Stuart G Tangye

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage
    Danielle T Avery
    Centenary Institute of Cancer Medicine and Cell Biology, New South Wales, Australia
    J Immunol 174:4034-42. 2005
  2. ncbi request reprint Follicular B helper T cells in antibody responses and autoimmunity
    Carola G Vinuesa
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra 2601, Australia
    Nat Rev Immunol 5:853-65. 2005
  3. ncbi request reprint Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation
    Jhagvaral Hasbold
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag Number 6, Newtown, NSW 2042, Australia
    Nat Immunol 5:55-63. 2004
  4. ncbi request reprint Regulation of NKT cell development by SAP, the protein defective in XLP
    Kim E Nichols
    Pediatric Oncology, Wood, 4th Floor, 3615 Civic Center Boulevard, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nat Med 11:340-5. 2005
  5. ncbi request reprint Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome
    S G Tangye
    Centenary Institute for Cancer Medicine and Cell Biology, and University of Sydney, New South Wales, Australia
    J Immunol 165:2932-6. 2000
  6. pmc Divide and conquer: the importance of cell division in regulating B-cell responses
    Stuart G Tangye
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown 2042, NSW, Australia
    Immunology 112:509-20. 2004
  7. ncbi request reprint Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation
    Stuart G Tangye
    Centenary Institute for Cancer Medicine and Cell Biology, Newtown 2042, Sydney, New South Wales, Australia
    J Immunol 171:2485-95. 2003
  8. ncbi request reprint Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses
    Stuart G Tangye
    Immune Regulation Group, Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
    J Immunol 170:686-94. 2003
  9. ncbi request reprint A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells
    Stuart G Tangye
    Immune Regulation Group, Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales, Australia
    J Immunol 170:261-9. 2003
  10. ncbi request reprint CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2
    Stuart G Tangye
    Immune Regulation Group, Centenary Institute for Cancer Medicine and Cell Biology, Newtown, Australia
    Eur J Immunol 32:1640-9. 2002

Detail Information

Publications54

  1. ncbi request reprint Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage
    Danielle T Avery
    Centenary Institute of Cancer Medicine and Cell Biology, New South Wales, Australia
    J Immunol 174:4034-42. 2005
    ..We propose that the differentiation of memory B cells into PC involves a transitional stage characterized by a CD27(high)CD38(-) phenotype with the acquired ability to secrete high levels of Ig...
  2. ncbi request reprint Follicular B helper T cells in antibody responses and autoimmunity
    Carola G Vinuesa
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra 2601, Australia
    Nat Rev Immunol 5:853-65. 2005
    ..Here, we outline the central role of this subset in normal and pathological immune responses...
  3. ncbi request reprint Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation
    Jhagvaral Hasbold
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag Number 6, Newtown, NSW 2042, Australia
    Nat Immunol 5:55-63. 2004
    ..Stochastic division-linked regulation of heterogeneity challenges the conventional paradigms linking distinct phenotypes to unique combinations of signals and has the potential to simplify our concept of immune complexity considerably...
  4. ncbi request reprint Regulation of NKT cell development by SAP, the protein defective in XLP
    Kim E Nichols
    Pediatric Oncology, Wood, 4th Floor, 3615 Civic Center Boulevard, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nat Med 11:340-5. 2005
    ..Thus, SAP is a crucial regulator of NKT cell ontogeny in humans and in mice. The absence of NKT cells may contribute to the phenotypes of SAP deficiency, including abnormal antiviral and antitumor immunity and hypogammaglobulinemia...
  5. ncbi request reprint Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome
    S G Tangye
    Centenary Institute for Cancer Medicine and Cell Biology, and University of Sydney, New South Wales, Australia
    J Immunol 165:2932-6. 2000
    ..Despite this, CD2 or CD16-induced cytotoxicity of SAP-deficient NK cells was similar to that of normal NK cells. Thus, selective impairment of 2B4-mediated NK cell activation may contribute to the immunopathology of XLP...
  6. pmc Divide and conquer: the importance of cell division in regulating B-cell responses
    Stuart G Tangye
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown 2042, NSW, Australia
    Immunology 112:509-20. 2004
    ..New data for mouse and human B cells point to an important role for division in regulating isotype class and in optimizing development of protective immunity by the regulated entry of cells to the plasma cell lineage...
  7. ncbi request reprint Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation
    Stuart G Tangye
    Centenary Institute for Cancer Medicine and Cell Biology, Newtown 2042, Sydney, New South Wales, Australia
    J Immunol 171:2485-95. 2003
    ..These results reveal a novel function of CD84 on human lymphocytes and suggest that CD84 can activate human T cells via a SAP-independent mechanism...
  8. ncbi request reprint Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses
    Stuart G Tangye
    Immune Regulation Group, Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
    J Immunol 170:686-94. 2003
    ..These differences help explain the accelerated Ab response exhibited by memory B cells after secondary challenge by an invading pathogen, a hallmark of immunological memory...
  9. ncbi request reprint A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells
    Stuart G Tangye
    Immune Regulation Group, Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales, Australia
    J Immunol 170:261-9. 2003
    ....
  10. ncbi request reprint CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2
    Stuart G Tangye
    Immune Regulation Group, Centenary Institute for Cancer Medicine and Cell Biology, Newtown, Australia
    Eur J Immunol 32:1640-9. 2002
    ..Thus, investigation of expression and function of CD84 and CD27 is likely to contribute to a greater understanding of the development and biology of memory B cells in normal and immunocompromised hosts...
  11. ncbi request reprint 2B4-mediated activation of human natural killer cells
    S G Tangye
    Centenary Institute for Cancer Medicine and Cell Biology, Immune Relation Group, University of Sydney, Locked Bag 6, Newtown, NSW 2042, Sydney, Australia
    Mol Immunol 37:493-501. 2000
    ..This may contribute to the phenotype and progression of this disease...
  12. doi request reprint STAT3 is required for IL-21-induced secretion of IgE from human naive B cells
    Danielle T Avery
    Immunology and Inflammation Group, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Blood 112:1784-93. 2008
    ....
  13. pmc BAFF selectively enhances the survival of plasmablasts generated from human memory B cells
    Danielle T Avery
    Centenary Institute of Cancer Medicine and Cell Biology, Newton, Australia
    J Clin Invest 112:286-97. 2003
    ..These findings have wide-ranging implications for the treatment of human immunodeficiencies as well as autoimmune diseases...
  14. pmc Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease
    Cindy S Ma
    Lymphocyte Differentiation Laboratory, Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Clin Invest 116:322-33. 2006
    ..Production of affinity-matured IgM by IgMCD27 B cells may protect against pathogens to which a normal immune response is elicited in XLP patients...
  15. ncbi request reprint Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells
    Vanessa L Bryant
    Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    J Immunol 179:8180-90. 2007
    ..These findings suggest that IL-21 produced by TFH cells during the primary as well as the subsequent responses to T cell-dependent Ag makes a major contribution to eliciting and maintaining long-lived humoral immunity...
  16. pmc Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling
    Elissa K Deenick
    Immunology Program, Garvan Institute of Medical Research, Darlinghurst, 2010, NSW, Australia
    Immunity 33:241-53. 2010
    ....
  17. ncbi request reprint IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4
    Danielle T Avery
    Immunology and Inflammation Group, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    J Immunol 181:1767-79. 2008
    ..Our findings demonstrate the dynamic interplay between IL-4 and IL-21 in regulating the production of IgG subclasses and IgA, and suggest temporal roles for these cytokines in humoral immune responses to specific pathogens...
  18. doi request reprint Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12
    Cindy S Ma
    Garvan Institute of Medical Research, NSW, Australia
    Immunol Cell Biol 87:590-600. 2009
    ..Thus, these cytokines, particularly IL-12, are likely to act at an early stage during dendritic cell-mediated priming of naïve CD4(+) T cells into a T(FH) cell fate, and thus underpin antibody-mediated immunity...
  19. pmc Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells
    Cindy S Ma
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Clin Invest 115:1049-59. 2005
    ..Thus, insufficient IL-10 production may contribute to hypogammaglobulinemia in XLP. This finding suggests new strategies for treating this immunodeficiency...
  20. ncbi request reprint Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells
    Kim L Good
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Immunol 182:890-901. 2009
    ....
  21. ncbi request reprint Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity
    Amanda K Cuss
    Centenary Institute of Cancer Medicine and Cell Biology, New South Wales, Australia
    J Immunol 176:1506-16. 2006
    ..Further investigation of transitional B cells will improve our understanding of human B cell development and how alterations to this process may precipitate immunodeficiency or autoimmunity...
  22. ncbi request reprint Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules
    Cindy S Ma
    Garvan Institute of Medical Research, Darlinghurst, 2010, New South Wales, Australia
    Annu Rev Immunol 25:337-79. 2007
    ....
  23. ncbi request reprint Isotype switching by human B cells is division-associated and regulated by cytokines
    Stuart G Tangye
    Immune Regulation Group, Centenary Institute for Cancer Medicine and Cell Biology, Locked Bag 6, Newtown, New South Wales 2042, Australia
    J Immunol 169:4298-306. 2002
    ....
  24. ncbi request reprint Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow
    Julia I Ellyard
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Blood 103:3805-12. 2004
    ..Thus, our results suggest that splenic ISCs have an important role in humoral immunity and may represent the affected cell type in some B-cell dyscrasias...
  25. ncbi request reprint BAFF, APRIL and human B cell disorders
    Stuart G Tangye
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Semin Immunol 18:305-17. 2006
    ..It will also highlight relevant differences between the function of BAFF in humans and mice and the impact of this on the therapeutic utility of BAFF antagonists in the treatment of different human diseases...
  26. ncbi request reprint Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21
    Kim L Good
    Centenary Institute of Cancer Medicine and Cell Biology, New South Wales, Australia
    J Immunol 177:5236-47. 2006
    ..Thus, antagonizing IL-21 may be a novel strategy for treating Ab-mediated autoimmune diseases...
  27. pmc Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP
    Umaimainthan Palendira
    Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    PLoS Biol 9:e1001187. 2011
    ..This system may allow the study of other human diseases where heterozygous gene expression from random X-chromosome inactivation can be exploited...
  28. ncbi request reprint Automatic generation of lymphocyte heterogeneity: Division-dependent changes in the expression of CD27, CCR7 and CD45 by activated human naive CD4+ T cells are independently regulated
    Cindy S Ma
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia
    Immunol Cell Biol 82:67-74. 2004
    ....
  29. doi request reprint The good, the bad and the ugly - TFH cells in human health and disease
    Stuart G Tangye
    Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia
    Nat Rev Immunol 13:412-26. 2013
    ..The elucidation of the mechanisms that regulate TFH cell differentiation, function and fate should highlight targets for novel therapeutics...
  30. ncbi request reprint Missense mutations in SH2D1A identified in patients with X-linked lymphoproliferative disease differentially affect the expression and function of SAP
    Nathan J Hare
    Lymphocyte Differentiation, Centenary Institute for Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, New South Wales 2042, Australia
    Int Immunol 18:1055-65. 2006
    ....
  31. doi request reprint Memory B cells: effectors of long-lived immune responses
    Stuart G Tangye
    Immunology and Inflammation Department, Garvan Institute of Medical Research, NSW, Australia
    Eur J Immunol 39:2065-75. 2009
    ..Finally, we consider recent advances in the understanding of germinal center B-cell differentiation through analysis of transcription factor networks operating in these B cells...
  32. doi request reprint CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses
    Nina Chevalier
    Immunology Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia
    J Immunol 186:5556-68. 2011
    ..Taken together, we propose that CXCR5(+) T(CM) represent a distinct memory cell subset specialized in supporting Ab-mediated immune responses...
  33. doi request reprint Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome
    Simon T Cliffe
    Department of Haematology and Genetics, Prince of Wales Hospital, Sydney, Australia
    J Allergy Clin Immunol 130:735-742.e6. 2012
    ....
  34. ncbi request reprint Persistence of naive CD45RA+ regulatory T cells in adult life
    Nabila Seddiki
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW, Australia 2042
    Blood 107:2830-8. 2006
    ..Targeting naive TREGs in adults may offer new means of preventing and treating autoimmune disease...
  35. ncbi request reprint B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells
    Lai Guan Ng
    Arthritis and Asthma Research Program, The Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    J Immunol 173:807-17. 2004
    ..Thus, BAFF-R is important not only for splenic B cell maturation, but is the major mediator of BAFF-dependent costimulatory responses in peripheral B and T cells...
  36. pmc Decreased expression of Kruppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses
    Kim L Good
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown 2048 NSW, Australia
    Proc Natl Acad Sci U S A 104:13420-5. 2007
    ..Thus, the accelerated response of memory B cells correlates with reduced expression of KLF4, KLF9, and PLZF and the subsequent regulatory effects they exert on the cell cycle...
  37. ncbi request reprint Contribution of stromal cells to the migration, function and retention of plasma cells in human spleen: potential roles of CXCL12, IL-6 and CD54
    Julia I Ellyard
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
    Eur J Immunol 35:699-708. 2005
    ..Thus, we propose that stromal cells attract PC to the RP and contribute to their retention and function through the combined expression of CXCL12, CD54 and IL-6...
  38. doi request reprint T cell-B cell interactions in primary immunodeficiencies
    Stuart G Tangye
    Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Ann N Y Acad Sci 1250:1-13. 2012
    ....
  39. doi request reprint T follicular helper (TFH) cells in normal and dysregulated immune responses
    Cecile King
    Immunology and Inflammation Research Program, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia
    Annu Rev Immunol 26:741-66. 2008
    ..Consequently, dysregulation of T(FH) cell function, and over- or under-expression of T(FH) cell-associated molecules such as ICOS or IL-21, most likely contributes to the pathogenesis of certain autoimmune diseases or immunodeficiencies...
  40. doi request reprint Regulation of T follicular helper cell formation and function by antigen presenting cells
    Elissa K Deenick
    Immunology Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, 2010, NSW, Australia
    Curr Opin Immunol 23:111-8. 2011
    ..Recent studies have illuminated the key roles of APCs in TFH development, and have also re-defined the role of B cells in this process...
  41. doi request reprint Therapeutic implications of advances in our understanding of transitional B-cell development in humans
    Santi Suryani
    Immunology Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst 2010, NSW, Australia
    Expert Rev Clin Immunol 6:765-75. 2010
    ..Here, we overview the latest findings relating to human B cells in health and disease with a particular emphasis on the transitional stage of B-cell development...
  42. pmc Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function
    Megan L Ives
    Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, Australia St Vincent s Clinical School, University of New South Wales, Sydney, Australia
    J Allergy Clin Immunol 132:400-411.e9. 2013
    ..However, the role of IL-21 and associated signaling pathways in protective CD8(+) T-cell immunity in human subjects is unknown...
  43. doi request reprint Staying alive: regulation of plasma cell survival
    Stuart G Tangye
    Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Trends Immunol 32:595-602. 2011
    ....
  44. doi request reprint Immunology: Helpful T cells are sticky
    Elissa K Deenick
    Nature 455:745-7. 2008
  45. ncbi request reprint T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    Tatyana Chtanova
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Immunol 173:68-78. 2004
    ..Gene microarrays reveal a highly distinctive transcriptional profile for a third subset of effector T cells that differs markedly from Th1 and Th2 cells...
  46. ncbi request reprint Human IgM+CD27+ B cells: memory B cells or "memory" B cells?
    Stuart G Tangye
    Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia
    J Immunol 179:13-9. 2007
    ..In this review we will provide alternate interpretations of the biology of IgM+CD27+ B cells and propose that they are indeed memory cells...
  47. pmc The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation
    Cuiping Gu
    Department of Life Science and Biotechnology, Shanghai Jiaotong University, 1954 Huashan Road, Shanghai 200030, China
    Proc Natl Acad Sci U S A 103:14447-52. 2006
    ..Taken together, our data strongly suggest that, in addition to the known SAP-interacting kinase Fyn, PIX may be another key player in SAP-mediated T cell activation...
  48. pmc Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells
    David B Rosen
    Department of Microbiology and Immunology, Biomedical Sciences Graduate Program, and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 180:6508-17. 2008
    ..Expression of LLT1 on activated dendritic cells and B cells suggests that it might regulate the cross-talk between NK cells and APCs...
  49. doi request reprint Epstein-Barr virus persistence in the absence of conventional memory B cells: IgM+IgD+CD27+ B cells harbor the virus in X-linked lymphoproliferative disease patients
    Sridhar Chaganti
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
    Blood 112:672-9. 2008
    ..These results provide the first definitive evidence that EBV can establish persistence in the B-cell system in the absence of fully functional germinal center activity and of a class-switched memory B-cell compartment...
  50. ncbi request reprint Molecular and cellular pathogenesis of X-linked lymphoproliferative disease
    Kim E Nichols
    Pediatric Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Immunol Rev 203:180-99. 2005
    ..Further studies of SAP and the SLAM family receptors will provide insights into XLP and elucidate the signaling events regulating lymphocyte ontogeny and function...
  51. ncbi request reprint SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells
    Loïc Dupré
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132 Milan, Italy
    Blood 105:4383-9. 2005
    ..These results demonstrate that the SAP/2B4 pathway plays a key role in CTL lytic activity against EBV-positive targets by promoting the polarization of the lytic machinery...
  52. ncbi request reprint The role of the BAFF/APRIL system in B cell homeostasis and lymphoid cancers
    Fabienne Mackay
    The Garvan Institute of Medical Research, Department of Arthritis and Inflammation, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Curr Opin Pharmacol 4:347-54. 2004
    ..The strong dependence of certain lymphoid cancer cells on BAFF might be a point of vulnerability, which offers exciting new therapeutic possibilities...
  53. ncbi request reprint Autoimmunity: IL-21: a new player in Th17-cell differentiation
    Elissa K Deenick
    Immunology and Inflammation Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst corrected Sydney, New South Wales corrected Australia
    Immunol Cell Biol 85:503-5. 2007
  54. ncbi request reprint An important role for B-cell activation factor and B cells in the pathogenesis of Sjögren's syndrome
    Fabienne Mackay
    The Autoimmunity Research Unit, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Curr Opin Rheumatol 19:406-13. 2007
    ..This review provides an update on the specific, strong association between dysregulated production of the cytokine B-cell activation factor and Sjögren's syndrome, and offers new perspectives on potential pathogenic mechanisms...