Research Topics
| N J TalleySummaryAffiliation: University of Sydney Country: Australia Publications
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Detail Information
Publications
Body mass index and chronic unexplained gastrointestinal symptoms: an adult endoscopic population based studyP Aro
Center for Family Medicine, Karolinska Institiutet, Stockholm, Sweden
Gut 54:1377-83. 2005..9 (95% CI 1.3, 3.0)). CONCLUSIONS: GORS is associated with obesity; this appears to be explained by increased upper endoscopy findings in obesity...
Management guidelines for uninvestigated and functional dyspepsia in the Asia-Pacific region: First Asian Pacific Working Party on Functional DyspepsiaN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, New South Wales, Australia
J Gastroenterol Hepatol 13:335-53. 1998..Trials of management strategies are now needed to establish the efficacy and cost-effectiveness of the approaches recommended...- Efficacy of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies)N J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
Aliment Pharmacol Ther 12:1055-65. 1998..The efficacy of H2-receptor antagonists in functional dyspepsia is equivocal and the therapeutic place of proton pump inhibitors in functional dyspepsia is unknown... - Development of a new dyspepsia impact scale: the Nepean Dyspepsia IndexN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia
Aliment Pharmacol Ther 13:225-35. 1999..There is not at present a suitable disease-specific health-related quality of life instrument for uninvestigated dyspepsia and functional (non-ulcer) dyspepsia... - Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 months' follow up. The Optimal Regimen Cures Helicobacter Induced Dyspepsia (ORCHID) Study GroupN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, New South Wales 2751, Australia
BMJ 318:833-7. 1999..To determine whether eradication of Helicobacter pylori relieves the symptoms of functional dyspepsia... - Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of lifeN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Kingswood, New South Wales, Australia
Am J Gastroenterol 96:71-6. 2001..0001) associated with poorer quality of life in diabetes, independent of age, gender, smoking, alcohol use, and type of diabetes. CONCLUSIONS: GI symptoms impact negatively on health-related quality of life in diabetes mellitus... - Helicobacter pylori infection is not associated with diabetes mellitus, nor with upper gastrointestinal symptoms in diabetes mellitusH H Xia
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Am J Gastroenterol 96:1039-46. 2001..Smoking was a risk factor for bloating and early satiety. CONCLUSIONS: H. pylori infection appears not to be associated with diabetes mellitus or upper GI symptoms in diabetes mellitus... - Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsiaN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
N Engl J Med 341:1106-11. 1999..The relation between Helicobacter pylori infection and nonulcer dyspepsia is uncertain. We tested the hypothesis that curing the infection will relieve symptoms of dyspepsia... - Low socioeconomic class is a risk factor for upper and lower gastrointestinal symptoms: a population based study in 15 000 Australian adultsP Bytzer
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia
Gut 49:66-72. 2001..Low socioeconomic class should be considered a risk factor for both upper and lower gastrointestinal symptoms... 
Rectal bleeding: epidemiology, associated risk factors, and health care seeking behaviour: a population-based studyG D Eslick
School of Public Health, The University of Sydney, Sydney, New South Wales, Australia
Colorectal Dis 11:921-6. 2009..Moreover, there is little information as to whether individuals seek health care for this problem. This study aimed to determine the prevalence of rectal bleeding and levels of healthcare seeking amongst an Australian population...- Esomeprazole 20 mg maintains symptom control in endoscopy-negative gastro-oesophageal reflux disease: a controlled trial of 'on-demand' therapy for 6 monthsN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Aliment Pharmacol Ther 15:347-54. 2001..Most patients with gastro-oesophageal reflux disease (GERD), regardless of endoscopic status, suffer symptomatic relapse within 6 months of stopping acid suppressant therapy... - The brain--gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based studyN A Koloski
Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia
Gut 61:1284-90. 2012..In a 12-year longitudinal, prospective, population-based study, we aimed to determine the directionality of the brain-gut mechanism in FGIDs... - Failure of a motilin receptor agonist (ABT-229) to relieve the symptoms of functional dyspepsia in patients with and without delayed gastric emptying: a randomized double-blind placebo-controlled trialN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith NSW, Australia Abbott Laboratories, Abbott Park Illinois, USA
Aliment Pharmacol Ther 14:1653-61. 2000..We aimed to test the efficacy of the motilin agonist ABT-229 in functional dyspepsia patients with and without delayed gastric emptying... - Clinical and pathological implications of IgG antibody responses to Helicobacter pylori and its virulence factors in non-ulcer dyspepsiaH H-X Xia
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Aliment Pharmacol Ther 17:935-43. 2003..Although the 19.5-kDa antigen and VacA were associated with body gastritis, none of the six antigens tested predicted symptom relief after triple therapy... - Reduction of peptic ulcer disease and Helicobacter pylori infection but increase of reflux esophagitis in Western Sydney between 1990 and 1998H H Xia
Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Dig Dis Sci 46:2716-23. 2001..The decreased use of NSAIDs and decline of H. pylori infection have likely both contributed to the reduction of peptic ulcer disease, but the increase in reflux esophagitis remains to be fully explained... - Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia?N J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, Australia
Am J Gastroenterol 96:1422-8. 2001..We aimed to determine if symptom patterns or severity could identify those with abnormal gastric emptying among patients with dysmotility-like functional dyspepsia and, for comparison, type I diabetes mellitus... - Double-blind placebo-controlled multicentre studies of rebamipide, a gastroprotective drug, in the treatment of functional dyspepsia with or without Helicobacter pylori infectionN J Talley
Department of Medicine, The University of Sydney, Nepean Hospital, Penrith 2747, Sydney, Australia
Aliment Pharmacol Ther 15:1603-11. 2001..Functional dyspepsia is a problem that is difficult to treat in clinical practice... - Oral hypoglycaemic drugs and gastrointestinal symptoms in diabetes mellitusP Bytzer
Department of Medicine, University of Sydney, Nepean Hospital, Sydney, Australia
Aliment Pharmacol Ther 15:137-42. 2001..Gastrointestinal symptoms in diabetic patients have also been linked to factors associated with long-standing disease and suboptimal control... - Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adultsP Bytzer
Department of Medicine, University of Sydney, Nepean Hospital, Clinical Sciences Building, PO Box 63, Penrith, New South Wales 2751, Australia
Arch Intern Med 161:1989-96. 2001..CONCLUSIONS: Diabetes mellitus is associated with an increased prevalence of upper and lower gastrointestinal symptoms. This effect may be linked to poor glycemic control but not to duration of diabetes or type of treatment... - Epidemiology of the functional gastrointestinal disorders diagnosed according to Rome II criteria: an Australian population-based studyP M Boyce
Department of Psychological Medicine, University of Sydney, Westmead Hospital, Sydney, New South Wales, Australia
Intern Med J 36:28-36. 2006..It is also not certain whether subjects who meet the Rome II criteria for an FGID are different in terms of demographic and psychological characteristics from those subjects meeting exclusively the more restrictive Rome I criteria... - Helicobacter pylori and dyspepsiaN J Talley
Department of Medicine, University of Sydney, Penrith, New South Wales, Australia
Yale J Biol Med 72:145-51. 1999..pylori is etiologically linked to non-ulcer dyspepsia, but data from well designed large randomized controlled trials of eradication therapy, are awaited with great interest... - Predictors of health care seeking for irritable bowel syndrome and nonulcer dyspepsia: a critical review of the literature on symptom and psychosocial factorsN A Koloski
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
Am J Gastroenterol 96:1340-9. 2001..CONCLUSIONS: A model for health care seeking for IBS and NUD, with an emphasis on psychosocial factors is presented, but remains to be tested... - Therapeutic options in nonulcer dyspepsiaN J Talley
Department of Medicine, Nepean Hospital, Kingswood, Australia
J Clin Gastroenterol 32:286-93. 2001..Antidepressants are of uncertain efficacy but are widely used. New prokinetics and other enteric neuromodulating agents are being tested in NUD and are likely to find an important place in clinical practice in the future... - The potential role of acid suppression in functional dyspepsia: the BOND, OPERA, PILOT, and ENCORE studiesN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith 2751, Australia
Gut 50:iv36-41. 2002..ENCORE followed on from this, addressing the consequences of relieving symptoms in patients with functional dyspepsia once they are off therapy... - Non-cardiac chest pain: prevalence, risk factors, impact and consulting--a population-based studyG D Eslick
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Aliment Pharmacol Ther 17:1115-24. 2003..Little is known about the prevalence and importance of non-cardiac chest pain in the general population... - Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesisH H Xia
Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Am J Gastroenterol 96:16-26. 2001..CONCLUSIONS: It is hypothesized that H. pylori-induced apoptosis may play a key role in gastric carcinogenesis by increasing cell proliferation and/or resulting in gastric atrophy... - Empirically derived symptom sub-groups correspond poorly with diagnostic criteria for functional dyspepsia and irritable bowel syndrome. A factor and cluster analysis of a patient sampleG D Eslick
Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Aliment Pharmacol Ther 19:133-40. 2004..CONCLUSION: This study supports the concept of symptom subgroups, including the subdivision of patients into diarrhoea- and constipation-predominant irritable bowel syndrome... - Familial aggregation of irritable bowel syndrome: a prospective studyJ S Kalantar
Department of Medicine, University of Sydney, Australia
Gut 52:1703-7. 2003..5 (95% CI 0.9, 6.7). CONCLUSIONS: Familial aggregation of IBS occurs, supporting a genetic or intrafamilial environment component, but this may be explained in part by familial aggregation of somatisation... - Effects of a motilin receptor agonist (ABT-229) on upper gastrointestinal symptoms in type 1 diabetes mellitus: a randomised, double blind, placebo controlled trialN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith NSW, Australia
Gut 49:395-401. 2001..CONCLUSIONS: The motilin agonist ABT-229 was not efficacious in the relief of postprandial symptoms in diabetes mellitus in the presence or absence of delayed gastric emptying... - Natural history and predictors of outcome for non-cardiac chest pain: a prospective 4-year cohort studyG D Eslick
Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Neurogastroenterol Motil 20:989-97. 2008..Both groups experienced continued chest pain during the follow-up period. Non-cardiac chest pain does not always confer an excellent long-term prognosis... - A dose-ranging, placebo-controlled, randomized trial of alosetron in patients with functional dyspepsiaN J Talley
Department of Medicine, University of Sydney, Sydney, Australia
Aliment Pharmacol Ther 15:525-37. 2001..Patients with adequate relief of upper abdominal pain or discomfort showed improvements in multiple functional dyspepsia symptoms... - Quality of life in functional dyspepsia: responsiveness of the Nepean Dyspepsia Index and development of a new 10-item short formN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, NSW, Australia
Aliment Pharmacol Ther 15:207-16. 2001..It was subsequently shortened to 25 items, yielding five sub-scales... - Factors associated with consulting medical or non-medical practitioners for dyspepsia: an australian population-based studyJ I Westbrook
School of Health Information Management, Faculty of Health Sciences, University of Sydney, Australia
Aliment Pharmacol Ther 14:1581-8. 2000..Little is known about how many dyspeptics in the population consult medical and non-medical practitioners, or the factors associated with various consulting patterns... - Quality of life in patients with endoscopy-negative heartburn: reliability and sensitivity of disease-specific instrumentsN J Talley
Department of Medicine, The University of Sydney, The Nepean Hospital, Penrith, Australia
Am J Gastroenterol 96:1998-2004. 2001..5. CONCLUSIONS: The GSRS and QOLRAD are valid questionnaires that are reliable and sensitive to change. Both questionnaires should be suitable for use in clinical trials of therapeutic interventions for patients with heartburn... - Foetal intrauterine growth restrictions with Helicobacter pylori infectionG D Eslick
Department of Internal Medicine, The University of Sydney, Nepean Hospital, Penrith, Australia
Aliment Pharmacol Ther 16:1677-82. 2002..005) and H. pylori seropositivity (OR = 2.59; 95% CI, 1.12-5.95; P = 0.025) were all independent risk factors for intrauterine growth restriction. CONCLUSIONS: H. pylori infection in pregnant women may affect foetal intrauterine growth... - Development and validation of the Diabetes Bowel Symptom QuestionnaireC Quan
Department of Medicine, University of Sydney, Nepean Hospital, Sydney, Australia
Aliment Pharmacol Ther 17:1179-87. 2003..CONCLUSION: The Diabetes Bowel Symptom Questionnaire appears to be a useful measure of gastrointestinal symptoms and glycaemic control in diabetes mellitus, and should have applicability in epidemiological and clinical studies... - Review article: dyspepsia: how to manage and how to treat?N J Talley
Nepean Hospital, Penrith, NSW, Australia
Aliment Pharmacol Ther 16:95-104. 2002..Tricyclic antidepressants (at a low dose) may be useful in a subset, but adequate trials are lacking... - Dyspepsia: management guidelines for the millenniumN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith 2751, Australia
Gut 50:iv72-8; discussion iv79. 2002..Some of the outstanding issues and considerations in the management of dyspepsia are discussed, providing an overview of current thinking and recommendations on patient management by primary care physicians and specialists... - Cognitive-behaviour therapy as a treatment for irritable bowel syndrome: a pilot studyP Boyce
Department of Psychological Medicine, The University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
Aust N Z J Psychiatry 34:300-9. 2000..Psychological treatments, in particular cognitive and behavioural interventions, have been shown to be effective for this disorder. The aim of this study was to test the efficacy of a cognitive-behaviour program... - The irritable bowel syndrome and psychiatric disorders in the community: is there a link?N J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Am J Gastroenterol 96:1072-9. 2001..We hypothesized that psychiatric disorders are linked to IBS in the general community, but this is influenced by the criteria used to establish a diagnosis of IBS... - Non-cardiac chest pain: predictors of health care seeking, the types of health care professional consulted, work absenteeism and interruption of daily activitiesG D Eslick
Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
Aliment Pharmacol Ther 20:909-15. 2004..Work absenteeism and interruptions to daily activities is high among chest pain sufferers... - Serotoninergic neuroenteric modulatorsN J Talley
Department of Medicine, University of Sydney, Nepean Hospital, PO Box 63, NSW 2751, Penrith, Australia
Lancet 358:2061-8. 2001..However, for modulators of single receptors to achieve a substantial therapeutic gain, and to do so safely, drug targets based on the pathophysiology of IBS need to be better defined... - Treatment of irritable bowel syndrome with Chinese herbal medicine: a randomized controlled trialA Bensoussan
Research Unit for Complementary Medicine, University of Western Sydney Macarthur, Campbelltown, New South Wales, Australia
JAMA 280:1585-9. 1998..Irritable bowel syndrome (IBS) is a common functional bowel disorder for which there is no reliable medical treatment... - Predictors of conventional and alternative health care seeking for irritable bowel syndrome and functional dyspepsiaN A Koloski
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Aliment Pharmacol Ther 17:841-51. 2003..Being female independently predicted alternative health care use. CONCLUSIONS: Psychological morbidity did not predict conventional or alternative health care use for gastrointestinal symptoms. Other factors were more important... - Is irritable bowel syndrome more likely to be persistent in those with relatives who suffer from gastrointestinal symptoms? A population-based study at three time pointsJ S Kalantar
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Aliment Pharmacol Ther 17:1389-97. 2003..We tested the hypothesis that subjects with relatives who suffered from abdominal pain or bowel dysfunction would be at an increased risk of more persistent irritable bowel syndrome... - Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirinN D Yeomans
Western Hospital, Department of Medicine, University of Melbourne, Melbourne, and University of Western Sydney, Sydney, Australia
Aliment Pharmacol Ther 22:795-801. 2005..Aspirin is valuable for preventing vascular events, but information about ulcer frequency is necessary to inform risk-benefit decisions in individual patients... - Irritable bowel syndrome. Practical managementN J Talley
Department of Medicine, University of Sydney, New South Wales
Aust Fam Physician 29:823-8. 2000..Irritable bowel syndrome (IBS) is a common problem affecting one in six Australians. In any patient complaining of chronic or recurrent abdominal pain, chronic diarrhoea or constipation or bloating, IBS should top the list of possibilities... - Abdominal wall muscle activity in irritable bowel syndrome with bloatingP G McManis
Department of Medicine, University of Sydney, Nepean Hospital, NSW, Australia
Am J Gastroenterol 96:1139-42. 2001..Episodic distension is unlikely to be due to permanent anterior abdominal muscle weakness or a persistent inability of the muscles to activate with standing in irritable bowel syndrome... - Review article: Helicobacter pylori and nonulcer dyspepsiaN J Talley
University of Sydney, Nepean Hospital, Penrith, Australia
Aliment Pharmacol Ther 16:58-65. 2002..pylori infection in all patients with NUD. Hence, the management of these patients is challenging, but eradication of H. pylori infection may be beneficial in a small subgroup of cases with NUD that cannot be identified before treatment... - Review article: the burden of illness of non-cardiac chest painG D Eslick
Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Aliment Pharmacol Ther 16:1217-23. 2002..Further studies are required to determine methods of reducing health care costs... - Randomized-controlled trial of esomeprazole in functional dyspepsia patients with epigastric pain or burning: does a 1-week trial of acid suppression predict symptom response?N J Talley
Mayo Clinic College of Medicine, Rochester, MN, USA
Aliment Pharmacol Ther 26:673-82. 2007..Early identification of true responders to acid suppression in functional dyspepsia patients with symptoms of epigastric pain or burning may enable clinicians to optimally tailor treatment... - Dyspepsia management in primary care: a management trialM T Cuddihy
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
Int J Clin Pract 59:194-201. 2005..Regardless of initial management, most patients remained symptomatic, yet did not return for health care visits or undergo endoscopies. The cost of upfront endoscopy may not be the best choice for patients presenting with new dyspepsia... - Dyspepsia consulters and patterns of management: a population-based studyS K Ahlawat
Clinical Enteric Neurosciences and Epidemiological Research, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA
Aliment Pharmacol Ther 22:251-9. 2005..Although dyspepsia is common, management patterns in the United States are unknown... - H. pylori and functional dyspepsia: increased serum antibodies as an independent risk factor?G Holtmann
Department of Gastroenterology, University of Essen, Germany
Dig Dis Sci 46:1550-7. 2001..6, 95% CI 0.8-2.9) were not associated with frequent dyspepsia. In conclusion, in a subgroup of H. pylori-infected subjects who have high antibody titers, H. pylori appears to be associated with functional dyspepsia... - Self-reported effectiveness and physician consultation rate in users of over-the-counter histamine-2 receptor antagonistsM J Shaw
Health Research Center, Park Nicollet Clinic, HealthSystem Minnesota, St. Louis Park, USA
Am J Gastroenterol 96:673-6. 2001..CONCLUSIONS: OTC H2RA infrequently provided the complete relief desired by patients. Presentation frequency to physicians for dyspeptic complaints did not change with availability of H2RA OTC... - Review article: from gastrin to gastro-oesophageal reflux disease--a century of acid suppressionP Malfertheiner
Otto von Guericke University, Magdeburg, Germany
Aliment Pharmacol Ther 23:683-90. 2006..The major issue for the future resides within the epidemic of gastro-oesophageal reflux disease. How to diagnose, categorize and treat this condition and how to identify and prevent neoplasia, are the challenges of the new century... - Patterns of gastritis and the effect of eradicating Helicobacter pylori on gastro-oesophageal reflux disease in Western patients with non-ulcer dyspepsiaN Vakil
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Aliment Pharmacol Ther 24:55-63. 2006..Aim To determine the incidence of symptoms of reflux disease and of erosive oesophagitis, and the relationship to changes in histological gastritis, in patients with non-ulcer dyspepsia over 12 months... - Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population--the Kalixanda studyJ Ronkainen
Center for Family Medicine, Karolinska Institutet, Stockholm, Sweden
Aliment Pharmacol Ther 23:1725-33. 2006..The impact of gastro-oesophageal reflux symptoms on health-related quality of life in the general population is poorly characterized... - Dysphagia: epidemiology, risk factors and impact on quality of life--a population-based studyG D Eslick
School of Public Health, The University of Sydney, Sydney, NSW, Australia
Aliment Pharmacol Ther 27:971-9. 2008..Data on the population epidemiology of dysphagia are scarce. Little is known about the prevalence, risk factors and impact on quality of life of dysphagia in the general community... - Relationship between upper gastrointestinal symptoms and changes in body weight in a population-based cohortF Cremonini
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Neurogastroenterol Motil 18:987-94. 2006..91, 16.2). No association was found between weight loss >10 lb and the studied symptom complexes. Moderate body weight increases and decreases are generally not associated with upper GI symptom changes over time in the general population... - Combined analysis of the ORCHID and OCAY studies: does eradication of Helicobacter pylori lead to sustained improvement in functional dyspepsia symptoms?S J O Veldhuyzen van Zanten
Division of Gastroenterology, Dalhousie University, Queen Elizabeth II Health Sciences Centre, Victoria General Site, Room 928 Centennial Building, 5790 University Avenue, Halifax, Nova Scotia, Canada B3H 2YG, Canada
Gut 50:iv26-30; discussion iv31-2. 2002..Recently, two very similar studies, the ORCHID and OCAY studies, have been completed and the combined results of these two multicentre, multinational, randomised, double blind, controlled clinical trials are reviewed... - Influence of genetics on irritable bowel syndrome, gastro-oesophageal reflux and dyspepsia: a twin studyA Lembo
Beth Israel Deaconess Medical Center, Boston, MA, USA
Aliment Pharmacol Ther 25:1343-50. 2007..A genetic contribution has been proposed for irritable bowel syndrome (IBS) and gastro-oesophageal reflux disease (GERD), but is controversial. No twin data exist for dyspepsia... - Development and psychometric evaluation of the patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM) in patients with upper gastrointestinal disordersA M Rentz
MEDTAP International, Inc, Sindelfingen, Germany
Qual Life Res 13:1737-49. 2004.... - Management issues in dyspepsia: current consensus and controversiesN J Talley
Division of Gastroenterology and Internal Medicine, Mayo Clinic and Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Scand J Gastroenterol 39:913-8. 2004 - Natural history of gastroesophageal reflux disease and functional abdominal disorders: a population-based studyL Agreus
Family Medicine Stockholm, Karolinska Institutet, Stockholm, Sweden
Am J Gastroenterol 96:2905-14. 2001..We aimed to determine the natural history of these conditions... - Is it possible to predict treatment response to a proton pump inhibitor in functional dyspepsia?E Bolling-Sternevald
Department of Biomedicine and Surgery, Linkoping, Sweden
Aliment Pharmacol Ther 18:117-24. 2003..The efficacy of proton pump inhibitors in functional dyspepsia is modest and the prognostic factors are almost unknown... - pH-Hp: implications for dyspepsia managementAnthony Axon
Gut 50:iv1. 2002 - Bile reflux and Barrett's oesophagus: innocent bystander or sinister companion?N J Talley
University of Sydney, Nepean Hospital, Penrith, NSW, Australia
Dig Liver Dis 34:246-8. 2002 - Symptom evaluation in reflux disease: workshop background, processes, terminology, recommendations, and discussion outputsJ Dent
Department of Gastroenterology, Hepatology, and General Medicine, Royal Adelaide Hospital, Adelaide, Australia
Gut 53:iv1-24. 2004..The workshop was designed to give outputs that could be readily reported and to arrive at specific recommendations on best practice in symptom evaluation in reflux disease... - Health-related quality of life in functional dyspepsiaH B El-Serag
Section of Gastroenterology, The Houston Veterans Affairs Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
Aliment Pharmacol Ther 18:387-93. 2003..We performed a systematic review of the literature to compare the health-related quality of life (HRQOL) of patients with functional dyspepsia with either healthy controls or those with other diseases... - Diagnostic investigation rates and use of prescription and non-prescription medications amongst dyspeptics: a population-based study of 2300 AustraliansJ I Westbrook
Centre for Health Informatics, University of New South Wales, NSW, Australia
Aliment Pharmacol Ther 17:1171-8. 2003..There is limited knowledge of the diagnostic investigation rates and use of prescription and non-prescription drugs amongst dyspeptics... - Symptom patterns in functional dyspepsia and irritable bowel syndrome: relationship to disturbances in gastric emptying and response to a nutrient challenge in consulters and non-consultersS Haag
Department of Gastroenterology, Hepatology, and General Internal Medicine, Royal Adelaide Hospital, University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia
Gut 53:1445-51. 2004..CONCLUSION: Gastric emptying and the global symptom response to a standardised nutrient challenge are abnormal in population based (non-health care seeking) subjects with dyspepsia... - Review article: gastro-oesophageal reflux disease -- how wide is its span?N J Talley
Mayo Clinic College of Medicine and Division of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
Aliment Pharmacol Ther 20:27-37; discussion 38-9. 2004..Gastro-oesophageal reflux disease has also been implicated in an increasing array of other conditions, but arguably in these settings it is often over-diagnosed... - A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsiaG Holtmann
Division of Gastroenterology and Hepatology, University of Essen, Germany
Aliment Pharmacol Ther 16:1641-8. 2002..To compare the efficacy of simethicone with placebo and the prokinetic cisapride in patients with functional dyspepsia... - Empiric clustering of dyspepsia into symptom subgroups: a population-based studyJ I Westbrook
Centre for Health Informatics, University of New South Wales, Kensington, Australia
Scand J Gastroenterol 37:917-23. 2002..Despite continued debate regarding dyspepsia subgroups, few studies have used a data-drive approach to assess the existence and relevance of symptom clusters. We aimed to address both these issues... - Functional gastrointestinal disorders as a public health problemN J Talley
Department of Internal Medicine, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
Neurogastroenterol Motil 20:121-9. 2008.... - Mortality rates in patients with Barrett's oesophagusP Moayyedi
Division of Gastroenterology, Department of Medicine, McMaster University, Hamilton, ON, Canada
Aliment Pharmacol Ther 27:316-20. 2008..Patients with Barrett's oesophagus are at increased risk of oesophageal adenocarcinoma. Observational studies have suggested increase in overall mortality also but data are conflicting... - Itopride in functional dyspepsia: results of two phase III multicentre, randomised, double-blind, placebo-controlled trialsN J Talley
Mayo Clinic College of Medicine, Department of Internal Medicine, 4500 San Pablo Road, Jacksonville, FL 32082, USA
Gut 57:740-6. 2008..Itopride, a prokinetic approved in several countries, showed promising efficacy in FD in a phase IIb trial. The aim of this study was to test the efficacy and safety of this drug in FD... - Do gastrointestinal symptoms fluctuate in the short-term perspective? The Kalixanda studyE Bolling-Sternevald
Centre for Family and Community Medicine, Karolinska Institutet, Stockholm, Sweden
Dig Dis 26:256-63. 2008..We aimed to determine gastrointestinal symptom fluctuation in an random adult population using a validated questionnaire assessing gastrointestinal symptoms... - Impairment of health-related quality of life in functional dyspepsia and chronic liver disease: the influence of depression and anxietyS Haag
Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
Aliment Pharmacol Ther 27:561-71. 2008..Data on the relative impairment of HRQOL in chronic liver disease (CLD) and functional gastrointestinal disorders are lacking and no studies have assessed the link between impairment of HRQOL and psychosocial factors yet... - Is there a benefit from intensified medical and psychological interventions in patients with functional dyspepsia not responding to conventional therapy?S Haag
Department of Gastroenterology and Hepatology, and Clinic for Psychosomatic Medicine and Psychotherapy, University Hospital Essen, Essen, Germany
Aliment Pharmacol Ther 25:973-86. 2007..standard medical therapy in patients with refractory functional dyspepsia (FD), referred to a tertiary referral medical center... - Efficacy of esomeprazole for resolution of symptoms of heartburn and acid regurgitation in continuous users of non-steroidal anti-inflammatory drugsC J Hawkey
Institute of Clinical Research Trials Unit, University Hospital, Nottingham, UK
Aliment Pharmacol Ther 25:813-21. 2007..The use of non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with upper gastrointestinal symptoms such as heartburn and acid regurgitation... - Validation of the translation and cross-cultural adaptation into Finnish of the Abdominal Symptom Questionnaire, the Hospital Anxiety and Depression Scale and the Complaint Score QuestionnaireP Aro
Centre for Family Medicine, Karolinska Institutet, Stockholm, Sweden
Scand J Gastroenterol 39:1201-8. 2004..The aim of this study was to validate the Finnish translations of the Abdominal Symptom Questionnaire (ASQ), the Hospital Anxiety and Depression Scale (HAD) and the Complaint Score Questionnaire (CSQ)... - Diagnostic and therapeutic strategies in the irritable bowel syndromeF Cremonini
Clinical Enteric Neuroscience Translational and Epidemiological Research, CENTER) Program, Mayo Clinic, Rochester, MN, USA
Minerva Med 95:427-41. 2004..Limited evidence suggests that anti-enkephalinase agents, somatostatin analogues, alpha(2)-receptor agonists, opioid antagonists, selective serotonin reuptake inhibitors, probiotics and herbal treatments may be useful in IBS patients... - Aerophagia in children: characterization of a functional gastrointestinal disorderD K Chitkara
The Motility Unit, Division of Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neurogastroenterol Motil 17:518-22. 2005..Although many children with aerophagia present with upper gastrointestinal symptoms, the disorder appears to be distinct from functional dyspepsia... - Functional dyspepsia, delayed gastric emptying, and impaired quality of lifeN J Talley
Mayo Clinic Clinical Enteric Neuroscience, Translational and Epidemiological Research Program CENTER and Mayo Clinic College of Medicine, 200 First Street SW, Plummer 6 56, Rochester, MN 55905, USA
Gut 55:933-9. 2006..We aimed to evaluate the relationship between functional dyspepsia symptoms, gastric emptying, and HRQOL... - What the physician needs to know for correct management of gastro-oesophageal reflux disease and dyspepsiaN J Talley
Center for Enteric Neurosciences and Translational Epidemiological Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Aliment Pharmacol Ther 20:23-30. 2004..However, a PPI trial may offer a similar outcome and may be preferable in low H. pylori prevalence areas; head-to-head management trials in primary care are lacking... - Diagnostic yield of alarm features in irritable bowel syndrome and functional dyspepsiaJ Hammer
Universitatsklinik fur Innere Medizin IV, Abteilung für Gastroenterologie und Hepatologie, Vienna, Austria
Gut 53:666-72. 2004..We aimed to establish the value of alarm features in differentiating between organic disease and irritable bowel syndrome (IBS) and functional dyspepsia (FD)... - Systemic review: the prevalence and clinical course of functional dyspepsiaH B El-Serag
Sections of Gastroenterology and Health Services Research, Houston Veterans Affairs Medical Center, and Baylor College of Medicine, Houston, TX, USA
Aliment Pharmacol Ther 19:643-54. 2004..To examine the prevalence of functional dyspepsia in the general population, and to evaluate the natural history/clinical course of patients with functional dyspepsia... - Disturbed bowel habits in patients with non-ulcer dyspepsiaJ Hammer
Universitatsklinik fur Innere Medizin IV, Abteilung für Gastroenterologie und Hepatologie, Vienna, Austria
Aliment Pharmacol Ther 24:405-10. 2006..If drugs that alter colonic function were to prove useful in non-ulcer dyspepsia, knowledge of baseline bowel habit disturbances would be potentially critical... - Does delayed gastric emptying really cause symptoms in functional dyspepsia? We still doubt it!N J Talley
Gut 55:1674; author reply 1674. 2006 - Overlap of gastro-oesophageal reflux disease and irritable bowel syndrome: prevalence and risk factors in the general populationH K Jung
Dyspepsia Center and Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Aliment Pharmacol Ther 26:453-61. 2007..Gastro-oesophageal reflux disease (GERD) and irritable bowel syndrome may occur more often than expected by chance, but little community data exists and risk factors are unknown...