Xenopus revealed by the homeobox gene XHex
    C M Jones
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, UK
    Curr Biol 9:946-54. 1999
    ..Here, we report the origin and signalling properties of this population of cells in the early Xenopus embryo...
  8. ncbi request reprint Adrenocorticotropin deficiency in combined pituitary hormone deficiency patients homozygous for a novel PROP1 deletion
    G Agarwal
    Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226014 Lucknow, India
    J Clin Endocrinol Metab 85:4556-61. 2000
    ..From a clinical perspective, these data indicate that the presence of an impaired pituitary-adrenal axis in CPHD patients does not exclude the possibility of an underlying PROP1 gene defect...
  9. ncbi request reprint Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
    P Q Thomas
    MRC National Institute for Medical Research, London, UK
    Development 125:85-94. 1998
    ....
  10. ncbi request reprint Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression
    L T Raetzman
    Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Dev Biol 265:329-40. 2004
    ..The spatial and temporal expression patterns of Notch signaling genes in the pituitary suggest overlapping roles in pituitary growth and cell specification...
  11. ncbi request reprint Hesx1, a homeobox gene expressed by murine embryonic stem cells, maps to mouse chromosome 14, bands A3-B
    G C Webb
    Department of Genetics, Queen Elizabeth Hospital, Woodville, Australia
    Genomics 18:464-6. 1993
  12. ncbi request reprint Sequence, genomic organization, and expression of the novel homeobox gene Hesx1
    P Q Thomas
    Department of Biochemistry, University of Adelaide, Australia
    J Biol Chem 270:3869-75. 1995
    ..Expression in adult mice was not detected. These sites of expression are consistent with a role for Hesx1 in the regulation of developmental decisions in the early mouse embryo and during fetal hematopoiesis...
  13. pmc HES-1, a novel homeobox gene expressed by murine embryonic stem cells, identifies a new class of homeobox genes
    P Q Thomas
    Department of Biochemistry, University of Adelaide, Australia
    Nucleic Acids Res 20:5840. 1992