S E Starkstein

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. pmc A diagnostic formulation for anosognosia in Alzheimer's disease
    S E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia
    J Neurol Neurosurg Psychiatry 77:719-25. 2006
  2. ncbi request reprint The phenomenology of depression after brain injury
    Sergio E Starkstein
    Department of Neuropsychiatry and Neuropsychology, Raúl Carrea Institute of Neurological Research FLENI, and CENEBA, Buenos Aires, Argentina
    NeuroRehabilitation 17:105-13. 2002
  3. ncbi request reprint Depression in Alzheimer's disease
    Sergio E Starkstein
    University of Western Australia, Education Building T 7, School of Psychiatry and Clinical Neurosciences, and Fremantle Hospital, Western Australia, Australia
    Expert Rev Neurother 6:887-95. 2006
  4. doi request reprint Anosognosia is a significant predictor of apathy in Alzheimer's disease
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences at the University of Western Australia, Education Building T 7, Fremantle Hospital, Western Australia, Australia
    J Neuropsychiatry Clin Neurosci 22:378-83. 2010
  5. doi request reprint Apathy in Parkinson's disease: diagnostic and etiological dilemmas
    Sergio E Starkstein
    Department of Psychiatry and Clinical Neurosciences, University of Western Australia and Fremantle Hospital, Fremantle, Western Australia, Australia
    Mov Disord 27:174-8. 2012
  6. ncbi request reprint The construct of minor and major depression in Alzheimer's disease
    Sergio E Starkstein
    Fremantle Hospital, Education Building T 7, Fremantle, 6959 Western Australia, Australia
    Am J Psychiatry 162:2086-93. 2005
  7. pmc A prospective longitudinal study of apathy in Alzheimer's disease
    S E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, and Fremantle Hospital, Western Australia, Australia
    J Neurol Neurosurg Psychiatry 77:8-11. 2006
  8. ncbi request reprint The construct of generalized anxiety disorder in Alzheimer disease
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    Am J Geriatr Psychiatry 15:42-9. 2007
  9. ncbi request reprint The Unified Parkinson's Disease Rating Scale: validation study of the mentation, behavior, and mood section
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Western Australia, Australia
    Mov Disord 22:2156-61. 2007
  10. ncbi request reprint A validation study of depressive syndromes in Parkinson's disease
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Western Australia, Australia
    Mov Disord 23:538-46. 2008

Detail Information

Publications48

  1. pmc A diagnostic formulation for anosognosia in Alzheimer's disease
    S E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia
    J Neurol Neurosurg Psychiatry 77:719-25. 2006
    ..To determine the earliest symptoms of anosognosia in people with Alzheimer's disease and to validate a criteria-guided strategy to diagnose anosognosia in dementia...
  2. ncbi request reprint The phenomenology of depression after brain injury
    Sergio E Starkstein
    Department of Neuropsychiatry and Neuropsychology, Raúl Carrea Institute of Neurological Research FLENI, and CENEBA, Buenos Aires, Argentina
    NeuroRehabilitation 17:105-13. 2002
    ....
  3. ncbi request reprint Depression in Alzheimer's disease
    Sergio E Starkstein
    University of Western Australia, Education Building T 7, School of Psychiatry and Clinical Neurosciences, and Fremantle Hospital, Western Australia, Australia
    Expert Rev Neurother 6:887-95. 2006
    ..Other psychoactive compounds may be useful as well, but careful consideration must be given to potentially serious side effects...
  4. doi request reprint Anosognosia is a significant predictor of apathy in Alzheimer's disease
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences at the University of Western Australia, Education Building T 7, Fremantle Hospital, Western Australia, Australia
    J Neuropsychiatry Clin Neurosci 22:378-83. 2010
    ..This may be related to a specific pattern of progression of neuropathology and/or to poor adjustment of Alzheimer's disease patients with poor insight into their functional deficits...
  5. doi request reprint Apathy in Parkinson's disease: diagnostic and etiological dilemmas
    Sergio E Starkstein
    Department of Psychiatry and Clinical Neurosciences, University of Western Australia and Fremantle Hospital, Fremantle, Western Australia, Australia
    Mov Disord 27:174-8. 2012
    ..Finally, treatment for apathy in PD should not be restricted to psychoactive drugs, but should also include nonpharmacological techniques such as psychotherapy and occupational therapy...
  6. ncbi request reprint The construct of minor and major depression in Alzheimer's disease
    Sergio E Starkstein
    Fremantle Hospital, Education Building T 7, Fremantle, 6959 Western Australia, Australia
    Am J Psychiatry 162:2086-93. 2005
    ....
  7. pmc A prospective longitudinal study of apathy in Alzheimer's disease
    S E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, and Fremantle Hospital, Western Australia, Australia
    J Neurol Neurosurg Psychiatry 77:8-11. 2006
    ..Apathy and depression are the most frequent behavioural and psychiatric disorders in Alzheimer's disease, and may both have a negative impact on the progression of the illness...
  8. ncbi request reprint The construct of generalized anxiety disorder in Alzheimer disease
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    Am J Geriatr Psychiatry 15:42-9. 2007
    ....
  9. ncbi request reprint The Unified Parkinson's Disease Rating Scale: validation study of the mentation, behavior, and mood section
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Western Australia, Australia
    Mov Disord 22:2156-61. 2007
    ....
  10. ncbi request reprint A validation study of depressive syndromes in Parkinson's disease
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Western Australia, Australia
    Mov Disord 23:538-46. 2008
    ..This study provides validation to the DSM-IV diagnostic criteria for major depression and dysthymic disorder for use in PD. The categories of minor and subsyndromal depression may need further validation...
  11. doi request reprint The nosological position of apathy in clinical practice
    S E Starkstein
    School of Psychiatry, University of Western Australia, WA, Australia
    J Neurol Neurosurg Psychiatry 79:1088-92. 2008
    ..From a nosological perspective, future studies should examine the overlap with other psychiatric and neurodegenerative conditions and further validate specific diagnostic and assessment tools...
  12. ncbi request reprint Antidepressant therapy in post-stroke depression
    Sergio E Starkstein
    University of Western Australia, School of Psychiatry and Clinical Neurosciences, Australia
    Expert Opin Pharmacother 9:1291-8. 2008
    ..Depressed patients have more severe deficits in activities of daily living, a worse functional outcome, more severe cognitive deficits and increased mortality as compared to stroke patients without depression...
  13. doi request reprint Depression in Alzheimer's disease: phenomenology, clinical correlates and treatment
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Western Australia, Australia
    Int Rev Psychiatry 20:382-8. 2008
    ..Other psychoactive compounds may be useful as well, but careful consideration must be given to potentially serious side-effects...
  14. ncbi request reprint Apathy predicts more severe parkinsonism in Alzheimer's disease
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, WA, Australia
    Am J Geriatr Psychiatry 17:291-8. 2009
    ..Cross-sectional studies in AD reported a significant association between parkinsonism and apathy. The aim of this study was to assess the chronological association between apathy and parkinsonism in AD...
  15. doi request reprint The syndromal validity and nosological position of apathy in Parkinson's disease
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia
    Mov Disord 24:1211-6. 2009
    ..About one third of a series of patients attending a Movement Disorders Clinic showed apathy. Both depression and dementia were the most frequent comorbid conditions of apathy in PD...
  16. ncbi request reprint The frequency, clinical correlates, and mechanism of anosognosia after stroke
    Sergio E Starkstein
    The University of Western Australia, Perth, Australia
    Can J Psychiatry 55:355-61. 2010
    ..To review the frequency, clinical correlates, and mechanism of anosognosia after stroke...
  17. doi request reprint Diagnostic criteria for depression in Alzheimer disease: a study of symptom patterns using latent class analysis
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia and Fremantle Hospital, Australia
    Am J Geriatr Psychiatry 19:551-8. 2011
    ..Although depression in Alzheimer disease (AD) has a negative emotional and functional impact on patients and caregivers, specific criteria to diagnose depression in AD are still to be validated...
  18. doi request reprint Diagnostic criteria for depression in Parkinson's disease: a study of symptom patterns using latent class analysis
    Sergio Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia and Fremantle Hospital, Fremantle, Western Australia, Australia
    Mov Disord 26:2239-45. 2011
    ....
  19. ncbi request reprint Dementia after traumatic brain injury
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Fremantle Hospital, Western Australia, Australia
    Int Psychogeriatr 17:S93-107. 2005
    ....
  20. ncbi request reprint Uncommon causes of cerebrovascular dementia
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Fremantle Hospital, Western Australia, Australia
    Int Psychogeriatr 17:S51-64. 2005
    ..However, cognitive decline may be present in a proportion of patients with subarachnoid hemorrhages (SAH) or subdural hematomas (SH)...
  21. doi request reprint Neuroimaging correlates of apathy and depression in Alzheimer's disease
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia Fremantle Hospital, Western Australia, Australia
    J Neuropsychiatry Clin Neurosci 21:259-65. 2009
    ..Frontal and right parietal white matter hyperintensities are the strongest brain structural correlates of apathy and depression in Alzheimer's disease...
  22. ncbi request reprint Prevalence and clinical correlates of disinhibition in dementia
    Sergio E Starkstein
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, and Fremantle Hospital, Fremantle, Australia
    Cogn Behav Neurol 17:139-47. 2004
    ..A subset of patients was reexamined with the same instruments between 1 and 4 years after the initial evaluation...
  23. pmc On the overlap between apathy and depression in dementia
    S E Starkstein
    Raul Carrea Institute of Neurolgical Research, Buenos Aires, Argentina
    J Neurol Neurosurg Psychiatry 76:1070-4. 2005
    ..Whereas apathy is increasingly recognised as a frequent abnormal behaviour in dementia, its overlap with depression remains poorly understood...
  24. ncbi request reprint Specificity of symptoms of depression in Alzheimer disease: a longitudinal analysis
    Sergio E Starkstein
    Education Building T 7, Fremantle Hospital, Fremantle, 6959 WA, Australia
    Am J Geriatr Psychiatry 13:802-7. 2005
    ..Authors examined the temporal stability of symptoms of major and minor depression and apathy in dementia...
  25. ncbi request reprint A two-year follow-up study of remote memory in Alzheimer's disease
    Sergio E Starkstein
    Fremantle Hospital, Education Building T 7, Fremantle WA 6959, Australia
    J Neuropsychiatry Clin Neurosci 17:336-41. 2005
    ..The decline in anterograde verbal memory correlated significantly with the decline in autobiographical memory, suggesting a common final pathway for both deficits...
  26. ncbi request reprint Predictors of cognitive impairment and dementia in older people with diabetes
    D G Bruce
    School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
    Diabetologia 51:241-8. 2008
    ..We explored the relative contribution of diabetes-related variables as predictors of dementia in older individuals with diabetes...
  27. ncbi request reprint Vascular depression in older people with diabetes
    D G Bruce
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    Diabetologia 49:2828-36. 2006
    ..We explored a wide range of potential explanatory variables of depression in a longitudinal study of older diabetic subjects to investigate the vascular depression hypothesis in these patients...
  28. ncbi request reprint Explicit and implicit learning in patients with Alzheimer disease and Parkinson disease with dementia
    G Kuzis
    Department of Neuropsychiatry, Raul Carrea Institute of Neurological Research, Buenos Aires, Argentina
    Neuropsychiatry Neuropsychol Behav Neurol 12:265-9. 1999
    ..To examine the differential impairment of implicit and explicit memory systems in cortical and subcortical dementias...
  29. ncbi request reprint The specificity of depressive symptoms in patients with Alzheimer's disease
    E Chemerinski
    Department of Neuropsychiatry, , Buenos Aires, Argentina
    Am J Psychiatry 158:68-72. 2001
    ..Patients with Alzheimer's disease may not be fully aware of the extent of their depressive symptoms...
  30. ncbi request reprint Prevalence and correlates of aggressive behavior in Alzheimer's disease
    E Chemerinski
    Department of Neuropsychiatry, Raul Carrea Institute of Neurological Research, Buenos Aires, Argentina
    J Neuropsychiatry Clin Neurosci 10:421-5. 1998
    ..Physical aggression was significantly associated with more frequent delusions and more severe irritability...
  31. ncbi request reprint Theory of mind and pragmatic abilities in dementia
    A G Cuerva
    Department of Neuropsychiatry, Raul Carrea Institute of Neurologic Research FLENI, Buenos Aires, Argentina
    Neuropsychiatry Neuropsychol Behav Neurol 14:153-8. 2001
    ..Deficits in both ToM and pragmatic abilities have been described in patients with neurologic disorders, such as frontal lobe lesions and right hemisphere strokes, but have not been assessed in demented patients...
  32. ncbi request reprint Impairments of social cognition and decision making in Alzheimer's disease
    T Torralva
    Department of Neuropsychiatry, Raul Carrea Institute of Neurological Research, FLENI, Buenos Aires, Argentina
    Int Psychogeriatr 12:359-68. 2000
    ..To investigate the nature of deficits in social cognition and real-life decision making in a group of patients with Alzheimer's disease (AD)...
  33. ncbi request reprint Prevalence and correlates of parkinsonism in patients with primary depression
    S E Starkstein
    Department of Neuropsychiatry, Raúl Carrea Institute of Neurological Research FLENI, Buenos Aires, Argentina
    Neurology 57:553-5. 2001
    ..This syndrome was significantly associated with older age, more severe depression, and more severe cognitive impairment. In a subgroup of depressed patients, parkinsonism was reversible upon recovery from the mood disorder...
  34. ncbi request reprint A double-blind, placebo-controlled study of fluoxetine in depressed patients with Alzheimer's disease
    G M Petracca
    Department of Neuropsychiatry and Neuropsychology, Raúl Carrea Institute of Neurological Research FLENI, Buenos Aires, Argentina
    Int Psychogeriatr 13:233-40. 2001
    ..To examine the efficacy of fluoxetine in the treatment of depression in patients with probable Alzheimer's disease (AD)...
  35. ncbi request reprint Insight and danger in Alzheimer's disease
    S E Starkstein
    School of Psychiatry and Clinical Neurosciences University of Western Australia, WA, Australia
    Eur J Neurol 14:455-60. 2007
    ..Sixteen per cent of a consecutive series of patients with AD had dangerous behaviours during the month preceding the clinical evaluation. Anosognosia was the main clinical correlate of dangerous behaviours in this population...
  36. pmc White matter hyperintensities are significantly associated with cortical atrophy in Alzheimer's disease
    A A Capizzano
    MRI Unit, Fernandez Hospital, Buenos Aires, Argentina
    J Neurol Neurosurg Psychiatry 75:822-7. 2004
    ..We used a method of brain MRI segmentation for quantifying both tissue and WMH volumes in Alzheimer's disease (AD) and examined the association between WMH and structural and cognitive variables...
  37. pmc Predictors of cognitive decline in older individuals with diabetes
    David G Bruce
    1School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
    Diabetes Care 31:2103-7. 2008
    ..The purpose of this study was to determine longitudinal predictors of cognitive decline in older individuals with diabetes who did not have dementia...
  38. ncbi request reprint Apathy and Parkinson's disease
    Sergio E Starkstein
    University of Western Australia, Fremantle Hospital T 7, Fremantle, 6959, WA, Australia
    Curr Treat Options Neurol 13:267-73. 2011
    ..For those PD patients with "pure" apathy, specific psychotherapeutic techniques should be developed...
  39. ncbi request reprint A prospective study of depression and mortality in patients with type 2 diabetes: the Fremantle Diabetes Study
    D G Bruce
    School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
    Diabetologia 48:2532-9. 2005
    ..Depression is associated with excess mortality in patients with type 2 diabetes. We investigated the impact, and possible causal mechanisms, of depression on all-cause and cardiac mortality in patients with type 2 diabetes...
  40. ncbi request reprint SPECT findings in mentally retarded autistic individuals
    S E Starkstein
    Division of Child Psychiatry, Department of Neuropsychiatry, Raul Carrea Institute of Neurological Research, Buenos Aires, Argentina
    J Neuropsychiatry Clin Neurosci 12:370-5. 2000
    ..The study demonstrated significant perfusion deficits in specific brain areas of moderately to severely mentally retarded autistic patients...
  41. ncbi request reprint A randomized, double-blind, crossover study of methylphenidate and lithium in adults with attention-deficit/hyperactivity disorder: preliminary findings
    María Flavia Dorrego
    Department of Neuropsychiatry, Raúl Carrea Institute of Neurological Research FLENI, Montaneses 2325, 1428, Buenos Aires, Argentina
    J Neuropsychiatry Clin Neurosci 14:289-95. 2002
    ..In this preliminary study, lithium and MPH produced similar improvements on the primary outcome measure and on measures of irritability, aggressive outbursts, antisocial behavior, anxiety, and depression...
  42. ncbi request reprint Processing emotional information in Alzheimer's disease: effects on memory performance and neurophysiological correlates
    Francois Boller
    Unité 324 INSERM, Centre Paul Broca, Paris, France
    Dement Geriatr Cogn Disord 14:104-12. 2002
    ..Few studies have focused on the link between emotional processing and other cognitive functions, such as memory or attention...
  43. ncbi request reprint Epidemiology and management of apathy in patients with Alzheimer's disease
    Romina Mizrahi
    PET Center, Centre for Addiction and Mental Health CAMH, Toronto, Ontario, Canada
    Drugs Aging 24:547-54. 2007
    ..In this context, acetylcholinesterase inhibitors and psychosocial interventions are the only available modalities for treating apathy in AD with some efficacy...
  44. ncbi request reprint Hippocampal volume and mood disorders after traumatic brain injury
    Ricardo E Jorge
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    Biol Psychiatry 62:332-8. 2007
    ..We examined the relationship between hippocampal damage and mood disorders after TBI and the effect of hippocampal atrophy on the outcome of TBI patients...
  45. ncbi request reprint The effect of antipsychotic treatment on Theory of Mind
    Romina Mizrahi
    Centre for Addiction and Mental Health, and Department of Psychiatry, Faculty of Medicine, University of Toronto, Ontario, Canada
    Psychol Med 37:595-601. 2007
    ..However, it remains unclear whether TOM deficits constitute a trait- or a state-related deficit and whether they respond to antipsychotic treatment, and also whether the change in TOM and change in psychosis are associated...
  46. ncbi request reprint Phenomenology and clinical correlates of delusions in Alzheimer disease
    Romina Mizrahi
    PET Center for Addiction and Mental Health, Clarke Division, Toronto, Canada
    Am J Geriatr Psychiatry 14:573-81. 2006
    ....
  47. ncbi request reprint Alcohol misuse and mood disorders following traumatic brain injury
    Ricardo E Jorge
    Department of Psychiatry, The University of Iowa, Iowa City, USA
    Arch Gen Psychiatry 62:742-9. 2005
    ..Alcohol abuse and/or dependence (AA/D) and mood disturbance are co-occurring conditions among patients who have had a traumatic brain injury (TBI). However, the relationship between these disorders has not been extensively studied...
  48. ncbi request reprint Pathophysiologic aspects of major depression following traumatic brain injury
    Ricardo E Jorge
    Department of Psychiatry, University of Iowa, Iowa City, USA
    J Head Trauma Rehabil 20:475-87. 2005
    ..It is reasonable to assume that these symptomatic clusters have specific underlying mechanisms that need to be integrated in a comprehensive pathophysiologic model...