Patrick P L Tam

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. doi request reprint Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo
    Vanessa Franklin
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Mech Dev 125:587-600. 2008
  2. ncbi request reprint Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo
    P P Tam
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 126:5171-9. 1999
  3. ncbi request reprint Anne McLaren 1927-2007
    Patrick Tam
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Wentworthville, NSW 2145, Australia
    Cell 130:201-3. 2007
  4. ncbi request reprint Gene function in mouse embryogenesis: get set for gastrulation
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute and Faculty of Medicine, University of Sydney, Westmead, NSW 2145, Australia
    Nat Rev Genet 8:368-81. 2007
  5. ncbi request reprint The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo
    A Camus
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 127:1799-813. 2000
  6. ncbi request reprint Early endoderm development in vertebrates: lineage differentiation and morphogenetic function
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, New South Wales 2145, Australia
    Curr Opin Genet Dev 13:393-400. 2003
  7. ncbi request reprint Mouse embryonic chimeras: tools for studying mammalian development
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia
    Development 130:6155-63. 2003
  8. ncbi request reprint The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo
    S J Kinder
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 126:4691-701. 1999
  9. ncbi request reprint Embryonic axes: the long and short of it in the mouse
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Curr Biol 14:R239-41. 2004
  10. doi request reprint Specifying mouse embryonic germ cells
    Patrick P L Tam
    Children s Medical Research Institute, University of Sydney, Wentworthville, NSW, Australia
    Cell 137:398-400. 2009

Detail Information

Publications91

  1. doi request reprint Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo
    Vanessa Franklin
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Mech Dev 125:587-600. 2008
    ....
  2. ncbi request reprint Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo
    P P Tam
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 126:5171-9. 1999
    ..The formation of anterior neural structures therefore requires the synergistic interaction of the early gastrula organizer and anterior germ layer tissues...
  3. ncbi request reprint Anne McLaren 1927-2007
    Patrick Tam
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Wentworthville, NSW 2145, Australia
    Cell 130:201-3. 2007
  4. ncbi request reprint Gene function in mouse embryogenesis: get set for gastrulation
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute and Faculty of Medicine, University of Sydney, Westmead, NSW 2145, Australia
    Nat Rev Genet 8:368-81. 2007
    ....
  5. ncbi request reprint The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo
    A Camus
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 127:1799-813. 2000
    ..The maintenance and function of the rostral AML therefore require inductive signals emanating from the caudal AML. Our results point to a role for AML in the refinement of the anteroposterior patterning and morphogenesis of the brain...
  6. ncbi request reprint Early endoderm development in vertebrates: lineage differentiation and morphogenetic function
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, New South Wales 2145, Australia
    Curr Opin Genet Dev 13:393-400. 2003
    ..Morphogenetic interactions between the endoderm and the other germ layer derivatives are critical for the morphogenesis of head structures and organogenesis of gut derivatives...
  7. ncbi request reprint Mouse embryonic chimeras: tools for studying mammalian development
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Westmead, New South Wales, Australia
    Development 130:6155-63. 2003
    ..By combining embryonic stem cell technology, molecularly tagged mutations and sensitive cell lineage markers, chimeras can provide invaluable insights into the tissue-specific requirement and the mode of action of many mouse genes...
  8. ncbi request reprint The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo
    S J Kinder
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 126:4691-701. 1999
    ....
  9. ncbi request reprint Embryonic axes: the long and short of it in the mouse
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Curr Biol 14:R239-41. 2004
    ....
  10. doi request reprint Specifying mouse embryonic germ cells
    Patrick P L Tam
    Children s Medical Research Institute, University of Sydney, Wentworthville, NSW, Australia
    Cell 137:398-400. 2009
    ..Ohinata et al. (2009) now clarify the steps of mouse germ cell formation and use this genetic insight to direct the specification and differentiation of germline progenitor cells in vitro...
  11. ncbi request reprint Regionalization of cell fates and cell movement in the endoderm of the mouse gastrula and the impact of loss of Lhx1(Lim1) function
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute, University of Sydney, New South Wales, Australia
    Dev Biol 274:171-87. 2004
    ..The inefficient movement of the anterior endoderm, and the abnormal differentiation highlighted by the lack of Sox17 and Foxa2 expression, may underpin the malformation of the head of Lhx1 mutant embryos...
  12. ncbi request reprint Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Locked Bag 23, Wentworthville, New South Wales 2145, Australia
    Development 134:251-60. 2007
    ..The observation that the endoderm cells are inherently unable to move despite the expansion of the mesoderm in the Mixl1-null mutant suggests that the movement of the endoderm and the mesoderm is driven independently of one another...
  13. ncbi request reprint Building the mouse gastrula: signals, asymmetry and lineages
    Patrick P L Tam
    Embryology Unit, Children s Medical Research Institute and University of Sydney, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Curr Opin Genet Dev 16:419-25. 2006
    ..These signalling activities are also required for the specification of anterior and posterior fates of the epiblast cells and for the induction and navigation of the primordial germ cells...
  14. ncbi request reprint Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton
    David A F Loebel
    Embryology Unit, Children s Medical Research Institute, Sydney, Australia
    Dev Biol 362:132-40. 2012
    ....
  15. doi request reprint The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function
    Heidi Bildsoe
    Embryology Unit, Children s Medical Research Institute, Sydney, NSW, Australia
    Dev Biol 374:295-307. 2013
    ..Our findings point to a role of Twist1 in maintaining the mesenchyme architecture and the progenitor state of the mesoderm, as well as mediating mesoderm-neural crest interactions in craniofacial development...
  16. ncbi request reprint Dkk1 and Wnt3 interact to control head morphogenesis in the mouse
    Samara L Lewis
    Children s Medical Research Institute, University of Sydney, Wentworthville, New South Wales, NSW 2145, Australia
    Development 135:1791-801. 2008
    ..These findings highlight that head development is sensitive to the level of WNT3 signalling and that DKK1 is the key antagonist that modulates WNT3 activity during anterior morphogenesis...
  17. ncbi request reprint Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells
    Masato S Ota
    Embryology Unit, Children s Medical Research Institute, Westmead, NSW Australia
    Dev Dyn 230:216-28. 2004
    ....
  18. doi request reprint Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos
    Sabine Pfister
    Embryology Unit, Children s Medical Research Institute, New South Wales, Australia
    Int J Dev Biol 55:45-58. 2011
    ..This is associated with the defective development of the heart in the mutant embryos, which is accompanied by localised loss of Myocd-expressing cardiogenic progenitors and the malformation of the anterior intestinal portal...
  19. doi request reprint Twist2: role in corneal stromal keratocyte proliferation and corneal thickness
    Linda Weaving
    Eye Genetics Research Group, Embryology, Children s Medical Research Institute, The Children s Hospital at Westmead, Save Sight Institute, Sydney, NSW, Australia
    Invest Ophthalmol Vis Sci 51:5561-70. 2010
    ..In this study, the authors analyzed the role of Twist2 in the eye and cornea through examination of a Twist2 loss-of-function mouse mutant...
  20. ncbi request reprint Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity
    S J Kinder
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Int J Dev Biol 45:347-55. 2001
    ..By contrast, in T/T mutant embryos that display normal head fold development, the expression domains of organizer, primitive streak and anterior endoderm genes are regionalised correctly in the gastrula...
  21. ncbi request reprint Experimental analysis of the emergence of left-right asymmetry of the body axis in early postimplantation mouse embryos
    T E Tsang
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Cell Mol Biol (Noisy-le-grand) 45:493-503. 1999
    ....
  22. ncbi request reprint Twist plays an essential role in FGF and SHH signal transduction during mouse limb development
    Meredith P O'Rourke
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW 2145, Australia
    Dev Biol 248:143-56. 2002
    ..Twist activity is therefore essential for the growth and differentiation of the limb bud tissues as well as regulation of tissue patterning via the modulation of SHH and FGF signal transduction...
  23. ncbi request reprint Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo
    Kenneth Soo
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Dev Biol 247:251-70. 2002
    ..Twist is also required for the proper differentiation of the first arch tissues into bone, muscle, and teeth...
  24. ncbi request reprint Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo
    Heidi Bildsoe
    Children s Medical Research Institute, The University of Sydney, Wentworthville, NSW, Australia
    Dev Biol 331:176-88. 2009
    ..In contrast, the formation of other mesodermal skeletal derivatives such as the occipital bones and most of the chondrocranium are not affected by the loss of Twist1 in the neural crest cells...
  25. doi request reprint Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo
    Nicolas Fossat
    Embryology Unit, Children s Medical Research Institute, University of Sydney, 214 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia
    Development 138:667-76. 2011
    ....
  26. doi request reprint Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse
    Satomi S Tanaka
    Embryology Unit, Children s Medical Research Institute, Westmead, Australia
    Dev Dyn 239:2851-9. 2010
    ..Lhx1 therefore may influence the localization of PGCs by modulating Ifitm1-mediated repulsive activity...
  27. doi request reprint Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm
    David A F Loebel
    Embryology Unit, Children s Medical Research Institute, Westmead, NSW 2145, Australia
    Development 138:4511-22. 2011
    ....
  28. ncbi request reprint IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion
    Satomi S Tanaka
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW 2145, Australia
    Dev Cell 9:745-56. 2005
    ..Complex homo- and/or heterotypic intercellular interactions among various IFITMs in PGCs and neighboring cells may underpin coordinated germ cell guidance in mice...
  29. ncbi request reprint The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm
    S J Kinder
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 128:3623-34. 2001
    ..The gastrula organizer is therefore composed of a constantly changing population of cells that are allocated to different parts of the axial mesoderm...
  30. ncbi request reprint Impact of node ablation on the morphogenesis of the body axis and the lateral asymmetry of the mouse embryo during early organogenesis
    B P Davidson
    Embryology Unit, Children s Medical Research Institute, Wentworthville, New South Wales, 2145, Australia
    Dev Biol 211:11-26. 1999
    ..The node and its derivatives therefore play a critical role in the patterning of the ventral neural tube and lateral body axis but not of the anterior-posterior axis during early organogenesis...
  31. ncbi request reprint Introduction of cell markers into germ layer tissues of the mouse gastrula by whole embryo electroporation
    Bruce P Davidson
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Genesis 35:57-62. 2003
    ..This significant time lag also raises concern of the temporal precision at which tissue- or stage-specific knock-out or activation of genetic activity may be achieved by the Cre-loxP mechanism...
  32. ncbi request reprint Distinct expression profiles of Mecp2 transcripts with different lengths of 3'UTR in the brain and visceral organs during mouse development
    Gregory J Pelka
    Embryology Unit, Children s Medical Research Institute, Sydney, NSW 2145, Australia
    Genomics 85:441-52. 2005
    ..The developmental profile of Mecp2 mRNA highlights a potential tissue-specific function of the 3'UTR in the regulation of MeCP2 protein synthesis in response to the age-specific requirement of MeCP2 function during the life of the mouse...
  33. ncbi request reprint Twist functions in mouse development
    Meredith P O'Rourke
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Wentworthville, NSW, Australia
    Int J Dev Biol 46:401-13. 2002
    ....
  34. ncbi request reprint Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds
    David A F Loebel
    Embryology Unit, Children s Medical Research Institute, Westmead, New South Wales, Australia
    Genesis 33:103-13. 2002
    ....
  35. ncbi request reprint A conserved noncoding intronic transcript at the mouse Dnm3 locus
    David A F Loebel
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Genomics 85:782-9. 2005
    ....
  36. ncbi request reprint Reduced proportion of Purkinje cells expressing paternally derived mutant Mecp2308 allele in female mouse cerebellum is not due to a skewed primary pattern of X-chromosome inactivation
    Catherine M Watson
    Embryology Unit, Children s Medical Research Institute, NSW, Australia
    Hum Mol Genet 14:1851-61. 2005
    ..We also observed that the pattern of XCI in cultured fibroblasts was significantly correlated with patterns in the Purkinje cells in mutant animals but not in wild-type mice...
  37. ncbi request reprint Lim1 activity is required for intermediate mesoderm differentiation in the mouse embryo
    T E Tsang
    Embyology Unit, University of Sydney, New South Wales, Australia
    Dev Biol 223:77-90. 2000
    ..Lim1 activity may therefore be required for the full expression of this transgene that normally marks the differentiation of the lateral plate and intermediate mesoderm...
  38. ncbi request reprint Definitive endoderm of the mouse embryo: formation, cell fates, and morphogenetic function
    Samara L Lewis
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Sydney, NSW, Australia
    Dev Dyn 235:2315-29. 2006
    ....
  39. ncbi request reprint Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice
    Gregory J Pelka
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Brain 129:887-98. 2006
    ..Brain tissues containing the hippocampal formation of XY Mecp2-null mice also displayed significant changes in genetic activity, which are related to the severity of the mutant phenotype...
  40. ncbi request reprint Restricted expression of ETn-related sequences during post-implantation mouse development
    David A F Loebel
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Gene Expr Patterns 4:467-71. 2004
    ..The tissue specificity of expression suggests tight regulation of the activity of this early transposon element during embryogenesis...
  41. ncbi request reprint Modulation of WNT signaling activity is key to the formation of the embryonic head
    Nicolas Fossat
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Westmead, Australia
    Cell Cycle 11:26-32. 2012
    ..The findings highlight the requirement of a stringent control of the timing, domain and level of canonical WNT signalling activity for the formation of the embryonic head...
  42. pmc BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4
    Milena B Furtado
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    Genes Dev 22:3037-49. 2008
    ..We conclude that BMP/SMAD1 signaling sets a bilateral, repressive threshold for NODAL-dependent Nodal activation in LPM, limiting availability of SMAD4. This repressive threshold is essential for bistable output of the LR system...
  43. ncbi request reprint C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47
    Nicolas Fossat
    Embryology Unit, Children s Medical Research Institute, Westmead, NSW, Australia Discipline of Medicine, Sydney Medical School University of Sydney, Sydney, NSW, Australia
    EMBO Rep 15:903-10. 2014
    ..Editing is further impaired in Rbm47-deficient mutant mice. These findings suggest that RBM47 and APOBEC1 constitute the basic machinery for C to U RNA editing. ..
  44. ncbi request reprint Gene expression pattern and progression of embryogenesis in the immediate post-implantation period of mouse development
    Sabine Pfister
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Gene Expr Patterns 7:558-73. 2007
    ..Overall, the developmental changes in gene expression mirror key events of embryogenesis, and reveal the regionalization of signalling activity and the emergence of tissue patterning...
  45. ncbi request reprint The allocation of epiblast cells to ectodermal and germ-line lineages is influenced by the position of the cells in the gastrulating mouse embryo
    P P Tam
    Embryology Unit, Children s Medical Research Institute, Wentworthville, New South Wales, Australia
    Dev Biol 178:124-32. 1996
    ..Allocation of cells to the ectodermal and germ cell lineages may be subject to local tissue interactions and the restriction of morphogenetic tissue movement of different epiblast cell populations during gastrulation...
  46. ncbi request reprint Generation of mouse embryos with small hairpin RNA-mediated knockdown of gene expression
    David A F Loebel
    Children s Medical Research Institute, Sydney Medical School, The University of Sydney, Sydney, Australia
    Methods Mol Biol 1092:119-42. 2014
    ..In these embryos, the tetraploid cells become excluded from the fetal tissues, resulting in ES cell-derived embryos harboring the shRNA knockdown construct. Embryos can be collected and their phenotype assessed by appropriate means. ..
  47. ncbi request reprint Lineage choice and differentiation in mouse embryos and embryonic stem cells
    David A F Loebel
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Dev Biol 264:1-14. 2003
    ..Increasing the efficiency of this process can only result from a better understanding of the molecular control of cell lineage determination in the embryo...
  48. ncbi request reprint Stage-specific Importin13 activity influences meiosis of germ cells in the mouse
    Yasuka L Yamaguchi
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW, 2145, Australia
    Dev Biol 297:350-60. 2006
    ..Our findings strongly implicate a stage-specific role of IPO13 in nuclear-cytoplasmic translocation of cargoes that accompanies meiotic differentiation of the mouse germ cells...
  49. ncbi request reprint Sertoli cell differentiation and Y-chromosome activity: a developmental study of X-linked transgene activity in sex-reversed X/XSxra mouse embryos
    R V Jamieson
    Embryology Unit, Children s Medical Research Institute, Wentworthville, New South Wales, Australia
    Dev Biol 199:235-44. 1998
    ....
  50. ncbi request reprint Allocation and early differentiation of cardiovascular progenitors in the mouse embryo
    S J Kinder
    Embryology Unit, Children's Medical Research Institute, Wentworth, NSW, Australia
    Trends Cardiovasc Med 11:177-84. 2001
    ....
  51. pmc Novel SOX2 partner-factor domain mutation in a four-generation family
    Marija Mihelec
    The Children s Hospital at Westmead, Children s Medical Research Institute and Save Sight Institute, Sydney, NSW, Australia
    Eur J Hum Genet 17:1417-22. 2009
    ..Our findings indicate that investigation of SOX2 in a broad range of eye anomaly patients aids in the determination of particular functions of SOX2 in development...
  52. ncbi request reprint A transcriptome landscape of mouse embryogenesis
    Nicolas Fossat
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Locked Bag 23, Wentworthville NSW 2145, Australia
    Dev Cell 13:761-2. 2007
    ....
  53. pmc Mutations of CDKL5 cause a severe neurodevelopmental disorder with infantile spasms and mental retardation
    Linda S Weaving
    Western Sydney Genetics Program, The Children s Hospital at Westmead, New South Wales, Australia
    Am J Hum Genet 75:1079-93. 2004
    ..However, it remains to be determined whether CDKL5 mutations are more prevalent in specific clinical subgroups of RTT or in other clinical presentations...
  54. ncbi request reprint Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation
    Robyn V Jamieson
    Academic Unit of Medical Genetics and Regional Genetic Service, University of Manchester, St Mary s Hospital, Manchester, United Kingdom
    Hum Mutat 28:968-77. 2007
    ..Our findings implicate dysregulation of expression of this novel human gene, TMEM114, in mammalian cataract formation...
  55. ncbi request reprint Regulation of expression of mouse interferon-induced transmembrane protein like gene-3, Ifitm3 (mil-1, fragilis), in germ cells
    Satomi S Tanaka
    Department of Molecular Embryology, Research Institute, Osaka Medical Center for Maternal and Child Health, Osaka, Japan
    Dev Dyn 230:651-9. 2004
    ..The lack of any influence of the interferon-stimulable response elements on transgene expression in the germ-line suggests that interferon-mediated response is not critical for activating Ifitm3...
  56. ncbi request reprint Postimplantation mouse development: whole embryo culture and micro-manipulation
    P P Tam
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Int J Dev Biol 42:895-902. 1998
    ....
  57. ncbi request reprint Exogenous FGF-4 can suppress anterior development in the mouse embryo during neurulation and early organogenesis
    B P Davidson
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, 2145, Australia
    Dev Biol 221:41-52. 2000
    ..The early response associated with the expression of Spry2 suggests that the later phenotype observed could be primarily related to an inhibition of the FGF signaling pathway...
  58. ncbi request reprint Mouse gastrulation: the formation of a mammalian body plan
    P P Tam
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Mech Dev 68:3-25. 1997
    ..In this review, we explore the mouse embryo before and during gastrulation, highlighting its similarities with other vertebrate embryos and its unique characteristics...
  59. ncbi request reprint The allocation of epiblast cells to the embryonic heart and other mesodermal lineages: the role of ingression and tissue movement during gastrulation
    P P Tam
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Development 124:1631-42. 1997
    ....
  60. ncbi request reprint Cell lineage determination in the mouse
    C M Watson
    Embryology Unit, Children s Medical Research Institute, Wentworthville, New South Wales, Australia
    Cell Struct Funct 26:123-9. 2001
    ..The findings that primordial germ cells can be induced from any epiblast cells and that they share common progenitors with other somatic cells provide compelling evidence for the absence of a pre-determined germ line in the mouse embryo...
  61. ncbi request reprint Lineage allocation during early embryogenesis. Mapping of the neural primordia and application to the analysis of mouse mutants
    G A Quinlan
    Embryology Unit, Children's Medical Research Institute, Sydney, Australia
    Methods Mol Biol 158:227-50. 2001
    ..As the first step toward undertaking such analysis of the neural derivatives, we have outlined the mutant strains available and detailed a protocol for the introgression of the lacZ transgene onto the mutant background...
  62. ncbi request reprint X-chromosome inactivation during the development of the male urogenital ridge of the mouse
    R V Jamieson
    Embryology Unit, Children s Medical Research Institute, Wentworthville, Australia
    Int J Dev Biol 41:49-55. 1997
    ....
  63. ncbi request reprint Axis development: the mouse becomes a dachshund
    J M Gad
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Australia
    Curr Biol 9:R783-6. 1999
    ..This is the first hint that a secreted factor may influence the specification of segment identity...
  64. ncbi request reprint The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak
    Yoji Kojima
    Embryology Unit, Children s Medical Research Institute, Westmead NSW 2145, Australia
    Cell Stem Cell 14:107-20. 2014
    ..Our findings therefore highlight distinct identifying characteristics of EpiSCs and provide a foundation for further examination of EpiSC properties and potential...
  65. doi request reprint A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain
    Sarah L Williamson
    NSW Centre for Rett Syndrome Research, The Children s Hospital at Westmead, Sydney, Australia
    Hum Genet 131:187-200. 2012
    ....
  66. ncbi request reprint Morphogenetic tissue movement and the establishment of body plan during development from blastocyst to gastrula in the mouse
    P P Tam
    Embryology Unit, Children's Medical Research Institute, Wentworthville, Australia
    Bioessays 23:508-17. 2001
    ..This suggests that the asymmetry of the zygote that is established at fertilisation and early cleavage has a lasting impact on the delineation of body axes during embryogenesis...
  67. ncbi request reprint The allocation and differentiation of mouse primordial germ cells
    T E Tsang
    Embryology Unit, Children's Medical Research Institute, University of Sydney, Westmead, Australia
    Int J Dev Biol 45:549-55. 2001
    ..XXSxr germ cells can re-activate the X-chromosome in the sex-reversed testis, suggesting that the regulation of X-chromosome activity is independent of ovarian morphogenesis...
  68. ncbi request reprint Mechanisms for the development of esophageal atresia
    J Orford
    Department of Surgical Research, Royal Alexandra Hospital for Children, Westmead, and the Department of Paediatrics and Child Health, University of Sydney, Sydney, and the Embryology Unit, Children's Medical Research Institute, Westmead, NSW, Australia
    J Pediatr Surg 36:985-94. 2001
    ..CONCLUSION: The authors proposed that the ectopic location of the notochord leads to the disruption in Shh signalling that may underpin the development of esophageal atresia...
  69. pmc Timed deletion of Twist1 in the limb bud reveals age-specific impacts on autopod and zeugopod patterning
    David A F Loebel
    Embryology Unit, Children s Medical Research Institute, Westmead, New South Wales, Australia Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 9:e98945. 2014
    ....
  70. pmc Alternative lengthening of telomeres in normal mammalian somatic cells
    Axel A Neumann
    Cancer Research Unit, Children s Medical Research Institute, Westmead, New South Wales, Australia
    Genes Dev 27:18-23. 2013
    ..The tagged telomere was also copied by other telomeres when introgressed into CAST/EiJ mice, which have telomeres more similar in length to those of humans. We conclude that ALT activity occurs in normal mouse somatic tissues...
  71. doi request reprint Fate-mapping technique: using carbocyanine dyes for vital labeling of cells in gastrula-stage mouse embryos cultured in vitro
    Heidi Bildsoe
    Children s Medical Research Institute, University of Sydney, Wentworthville, New South Wales 2145, Australia
    CSH Protoc 2007:pdb.prot4915. 2007
    ..This protocol describes how to label cells in the endoderm (which, at this stage of development, is the superficial tissue layer) of live mouse embryos at 7.0-7.5 days post-coitum (dpc), using two carbocyanine dyes (DiI and DiO)...
  72. doi request reprint Fate-Mapping Technique: Grafting Fluorescent Cells into Gastrula-Stage Mouse Embryos at 7-7.5 Days Post-coitum
    Vanessa J Franklin
    Embryology Unit, Children s Medical Research Institute, University of Sydney, Wentworthville, NSW 2145, Australia
    CSH Protoc 2007:pdb.prot4892. 2007
    ..This protocol describes how to graft cells isolated from a donor embryo into the germ layer of a wild-type host mouse embryo at 7-7.5 days post-coitum (dpc)...
  73. doi request reprint Chromosomal rearrangements and novel genes in disorders of eye development, cataract and glaucoma
    Marija Mihelec
    Eye Genetics Research Group, Children s Medical Research Institute, The Children s Hospital at Westmead and Save Sight Institute, Sydney, Australia
    Twin Res Hum Genet 11:412-21. 2008
    ..More recently, new methods in chromosomal analysis such as comparative genomic hybridization (CGH) microarray, have also enhanced our ability in disease gene identification...
  74. ncbi request reprint Expression of an X-linked HMG-lacZ transgene in mouse embryos: implication of chromosomal imprinting and lineage-specific X-chromosome activity
    P P Tam
    Embryology Unit, Children s Medical Research Institute, Wentworthville NSW, Australia
    Dev Genet 15:491-503. 1994
    ....
  75. ncbi request reprint The distribution of stanniocalcin 1 protein in fetal mouse tissues suggests a role in bone and muscle development
    W Q Jiang
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Australia
    J Endocrinol 165:457-66. 2000
    ..The specific localization of STC1 to chondrocytes and muscle cells suggests a role for this protein in chondrogenic and myogenic differentiation...
  76. ncbi request reprint Pgk1 and Hprt gene activity in the peri-implantation mouse embryo is influenced by the parental origin of the X-chromosome
    K Sturm
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Int J Dev Biol 43:69-73. 1999
    ..One possible interpretation of these results is that, in the XX mouse embryos, the genetic loci on maternal X-chromosome may be transcriptionally more active than their paternal counterparts during peri-implantation development...
  77. ncbi request reprint Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein
    Hao Ding
    Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, Ontario, M5G 1X5, Canada
    Cell 117:873-86. 2004
    ..spretus chromosomes in F1 cells. We conclude that Rtel is an essential gene that regulates telomere length and prevents genetic instability...
  78. ncbi request reprint A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling
    Hao Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Nat Genet 36:1111-6. 2004
    ..Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated...
  79. ncbi request reprint Conserved requirement of Lim1 function for cell movements during gastrulation
    Neil A Hukriede
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 4:83-94. 2003
    ..We conclude that a primary function of Lim1 in the early embryo is to enable proper cell movements during gastrulation...
  80. ncbi request reprint A gut feeling
    David A F Loebel
    Nat Biotechnol 23:1491-2. 2005
  81. ncbi request reprint Ets2 is expressed during morphogenesis of the somite and limb in the mouse embryo
    Sika Ristevski
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
    Mech Dev 116:165-8. 2002
    ..In addition, Ets2 is expressed in the otic vesicle and its derivatives, the dorsal (posterior) root ganglia, the neuroepithelium in the dorsal part of the caudal neural tube and the inter-segmental vasculature...
  82. ncbi request reprint Gastrula organiser and embryonic patterning in the mouse
    Lorraine Robb
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Semin Cell Dev Biol 15:543-54. 2004
    ..Recent findings show that the organiser activity is augmented by morphogenetic activity of the extraembryonic and embryonic endoderm, suggesting embryonic patterning is not solely the function of the organiser...
  83. ncbi request reprint Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo
    Adam H Hart
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, VIC 3050, Australia
    Development 129:3597-608. 2002
    ..Mixl1 is therefore required for the morphogenesis of axial mesoderm, the heart and the gut during embryogenesis...
  84. ncbi request reprint Analysis of cell lineage relationships in taste buds
    Leslie M Stone
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 22:4522-9. 2002
    ..Thus, at least some of the cell types in a taste bud represent distinct lineages of cells and are not merely phenotypic stages as a cell progresses from a young to a mature state...
  85. ncbi request reprint Depletion of definitive gut endoderm in Sox17-null mutant mice
    Masami Kanai-Azuma
    Department of Veterinary Anatomy, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Development 129:2367-79. 2002
    ..Our findings indicate an important role of Sox17 in endoderm development in the mouse, highlighting the idea that the molecular mechanism for endoderm formation is likely to be conserved among vertebrates...
  86. ncbi request reprint Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development
    Shannon L Duffy
    Leukaemia Foundation Research Unit, Queensland Institute of Medical Research, Herston, Australia
    Gene Expr Patterns 6:719-23. 2006
    ..These results show complex and dynamic expression for all three genes with expression domains that are successively complementary, overlapping, and divergent...
  87. ncbi request reprint Emerging asymmetry and embryonic patterning in early mouse development
    Janet Rossant
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Ontario M5G 1X5, Canada
    Dev Cell 7:155-64. 2004
    ..Whether these asymmetries are causally related to embryonic patterning or are coincidental outcomes of the topology of normal development remains uncertain...
  88. ncbi request reprint Genomic imprinting: mice without a father
    David A F Loebel
    Nature 428:809-11. 2004
  89. ncbi request reprint First mitotic division: getting it right at the start
    Patrick P L Tam
    Nat Cell Biol 4:E232. 2002
  90. doi request reprint Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome--Mecp2 gene dosage effects and BDNF expression
    Mari Kondo
    Howard Florey Institute and Department of Anatomy and Cell Biology, University of Melbourne, Melbourne, Vic, Australia
    Eur J Neurosci 27:3342-50. 2008
    ..Our findings demonstrate a positive impact of environmental enrichment in a Rett syndrome model; this impact may be dependent on the existence of one functional copy of Mecp2...
  91. ncbi request reprint Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells
    Yasuka L Yamaguchi
    Department of Molecular Embryology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Gene Expr Patterns 6:607-12. 2006
    ..The absence of Lrp4 expression in the blastocyst, embryonic stem cells and embryonic germ cells suggests the Lrp4 is a molecular marker that distinguishes the germ cells from embryo-derived pluripotent stem cells...