R Stocker

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Dealcoholized red wine decreases atherosclerosis in apolipoprotein E gene-deficient mice independently of inhibition of lipid peroxidation in the artery wall
    Roland Stocker
    Heart Research Institute, Camperdown, Australia
    Am J Clin Nutr 79:123-30. 2004
  2. ncbi request reprint Antioxidant activities of bile pigments
    Roland Stocker
    Centre for Vascular Research, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Antioxid Redox Signal 6:841-9. 2004
  3. ncbi request reprint Role of oxidative modifications in atherosclerosis
    Roland Stocker
    Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia
    Physiol Rev 84:1381-478. 2004
  4. ncbi request reprint New insights on oxidative stress in the artery wall
    R Stocker
    Centre for Vascular Research, University of New South Wales, UNSW Sydney, Australia
    J Thromb Haemost 3:1825-34. 2005
  5. ncbi request reprint Heme oxygenase-1: a novel drug target for atherosclerotic diseases?
    Roland Stocker
    Centre for Vascular Research, School of Medical Sciences, Faculty of Medicine, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Circulation 114:2178-89. 2006
  6. ncbi request reprint Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice
    S R Thomas
    Biochemistry Group, The Heart Research Institute, Camperdown, NSW, Australia
    Arterioscler Thromb Vasc Biol 21:585-93. 2001
  7. ncbi request reprint Oxidants and antioxidants in atherosclerosis
    R Mashima
    Biochemistry Group, The Heart Research Institute, Sydney, Australia
    Curr Opin Lipidol 12:411-8. 2001
  8. ncbi request reprint Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite
    S R Thomas
    The Biochemistry and EPR Groups, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW 2050, Australia
    Chem Res Toxicol 11:484-94. 1998
  9. ncbi request reprint Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits
    J M Upston
    Biochemistry Group, The Heart Research Institute, Sydney, Australia
    Free Radic Biol Med 31:1245-53. 2001
  10. ncbi request reprint 3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for alpha-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation
    S R Thomas
    Biochemistry Unit, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, New South Wales 2050, Australia
    J Biol Chem 271:32714-21. 1996

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Dealcoholized red wine decreases atherosclerosis in apolipoprotein E gene-deficient mice independently of inhibition of lipid peroxidation in the artery wall
    Roland Stocker
    Heart Research Institute, Camperdown, Australia
    Am J Clin Nutr 79:123-30. 2004
    ..compounds that prevent the prooxidant activity of the vitamin. Wines contain a large number of polyphenols, micronutrients that may act as coantioxidants and may enhance the in vivo antioxidant activity of vitamin E...
  2. ncbi request reprint Antioxidant activities of bile pigments
    Roland Stocker
    Centre for Vascular Research, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Antioxid Redox Signal 6:841-9. 2004
    ....
  3. ncbi request reprint Role of oxidative modifications in atherosclerosis
    Roland Stocker
    Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia
    Physiol Rev 84:1381-478. 2004
    ..To address this issue, we have proposed an "oxidative response to inflammation" model as a means of reconciling the response-to-injury and oxidative modification hypotheses of atherosclerosis...
  4. ncbi request reprint New insights on oxidative stress in the artery wall
    R Stocker
    Centre for Vascular Research, University of New South Wales, UNSW Sydney, Australia
    J Thromb Haemost 3:1825-34. 2005
    ..Only then will we know what components of atherosclerosis are directly due to oxidative stress...
  5. ncbi request reprint Heme oxygenase-1: a novel drug target for atherosclerotic diseases?
    Roland Stocker
    Centre for Vascular Research, School of Medical Sciences, Faculty of Medicine, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Circulation 114:2178-89. 2006
  6. ncbi request reprint Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice
    S R Thomas
    Biochemistry Group, The Heart Research Institute, Camperdown, NSW, Australia
    Arterioscler Thromb Vasc Biol 21:585-93. 2001
    ..Thus, in apoE-/- mice, VitE+CoQ(10) supplements are more antiatherogenic than CoQ(10) or VitE supplements alone and disease inhibition is associated with a decrease in aortic lipid hydroperoxides but not 7-ketocholesterol...
  7. ncbi request reprint Oxidants and antioxidants in atherosclerosis
    R Mashima
    Biochemistry Group, The Heart Research Institute, Sydney, Australia
    Curr Opin Lipidol 12:411-8. 2001
    ..The present review summarizes recent data on potential biological oxidants for LDL in the vessel wall, and discusses the antiatherogenic role(s) of selected antioxidants...
  8. ncbi request reprint Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite
    S R Thomas
    The Biochemistry and EPR Groups, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW 2050, Australia
    Chem Res Toxicol 11:484-94. 1998
    ..The studies also highlight differences between ONOO-- and SIN-1-induced LDL oxidation with regards to the effects of bicarbonate, ascorbate, and urate...
  9. ncbi request reprint Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits
    J M Upston
    Biochemistry Group, The Heart Research Institute, Sydney, Australia
    Free Radic Biol Med 31:1245-53. 2001
    ..Thus, the study demonstrates a dissociation of aortic lipid oxidation and lesion development, and suggests that vitamin E does not prevent lesion development in this animal model...
  10. ncbi request reprint 3-Hydroxyanthranilic acid is an efficient, cell-derived co-antioxidant for alpha-tocopherol, inhibiting human low density lipoprotein and plasma lipid peroxidation
    S R Thomas
    Biochemistry Unit, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, New South Wales 2050, Australia
    J Biol Chem 271:32714-21. 1996
    ..Since interferon-gamma is the principal inducer of tryptophan degradation and release of 3HAA by monocytes/macrophages, this may represent a localized extracellular antioxidant defense against LDL oxidation in inflammation...
  11. ncbi request reprint Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout mice
    P K Witting
    Biochemistry Group, Heart Research Institute, Sydney, Australia
    FASEB J 13:667-75. 1999
    ....
  12. ncbi request reprint Antioxidants inhibit indoleamine 2,3-dioxygenase in IFN-gamma-activated human macrophages: posttranslational regulation by pyrrolidine dithiocarbamate
    S R Thomas
    Biochemistry and Iron Groups, The Heart Research Institute, Camperdown, New South Wales, Australia
    J Immunol 166:6332-40. 2001
    ....
  13. ncbi request reprint Radical-induced lipoprotein and plasma lipid oxidation in normal and apolipoprotein E gene knockout (apoE-/-) mice: apoE-/- mouse as a model for testing the role of tocopherol-mediated peroxidation in atherogenesis
    J Neuzil
    Biochemistry Unit, Heart Research Institute, Camperdown, NSW, Australia
    J Lipid Res 39:354-68. 1998
    ..Therefore, apoE-/- mice may represent a suitable animal model to test a role for TMP in atherogenesis and the prevention of this disease by anti-TMP agents...
  14. ncbi request reprint Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions
    D Heydeck
    Biochemistry Group, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, 2050 N.S.W, Australia
    J Lipid Res 42:1082-8. 2001
    ..We conclude that although purified 15-LO can oxidize isolated LDL lipids in vitro, such oxygenation always includes nonenzymatic reactions that likely play a major role in the more extensive oxidation of LDL by cell-derived 15-LO...
  15. ncbi request reprint Reaction of human myoglobin and peroxynitrite: characterizing biomarkers for myoglobin-derived oxidative stress
    P K Witting
    Heart Research Institute, 145 Missenden Road, Camperdown Sydney, New South Wales, 2050, Australia
    Biochem Biophys Res Commun 286:352-6. 2001
    ..These products may serve as biomarkers for the participation of Mb-derived radicals in the oxidative damage associated with myocardial reperfusion injury...
  16. ncbi request reprint Lipid oxidation in atherogenesis: an overview
    W Jessup
    Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Biochem Soc Trans 32:134-8. 2004
    ..These subjects require more rigorous study before the oxidation theory can be fairly tested...
  17. ncbi request reprint The ambivalence of vitamin E in atherogenesis
    R Stocker
    Biochemistry Group, The Heart Research Institute, 145 Missenden Rd, Camperdown, NSW 2050, Australia
    Trends Biochem Sci 24:219-23. 1999
    ....
  18. ncbi request reprint Correlation between intima-to-media ratio, apolipoprotein B-100, myeloperoxidase, and hypochlorite-oxidized proteins in human atherosclerosis
    L J Hazell
    Biochemistry Group, The Heart Research Institute, Sydney, NSW, Australia
    Free Radic Biol Med 31:1254-62. 2001
    ..Our results support a contribution to atherogenesis of all three parameters assessed, although MPO and HOCl-oxidized proteins appear to participate in the disease process at a later stage than apoB...
  19. pmc Efflux of hepatic ascorbate: a potential contributor to the maintenance of plasma vitamin C
    J M Upston
    Biochemistry Group, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW 2050, Australia
    Biochem J 342:49-56. 1999
    ..By converting extracellular DHA to extracellular AH, the liver might contribute to the maintenance of plasma AH, a process that could be important under conditions of oxidative stress...
  20. ncbi request reprint Vitamin E ingestion does not improve arterial endothelial dysfunction in older adults
    L A Simons
    University of New South Wales Lipid Research Department, St Vincent s Hospital, Darlinghurst NSW, Australia
    Atherosclerosis 143:193-9. 1999
    ..7+/-1.3% versus 13.6+/-1.4%,). These results exclude a major impact of medium-term supplementation with vitamin E on arterial endothelial function when age-related dysfunction is already present...
  21. ncbi request reprint Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice
    Katherine Choy
    Centre for Vascular Research, University of New South Wales, Sydney, Australia
    Arterioscler Thromb Vasc Biol 25:1684-90. 2005
    ..To elucidate processes by which the antioxidant probucol increases lesion size at the aortic sinus and decreases atherosclerosis at more distal sites in apolipoprotein E-deficient (apoE(-/-)) mice...
  22. ncbi request reprint Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency
    Cacang Suarna
    Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Free Radic Biol Med 41:722-30. 2006
    ..These results show that vitamin E at best has a modest effect on experimental atherosclerosis in hyperlipidemic mice, and only in situations of severe vitamin E deficiency and independent of lipid oxidation in the vessel wall...
  23. ncbi request reprint Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide
    Shane R Thomas
    Centre for Vascular Research, Faculty of Medicine, University of New South Wales, Sydney 2052, Australia
    J Biol Chem 282:23778-87. 2007
    ..Reversible inhibition by NO may represent an important mechanism in controlling the immune regulatory actions of IDO...
  24. pmc Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase
    Ghassan J Maghzal
    Centre for Vascular Research, School of Medical Sciences Pathology and Bosch Institute, Sydney Medical School, University of Sydney, Medical Foundation Building K25, 92 94 Parramatta Road, Camperdown, New South Wales 2006, Australia
    J Biol Chem 284:29251-9. 2009
    ..Together, these results argue against the BVR-mediated redox cycle playing a general or important role as cellular antioxidant defense mechanism...
  25. doi request reprint Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2
    Christopher Jonathan Daraius Austin
    Molecular Immunopathology Unit, Discipline of Pathology and Bosch Institute, University of Sydney, Camperdown, NSW, 2006, Australia
    Amino Acids 39:565-78. 2010
    ..The different biochemical characteristics of the mouse IDO proteins suggest that they have evolved to have distinct biological roles...
  26. ncbi request reprint Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway
    S R Thomas
    The Biochemistry Group, The Heart Research Institute, Sydney, New South Wales, Australia
    Redox Rep 4:199-220. 1999
    ..This article reviews findings indicating that redox reactions are involved in the regulation of IDO and Trp metabolism along the Kyn pathway and also participate in the biological activities exhibited by Kyn pathway metabolites...
  27. ncbi request reprint Dietary and pharmacological antioxidants in atherosclerosis
    R Stocker
    Biochemistry Group, Heart Research Institute, Camperdown, NSW, Australia
    Curr Opin Lipidol 10:589-97. 1999
    ....
  28. ncbi request reprint Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide
    Benjamin S Rayner
    Centre for Vascular Research and Biomedical Mass Spectrometry Unit, University of New South Wales, Sydney 2052, New South Wales, Australia
    J Biol Chem 280:9985-93. 2005
    ..Furthermore, S-NO oxyMb can be isolated from cultured human VSMCs exposed to an exogenous .NO donor at physiologic concentration. The potential biologic implications of S-NO oxyMb acting as a source of .NO are discussed...
  29. ncbi request reprint Characterization of the oxidation products of BO-653 formed during peroxyl radical-mediated oxidation of human plasma
    Ryo Yamauchi
    Centre for Vascular Research, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Free Radic Biol Med 38:32-40. 2005
    ..butyl-2,3,5,7a-tetrahydro-2,2-dipentylbenzofuran-5-one). These dialkylperoxides of BO-653 might be useful markers to assess the antioxidant function of BO-653 in biological systems in vivo...
  30. ncbi request reprint The role of vitamin E in atherosclerosis
    Joanne M Upston
    Centre for Vascular Research, School of Medical Sciences, University of New South Wales, UNSW Sydney, NSW 2052, Australia
    Prog Lipid Res 42:405-22. 2003
    ..It also remains unclear as to whether oxidation plays a bystander or a casual role in atherosclerosis. This lack of knowledge may explain the ambivalence of vitamin E and other antioxidant supplementation in atherosclerosis...
  31. pmc Kynurenine is an endothelium-derived relaxing factor produced during inflammation
    Yutang Wang
    Centre for Vascular Research, School of Medical Sciences Pathology and Bosch Institute, Faculty of Medicine, University of Sydney, Sydney, Australia
    Nat Med 16:279-85. 2010
    ..Kynurenine administration decreased blood pressure in a dose-dependent manner in spontaneously hypertensive rats. Our results identify tryptophan metabolism by Ido as a new pathway contributing to the regulation of vascular tone...
  32. ncbi request reprint Vitamin E oxidation in human atherosclerotic lesions
    Andrew C Terentis
    Biochemistry Group, The Heart Research Institute, Camperdown, New South Wales, Australia
    Circ Res 90:333-9. 2002
    ..This study may have important implications regarding antioxidant supplements aimed at preventing LDL oxidation and hence atherogenesis...
  33. pmc Oxidized lipid accumulates in the presence of alpha-tocopherol in atherosclerosis
    Joanne M Upston
    Biochemistry Group, The Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW, 2050, Australia
    Biochem J 363:753-60. 2002
    ..These data are fully consistent with alpha-tocopherol acting as a hydrogen donor during lipid oxidation in vivo and suggest that alpha-tocopherol does not prevent lipoprotein lipid oxidation in the diseased vessel wall...
  34. pmc Is ischemia involved in the pathogenesis of murine cerebral malaria?
    L A Sanni
    Department of Pathology, University of Sydney, Sydney, Australia
    Am J Pathol 159:1105-12. 2001
    ..Mild obstructive ischemia is a likely cause of the metabolic changes during CM, but a role for immune cell effector molecules cannot be ruled out...
  35. ncbi request reprint Vascular microdissection, perfusion, and excision of the murine arterial tree for use in atherogenic disease investigations
    Gary Martinic
    Biological Services, The Heart Research Institute, 145 Missenden Road, Camperdown, New South Wales 2050, Australia
    Contemp Top Lab Anim Sci 42:47-53. 2003
    ..Thus, our article likely will provide a useful guide to those new to this technique, and for researchers undertaking similar studies, and the technique could be adapted to other species easily...
  36. ncbi request reprint Probucol protects against smooth muscle cell proliferation by upregulating heme oxygenase-1
    Yi Mo Deng
    Centre for Vascular Research, University of New South Wales, and the Department of Haematology, Prince of Wales Hospital, Sydney Australia
    Circulation 110:1855-60. 2004
    ..Probucol is the only oral drug that inhibits restenosis in humans and intimal thickening in animals, although its underlying mechanism remains unclear...
  37. ncbi request reprint Intimal thickening after arterial balloon injury is increased by intermittent repetitive hypoxia, but intermittent repetitive hyperoxia is not protective
    Antony K Lau
    The Heart Research Institute, University of Sydney, Sydney, Australia
    Atherosclerosis 185:254-63. 2006
    ..These results suggest that intermittent repetitive hyperoxia is not protective and intermittent repetitive hypoxia promotes arterial disease in normal and injured arteries independent of lipid peroxidation...
  38. doi request reprint Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells
    Ghassan J Maghzal
    Centre for Vascular Research and Molecular Immunopathology Unit, Bosch Institute and Discipline of Pathology, School of Medical Sciences, University of Sydney, Sydney, New South Wales 2006, Australia
    J Biol Chem 283:12014-25. 2008
    ..Together, our data show that cytochrome b(5) rather than O(2)(*-) plays a major role in the activation of IDO in human cells...
  39. pmc Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis
    Joanne M Upston
    Department of Biochemistry, Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW 2050, Australia
    Am J Pathol 160:701-10. 2002
    ..Our data show that accumulation of nonoxidized lipid precedes that of oxidized lipid in human aortic lesions...
  40. ncbi request reprint The use of antioxidant supplements in coronary heart disease
    Leonard Kritharides
    Clinical Research Group Heart Research Institute, NSW, Sydney, Australia
    Atherosclerosis 164:211-9. 2002
    ..However, this will require positive results from combined antioxidant studies currently in progress, and the targeting of oxidative processes that operate in the artery wall and cause or contribute to disease...
  41. ncbi request reprint Vitamin E
    Roland Stocker
    Centre for VascularResearch, School of Medical Sciences, Faculty of Medicine, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, Sydney, NSW 2052, Australia
    Novartis Found Symp 282:77-87; discussion 87-92, 212-8. 2007
    ....
  42. ncbi request reprint Pharmacologic induction of heme oxygenase-1
    Cheng Li
    Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Australia
    Antioxid Redox Signal 9:2227-39. 2007
    ..Understanding both the pathways by which HO-1 is induced and the mechanism through which the enzyme exerts its beneficial effects may facilitate the development of novel drugs...
  43. ncbi request reprint Probucol protects against hypochlorite-induced endothelial dysfunction: identification of a novel pathway of probucol oxidation to a biologically active intermediate
    Paul K Witting
    Centre for Vascular Research, Bioanalytical Mass Spectrometry Facility, and School of Chemistry, University of New South Wales, UNSW Sydney, New South Wales 2052, Australia
    J Biol Chem 280:15612-8. 2005
    ....
  44. ncbi request reprint The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions
    Andrew C Terentis
    Biochemistry Group, The Heart Research Institute, 145 Missenden Road, Camperdown, New South Wales 2050, Australia
    J Biol Chem 277:15788-94. 2002
    ..Together these data indicate that the strong proximal Fe-His bond and the strong H-bonding and/or steric interactions between l-Trp and dioxygen in the distal pocket are likely crucial for the enzymatic activity of hIDO...
  45. ncbi request reprint Probucol promotes functional reendothelialization in balloon-injured rabbit aortas
    Antony K Lau
    The Heart Research Institute, Sydney, Australia
    Circulation 107:2031-6. 2003
    ..Probucol remains the only conventional drug that reduces restenosis after coronary angioplasty. Apart from its weak cholesterol-lowering effect, probucol has antioxidant properties, but it remains unclear how this drug inhibits restenosis...
  46. doi request reprint Heme oxygenase and iron: from bacteria to humans
    Cheng Li
    Centre for Vascular Research, School of Medical Sciences Pathology and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia
    Redox Rep 14:95-101. 2009
    ..This review summarises the current knowledge in the dynamic relationship between heme oxygenase and iron in metabolism and in the clinical context...
  47. ncbi request reprint Plasmodium falciparum histidine-rich protein-2 (PfHRP2) modulates the redox activity of ferri-protoporphyrin IX (FePPIX): peroxidase-like activity of the PfHRP2-FePPIX complex
    Ryuichi Mashima
    Biochemistry Group, The Heart Research Institute, 145 Missenden Road, Camperdown, New South Wales 2050, Australia
    J Biol Chem 277:14514-20. 2002
    ..These data show that PfHRP2 modulates the redox activity of FePPIX and that the PfHRP2-FePPIX complex may have previously unrecognized antioxidant properties...
  48. ncbi request reprint Coenzyme Q(10) supplementation inhibits aortic lipid oxidation but fails to attenuate intimal thickening in balloon-injured New Zealand white rabbits
    Katherine J Choy
    Biochemistry Group, The Heart Research Institute, Camperdown, New South Wales, Australia
    Free Radic Biol Med 35:300-9. 2003
    ..However, unlike its antiatherosclerosis activity in the mice, CoQ(10) does not inhibit intimal hyperplasia in rabbits, thereby dissociating this disease process from lipid oxidation in the vessel wall...
  49. ncbi request reprint Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice
    Ben J Wu
    Centre for Vascular Research and Inflammatory Diseases Research Unit, School of Medical Sciences, University of New South Wales, and Royal North Shore Hospital, Sydney, Australia
    J Pharmacol Exp Ther 321:477-84. 2007
    ..Our findings suggest that lumen volume is not a suitable surrogate to assess the antiatherosclerotic activity of probucol and related drugs...
  50. doi request reprint Equivalent lipid oxidation profiles in advanced atherosclerotic lesions of carotid endarterectomy plaques obtained from symptomatic type 2 diabetic and nondiabetic subjects
    Krishna Kathir
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Free Radic Biol Med 49:481-6. 2010
    ..Our results do not support the notion that advanced atherosclerotic lesions from T2D patients contain more oxidized lipids than corresponding lesions from nondiabetic subjects...
  51. ncbi request reprint Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability
    Paul K Witting
    Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Cell Physiol Biochem 20:255-68. 2007
    ..likely derived from xanthine oxidase, NADPH-oxidase and mitochondria. These processes could contribute to H(2)O(2)-induced vascular dysfunction that may be relevant under conditions of oxidative stress such as inflammation...
  52. pmc A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL
    Xiao Suo Wang
    Centre for Vascular Research, School of Medical Sciences Pathology and Bosch Institute, The University of Sydney, Sydney, Australia
    J Lipid Res 50:586-94. 2009
    ..Because the ELISA we have developed specifically detects apoA-I containing MetO in HDL and plasma, it should provide a useful tool for investigating the relationship between oxidized HDL and coronary artery disease...
  53. doi request reprint Heme oxygenase-1 increases endothelial progenitor cells
    Ben J Wu
    Centre for Vascular Research, School of Medical Sciences and Bosch Institute, Faculty of Medicine, University of Sydney, NSW 2006, Australia
    Arterioscler Thromb Vasc Biol 29:1537-42. 2009
    ..As endothelial progenitor cells (EPCs) contribute to reendothelialization, we examined the role of HO-1 on bone marrow and circulating EPCs...
  54. doi request reprint Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells
    Paul R Coleman
    Vascular Biology Program, Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
    Blood 116:4016-24. 2010
    ..Together, these findings expand our understanding of the role of senescence in the vasculature and identify SENEX as a fulcrum for driving the resultant phenotype of the endothelium after activation...
  55. doi request reprint Detection of specifically oxidized apolipoproteins in oxidized HDL
    Xiao Suo Wang
    Centre for Vascular Research, Bosch Institute and Discipline of Pathology, The University of Sydney, Sydney, Australia
    Methods Mol Biol 477:49-63. 2008
    ..Here we describe an HPLC-based method to detect oxidized HDL containing specifically oxidized forms of apoA-I and apoA-II. This method may be useful to assess the early stages of HDL oxidation in biological samples...
  56. ncbi request reprint Maternal undernutrition reduces aortic wall thickness and elastin content in offspring rats without altering endothelial function
    Michael R Skilton
    Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia
    Clin Sci (Lond) 111:281-7. 2006
    ..These changes in vascular structure may amplify aging-related changes to the vasculature and contribute to the pathophysiology of the putative link between impaired fetal growth and adult cardiovascular disease...
  57. ncbi request reprint Probucol inhibits in-stent thrombosis and neointimal hyperplasia by promoting re-endothelialization
    David Tanous
    Centre for Vascular Research, School of Medical Sciences, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Atherosclerosis 189:342-9. 2006
    ..Here, we examined the effects of probucol on re-endothelialization and neointimal formation in a stent model...
  58. pmc Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging
    Ben J Wu
    Centre for Vascular Research, School of Medical Sciences, University of New South Wales, and Department of Haematology, Prince of Wales Hospital, Sydney NSW 2052, Australia
    J Exp Med 203:1117-27. 2006
    ..They indicate 2-electron rather than radical (1-electron) oxidants as important contributors to atherogenesis, and point to novel lead compounds for therapeutic intervention against atherosclerotic diseases...
  59. doi request reprint Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and FasL-Fas engagement
    Nicole Y Tan
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Circ Res 105:422-30. 2009
    ..Fas ligand (FasL)-mediated smooth muscle cell (SMC) apoptosis within the vulnerable plaque may lead to plaque instability and rupture, events that underlie myocardial infarction and stroke...
  60. ncbi request reprint Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine
    Benjamin Hack
    Heart Foundation Research Center, Griffith University, Gold Coast Campus, Southport, QLD, 4217, Australia
    Mol Cell Biochem 287:165-75. 2006
    ..Correlation of post-ischemic cardiovascular outcomes with specific oxidative events (glutathione redox state, alpha-TQ) supports an important anti-oxidant component to adenosinergic protection...
  61. ncbi request reprint Determination of the nature of the heme environment in nitrosyl indoleamine 2,3-dioxygenase using Multiple-scattering analyses of X-ray absorption fine structure
    Jade B Aitken
    Centre for Structural Biology and Structural Chemistry, and Centre for Heavy Metals Research, School of Chemistry, The University of Sydney, New South Wales 2006, Australia
    Biochemistry 43:4892-8. 2004
    ..The results indicate that both the blocking of the heme site to O(2) binding and conformational changes induced by breaking the Fe-N(epsilon) bond may be important mechanisms by which NO inhibits IDO in vitro and in vivo...
  62. ncbi request reprint Hypochlorous acid impairs endothelium-derived nitric oxide bioactivity through a superoxide-dependent mechanism
    Roland Stocker
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Mass 02118, USA
    Arterioscler Thromb Vasc Biol 24:2028-33. 2004
    ..To determine how hypochlorous acid (HOCl), the principal product of myeloperoxidase, modulates vascular function...
  63. pmc Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons
    Xing Li Wang
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Am J Clin Nutr 80:649-55. 2004
    ..Inflammation and oxidative stress are processes that mark early metabolic abnormalities in vascular diseases...
  64. ncbi request reprint Vitamin E is not deficient in human atherosclerotic plaques
    Anatol Kontush
    Arterioscler Thromb Vasc Biol 24:e139-40; author reply e141-2. 2004
  65. ncbi request reprint Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits
    Jan Hinrich Bräsen
    HELIOS Klinikum Berlin, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University, Wiltbergstr 50, 13125 Berlin, Germany
    Atherosclerosis 163:249-59. 2002
    ....
  66. pmc Regio- and stereo-chemical oxidation of linoleic acid by human myoglobin and hydrogen peroxide: Tyr(103) affects rate and product distribution
    Benjamin S Rayner
    Vascular Biology Group, ANZAC Research Institute, Hospital Road, Concord Repatriation General Hospital, Concord, NSW 2139, Australia
    Biochem J 381:365-72. 2004
    ....
  67. ncbi request reprint Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria
    Isabelle M Medana
    Nuffield Department of Clinical Laboratory Sciences, Oxford Wellcome Centre for Tropical Medicine, John Radcliffe Hospital, Oxford, UK
    J Infect Dis 188:844-9. 2003
    ..Elevated levels of KA in children with CM may serve to contain injury in the developing brain, which is more susceptible to excitotoxic damage than is the adult brain...
  68. ncbi request reprint Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein
    Greg Pankhurst
    The Heart Research Institute, 145 Missenden Road, Camperdown NSW 2050, Australia
    J Lipid Res 44:349-55. 2003
    ..Our results show that during the early stages, oxidation of HDL gives rise to specifically oxidized forms of apoA-I and apoA-II, some of which may be useful markers of in vivo HDL oxidation, and hence potentially atherosclerosis...
  69. ncbi request reprint Lack of inhibitory effect of HDL on TNFalpha-induced adhesion molecule expression in human aortic endothelial cells
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Atherosclerosis 165:241-9. 2002
    ..The ability of polyunsaturated phospholipids in HDL to affect endothelial activation remains to be further investigated...
  70. ncbi request reprint Formation of methionine sulfoxide-containing specific forms of oxidized high-density lipoproteins
    Ute Panzenböck
    Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria
    Biochim Biophys Acta 1703:171-81. 2005
    ....
  71. ncbi request reprint Neither plasma coenzyme Q10 concentration, nor its decline during pravastatin therapy, is linked to recurrent cardiovascular disease events: a prospective case-control study from the LIPID study
    Roland Stocker
    Centre for Vascular Research, School of Medical Sciences, University of New South Wales, UNSW, Sydney, NSW 2052, Australia
    Atherosclerosis 187:198-204. 2006
    ..This study confirms that pravastatin lowers plasma CoQ10 concentrations, but this does not appear to predict the risk of recurrent CVD events...
  72. ncbi request reprint Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet
    Judy B de Haan
    Oxidative Stress Group, Baker Heart Research Institute, Melbourne, Australia
    J Lipid Res 47:1157-67. 2006
    ..In summary, a specific deficiency in Gpx1 was not accompanied by an increase in markers of oxidative damage or increased atherosclerosis in a murine model of HFD-induced atherogenesis...
  73. ncbi request reprint Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration
    Elias N Glaros
    Prince of Wales Medical Research Institute, Randwick, NSW 2031, Australia
    Biochem Pharmacol 73:1340-6. 2007
    ..These data indicate that therapeutic reduction of plasma SM and/or GSL concentrations may offer a novel treatment for atherosclerosis...
  74. ncbi request reprint Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout mice
    Brett Garner
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    J Lipid Res 43:205-14. 2002
    ..The apoE-/- mouse therefore represents a useful model to study the potential role of GSL metabolism in atherogenesis...
  75. doi request reprint Anti-atherosclerotic and anti-diabetic properties of probucol and related compounds
    David Tanous
    Toronto Congenital Cardiac Centre for Adults, Toronto General Hospital, University Health Network, Toronto, Canada
    Redox Rep 13:48-59. 2008
    ..In this review, the molecular mechanisms underlying the beneficial activities of probucol and related compounds are described...