Roger Smith

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. ncbi request reprint Parturition
    Roger Smith
    Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    N Engl J Med 356:271-83. 2007
  2. pmc Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP)
    Yuxia Chen
    Department of Pathophysiology, Second Military Medical University, Shanghai 200433, China
    Reprod Biol Endocrinol 11:30. 2013
  3. doi request reprint Unexplained antepartum stillbirth: a consequence of placental aging?
    R Smith
    Hunter Medical Research Institute, University of Newcastle, Lookout Road, Newcastle, NSW 2310, Australia
    Placenta 34:310-3. 2013
  4. doi request reprint Recent advances in understanding the endocrinology of human birth
    Roger Smith
    Mothers and Babies Research Centre, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia
    Trends Endocrinol Metab 23:516-23. 2012
  5. pmc A recruiting failure turned success
    Alexis J Hure
    Nutrition and Dietetics, School of Health Sciences, The University of Newcastle, Callaghan, NSW, Australia
    BMC Health Serv Res 8:64. 2008
  6. ncbi request reprint Pathological interactions with the timing of birth and uterine activation
    Roger Smith
    Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, and School of Biomedical Sciences, University of Newcastle, New South Wales, Australia
    Aust N Z J Obstet Gynaecol 47:430-7. 2007
  7. doi request reprint Patterns of plasma corticotropin-releasing hormone, progesterone, estradiol, and estriol change and the onset of human labor
    Roger Smith
    Mothers and Babies Research Centre, University of Newcastle, Endocrine Unit, John Hunter Hospital, Newcastle, NSW 2305, Australia
    J Clin Endocrinol Metab 94:2066-74. 2009
  8. ncbi request reprint Corticotrophin releasing hormone and the timing of birth
    Roger Smith
    Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, NSW 2310, Australia
    Front Biosci 12:912-8. 2007
  9. ncbi request reprint Maternal asthma is associated with reduced female fetal growth
    Vanessa E Murphy
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW 2310, Australia
    Am J Respir Crit Care Med 168:1317-23. 2003
  10. ncbi request reprint Intracrine control of estrogen action in human gestational tissues at parturition
    Gemma Madsen
    Mothers and Babies Research Centre, University of Newcastle and John Hunter Hospital, Newcastle, New South Wales, Australia
    J Soc Gynecol Investig 11:213-9. 2004

Detail Information

Publications70

  1. ncbi request reprint Parturition
    Roger Smith
    Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    N Engl J Med 356:271-83. 2007
  2. pmc Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP)
    Yuxia Chen
    Department of Pathophysiology, Second Military Medical University, Shanghai 200433, China
    Reprod Biol Endocrinol 11:30. 2013
    ..As CRH can stimulate cAMP pathways we have tested whether a feed-forward system may exist in placental cells during syncytialisation...
  3. doi request reprint Unexplained antepartum stillbirth: a consequence of placental aging?
    R Smith
    Hunter Medical Research Institute, University of Newcastle, Lookout Road, Newcastle, NSW 2310, Australia
    Placenta 34:310-3. 2013
    ..Premature aging may also play an important role in antepartum stillbirth occurring earlier in pregnancy, especially in the context of growth restriction...
  4. doi request reprint Recent advances in understanding the endocrinology of human birth
    Roger Smith
    Mothers and Babies Research Centre, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia
    Trends Endocrinol Metab 23:516-23. 2012
    ..From this work, new therapeutic targets have been identified that may be used to regulate the onset of labor and improve neonatal mortality...
  5. pmc A recruiting failure turned success
    Alexis J Hure
    Nutrition and Dietetics, School of Health Sciences, The University of Newcastle, Callaghan, NSW, Australia
    BMC Health Serv Res 8:64. 2008
    ..The Assessment Before Children Develop Obesity Study was a cross-sectional survey which planned to follow-up women and children who had previously been, or were currently enrolled in the Mathematical Model of Pregnancy Study...
  6. ncbi request reprint Pathological interactions with the timing of birth and uterine activation
    Roger Smith
    Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, and School of Biomedical Sciences, University of Newcastle, New South Wales, Australia
    Aust N Z J Obstet Gynaecol 47:430-7. 2007
    ..It may also be necessary to divide preterm labour into groups based on underlying mechanisms and to tailor therapy accordingly...
  7. doi request reprint Patterns of plasma corticotropin-releasing hormone, progesterone, estradiol, and estriol change and the onset of human labor
    Roger Smith
    Mothers and Babies Research Centre, University of Newcastle, Endocrine Unit, John Hunter Hospital, Newcastle, NSW 2305, Australia
    J Clin Endocrinol Metab 94:2066-74. 2009
    ..Clinical prediction of preterm delivery is largely ineffective, and the mechanism mediating progesterone (P) withdrawal and estrogen activation at the onset of human labor is unclear...
  8. ncbi request reprint Corticotrophin releasing hormone and the timing of birth
    Roger Smith
    Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, NSW 2310, Australia
    Front Biosci 12:912-8. 2007
    ..A number of significant gaps remain in our knowledge of the function of this peptide in pregnancy. This review examines the current evidence regarding the role of CRH in human parturition...
  9. ncbi request reprint Maternal asthma is associated with reduced female fetal growth
    Vanessa E Murphy
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW 2310, Australia
    Am J Respir Crit Care Med 168:1317-23. 2003
    ..This study provides evidence that in pregnancies complicated by asthma there is a fetal sex-specific effect on the maternal immune system with adverse effects on placental function and female fetal growth...
  10. ncbi request reprint Intracrine control of estrogen action in human gestational tissues at parturition
    Gemma Madsen
    Mothers and Babies Research Centre, University of Newcastle and John Hunter Hospital, Newcastle, New South Wales, Australia
    J Soc Gynecol Investig 11:213-9. 2004
    ....
  11. ncbi request reprint Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus
    Vanessa E Murphy
    Mothers and Babies Research Centre, and Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia
    Endocr Rev 27:141-69. 2006
    ..Endocrine regulation of fetal growth involves interactions between the mother, placenta, and fetus, and these effects may program long-term physiology...
  12. doi request reprint Evidence that a protein kinase A substrate, small heat-shock protein 20, modulates myometrial relaxation in human pregnancy
    Elisa K Tyson
    Department of Endocrinology, Mothers and Babies Research Centre, John Hunter Hospital, Lookout Road, New Lambton Heights, Newcastle 2305, Australia
    Endocrinology 149:6157-65. 2008
    ..Our data support a novel role for pHSP20 in the modulation of cyclic-nucleotide-mediated myometrial relaxation, through interaction with actin. pHSP20 represents an important new target for future tocolytic therapy...
  13. doi request reprint Evidence that corticotropin-releasing hormone modulates myometrial contractility during human pregnancy
    Elisa K Tyson
    Department of Endocrinology, Mothers and Babies Research Centre, John Hunter Hospital, New Lambton Heights, Newcastle 2305, Australia
    Endocrinology 150:5617-25. 2009
    ..PDE inhibition potentiates CRH and salbutamol-induced relaxation. Up-regulation of PDEs, through chronic cAMP elevation by CRH, could provide a mechanism for down-regulation of agonist-stimulated-cAMP pathways at term...
  14. doi request reprint Dietary balance during pregnancy is associated with fetal adiposity and fat distribution
    Michelle L Blumfield
    School of Health Sciences and Obstetrics, Gynaecology and Neonatology, Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia
    Am J Clin Nutr 96:1032-41. 2012
    ..The prenatal environment can induce permanent changes in offspring phenotype. Thinness at birth is associated with adult risk of cardiometabolic disease...
  15. ncbi request reprint Placental cytokine expression covaries with maternal asthma severity and fetal sex
    Naomi M Scott
    Mothers and Babies Research Centre, Newcastle, New South Wales, Australia
    J Immunol 182:1411-20. 2009
    ..These data suggest that placental basal cytokine mRNA expression is sex specifically regulated in pregnancies complicated by asthma, and interestingly these changes are more prevalent in mild rather than severe asthma...
  16. ncbi request reprint Proteomic study of plasma proteins in pregnant women with asthma
    Vanessa E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NWS, Australia
    Respirology 11:41-8. 2006
    ..This study used the novel proteomic technique, surface-enhanced laser desorption ionization-time of flight mass spectrometry to determine if the presence of asthma during pregnancy was associated with alterations in plasma proteins...
  17. ncbi request reprint Contraction in human myometrium is associated with changes in small heat shock proteins
    David A MacIntyre
    Mothers and Babies Research Centre, The University of Newcastle, John Hunter Hospital, 1 Lookout Road, New Lambton Heights, Newcastle 2305, Australia
    Endocrinology 149:245-52. 2008
    ..Our findings provide data consistent with a novel pathway regulating human myometrial contraction at labor and identify HSP27 and alphaB-crystallin as potential targets for future tocolytic design...
  18. pmc The association between the macronutrient content of maternal diet and the adequacy of micronutrients during pregnancy in the Women and Their Children’s Health (WATCH) study
    Michelle Blumfield
    School of Health Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Nutrients 4:1958-76. 2012
    ..Results suggest a moderate protein intake may support pregnant women to consume the largest variety of nutrients across all food groups...
  19. pmc Phasic phosphorylation of caldesmon and ERK 1/2 during contractions in human myometrium
    Jonathan Paul
    Faculty of Health, Mothers and Babies Research Centre, University of Newcastle, Callaghan, Australia
    PLoS ONE 6:e21542. 2011
    ..Comparisons of NIL and L tissue are at risk of failing to detect these changes, as L samples are not necessarily preserved in the midst of an active contraction...
  20. ncbi request reprint Protocol for the Women And Their Children's Health (WATCH) study: a cohort of pregnancy and beyond
    Alexis J Hure
    Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, NSW, Australia
    J Epidemiol 22:267-75. 2012
    ..In this report, we describe the study protocol used in a prospective cohort of women recruited during pregnancy, with postnatal follow-up of the mothers and offspring...
  21. doi request reprint A systematic review and meta-analysis of micronutrient intakes during pregnancy in developed countries
    Michelle L Blumfield
    School of Health Sciences, Faculty of Health, University of Newcastle, Callaghan, New South Wales, Australia
    Nutr Rev 71:118-32. 2013
    ..Research examining the implications of potential nutrient insufficiency on maternal and offspring health outcomes is needed along with improvements in the quality of dietary intake reporting...
  22. ncbi request reprint The effect of maternal asthma on placental and cord blood protein profiles
    Vanessa E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle NSW, Australia
    J Soc Gynecol Investig 12:349-55. 2005
    ....
  23. doi request reprint Greater maternal weight gain during pregnancy predicts a large but lean fetal phenotype: a prospective cohort study
    Alexis Jayne Hure
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NSW, Australia
    Matern Child Health J 16:1374-84. 2012
    ..Prenatal counselling should focus on achieving a healthy BMI prior to conception so that gestational weight gain restrictions can be minimised...
  24. doi request reprint A longitudinal study of maternal folate and vitamin B12 status in pregnancy and postpartum, with the same infant markers at 6 months of age
    Alexis J Hure
    Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia
    Matern Child Health J 16:792-801. 2012
    ..04). Changes in maternal B12 and folate occur during pregnancy and after birth. Infant homocysteine metabolism may be regulated through maternal folate concentrations during pregnancy and postnatal feeding...
  25. ncbi request reprint Complex regulatory interactions control CRH gene expression
    Richard C Nicholson
    Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, NSW 2310, Australia
    Front Biosci 9:32-9. 2004
    ..A model is presented whereby CRH gene regulation is mediated via tissue specific expression of transcription factors...
  26. doi request reprint Expression of glucocorticoid receptor messenger ribonucleic acid transcripts in the human placenta at term
    Renee F Johnson
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, New South Wales, 2305 Australia
    J Clin Endocrinol Metab 93:4887-93. 2008
    ..Differential promoter use and alternative splicing generate a variety of glucocorticoid receptor (GR) mRNA transcripts, potentially altering the cortisol responsiveness of gestational tissues during pregnancy and labor...
  27. ncbi request reprint Prostaglandins differentially modulate progesterone receptor-A and -B expression in human myometrial cells: evidence for prostaglandin-induced functional progesterone withdrawal
    Gemma Madsen
    Mothers and Babies Research Centre, University of Newcastle and John Hunter Hospital, Newcastle, NSW, Australia
    J Clin Endocrinol Metab 89:1010-3. 2004
    ..We conclude that PGs acting via the PKC pathway facilitate functional progesterone withdrawal by increasing the myometrial PR-A/PR-B expression ratio...
  28. ncbi request reprint Tissue specific epigenetic differences in CRH gene expression
    Claire Abou-Seif
    Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, NSW 2305, Australia
    Front Biosci (Landmark Ed) 17:713-25. 2012
    ..In this paper we review tissue specific differences in CRH gene expression, and discuss how epigenetic chromatin modification mechanisms can relate to tissue specific differences in expression of CRH...
  29. ncbi request reprint Hormone trajectories leading to human birth
    Roger Smith
    Mothers and Babies Research Center, John Hunter Hospital, The University of Newcastle, NSW 2308, Newcastle, Australia newcstle edu au
    Regul Pept 108:159-64. 2002
    ..Preliminary studies strongly support the hypothesis that the onset of human parturition is initiated by rising concentrations of PR-A in the myometrium...
  30. ncbi request reprint Progesterone receptor or cytoskeletal protein?
    Gemma Madsen
    Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, Newcastle, NSW, Australia
    Reprod Sci 14:217-22. 2007
    ..The sc-538 nPR antibody therefore cross-reacts with cytoskeletal proteins that could be misinterpreted as nPR isoforms. Such misinterpretation has confused the progesterone response literature...
  31. ncbi request reprint Column-based method to simultaneously extract DNA, RNA, and proteins from the same sample
    Jorge M Tolosa
    University of Newcastle, New Lambton Heights, NSW, Australia
    Biotechniques 43:799-804. 2007
    ..This technique provides a simple and effective way to analyze protein and nucleic acids simultaneously from the same sample without affecting yield and quality...
  32. pmc Human uterine wall tension trajectories and the onset of parturition
    Peter Sokolowski
    Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, Newcastle, Australia
    PLoS ONE 5:e11037. 2010
    ..It seems likely that hormonal differences in multiple gestations are responsible for increased rates of preterm birth in this group rather than increased tension...
  33. doi request reprint Systematic review and meta-analysis of energy and macronutrient intakes during pregnancy in developed countries
    Michelle L Blumfield
    Nutrition and Dietetics, School of Health Sciences, Faculty of Health, University of Newcastle, Australia
    Nutr Rev 70:322-36. 2012
    ..The implications of these practices are unknown until further research compares maternal diet with short-term and long-term maternal and offspring health outcomes...
  34. doi request reprint Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma
    Annette Osei-Kumah
    Mothers and Babies Research Centre, Department of Endocrinology, Locked Bag 1, Hunter Medical Research Institute, Newcastle NSW 2310, Australia
    Cytokine 43:187-93. 2008
    ..This is the first study to show increased eotaxin production in the feto-placental unit of asthmatic pregnancies and may be one mechanism by which allergy susceptibility is increased in the offspring of asthmatic women...
  35. ncbi request reprint Reduced 11beta-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma
    Vanessa E Murphy
    Mothers and Babies Research Centre, University of Newcastle, New South Wales, Australia
    J Clin Endocrinol Metab 87:1660-8. 2002
    ....
  36. doi request reprint Asthma during pregnancy alters immune cell profile and airway epithelial chemokine release
    Annette Osei-Kumah
    Department of Endocrinology, Mothers and Babies Research Centre, Hunter Medical Research Institute, Locked Bag 1, Hunter Regional Mail Centre, Newcastle, NSW, 2310, Australia
    Inflamm Res 59:349-58. 2010
    ..The aim of the present study was to access maternal immune cell profiles in the presence and absence of asthma and to determine the effect of pregnancy-derived factors on epithelial cell function...
  37. ncbi request reprint Corticotropin-releasing hormone causes vasodilation in human skin via mast cell-dependent pathways
    Renee Crompton
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle NSW, Australia
    J Clin Endocrinol Metab 88:5427-32. 2003
    ..These findings provide novel evidence that CRH-induced vasodilation in human skin occurs via mast cell degranulation and is principally mediated by histamine and, to a lesser extent, by prostacyclin and nitric oxide...
  38. ncbi request reprint Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium
    Sam Mesiano
    Mothers and Babies Research Center, John Hunter Hospital, Newcastle, New South Wales 2310, Australia
    J Clin Endocrinol Metab 87:2924-30. 2002
    ..Interaction between the PR and ER systems in the human myometrium may be critical for the control of human parturition and the coordination of progesterone withdrawal and estrogen activation required for parturition...
  39. doi request reprint Role of serine-threonine phosphoprotein phosphatases in smooth muscle contractility
    Trent Butler
    Mothers and Babies Research Centre, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia
    Am J Physiol Cell Physiol 304:C485-504. 2013
    ....
  40. pmc Disparities exist between National food group recommendations and the dietary intakes of women
    Michelle L Blumfield
    School of Health Sciences, Faculty of Health, University of Newcastle, Callaghan, NSW, 2308, Australia
    BMC Womens Health 11:37. 2011
    ..Preconception and pregnancy dietary intakes can influence the health of future generations. In this study we compared the food intakes of reproductive-aged women by pregnancy status, to current Australian recommendations...
  41. ncbi request reprint Novel glucocorticoid and cAMP interactions on the CRH gene promoter
    Bruce R King
    Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Newcastle, NSW 2310, Australia
    Mol Cell Endocrinol 194:19-28. 2002
    ..Tissue specific expression of transcription factors may mediate regulation of the CRH gene...
  42. ncbi request reprint Short-term effects of glucocorticoids in the human fetal-placental circulation in vitro
    Vicki L Clifton
    Mothers and Babies Research Centre, Department of Endocrinology, John Hunter Hospital, Hunter Region Mail Center, Newcastle, New South Wales 2310, Australia
    J Clin Endocrinol Metab 87:2838-42. 2002
    ..These data suggest that dexamethasone can cause dilation in the fetal-placental circulation, possibly via an endothelium-independent pathway...
  43. doi request reprint Male sex and pre-existing diabetes are independent risk factors for stillbirth
    Patricia J Engel
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
    Aust N Z J Obstet Gynaecol 48:375-83. 2008
    ..To determine whether the risk of stillbirth is associated with male fetal sex, fetal growth and maternal factors in an Australian population...
  44. ncbi request reprint A profile of the immediate endocrine, metabolic and behavioural responses following a dual exposure to endotoxin in early life
    Frederick R Walker
    Laboratory of Neuroimmunology, School of Behavioural Sciences, Building W, University of Newcastle, Newcastle, N S W 2308, Australia
    Physiol Behav 83:495-504. 2004
    ..These findings demonstrate that postnatal endotoxin exposure impacts on both endocrine and metabolic activity and that alterations in these two systems may in part be mediated by the impact of endotoxin exposure on maternal behaviour...
  45. ncbi request reprint Identification of a family of DNA-binding proteins with homology to RNA splicing factors
    Kristy L Shipman
    Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, Australia
    Biochem Cell Biol 84:9-19. 2006
    ..The 3 human CREAP proteins form a unique family with the potential to act as transcription factors that link to RNA processing...
  46. ncbi request reprint Prediction of preterm delivery using plasma corticotrophin-releasing hormone and other biochemical variables
    Shaun McGrath
    Mothers and Babies Research Centre, University of Newcastle and John Hunter Hospital, NSW, Australia
    Ann Med 34:28-36. 2002
    ....
  47. ncbi request reprint Neonatal neurodevelopmental outcomes following tocolysis with glycerol trinitrate patches
    Andrew Gill
    Mothers and Babies Research Centre, University of Newcastle, Newcastle, Australia
    Am J Obstet Gynecol 195:484-7. 2006
    ..The object of this study was to determine the effects of maternal tocolysis with glycerol trinitrate (GTN) patches on the neurodevelopment of infants...
  48. doi request reprint Oxytocin in postnatally depressed mothers: its influence on mood and expressed emotion
    Beth L Mah
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Lookout Road, New Lambton Heights, NSW 2305, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 40:267-72. 2013
    ..We hypothesize that intranasal administration of oxytocin to mothers with depression will influence their parenting related expressed emotion, creating a better basis for sensitive parenting...
  49. doi request reprint Vascular and myometrial changes in the human uterus at term
    Anthony S Y Leong
    Hunter Area Pathology Service, University of Newcastle, Newcastle, Australia
    Reprod Sci 15:59-65. 2008
    ..The authors' studies give no support to the suggestion that fetal macrophages might invade the human myometrium at term...
  50. ncbi request reprint Developing research in partnership with Aboriginal communities - strategies for improving recruitment and retention
    K Rae
    Faculty of Health, University of Newcastle, Tamworth, New South Wales, Australia
    Rural Remote Health 13:2255. 2013
    ..It is anticipated that these strategies would also apply for health practitioners in maintaining their patients for clinical care management...
  51. doi request reprint Measuring cystatin C to determine renal function in neonates
    Yogavijayan Kandasamy
    Department of Neonatology, The Townsville Hospital, Queensland, Australia
    Pediatr Crit Care Med 14:318-22. 2013
    ..The purpose of this review was to determine the feasibility of using serum cystatin C measurements to assist clinicians in making early and accurate diagnoses of acute kidney injury in neonates...
  52. ncbi request reprint Maternal plasma corticotropin-releasing hormone trajectories vary depending on the cause of preterm delivery
    Shaun McGrath
    Mothers and Babies Research Centre, John Hunter Hospital, Newcastle, NSW, Australia
    Am J Obstet Gynecol 186:257-60. 2002
    ..We have reanalyzed data from a previous cohort of women with multiple samplings to determine whether the trajectory of increase of placental corticotropin-releasing hormone provided more information than did a single sample...
  53. doi request reprint Diet and pregnancy status in Australian women
    Alexis Hure
    Nutrition and Dietetics, School of Health Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Public Health Nutr 12:853-61. 2009
    ..To investigate and report the diet quality of young Australian women by pregnancy status...
  54. ncbi request reprint Differential enrichment of high- and low-molecular weight proteins and concurrent RNA extraction
    David A MacIntyre
    Mothers and Babies Research Center, University of Newcastle, Newcastle, NSW 2305, Australia
    Anal Biochem 359:274-6. 2006
  55. ncbi request reprint Estrogen represses whereas the estrogen-antagonist ICI 182780 stimulates placental CRH gene expression
    Xin Ni
    Department of Physiology, Second Military Medical University, Shanghai, People s Republic of China
    J Clin Endocrinol Metab 87:3774-8. 2002
    ..Estrogen may therefore modulate placental CRH production, influencing the rate of rise of maternal plasma CRH concentrations and potentially the length of gestation...
  56. ncbi request reprint Urocortin: a mechanism for the sustained activation of the HPA axis in the late-gestation ovine fetus?
    Alison C Holloway
    Department of Physiology, Canadian Institute for Health Research Groups in Fetal and Neonatal Health and Development, University of Toronto, Toronto, Ontario M55 1A8, Canada
    Am J Physiol Endocrinol Metab 283:E165-71. 2002
    ..Regulation of urocortin by cortisol suggests a mechanism to override negative feedback and sustain feedforward of fetal hypothalamic-pituitary-adrenal function, leading to birth...
  57. ncbi request reprint Estrogen receptor-mediated down-regulation of corticotropin-releasing hormone gene expression is dependent on a cyclic adenosine 3',5'-monophosphate regulatory element in human placental syncytiotrophoblast cells
    Xin Ni
    Department of Physiology, Second Military Medical University, Shanghai 200433, People s Republic of China
    J Clin Endocrinol Metab 89:2312-8. 2004
    ..In summary, our results demonstrate that a consensus CRE is required for the action of estrogen receptor ligands in human placental syncytiotrophoblast cells...
  58. ncbi request reprint Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells
    Chunhua Qin
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843, USA
    Cancer Res 63:958-64. 2003
    ..Thus, PPARgamma-induced inhibition of breast cancer cell growth is due, in part, to proteasome-dependent degradation of cyclin D1 (and ER alpha), and this pathway may be important for other cancer cell lines...
  59. ncbi request reprint Expression of fatty acid binding proteins inhibits lipid accumulation and alters toxicity in L cell fibroblasts
    Barbara P Atshaves
    Department of Physiology and Pharmacology, Texas A and M University, Texas Veterinary Medical Center, College Station 77843 4466, USA
    Am J Physiol Cell Physiol 283:C688-703. 2002
    ..These beneficial effects were offset by inhibition of branched-chain fatty acid oxidation that correlated with the enhanced toxicity of high levels of branched-chain fatty acid...
  60. pmc Lipopolysaccharide stimulation of trophoblasts induces corticotropin-releasing hormone expression through MyD88
    Andy Uh
    Division of Pediatric Infectious Diseases, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Obstet Gynecol 199:317.e1-6. 2008
    ..We hypothesized that intrauterine infection may lead to placental corticotrophin-releasing hormone (CRH) expression via Toll-like receptor signaling...
  61. ncbi request reprint Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells
    Maen Abdelrahim
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    J Biol Chem 277:28815-22. 2002
    ..These results clearly demonstrate the key role of the Sp1 protein in basal and estrogen-induced growth and gene expression in breast cancer cells...
  62. ncbi request reprint Assessment of temporal biochemical and gene transcription changes in rat liver cytochrome P450: utility of real-time quantitative RT-PCR
    Federico M Goodsaid
    Department of Genetic and Molecular Toxicology, Schering Plough Research Institute, PO Box 32, Lafayette, New Jersey 07848, USA
    Pharm Res 20:1373-80. 2003
    ....
  63. ncbi request reprint Effect of antalarmin, a novel corticotropin-releasing hormone antagonist, on the dynamic function of the preterm ovine fetal hypothalamo-pituitary-adrenal axis
    I Ross Young
    Department of Physiology, Monash University, Clayton, Vic, Australia young med monash edu au
    Neuroendocrinology 76:47-54. 2002
    ..These results confirm a role for CRH in stress-induced ACTH secretion in the ovine fetus, though its role in the regulation of basal ACTH and cortisol secretion is unclear...
  64. ncbi request reprint Fibronectin fragments cause release and degradation of collagen-binding molecules from equine explant cultures
    Anna Johnson
    Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, Lund, Sweden
    Osteoarthritis Cartilage 12:149-59. 2004
    ..In this study we investigated the fate of the collagen- and cell-binding molecules Cartilage oligomeric matrix protein (COMP) and chondroadherin...
  65. ncbi request reprint A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes
    Chunhua Qin
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A and M University, College Station, TX, USA
    Mol Cancer Ther 3:247-60. 2004
    ..These compounds are a novel class of synthetic PPARgamma agonists that induce responses in MCF-7 cells similar to those observed for PGJ2...
  66. ncbi request reprint Tocolysis: current controversies, future directions
    Stephen Cole
    Department of Maternal Fetal Medicine, Royal Women s Hospital, Grattan Street, Carlton, VIC 3053, Australia
    Curr Opin Investig Drugs 5:424-9. 2004
    ....
  67. ncbi request reprint Determination of steroids in human plasma using temperature-dependent inclusion chromatography for metabolomic investigations
    Paweł K Zarzycki
    Laboratory of Toxicology, Department of Environmental Biology, Technical University of Koszalin, Sniadeckich 2, 75 453 Koszalin, Poland
    J Chromatogr A 1104:203-8. 2006
    ..This method is simplistic, inexpensive and reproducible with the capabilities of accurate quantification of steroids. Therefore it could have numerous clinical and metabolomic applications...
  68. ncbi request reprint Pattern of maternal serum corticotropin-releasing hormone concentration during pregnancy in the common marmoset (Callithrix jacchus)
    Michael L Power
    Smithsonian s National Zoological Park, Washington, DC 20008, USA
    Am J Primatol 68:181-8. 2006
    ..The function of the early rapid rise of CRH in baboons and marmosets, and the significance of this difference between monkeys and apes, are not known...
  69. ncbi request reprint 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways
    Kathy Vanderlaag
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843, USA
    Breast Cancer Res Treat 109:273-83. 2008
    ..The growth inhibition of tumors derived from highly aggressive MDA-MB-231 cells suggests a potential role for the C-DIM compounds in the clinical treatment of ER-negative breast cancer...
  70. ncbi request reprint Age-related changes in lymphocyte subsets of quarter horse foals
    Roger Smith
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4467, USA
    Am J Vet Res 63:531-7. 2002
    ....