Research Topics
| R StockerSummaryAffiliation: University of New South Wales Country: Australia Publications
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Publications
Dealcoholized red wine decreases atherosclerosis in apolipoprotein E gene-deficient mice independently of inhibition of lipid peroxidation in the artery wallRoland Stocker
Heart Research Institute, Camperdown, Australia
Am J Clin Nutr 79:123-30. 2004..compounds that prevent the prooxidant activity of the vitamin. Wines contain a large number of polyphenols, micronutrients that may act as coantioxidants and may enhance the in vivo antioxidant activity of vitamin E...- Antioxidant activities of bile pigmentsRoland Stocker
Centre for Vascular Research, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, Australia
Antioxid Redox Signal 6:841-9. 2004.... - Role of oxidative modifications in atherosclerosisRoland Stocker
Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia
Physiol Rev 84:1381-478. 2004..To address this issue, we have proposed an "oxidative response to inflammation" model as a means of reconciling the response-to-injury and oxidative modification hypotheses of atherosclerosis... - New insights on oxidative stress in the artery wallR Stocker
Centre for Vascular Research, University of New South Wales, UNSW Sydney, Australia
J Thromb Haemost 3:1825-34. 2005..Only then will we know what components of atherosclerosis are directly due to oxidative stress... - Heme oxygenase-1: a novel drug target for atherosclerotic diseases?Roland Stocker
Centre for Vascular Research, School of Medical Sciences, Faculty of Medicine, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, Sydney, Australia
Circulation 114:2178-89. 2006 - Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout miceS R Thomas
Biochemistry Group, The Heart Research Institute, Camperdown, NSW, Australia
Arterioscler Thromb Vasc Biol 21:585-93. 2001..Thus, in apoE-/- mice, VitE+CoQ(10) supplements are more antiatherogenic than CoQ(10) or VitE supplements alone and disease inhibition is associated with a decrease in aortic lipid hydroperoxides but not 7-ketocholesterol... - Oxidants and antioxidants in atherosclerosisR Mashima
Biochemistry Group, The Heart Research Institute, Sydney, Australia
Curr Opin Lipidol 12:411-8. 2001..The present review summarizes recent data on potential biological oxidants for LDL in the vessel wall, and discusses the antiatherogenic role(s) of selected antioxidants... - Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitriteS R Thomas
The Biochemistry and EPR Groups, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW 2050, Australia
Chem Res Toxicol 11:484-94. 1998..The studies also highlight differences between ONOO-- and SIN-1-induced LDL oxidation with regards to the effects of bicarbonate, ascorbate, and urate... - Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbitsJ M Upston
Biochemistry Group, The Heart Research Institute, Sydney, Australia
Free Radic Biol Med 31:1245-53. 2001..Thus, the study demonstrates a dissociation of aortic lipid oxidation and lesion development, and suggests that vitamin E does not prevent lesion development in this animal model... - 3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for alpha-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidationS R Thomas
Biochemistry Unit, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, New South Wales 2050, Australia
J Biol Chem 271:32714-21. 1996..Since interferon-gamma is the principal inducer of tryptophan degradation and release of 3HAA by monocytes/macrophages, this may represent a localized extracellular antioxidant defense against LDL oxidation in inflammation... - Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout miceP K Witting
Biochemistry Group, Heart Research Institute, Sydney, Australia
FASEB J 13:667-75. 1999.... - Antioxidants inhibit indoleamine 2,3-dioxygenase in IFN-gamma-activated human macrophages: posttranslational regulation by pyrrolidine dithiocarbamateS R Thomas
Biochemistry and Iron Groups, The Heart Research Institute, Camperdown, New South Wales, Australia
J Immunol 166:6332-40. 2001.... - Radical-induced lipoprotein and plasma lipid oxidation in normal and apolipoprotein E gene knockout (apoE-/-) mice: apoE-/- mouse as a model for testing the role of tocopherol-mediated peroxidation in atherogenesisJ Neuzil
Biochemistry Unit, Heart Research Institute, Camperdown, NSW, Australia
J Lipid Res 39:354-68. 1998..Therefore, apoE-/- mice may represent a suitable animal model to test a role for TMP in atherogenesis and the prevention of this disease by anti-TMP agents... - Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactionsD Heydeck
Biochemistry Group, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, 2050 N.S.W, Australia
J Lipid Res 42:1082-8. 2001..We conclude that although purified 15-LO can oxidize isolated LDL lipids in vitro, such oxygenation always includes nonenzymatic reactions that likely play a major role in the more extensive oxidation of LDL by cell-derived 15-LO... - Reaction of human myoglobin and peroxynitrite: characterizing biomarkers for myoglobin-derived oxidative stressP K Witting
Heart Research Institute, 145 Missenden Road, Camperdown Sydney, New South Wales, 2050, Australia
Biochem Biophys Res Commun 286:352-6. 2001..These products may serve as biomarkers for the participation of Mb-derived radicals in the oxidative damage associated with myocardial reperfusion injury... - Lipid oxidation in atherogenesis: an overviewW Jessup
Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Biochem Soc Trans 32:134-8. 2004..These subjects require more rigorous study before the oxidation theory can be fairly tested... - The ambivalence of vitamin E in atherogenesisR Stocker
Biochemistry Group, The Heart Research Institute, 145 Missenden Rd, Camperdown, NSW 2050, Australia
Trends Biochem Sci 24:219-23. 1999.... - Correlation between intima-to-media ratio, apolipoprotein B-100, myeloperoxidase, and hypochlorite-oxidized proteins in human atherosclerosisL J Hazell
Biochemistry Group, The Heart Research Institute, Sydney, NSW, Australia
Free Radic Biol Med 31:1254-62. 2001..Our results support a contribution to atherogenesis of all three parameters assessed, although MPO and HOCl-oxidized proteins appear to participate in the disease process at a later stage than apoB... 
Efflux of hepatic ascorbate: a potential contributor to the maintenance of plasma vitamin CJ M Upston
Biochemistry Group, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW 2050, Australia
Biochem J 342:49-56. 1999..By converting extracellular DHA to extracellular AH, the liver might contribute to the maintenance of plasma AH, a process that could be important under conditions of oxidative stress...- Vitamin E ingestion does not improve arterial endothelial dysfunction in older adultsL A Simons
University of New South Wales Lipid Research Department, St Vincent s Hospital, Darlinghurst NSW, Australia
Atherosclerosis 143:193-9. 1999..7+/-1.3% versus 13.6+/-1.4%,). These results exclude a major impact of medium-term supplementation with vitamin E on arterial endothelial function when age-related dysfunction is already present... - Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout miceKatherine Choy
Centre for Vascular Research, University of New South Wales, Sydney, Australia
Arterioscler Thromb Vasc Biol 25:1684-90. 2005..To elucidate processes by which the antioxidant probucol increases lesion size at the aortic sinus and decreases atherosclerosis at more distal sites in apolipoprotein E-deficient (apoE(-/-)) mice... - Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiencyCacang Suarna
Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
Free Radic Biol Med 41:722-30. 2006..These results show that vitamin E at best has a modest effect on experimental atherosclerosis in hyperlipidemic mice, and only in situations of severe vitamin E deficiency and independent of lipid oxidation in the vessel wall... - Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxideShane R Thomas
Centre for Vascular Research, Faculty of Medicine, University of New South Wales, Sydney 2052, Australia
J Biol Chem 282:23778-87. 2007..Reversible inhibition by NO may represent an important mechanism in controlling the immune regulatory actions of IDO... - Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductaseGhassan J Maghzal
Centre for Vascular Research, School of Medical Sciences Pathology and Bosch Institute, Sydney Medical School, University of Sydney, Medical Foundation Building K25, 92 94 Parramatta Road, Camperdown, New South Wales 2006, Australia
J Biol Chem 284:29251-9. 2009..Together, these results argue against the BVR-mediated redox cycle playing a general or important role as cellular antioxidant defense mechanism... 
Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2Christopher Jonathan Daraius Austin
Molecular Immunopathology Unit, Discipline of Pathology and Bosch Institute, University of Sydney, Camperdown, NSW, 2006, Australia
Amino Acids 39:565-78. 2010..The different biochemical characteristics of the mouse IDO proteins suggest that they have evolved to have distinct biological roles...- Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathwayS R Thomas
The Biochemistry Group, The Heart Research Institute, Sydney, New South Wales, Australia
Redox Rep 4:199-220. 1999..This article reviews findings indicating that redox reactions are involved in the regulation of IDO and Trp metabolism along the Kyn pathway and also participate in the biological activities exhibited by Kyn pathway metabolites... - Dietary and pharmacological antioxidants in atherosclerosisR Stocker
Biochemistry Group, Heart Research Institute, Camperdown, NSW, Australia
Curr Opin Lipidol 10:589-97. 1999.... - Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxideBenjamin S Rayner
Centre for Vascular Research and Biomedical Mass Spectrometry Unit, University of New South Wales, Sydney 2052, New South Wales, Australia
J Biol Chem 280:9985-93. 2005..Furthermore, S-NO oxyMb can be isolated from cultured human VSMCs exposed to an exogenous .NO donor at physiologic concentration. The potential biologic implications of S-NO oxyMb acting as a source of .NO are discussed... - Characterization of the oxidation products of BO-653 formed during peroxyl radical-mediated oxidation of human plasmaRyo Yamauchi
Centre for Vascular Research, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, Sydney, New South Wales, Australia
Free Radic Biol Med 38:32-40. 2005..butyl-2,3,5,7a-tetrahydro-2,2-dipentylbenzofuran-5-one). These dialkylperoxides of BO-653 might be useful markers to assess the antioxidant function of BO-653 in biological systems in vivo... - The role of vitamin E in atherosclerosisJoanne M Upston
Centre for Vascular Research, School of Medical Sciences, University of New South Wales, UNSW Sydney, NSW 2052, Australia
Prog Lipid Res 42:405-22. 2003..It also remains unclear as to whether oxidation plays a bystander or a casual role in atherosclerosis. This lack of knowledge may explain the ambivalence of vitamin E and other antioxidant supplementation in atherosclerosis... - Kynurenine is an endothelium-derived relaxing factor produced during inflammationYutang Wang
Centre for Vascular Research, School of Medical Sciences Pathology and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, Australia
Nat Med 16:279-85. 2010..Kynurenine administration decreased blood pressure in a dose-dependent manner in spontaneously hypertensive rats. Our results identify tryptophan metabolism by Ido as a new pathway contributing to the regulation of vascular tone... - Vitamin E oxidation in human atherosclerotic lesionsAndrew C Terentis
Biochemistry Group, The Heart Research Institute, Camperdown, New South Wales, Australia
Circ Res 90:333-9. 2002..This study may have important implications regarding antioxidant supplements aimed at preventing LDL oxidation and hence atherogenesis... - Oxidized lipid accumulates in the presence of alpha-tocopherol in atherosclerosisJoanne M Upston
Biochemistry Group, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW, 2050, Australia
Biochem J 363:753-60. 2002..These data are fully consistent with alpha-tocopherol acting as a hydrogen donor during lipid oxidation in vivo and suggest that alpha-tocopherol does not prevent lipoprotein lipid oxidation in the diseased vessel wall... - Is ischemia involved in the pathogenesis of murine cerebral malaria?L A Sanni
Department of Pathology, University of Sydney, Sydney, Australia
Am J Pathol 159:1105-12. 2001..Mild obstructive ischemia is a likely cause of the metabolic changes during CM, but a role for immune cell effector molecules cannot be ruled out... - Vascular microdissection, perfusion, and excision of the murine arterial tree for use in atherogenic disease investigationsGary Martinic
Biological Services, The Heart Research Institute, 145 Missenden Road, Camperdown, New South Wales 2050, Australia
Contemp Top Lab Anim Sci 42:47-53. 2003..Thus, our article likely will provide a useful guide to those new to this technique, and for researchers undertaking similar studies, and the technique could be adapted to other species easily... - Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1Yi-Mo Deng
Centre for Vascular Research, University of New South Wales, and the Department of Haematology, Prince of Wales Hospital, Sydney. Australia
Circulation 110:1855-60. 2004..This novel finding may explain how probucol inhibits restenosis and highlights HO-1 as a target for therapeutic intervention against occlusive vascular disease... - Intimal thickening after arterial balloon injury is increased by intermittent repetitive hypoxia, but intermittent repetitive hyperoxia is not protectiveAntony K Lau
The Heart Research Institute, University of Sydney, Sydney, Australia
Atherosclerosis 185:254-63. 2006..These results suggest that intermittent repetitive hyperoxia is not protective and intermittent repetitive hypoxia promotes arterial disease in normal and injured arteries independent of lipid peroxidation... - Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cellsGhassan J Maghzal
Centre for Vascular Research and Molecular Immunopathology Unit, Bosch Institute and Discipline of Pathology, School of Medical Sciences, University of Sydney, Sydney, New South Wales 2006, Australia
J Biol Chem 283:12014-25. 2008..Together, our data show that cytochrome b(5) rather than O(2)(*-) plays a major role in the activation of IDO in human cells... - Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosisJoanne M Upston
Department of Biochemistry, Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW 2050, Australia
Am J Pathol 160:701-10. 2002..Our data show that accumulation of nonoxidized lipid precedes that of oxidized lipid in human aortic lesions... - The use of antioxidant supplements in coronary heart diseaseLeonard Kritharides
Clinical Research Group Heart Research Institute, NSW, Sydney, Australia
Atherosclerosis 164:211-9. 2002..However, this will require positive results from combined antioxidant studies currently in progress, and the targeting of oxidative processes that operate in the artery wall and cause or contribute to disease... - Vitamin ERoland Stocker
Centre for VascularResearch, School of Medical Sciences, Faculty of Medicine, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, Sydney, NSW 2052, Australia
Novartis Found Symp 282:77-87; discussion 87-92, 212-8. 2007.... - Pharmacologic induction of heme oxygenase-1Cheng Li
Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Australia
Antioxid Redox Signal 9:2227-39. 2007..Understanding both the pathways by which HO-1 is induced and the mechanism through which the enzyme exerts its beneficial effects may facilitate the development of novel drugs... - Probucol protects against hypochlorite-induced endothelial dysfunction: identification of a novel pathway of probucol oxidation to a biologically active intermediatePaul K Witting
Centre for Vascular Research, Bioanalytical Mass Spectrometry Facility, and School of Chemistry, University of New South Wales, UNSW Sydney, New South Wales 2052, Australia
J Biol Chem 280:15612-8. 2005.... - The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactionsAndrew C Terentis
Biochemistry Group, The Heart Research Institute, 145 Missenden Road, Camperdown, New South Wales 2050, Australia
J Biol Chem 277:15788-94. 2002..Together these data indicate that the strong proximal Fe-His bond and the strong H-bonding and/or steric interactions between l-Trp and dioxygen in the distal pocket are likely crucial for the enzymatic activity of hIDO... - Probucol promotes functional reendothelialization in balloon-injured rabbit aortasAntony K Lau
The Heart Research Institute, Sydney, Australia
Circulation 107:2031-6. 2003..This novel in vivo finding helps explain how probucol inhibits restenosis after coronary angioplasty and highlights potential new targets for therapeutic intervention... - Heme oxygenase and iron: from bacteria to humansCheng Li
Centre for Vascular Research, School of Medical Sciences Pathology and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia
Redox Rep 14:95-101. 2009..This review summarises the current knowledge in the dynamic relationship between heme oxygenase and iron in metabolism and in the clinical context... - Plasmodium falciparum histidine-rich protein-2 (PfHRP2) modulates the redox activity of ferri-protoporphyrin IX (FePPIX): peroxidase-like activity of the PfHRP2-FePPIX complexRyuichi Mashima
Biochemistry Group, The Heart Research Institute, 145 Missenden Road, Camperdown, New South Wales 2050, Australia
J Biol Chem 277:14514-20. 2002..These data show that PfHRP2 modulates the redox activity of FePPIX and that the PfHRP2-FePPIX complex may have previously unrecognized antioxidant properties... - Coenzyme Q(10) supplementation inhibits aortic lipid oxidation but fails to attenuate intimal thickening in balloon-injured New Zealand white rabbitsKatherine J Choy
Biochemistry Group, The Heart Research Institute, Camperdown, New South Wales, Australia
Free Radic Biol Med 35:300-9. 2003..However, unlike its antiatherosclerosis activity in the mice, CoQ(10) does not inhibit intimal hyperplasia in rabbits, thereby dissociating this disease process from lipid oxidation in the vessel wall... - Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient miceBen J Wu
Centre for Vascular Research and Inflammatory Diseases Research Unit, School of Medical Sciences, University of New South Wales, and Royal North Shore Hospital, Sydney, Australia
J Pharmacol Exp Ther 321:477-84. 2007..Our findings suggest that lumen volume is not a suitable surrogate to assess the antiatherosclerotic activity of probucol and related drugs... - Equivalent lipid oxidation profiles in advanced atherosclerotic lesions of carotid endarterectomy plaques obtained from symptomatic type 2 diabetic and nondiabetic subjectsKrishna Kathir
Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
Free Radic Biol Med 49:481-6. 2010..Our results do not support the notion that advanced atherosclerotic lesions from T2D patients contain more oxidized lipids than corresponding lesions from nondiabetic subjects... - Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailabilityPaul K Witting
Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, Australia
Cell Physiol Biochem 20:255-68. 2007..likely derived from xanthine oxidase, NADPH-oxidase and mitochondria. These processes could contribute to H(2)O(2)-induced vascular dysfunction that may be relevant under conditions of oxidative stress such as inflammation... - A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDLXiao Suo Wang
Centre for Vascular Research, School of Medical Sciences Pathology and Bosch Institute, The University of Sydney, Sydney, Australia
J Lipid Res 50:586-94. 2009..Because the ELISA we have developed specifically detects apoA-I containing MetO in HDL and plasma, it should provide a useful tool for investigating the relationship between oxidized HDL and coronary artery disease... - Heme oxygenase-1 increases endothelial progenitor cellsBen J Wu
Centre for Vascular Research, School of Medical Sciences and Bosch Institute, Faculty of Medicine, University of Sydney, NSW 2006, Australia
Arterioscler Thromb Vasc Biol 29:1537-42. 2009..As endothelial progenitor cells (EPCs) contribute to reendothelialization, we examined the role of HO-1 on bone marrow and circulating EPCs... - Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cellsPaul R Coleman
Vascular Biology Program, Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
Blood 116:4016-24. 2010..Together, these findings expand our understanding of the role of senescence in the vasculature and identify SENEX as a fulcrum for driving the resultant phenotype of the endothelium after activation... - Detection of specifically oxidized apolipoproteins in oxidized HDLXiao Suo Wang
Centre for Vascular Research, Bosch Institute and Discipline of Pathology, The University of Sydney, Sydney, Australia
Methods Mol Biol 477:49-63. 2008..Here we describe an HPLC-based method to detect oxidized HDL containing specifically oxidized forms of apoA-I and apoA-II. This method may be useful to assess the early stages of HDL oxidation in biological samples... - Maternal undernutrition reduces aortic wall thickness and elastin content in offspring rats without altering endothelial functionMichael R Skilton
Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia
Clin Sci (Lond) 111:281-7. 2006..These changes in vascular structure may amplify aging-related changes to the vasculature and contribute to the pathophysiology of the putative link between impaired fetal growth and adult cardiovascular disease... - Probucol inhibits in-stent thrombosis and neointimal hyperplasia by promoting re-endothelializationDavid Tanous
Centre for Vascular Research, School of Medical Sciences, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, Australia
Atherosclerosis 189:342-9. 2006..04). CONCLUSIONS: Probucol demonstrates anti-restenotic and appears to have anti-thrombotic properties that are likely related to its ability to promote in-stent re-endothelialization... - Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavengingBen J Wu
Centre for Vascular Research, School of Medical Sciences, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, Sydney NSW 2052, Australia
J Exp Med 203:1117-27. 2006..They indicate 2-electron rather than radical (1-electron) oxidants as important contributors to atherogenesis, and point to novel lead compounds for therapeutic intervention against atherosclerotic diseases... - Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and FasL-Fas engagementNicole Y Tan
Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
Circ Res 105:422-30. 2009..Fas ligand (FasL)-mediated smooth muscle cell (SMC) apoptosis within the vulnerable plaque may lead to plaque instability and rupture, events that underlie myocardial infarction and stroke... - Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosineBenjamin Hack
Heart Foundation Research Center, Griffith University, Gold Coast Campus, Southport, QLD, 4217, Australia
Mol Cell Biochem 287:165-75. 2006..Correlation of post-ischemic cardiovascular outcomes with specific oxidative events (glutathione redox state, alpha-TQ) supports an important anti-oxidant component to adenosinergic protection... - Determination of the nature of the heme environment in nitrosyl indoleamine 2,3-dioxygenase using Multiple-scattering analyses of X-ray absorption fine structureJade B Aitken
Centre for Structural Biology and Structural Chemistry, and Centre for Heavy Metals Research, School of Chemistry, The University of Sydney, New South Wales 2006, Australia
Biochemistry 43:4892-8. 2004..The results indicate that both the blocking of the heme site to O(2) binding and conformational changes induced by breaking the Fe-N(epsilon) bond may be important mechanisms by which NO inhibits IDO in vitro and in vivo... - Hypochlorous acid impairs endothelium-derived nitric oxide bioactivity through a superoxide-dependent mechanismRoland Stocker
Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Mass 02118, USA
Arterioscler Thromb Vasc Biol 24:2028-33. 2004..These data provide another mechanism whereby myeloperoxidase-derived oxidants can contribute to the impairment of NO bioactivity that is characteristic of atherosclerosis... - Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboonsXing Li Wang
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
Am J Clin Nutr 80:649-55. 2004..Inflammation and oxidative stress are processes that mark early metabolic abnormalities in vascular diseases... - Vitamin E is not deficient in human atherosclerotic plaquesAnatol Kontush
Arterioscler Thromb Vasc Biol 24:e139-40; author reply e141-2. 2004 - Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbitsJan Hinrich Bräsen
HELIOS Klinikum Berlin, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University, Wiltbergstr 50, 13125 Berlin, Germany
Atherosclerosis 163:249-59. 2002.... - Regio- and stereo-chemical oxidation of linoleic acid by human myoglobin and hydrogen peroxide: Tyr(103) affects rate and product distributionBenjamin S Rayner
Vascular Biology Group, ANZAC Research Institute, Hospital Road, Concord Repatriation General Hospital, Concord, NSW 2139, Australia
Biochem J 381:365-72. 2004.... - Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malariaIsabelle M Medana
Nuffield Department of Clinical Laboratory Sciences, Oxford Wellcome Centre for Tropical Medicine, John Radcliffe Hospital, Oxford, UK
J Infect Dis 188:844-9. 2003..Elevated levels of KA in children with CM may serve to contain injury in the developing brain, which is more susceptible to excitotoxic damage than is the adult brain... - Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoproteinGreg Pankhurst
The Heart Research Institute, 145 Missenden Road, Camperdown NSW 2050, Australia
J Lipid Res 44:349-55. 2003..Our results show that during the early stages, oxidation of HDL gives rise to specifically oxidized forms of apoA-I and apoA-II, some of which may be useful markers of in vivo HDL oxidation, and hence potentially atherosclerosis... - Lack of inhibitory effect of HDL on TNFalpha-induced adhesion molecule expression in human aortic endothelial cellsWei Jian Zhang
Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
Atherosclerosis 165:241-9. 2002..The ability of polyunsaturated phospholipids in HDL to affect endothelial activation remains to be further investigated... - Formation of methionine sulfoxide-containing specific forms of oxidized high-density lipoproteinsUte Panzenböck
Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria
Biochim Biophys Acta 1703:171-81. 2005.... - Neither plasma coenzyme Q10 concentration, nor its decline during pravastatin therapy, is linked to recurrent cardiovascular disease events: a prospective case-control study from the LIPID studyRoland Stocker
Centre for Vascular Research, School of Medical Sciences, University of New South Wales, UNSW, Sydney, NSW 2052, Australia
Atherosclerosis 187:198-204. 2006..This study confirms that pravastatin lowers plasma CoQ10 concentrations, but this does not appear to predict the risk of recurrent CVD events... - Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat dietJudy B de Haan
Oxidative Stress Group, Baker Heart Research Institute, Melbourne, Australia
J Lipid Res 47:1157-67. 2006..In summary, a specific deficiency in Gpx1 was not accompanied by an increase in markers of oxidative damage or increased atherosclerosis in a murine model of HFD-induced atherogenesis... - Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentrationElias N Glaros
Prince of Wales Medical Research Institute, Randwick, NSW 2031, Australia
Biochem Pharmacol 73:1340-6. 2007..These data indicate that therapeutic reduction of plasma SM and/or GSL concentrations may offer a novel treatment for atherosclerosis... - Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout miceBrett Garner
Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
J Lipid Res 43:205-14. 2002..The apoE-/- mouse therefore represents a useful model to study the potential role of GSL metabolism in atherogenesis... - Anti-atherosclerotic and anti-diabetic properties of probucol and related compoundsDavid Tanous
Toronto Congenital Cardiac Centre for Adults, Toronto General Hospital, University Health Network, Toronto, Canada
Redox Rep 13:48-59. 2008..In this review, the molecular mechanisms underlying the beneficial activities of probucol and related compounds are described...