N J Talley

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. pmc Body mass index and chronic unexplained gastrointestinal symptoms: an adult endoscopic population based study
    P Aro
    Center for Family Medicine, Karolinska Institiutet, Stockholm, Sweden
    Gut 54:1377-83. 2005
  2. ncbi request reprint Management guidelines for uninvestigated and functional dyspepsia in the Asia-Pacific region: First Asian Pacific Working Party on Functional Dyspepsia
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, New South Wales, Australia
    J Gastroenterol Hepatol 13:335-53. 1998
  3. ncbi request reprint Efficacy of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies)
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
    Aliment Pharmacol Ther 12:1055-65. 1998
  4. ncbi request reprint Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia
    Aliment Pharmacol Ther 13:225-35. 1999
  5. pmc Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 months' follow up. The Optimal Regimen Cures Helicobacter Induced Dyspepsia (ORCHID) Study Group
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, New South Wales 2751, Australia
    BMJ 318:833-7. 1999
  6. ncbi request reprint Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Kingswood, New South Wales, Australia
    Am J Gastroenterol 96:71-6. 2001
  7. ncbi request reprint Helicobacter pylori infection is not associated with diabetes mellitus, nor with upper gastrointestinal symptoms in diabetes mellitus
    H H Xia
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Am J Gastroenterol 96:1039-46. 2001
  8. ncbi request reprint Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    N Engl J Med 341:1106-11. 1999
  9. pmc Low socioeconomic class is a risk factor for upper and lower gastrointestinal symptoms: a population based study in 15 000 Australian adults
    P Bytzer
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia
    Gut 49:66-72. 2001
  10. doi request reprint Rectal bleeding: epidemiology, associated risk factors, and health care seeking behaviour: a population-based study
    G D Eslick
    School of Public Health, The University of Sydney, Sydney, New South Wales, Australia
    Colorectal Dis 11:921-6. 2009

Detail Information

Publications92

  1. pmc Body mass index and chronic unexplained gastrointestinal symptoms: an adult endoscopic population based study
    P Aro
    Center for Family Medicine, Karolinska Institiutet, Stockholm, Sweden
    Gut 54:1377-83. 2005
    ....
  2. ncbi request reprint Management guidelines for uninvestigated and functional dyspepsia in the Asia-Pacific region: First Asian Pacific Working Party on Functional Dyspepsia
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, New South Wales, Australia
    J Gastroenterol Hepatol 13:335-53. 1998
    ..Trials of management strategies are now needed to establish the efficacy and cost-effectiveness of the approaches recommended...
  3. ncbi request reprint Efficacy of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies)
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
    Aliment Pharmacol Ther 12:1055-65. 1998
    ..The efficacy of H2-receptor antagonists in functional dyspepsia is equivocal and the therapeutic place of proton pump inhibitors in functional dyspepsia is unknown...
  4. ncbi request reprint Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia
    Aliment Pharmacol Ther 13:225-35. 1999
    ..There is not at present a suitable disease-specific health-related quality of life instrument for uninvestigated dyspepsia and functional (non-ulcer) dyspepsia...
  5. pmc Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 months' follow up. The Optimal Regimen Cures Helicobacter Induced Dyspepsia (ORCHID) Study Group
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, New South Wales 2751, Australia
    BMJ 318:833-7. 1999
    ..To determine whether eradication of Helicobacter pylori relieves the symptoms of functional dyspepsia...
  6. ncbi request reprint Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Kingswood, New South Wales, Australia
    Am J Gastroenterol 96:71-6. 2001
    ..0001) associated with poorer quality of life in diabetes, independent of age, gender, smoking, alcohol use, and type of diabetes. CONCLUSIONS: GI symptoms impact negatively on health-related quality of life in diabetes mellitus...
  7. ncbi request reprint Helicobacter pylori infection is not associated with diabetes mellitus, nor with upper gastrointestinal symptoms in diabetes mellitus
    H H Xia
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Am J Gastroenterol 96:1039-46. 2001
    ..Smoking was a risk factor for bloating and early satiety. CONCLUSIONS: H. pylori infection appears not to be associated with diabetes mellitus or upper GI symptoms in diabetes mellitus...
  8. ncbi request reprint Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    N Engl J Med 341:1106-11. 1999
    ..The relation between Helicobacter pylori infection and nonulcer dyspepsia is uncertain. We tested the hypothesis that curing the infection will relieve symptoms of dyspepsia...
  9. pmc Low socioeconomic class is a risk factor for upper and lower gastrointestinal symptoms: a population based study in 15 000 Australian adults
    P Bytzer
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia
    Gut 49:66-72. 2001
    ..Low socioeconomic class should be considered a risk factor for both upper and lower gastrointestinal symptoms...
  10. doi request reprint Rectal bleeding: epidemiology, associated risk factors, and health care seeking behaviour: a population-based study
    G D Eslick
    School of Public Health, The University of Sydney, Sydney, New South Wales, Australia
    Colorectal Dis 11:921-6. 2009
    ..Moreover, there is little information as to whether individuals seek health care for this problem. This study aimed to determine the prevalence of rectal bleeding and levels of healthcare seeking amongst an Australian population...
  11. ncbi request reprint Esomeprazole 20 mg maintains symptom control in endoscopy-negative gastro-oesophageal reflux disease: a controlled trial of 'on-demand' therapy for 6 months
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Aliment Pharmacol Ther 15:347-54. 2001
    ..Most patients with gastro-oesophageal reflux disease (GERD), regardless of endoscopic status, suffer symptomatic relapse within 6 months of stopping acid suppressant therapy...
  12. doi request reprint The brain--gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study
    N A Koloski
    Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia
    Gut 61:1284-90. 2012
    ..In a 12-year longitudinal, prospective, population-based study, we aimed to determine the directionality of the brain-gut mechanism in FGIDs...
  13. ncbi request reprint Failure of a motilin receptor agonist (ABT-229) to relieve the symptoms of functional dyspepsia in patients with and without delayed gastric emptying: a randomized double-blind placebo-controlled trial
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith NSW, Australia Abbott Laboratories, Abbott Park Illinois, USA
    Aliment Pharmacol Ther 14:1653-61. 2000
    ..We aimed to test the efficacy of the motilin agonist ABT-229 in functional dyspepsia patients with and without delayed gastric emptying...
  14. ncbi request reprint Clinical and pathological implications of IgG antibody responses to Helicobacter pylori and its virulence factors in non-ulcer dyspepsia
    H H X Xia
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Aliment Pharmacol Ther 17:935-43. 2003
    ..To determine whether pre-treatment antibody response to Helicobacter pylori virulence factors predicts eradication success and symptom relief 12 months after triple therapy in non-ulcer dyspepsia...
  15. ncbi request reprint Reduction of peptic ulcer disease and Helicobacter pylori infection but increase of reflux esophagitis in Western Sydney between 1990 and 1998
    H H Xia
    Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Dig Dis Sci 46:2716-23. 2001
    ..The decreased use of NSAIDs and decline of H. pylori infection have likely both contributed to the reduction of peptic ulcer disease, but the increase in reflux esophagitis remains to be fully explained...
  16. ncbi request reprint Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia?
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia
    Am J Gastroenterol 96:1422-8. 2001
    ..We aimed to determine if symptom patterns or severity could identify those with abnormal gastric emptying among patients with dysmotility-like functional dyspepsia and, for comparison, type I diabetes mellitus...
  17. ncbi request reprint Double-blind placebo-controlled multicentre studies of rebamipide, a gastroprotective drug, in the treatment of functional dyspepsia with or without Helicobacter pylori infection
    N J Talley
    Department of Medicine, The University of Sydney, Nepean Hospital, Penrith 2747, Sydney, Australia
    Aliment Pharmacol Ther 15:1603-11. 2001
    ..Functional dyspepsia is a problem that is difficult to treat in clinical practice...
  18. ncbi request reprint Oral hypoglycaemic drugs and gastrointestinal symptoms in diabetes mellitus
    P Bytzer
    Department of Medicine, University of Sydney, Nepean Hospital, Sydney, Australia
    Aliment Pharmacol Ther 15:137-42. 2001
    ..Gastrointestinal symptoms in diabetic patients have also been linked to factors associated with long-standing disease and suboptimal control...
  19. ncbi request reprint Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults
    P Bytzer
    Department of Medicine, University of Sydney, Nepean Hospital, Clinical Sciences Building, PO Box 63, Penrith, New South Wales 2751, Australia
    Arch Intern Med 161:1989-96. 2001
    ..CONCLUSIONS: Diabetes mellitus is associated with an increased prevalence of upper and lower gastrointestinal symptoms. This effect may be linked to poor glycemic control but not to duration of diabetes or type of treatment...
  20. ncbi request reprint Epidemiology of the functional gastrointestinal disorders diagnosed according to Rome II criteria: an Australian population-based study
    P M Boyce
    Department of Psychological Medicine, University of Sydney, Westmead Hospital, Sydney, New South Wales, Australia
    Intern Med J 36:28-36. 2006
    ..It is also not certain whether subjects who meet the Rome II criteria for an FGID are different in terms of demographic and psychological characteristics from those subjects meeting exclusively the more restrictive Rome I criteria...
  21. pmc Helicobacter pylori and dyspepsia
    N J Talley
    Department of Medicine, University of Sydney, Penrith, New South Wales, Australia
    Yale J Biol Med 72:145-51. 1999
    ..pylori is etiologically linked to non-ulcer dyspepsia, but data from well designed large randomized controlled trials of eradication therapy, are awaited with great interest...
  22. ncbi request reprint Predictors of health care seeking for irritable bowel syndrome and nonulcer dyspepsia: a critical review of the literature on symptom and psychosocial factors
    N A Koloski
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
    Am J Gastroenterol 96:1340-9. 2001
    ..CONCLUSIONS: A model for health care seeking for IBS and NUD, with an emphasis on psychosocial factors is presented, but remains to be tested...
  23. ncbi request reprint Therapeutic options in nonulcer dyspepsia
    N J Talley
    Department of Medicine, Nepean Hospital, Kingswood, Australia
    J Clin Gastroenterol 32:286-93. 2001
    ..Antidepressants are of uncertain efficacy but are widely used. New prokinetics and other enteric neuromodulating agents are being tested in NUD and are likely to find an important place in clinical practice in the future...
  24. pmc The potential role of acid suppression in functional dyspepsia: the BOND, OPERA, PILOT, and ENCORE studies
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith 2751, Australia
    Gut 50:iv36-41. 2002
    ..ENCORE followed on from this, addressing the consequences of relieving symptoms in patients with functional dyspepsia once they are off therapy...
  25. ncbi request reprint Non-cardiac chest pain: prevalence, risk factors, impact and consulting--a population-based study
    G D Eslick
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Aliment Pharmacol Ther 17:1115-24. 2003
    ..Little is known about the prevalence and importance of non-cardiac chest pain in the general population...
  26. ncbi request reprint Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesis
    H H Xia
    Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Am J Gastroenterol 96:16-26. 2001
    ..CONCLUSIONS: It is hypothesized that H. pylori-induced apoptosis may play a key role in gastric carcinogenesis by increasing cell proliferation and/or resulting in gastric atrophy...
  27. ncbi request reprint Empirically derived symptom sub-groups correspond poorly with diagnostic criteria for functional dyspepsia and irritable bowel syndrome. A factor and cluster analysis of a patient sample
    G D Eslick
    Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Aliment Pharmacol Ther 19:133-40. 2004
    ..To determine how clusters (groups) of patients with respect to symptoms compare with a clinical diagnosis in patients with irritable bowel syndrome and non-ulcer dyspepsia...
  28. pmc Familial aggregation of irritable bowel syndrome: a prospective study
    J S Kalantar
    Department of Medicine, University of Sydney, Australia
    Gut 52:1703-7. 2003
    ..We hypothesised that if there is familial aggregation, there would be an increased frequency of IBS in first degree relatives of IBS patients compared with relatives of controls (the patient's spouse)...
  29. pmc Effects of a motilin receptor agonist (ABT-229) on upper gastrointestinal symptoms in type 1 diabetes mellitus: a randomised, double blind, placebo controlled trial
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith NSW, Australia
    Gut 49:395-401. 2001
    ..CONCLUSIONS: The motilin agonist ABT-229 was not efficacious in the relief of postprandial symptoms in diabetes mellitus in the presence or absence of delayed gastric emptying...
  30. doi request reprint Natural history and predictors of outcome for non-cardiac chest pain: a prospective 4-year cohort study
    G D Eslick
    Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Neurogastroenterol Motil 20:989-97. 2008
    ..Both groups experienced continued chest pain during the follow-up period. Non-cardiac chest pain does not always confer an excellent long-term prognosis...
  31. ncbi request reprint A dose-ranging, placebo-controlled, randomized trial of alosetron in patients with functional dyspepsia
    N J Talley
    Department of Medicine, University of Sydney, Sydney, Australia
    Aliment Pharmacol Ther 15:525-37. 2001
    ..Patients with adequate relief of upper abdominal pain or discomfort showed improvements in multiple functional dyspepsia symptoms...
  32. ncbi request reprint Quality of life in functional dyspepsia: responsiveness of the Nepean Dyspepsia Index and development of a new 10-item short form
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, NSW, Australia
    Aliment Pharmacol Ther 15:207-16. 2001
    ..It was subsequently shortened to 25 items, yielding five sub-scales...
  33. ncbi request reprint Factors associated with consulting medical or non-medical practitioners for dyspepsia: an australian population-based study
    J I Westbrook
    School of Health Information Management, Faculty of Health Sciences, University of Sydney, Australia
    Aliment Pharmacol Ther 14:1581-8. 2000
    ..Little is known about how many dyspeptics in the population consult medical and non-medical practitioners, or the factors associated with various consulting patterns...
  34. ncbi request reprint Quality of life in patients with endoscopy-negative heartburn: reliability and sensitivity of disease-specific instruments
    N J Talley
    Department of Medicine, The University of Sydney, The Nepean Hospital, Penrith, Australia
    Am J Gastroenterol 96:1998-2004. 2001
    ..5. CONCLUSIONS: The GSRS and QOLRAD are valid questionnaires that are reliable and sensitive to change. Both questionnaires should be suitable for use in clinical trials of therapeutic interventions for patients with heartburn...
  35. ncbi request reprint Foetal intrauterine growth restrictions with Helicobacter pylori infection
    G D Eslick
    Department of Internal Medicine, The University of Sydney, Nepean Hospital, Penrith, Australia
    Aliment Pharmacol Ther 16:1677-82. 2002
    ..Helicobacter pylori infection has been associated with growth restriction in young children...
  36. ncbi request reprint Development and validation of the Diabetes Bowel Symptom Questionnaire
    C Quan
    Department of Medicine, University of Sydney, Nepean Hospital, Sydney, Australia
    Aliment Pharmacol Ther 17:1179-87. 2003
    ..Although gastrointestinal symptoms occur frequently, there is no validated measure of gastrointestinal symptoms in patients with diabetes mellitus...
  37. ncbi request reprint Review article: dyspepsia: how to manage and how to treat?
    N J Talley
    Nepean Hospital, Penrith, NSW, Australia
    Aliment Pharmacol Ther 16:95-104. 2002
    ..Tricyclic antidepressants (at a low dose) may be useful in a subset, but adequate trials are lacking...
  38. pmc Dyspepsia: management guidelines for the millennium
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith 2751, Australia
    Gut 50:iv72-8; discussion iv79. 2002
    ..Some of the outstanding issues and considerations in the management of dyspepsia are discussed, providing an overview of current thinking and recommendations on patient management by primary care physicians and specialists...
  39. ncbi request reprint Cognitive-behaviour therapy as a treatment for irritable bowel syndrome: a pilot study
    P Boyce
    Department of Psychological Medicine, The University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
    Aust N Z J Psychiatry 34:300-9. 2000
    ..Psychological treatments, in particular cognitive and behavioural interventions, have been shown to be effective for this disorder. The aim of this study was to test the efficacy of a cognitive-behaviour program...
  40. ncbi request reprint The irritable bowel syndrome and psychiatric disorders in the community: is there a link?
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Am J Gastroenterol 96:1072-9. 2001
    ..We hypothesized that psychiatric disorders are linked to IBS in the general community, but this is influenced by the criteria used to establish a diagnosis of IBS...
  41. ncbi request reprint Non-cardiac chest pain: predictors of health care seeking, the types of health care professional consulted, work absenteeism and interruption of daily activities
    G D Eslick
    Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
    Aliment Pharmacol Ther 20:909-15. 2004
    ..To determine the predictors of health care seeking, assess the types of health care professional consulted and to calculate the work absenteeism rates and interruptions to daily activities among non-cardiac chest pain patients...
  42. ncbi request reprint Serotoninergic neuroenteric modulators
    N J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, PO Box 63, NSW 2751, Penrith, Australia
    Lancet 358:2061-8. 2001
    ..However, for modulators of single receptors to achieve a substantial therapeutic gain, and to do so safely, drug targets based on the pathophysiology of IBS need to be better defined...
  43. ncbi request reprint Treatment of irritable bowel syndrome with Chinese herbal medicine: a randomized controlled trial
    A Bensoussan
    Research Unit for Complementary Medicine, University of Western Sydney Macarthur, Campbelltown, New South Wales, Australia
    JAMA 280:1585-9. 1998
    ..Irritable bowel syndrome (IBS) is a common functional bowel disorder for which there is no reliable medical treatment...
  44. ncbi request reprint Predictors of conventional and alternative health care seeking for irritable bowel syndrome and functional dyspepsia
    N A Koloski
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Aliment Pharmacol Ther 17:841-51. 2003
    ..The drivers of conventional and, especially, alternative health care use for irritable bowel syndrome and functional dyspepsia are not clear...
  45. ncbi request reprint Is irritable bowel syndrome more likely to be persistent in those with relatives who suffer from gastrointestinal symptoms? A population-based study at three time points
    J S Kalantar
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Aliment Pharmacol Ther 17:1389-97. 2003
    ..We tested the hypothesis that subjects with relatives who suffered from abdominal pain or bowel dysfunction would be at an increased risk of more persistent irritable bowel syndrome...
  46. ncbi request reprint Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin
    N D Yeomans
    Western Hospital, Department of Medicine, University of Melbourne, Melbourne, and University of Western Sydney, Sydney, Australia
    Aliment Pharmacol Ther 22:795-801. 2005
    ..Aspirin is valuable for preventing vascular events, but information about ulcer frequency is necessary to inform risk-benefit decisions in individual patients...
  47. ncbi request reprint Irritable bowel syndrome. Practical management
    N J Talley
    Department of Medicine, University of Sydney, New South Wales
    Aust Fam Physician 29:823-8. 2000
    ..Irritable bowel syndrome (IBS) is a common problem affecting one in six Australians. In any patient complaining of chronic or recurrent abdominal pain, chronic diarrhoea or constipation or bloating, IBS should top the list of possibilities...
  48. ncbi request reprint Abdominal wall muscle activity in irritable bowel syndrome with bloating
    P G McManis
    Department of Medicine, University of Sydney, Nepean Hospital, NSW, Australia
    Am J Gastroenterol 96:1139-42. 2001
    ..Episodic distension is unlikely to be due to permanent anterior abdominal muscle weakness or a persistent inability of the muscles to activate with standing in irritable bowel syndrome...
  49. ncbi request reprint Review article: Helicobacter pylori and nonulcer dyspepsia
    N J Talley
    University of Sydney, Nepean Hospital, Penrith, Australia
    Aliment Pharmacol Ther 16:58-65. 2002
    ..pylori infection in all patients with NUD. Hence, the management of these patients is challenging, but eradication of H. pylori infection may be beneficial in a small subgroup of cases with NUD that cannot be identified before treatment...
  50. ncbi request reprint Review article: the burden of illness of non-cardiac chest pain
    G D Eslick
    Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Aliment Pharmacol Ther 16:1217-23. 2002
    ..Non-cardiac chest pain is a common condition affecting approximately one-quarter of the population during their lifetime, but the long-term economic costs of non-cardiac chest pain are poorly defined...
  51. ncbi request reprint Randomized-controlled trial of esomeprazole in functional dyspepsia patients with epigastric pain or burning: does a 1-week trial of acid suppression predict symptom response?
    N J Talley
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Aliment Pharmacol Ther 26:673-82. 2007
    ..Early identification of true responders to acid suppression in functional dyspepsia patients with symptoms of epigastric pain or burning may enable clinicians to optimally tailor treatment...
  52. ncbi request reprint Dyspepsia management in primary care: a management trial
    M T Cuddihy
    Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Int J Clin Pract 59:194-201. 2005
    ..Regardless of initial management, most patients remained symptomatic, yet did not return for health care visits or undergo endoscopies. The cost of upfront endoscopy may not be the best choice for patients presenting with new dyspepsia...
  53. ncbi request reprint Dyspepsia consulters and patterns of management: a population-based study
    S K Ahlawat
    Clinical Enteric Neurosciences and Epidemiological Research, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Aliment Pharmacol Ther 22:251-9. 2005
    ..Although dyspepsia is common, management patterns in the United States are unknown...
  54. ncbi request reprint H. pylori and functional dyspepsia: increased serum antibodies as an independent risk factor?
    G Holtmann
    Department of Gastroenterology, University of Essen, Germany
    Dig Dis Sci 46:1550-7. 2001
    ..6, 95% CI 0.8-2.9) were not associated with frequent dyspepsia. In conclusion, in a subgroup of H. pylori-infected subjects who have high antibody titers, H. pylori appears to be associated with functional dyspepsia...
  55. ncbi request reprint Self-reported effectiveness and physician consultation rate in users of over-the-counter histamine-2 receptor antagonists
    M J Shaw
    Health Research Center, Park Nicollet Clinic, HealthSystem Minnesota, St. Louis Park, USA
    Am J Gastroenterol 96:673-6. 2001
    ..CONCLUSIONS: OTC H2RA infrequently provided the complete relief desired by patients. Presentation frequency to physicians for dyspeptic complaints did not change with availability of H2RA OTC...
  56. ncbi request reprint Review article: from gastrin to gastro-oesophageal reflux disease--a century of acid suppression
    P Malfertheiner
    Otto von Guericke University, Magdeburg, Germany
    Aliment Pharmacol Ther 23:683-90. 2006
    ..The major issue for the future resides within the epidemic of gastro-oesophageal reflux disease. How to diagnose, categorize and treat this condition and how to identify and prevent neoplasia, are the challenges of the new century...
  57. ncbi request reprint Patterns of gastritis and the effect of eradicating Helicobacter pylori on gastro-oesophageal reflux disease in Western patients with non-ulcer dyspepsia
    N Vakil
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Aliment Pharmacol Ther 24:55-63. 2006
    ..Aim To determine the incidence of symptoms of reflux disease and of erosive oesophagitis, and the relationship to changes in histological gastritis, in patients with non-ulcer dyspepsia over 12 months...
  58. ncbi request reprint Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population--the Kalixanda study
    J Ronkainen
    Center for Family Medicine, Karolinska Institutet, Stockholm, Sweden
    Aliment Pharmacol Ther 23:1725-33. 2006
    ..The impact of gastro-oesophageal reflux symptoms on health-related quality of life in the general population is poorly characterized...
  59. doi request reprint Dysphagia: epidemiology, risk factors and impact on quality of life--a population-based study
    G D Eslick
    School of Public Health, The University of Sydney, Sydney, NSW, Australia
    Aliment Pharmacol Ther 27:971-9. 2008
    ..Data on the population epidemiology of dysphagia are scarce. Little is known about the prevalence, risk factors and impact on quality of life of dysphagia in the general community...
  60. ncbi request reprint Relationship between upper gastrointestinal symptoms and changes in body weight in a population-based cohort
    F Cremonini
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 18:987-94. 2006
    ..91, 16.2). No association was found between weight loss >10 lb and the studied symptom complexes. Moderate body weight increases and decreases are generally not associated with upper GI symptom changes over time in the general population...
  61. pmc Combined analysis of the ORCHID and OCAY studies: does eradication of Helicobacter pylori lead to sustained improvement in functional dyspepsia symptoms?
    S J O Veldhuyzen van Zanten
    Division of Gastroenterology, Dalhousie University, Queen Elizabeth II Health Sciences Centre, Victoria General Site, Room 928 Centennial Building, 5790 University Avenue, Halifax, Nova Scotia, Canada B3H 2YG, Canada
    Gut 50:iv26-30; discussion iv31-2. 2002
    ..Recently, two very similar studies, the ORCHID and OCAY studies, have been completed and the combined results of these two multicentre, multinational, randomised, double blind, controlled clinical trials are reviewed...
  62. ncbi request reprint Influence of genetics on irritable bowel syndrome, gastro-oesophageal reflux and dyspepsia: a twin study
    A Lembo
    Beth Israel Deaconess Medical Center, Boston, MA, USA
    Aliment Pharmacol Ther 25:1343-50. 2007
    ..A genetic contribution has been proposed for irritable bowel syndrome (IBS) and gastro-oesophageal reflux disease (GERD), but is controversial. No twin data exist for dyspepsia...
  63. ncbi request reprint Development and psychometric evaluation of the patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM) in patients with upper gastrointestinal disorders
    A M Rentz
    MEDTAP International, Inc, Sindelfingen, Germany
    Qual Life Res 13:1737-49. 2004
    ....
  64. ncbi request reprint Management issues in dyspepsia: current consensus and controversies
    N J Talley
    Division of Gastroenterology and Internal Medicine, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Scand J Gastroenterol 39:913-8. 2004
  65. ncbi request reprint Natural history of gastroesophageal reflux disease and functional abdominal disorders: a population-based study
    L Agreus
    Family Medicine Stockholm, Karolinska Institutet, Stockholm, Sweden
    Am J Gastroenterol 96:2905-14. 2001
    ..We aimed to determine the natural history of these conditions...
  66. ncbi request reprint Is it possible to predict treatment response to a proton pump inhibitor in functional dyspepsia?
    E Bolling-Sternevald
    Department of Biomedicine and Surgery, Linkoping, Sweden
    Aliment Pharmacol Ther 18:117-24. 2003
    ..The efficacy of proton pump inhibitors in functional dyspepsia is modest and the prognostic factors are almost unknown...
  67. pmc pH-Hp: implications for dyspepsia management
    Anthony Axon
    Gut 50:iv1. 2002
  68. ncbi request reprint Bile reflux and Barrett's oesophagus: innocent bystander or sinister companion?
    N J Talley
    University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Dig Liver Dis 34:246-8. 2002
  69. pmc Symptom evaluation in reflux disease: workshop background, processes, terminology, recommendations, and discussion outputs
    J Dent
    Department of Gastroenterology, Hepatology, and General Medicine, Royal Adelaide Hospital, Adelaide, Australia
    Gut 53:iv1-24. 2004
    ..The workshop was designed to give outputs that could be readily reported and to arrive at specific recommendations on best practice in symptom evaluation in reflux disease...
  70. ncbi request reprint Health-related quality of life in functional dyspepsia
    H B El-Serag
    Section of Gastroenterology, The Houston Veterans Affairs Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Aliment Pharmacol Ther 18:387-93. 2003
    ..We performed a systematic review of the literature to compare the health-related quality of life (HRQOL) of patients with functional dyspepsia with either healthy controls or those with other diseases...
  71. ncbi request reprint Diagnostic investigation rates and use of prescription and non-prescription medications amongst dyspeptics: a population-based study of 2300 Australians
    J I Westbrook
    Centre for Health Informatics, University of New South Wales, NSW, Australia
    Aliment Pharmacol Ther 17:1171-8. 2003
    ..There is limited knowledge of the diagnostic investigation rates and use of prescription and non-prescription drugs amongst dyspeptics...
  72. pmc Symptom patterns in functional dyspepsia and irritable bowel syndrome: relationship to disturbances in gastric emptying and response to a nutrient challenge in consulters and non-consulters
    S Haag
    Department of Gastroenterology, Hepatology, and General Internal Medicine, Royal Adelaide Hospital, University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia
    Gut 53:1445-51. 2004
    ..Our aim was to assess the relationship between gastric motor and sensory function and symptom patterns in community subjects and patients with functional dyspepsia (FD) or irritable bowel syndrome (IBS)...
  73. ncbi request reprint Review article: gastro-oesophageal reflux disease -- how wide is its span?
    N J Talley
    Mayo Clinic College of Medicine and Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
    Aliment Pharmacol Ther 20:27-37; discussion 38-9. 2004
    ..Gastro-oesophageal reflux disease has also been implicated in an increasing array of other conditions, but arguably in these settings it is often over-diagnosed...
  74. ncbi request reprint A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia
    G Holtmann
    Division of Gastroenterology and Hepatology, University of Essen, Germany
    Aliment Pharmacol Ther 16:1641-8. 2002
    ..To compare the efficacy of simethicone with placebo and the prokinetic cisapride in patients with functional dyspepsia...
  75. ncbi request reprint Empiric clustering of dyspepsia into symptom subgroups: a population-based study
    J I Westbrook
    Centre for Health Informatics, University of New South Wales, Kensington, Australia
    Scand J Gastroenterol 37:917-23. 2002
    ..Despite continued debate regarding dyspepsia subgroups, few studies have used a data-drive approach to assess the existence and relevance of symptom clusters. We aimed to address both these issues...
  76. doi request reprint Functional gastrointestinal disorders as a public health problem
    N J Talley
    Department of Internal Medicine, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Neurogastroenterol Motil 20:121-9. 2008
    ....
  77. ncbi request reprint Mortality rates in patients with Barrett's oesophagus
    P Moayyedi
    Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, ON, Canada
    Aliment Pharmacol Ther 27:316-20. 2008
    ..Patients with Barrett's oesophagus are at increased risk of oesophageal adenocarcinoma. Observational studies have suggested increase in overall mortality also but data are conflicting...
  78. ncbi request reprint Itopride in functional dyspepsia: results of two phase III multicentre, randomised, double-blind, placebo-controlled trials
    N J Talley
    Mayo Clinic College of Medicine, Department of Internal Medicine, 4500 San Pablo Road, Jacksonville, FL 32082, USA
    Gut 57:740-6. 2008
    ..Itopride, a prokinetic approved in several countries, showed promising efficacy in FD in a phase IIb trial. The aim of this study was to test the efficacy and safety of this drug in FD...
  79. doi request reprint Do gastrointestinal symptoms fluctuate in the short-term perspective? The Kalixanda study
    E Bolling-Sternevald
    Centre for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden
    Dig Dis 26:256-63. 2008
    ..We aimed to determine gastrointestinal symptom fluctuation in an random adult population using a validated questionnaire assessing gastrointestinal symptoms...
  80. doi request reprint Impairment of health-related quality of life in functional dyspepsia and chronic liver disease: the influence of depression and anxiety
    S Haag
    Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    Aliment Pharmacol Ther 27:561-71. 2008
    ..Data on the relative impairment of HRQOL in chronic liver disease (CLD) and functional gastrointestinal disorders are lacking and no studies have assessed the link between impairment of HRQOL and psychosocial factors yet...
  81. ncbi request reprint Is there a benefit from intensified medical and psychological interventions in patients with functional dyspepsia not responding to conventional therapy?
    S Haag
    Department of Gastroenterology and Hepatology, and Clinic for Psychosomatic Medicine and Psychotherapy, University Hospital Essen, Essen, Germany
    Aliment Pharmacol Ther 25:973-86. 2007
    ..standard medical therapy in patients with refractory functional dyspepsia (FD), referred to a tertiary referral medical center...
  82. ncbi request reprint Efficacy of esomeprazole for resolution of symptoms of heartburn and acid regurgitation in continuous users of non-steroidal anti-inflammatory drugs
    C J Hawkey
    Institute of Clinical Research Trials Unit, University Hospital, Nottingham, UK
    Aliment Pharmacol Ther 25:813-21. 2007
    ..The use of non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with upper gastrointestinal symptoms such as heartburn and acid regurgitation...
  83. ncbi request reprint Validation of the translation and cross-cultural adaptation into Finnish of the Abdominal Symptom Questionnaire, the Hospital Anxiety and Depression Scale and the Complaint Score Questionnaire
    P Aro
    Centre for Family Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Gastroenterol 39:1201-8. 2004
    ..The aim of this study was to validate the Finnish translations of the Abdominal Symptom Questionnaire (ASQ), the Hospital Anxiety and Depression Scale (HAD) and the Complaint Score Questionnaire (CSQ)...
  84. ncbi request reprint Diagnostic and therapeutic strategies in the irritable bowel syndrome
    F Cremonini
    Clinical Enteric Neuroscience Translational and Epidemiological Research, CENTER Program, Mayo Clinic, Rochester, MN, USA
    Minerva Med 95:427-41. 2004
    ..Limited evidence suggests that anti-enkephalinase agents, somatostatin analogues, alpha(2)-receptor agonists, opioid antagonists, selective serotonin reuptake inhibitors, probiotics and herbal treatments may be useful in IBS patients...
  85. ncbi request reprint Aerophagia in children: characterization of a functional gastrointestinal disorder
    D K Chitkara
    The Motility Unit, Division of Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurogastroenterol Motil 17:518-22. 2005
    ..Although many children with aerophagia present with upper gastrointestinal symptoms, the disorder appears to be distinct from functional dyspepsia...
  86. pmc Functional dyspepsia, delayed gastric emptying, and impaired quality of life
    N J Talley
    Mayo Clinic Clinical Enteric Neuroscience, Translational and Epidemiological Research Program CENTER and Mayo Clinic College of Medicine, 200 First Street SW, Plummer 6 56, Rochester, MN 55905, USA
    Gut 55:933-9. 2006
    ..We aimed to evaluate the relationship between functional dyspepsia symptoms, gastric emptying, and HRQOL...
  87. ncbi request reprint What the physician needs to know for correct management of gastro-oesophageal reflux disease and dyspepsia
    N J Talley
    Center for Enteric Neurosciences and Translational Epidemiological Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Aliment Pharmacol Ther 20:23-30. 2004
    ..However, a PPI trial may offer a similar outcome and may be preferable in low H. pylori prevalence areas; head-to-head management trials in primary care are lacking...
  88. pmc Diagnostic yield of alarm features in irritable bowel syndrome and functional dyspepsia
    J Hammer
    Universitatsklinik fur Innere Medizin IV, Abteilung für Gastroenterologie und Hepatologie, Vienna, Austria
    Gut 53:666-72. 2004
    ..We aimed to establish the value of alarm features in differentiating between organic disease and irritable bowel syndrome (IBS) and functional dyspepsia (FD)...
  89. ncbi request reprint Systemic review: the prevalence and clinical course of functional dyspepsia
    H B El-Serag
    Sections of Gastroenterology and Health Services Research, Houston Veterans Affairs Medical Center, and Baylor College of Medicine, Houston, TX, USA
    Aliment Pharmacol Ther 19:643-54. 2004
    ..To examine the prevalence of functional dyspepsia in the general population, and to evaluate the natural history/clinical course of patients with functional dyspepsia...
  90. ncbi request reprint Disturbed bowel habits in patients with non-ulcer dyspepsia
    J Hammer
    Universitatsklinik fur Innere Medizin IV, Abteilung für Gastroenterologie und Hepatologie, Vienna, Austria
    Aliment Pharmacol Ther 24:405-10. 2006
    ..If drugs that alter colonic function were to prove useful in non-ulcer dyspepsia, knowledge of baseline bowel habit disturbances would be potentially critical...
  91. pmc Does delayed gastric emptying really cause symptoms in functional dyspepsia? We still doubt it!
    N J Talley
    Gut 55:1674; author reply 1674. 2006
  92. ncbi request reprint Overlap of gastro-oesophageal reflux disease and irritable bowel syndrome: prevalence and risk factors in the general population
    H K Jung
    Dyspepsia Center and Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Aliment Pharmacol Ther 26:453-61. 2007
    ..Gastro-oesophageal reflux disease (GERD) and irritable bowel syndrome may occur more often than expected by chance, but little community data exists and risk factors are unknown...