Jeremy T Smith

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. pmc Kisspeptin signaling is required for the luteinizing hormone response in anestrous ewes following the introduction of males
    Julie Ann P De Bond
    Department of Physiology, Monash University, Melbourne, Victoria, Australia
    PLoS ONE 8:e57972. 2013
  2. pmc An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice
    Jeremy T Smith
    School of Anatomy, Physiology and Human Biology, University of Western Australia, Perth 6009, Australia
    Peptides 47:45-53. 2013
  3. doi request reprint Sex steroid regulation of kisspeptin circuits
    Jeremy T Smith
    Department of Anatomy, Physiology and Human Biology, The University of Western Australia, Nedlands, Perth, WA 6009, Australia
    Adv Exp Med Biol 784:275-95. 2013
  4. doi request reprint Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells
    Kathryn Backholer
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Endocrinology 151:2233-43. 2010
  5. doi request reprint Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence
    Jeremy T Smith
    Department of Physiology, Building 13F, Monash University, Clayton, Victoria 3880, Australia
    Endocrinology 152:1001-12. 2011
  6. pmc Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep
    Jeremy T Smith
    Department of Physiology, Monash University, Victoria 3880, Australia
    Endocrinology 149:5770-82. 2008
  7. doi request reprint Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion
    Iain J Clarke
    Department Physiology, Building 13F, Monash University, Clayton Victoria 3800, Australia
    Endocrinology 149:5811-21. 2008
  8. ncbi request reprint Leptin distribution and metabolism in the pregnant rat: transplacental leptin passage increases in late gestation but is reduced by excess glucocorticoids
    Jeremy T Smith
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Endocrinology 144:3024-30. 2003
  9. pmc Kisspeptin and seasonality in sheep
    Iain J Clarke
    Department of Physiology, Monash University, Victoria 3800, Australia
    Peptides 30:154-63. 2009
  10. ncbi request reprint Seasonal and cyclical change in the luteinizing hormone response to kisspeptin in the ewe
    Jeremy T Smith
    Department of Physiology, Monash University, Melbourne, Vic, Australia
    Neuroendocrinology 90:283-91. 2009

Detail Information

Publications26

  1. pmc Kisspeptin signaling is required for the luteinizing hormone response in anestrous ewes following the introduction of males
    Julie Ann P De Bond
    Department of Physiology, Monash University, Melbourne, Victoria, Australia
    PLoS ONE 8:e57972. 2013
    ..We conclude that introduction of male sheep to seasonally anestrous female sheep activates kisspeptin neurons and other cells in the hypothalamus, leading to increased GnRH/LH secretion...
  2. pmc An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice
    Jeremy T Smith
    School of Anatomy, Physiology and Human Biology, University of Western Australia, Perth 6009, Australia
    Peptides 47:45-53. 2013
    ....
  3. doi request reprint Sex steroid regulation of kisspeptin circuits
    Jeremy T Smith
    Department of Anatomy, Physiology and Human Biology, The University of Western Australia, Nedlands, Perth, WA 6009, Australia
    Adv Exp Med Biol 784:275-95. 2013
    ..This chapter discusses the current consensus knowledge regarding the interaction between sex steroids and kisspeptin neurons in mammals...
  4. doi request reprint Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells
    Kathryn Backholer
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Endocrinology 151:2233-43. 2010
    ..This network between the three cell types could coordinate brain control of reproduction and metabolic homeostatic systems...
  5. doi request reprint Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence
    Jeremy T Smith
    Department of Physiology, Building 13F, Monash University, Clayton, Victoria 3880, Australia
    Endocrinology 152:1001-12. 2011
    ..Kisspeptin neurons of the ARC project to the external zone of the ME and kisspeptin acts upon the GnRH fibers at this level...
  6. pmc Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep
    Jeremy T Smith
    Department of Physiology, Monash University, Victoria 3880, Australia
    Endocrinology 149:5770-82. 2008
    ....
  7. doi request reprint Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion
    Iain J Clarke
    Department Physiology, Building 13F, Monash University, Clayton Victoria 3800, Australia
    Endocrinology 149:5811-21. 2008
    ..These data indicate that RFRP-3 is a specific and potent mammalian gonadotropin-inhibiting hormone, and that it acts upon pituitary gonadotropes to reduce GnRH-stimulated gonadotropin secretion...
  8. ncbi request reprint Leptin distribution and metabolism in the pregnant rat: transplacental leptin passage increases in late gestation but is reduced by excess glucocorticoids
    Jeremy T Smith
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Endocrinology 144:3024-30. 2003
    ..Consistent with the proposed role of leptin as a fetal growth factor, transplacental leptin passage is reduced in association with glucocorticoid-induced fetal growth retardation...
  9. pmc Kisspeptin and seasonality in sheep
    Iain J Clarke
    Department of Physiology, Monash University, Victoria 3800, Australia
    Peptides 30:154-63. 2009
    ..The reduction in kisspeptin neuronal function during the non-breeding season can be corrected by infusion of kisspeptin, which causes ovulation in seasonally acyclic females...
  10. ncbi request reprint Seasonal and cyclical change in the luteinizing hormone response to kisspeptin in the ewe
    Jeremy T Smith
    Department of Physiology, Monash University, Melbourne, Vic, Australia
    Neuroendocrinology 90:283-91. 2009
    ..The aim of the present study was to determine whether the response to kisspeptin treatment varies between the breeding and nonbreeding seasons...
  11. doi request reprint Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding
    Iain J Clarke
    Department of Physiology, Monash University, Clayton, VIC 3800, Australia iainclarke monash edu
    Neuroendocrinology 95:305-16. 2012
    ..Gonadotropin-inhibitory hormone (GnIH)-3 is a neuropeptide that plays a major role in the regulation of reproduction and feeding in mammals...
  12. pmc Hypothalamic expression of KISS1 and gonadotropin inhibitory hormone genes during the menstrual cycle of a non-human primate
    Jeremy T Smith
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Biol Reprod 83:568-77. 2010
    ..The role of GnIH is less clear, with paradoxical up-regulation of gene expression in the late follicular phase of the menstrual cycle...
  13. doi request reprint Seasonal variation in the gonadotropin-releasing hormone response to kisspeptin in sheep: possible kisspeptin regulation of the kisspeptin receptor
    Qun Li
    Department of Physiology, Monash University, Melbourne, Vic, Australia
    Neuroendocrinology 96:212-21. 2012
    ..We also show that kisspeptin may regulate the expression of its own receptor...
  14. pmc Gonadotropin-inhibitory hormone (GnIH) secretion into the ovine hypophyseal portal system
    Jeremy T Smith
    Department of Physiology, Building 13F, Monash University, Clayton, Victoria 3880, Australia
    Endocrinology 153:3368-75. 2012
    ..These data show GnIH-3 is secreted into portal blood to act on pituitary gonadotropes, reducing the action of GnRH...
  15. doi request reprint Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes
    Ika P Sari
    Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Endocrinology 150:5549-56. 2009
    ..We conclude that RFRP-3 acts on the pituitary gonadotropes to inhibit synthesis of the gonadotropins, and this effect may be mediated by a reduction in the GnRH-stimulated second messenger phospho-ERK-1/2...
  16. ncbi request reprint KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season
    Jeremy T Smith
    Department of Physiology, P O Box 13F, Monash University, Victoria 3800, Australia
    Endocrinology 148:1150-7. 2007
    ..Furthermore, a seasonal alteration in KiSS-1 expression in the ARC of OVX ewes strongly suggests that kisspeptin is fundamentally involved in the control of seasonal changes in reproductive function...
  17. doi request reprint Gonadotropin inhibitory hormone function in mammals
    Jeremy T Smith
    Department of Physiology, PO Box 13F, Monash University, Clayton, Victoria 3800, Australia
    Trends Endocrinol Metab 21:255-60. 2010
    ..It appears to play a major role in seasonal regulation of reproduction and also to be involved in regulation of stress and food intake...
  18. ncbi request reprint Leptin receptor expression in the rat placenta: changes in ob-ra, ob-rb, and ob-re with gestational age and suppression by glucocorticoids
    Jeremy T Smith
    School of Anatomy and Human Biology and The Western Australian Institute for Medical Research, The University of Western Australia, Crawley, Perth, Australia
    Biol Reprod 67:1204-10. 2002
    ....
  19. ncbi request reprint Developmental increases in plasma leptin binding activity and tissue Ob-Re mRNA expression in the rat
    Jeremy T Smith
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Hwy Crawley, Perth, Western Australia 6009, Australia
    J Endocrinol 184:535-41. 2005
    ..This suggests that the actions of leptin depend not only on its synthesis in adipose tissue and Ob-Rb expression in target cells, but also on factors that regulate tissue expression of Ob-Re and thus leptin transport within plasma...
  20. ncbi request reprint Kisspeptin signalling in the brain: steroid regulation in the rodent and ewe
    Jeremy T Smith
    Department of Physiology, PO Box 13F, Monash University, Victoria 3800, Australia
    Brain Res Rev 57:288-98. 2008
    ..Thus, kisspeptin neurons in the ARC of the ewe appear well placed to play a role in the negative and positive feedback regulation of GnRH exerted by sex steroids...
  21. doi request reprint Seasonal breeding as a neuroendocrine model for puberty in sheep
    Jeremy T Smith
    Dept Physiology, PO Box 13F, Monash University, Clayton, Victoria 3800, Australia
    Mol Cell Endocrinol 324:102-9. 2010
    ..This review compares and contrasts seasonal cycles of reproduction with the mechanisms that relate to the onset of puberty...
  22. ncbi request reprint Evidence that RF-amide related peptides are inhibitors of reproduction in mammals
    Iain J Clarke
    Department Physiology, Building 13F, Monash University, Clayton VIC 3800, Australia
    Front Neuroendocrinol 30:371-8. 2009
    ..This review will focus on the significant advances in RFRP research in mammalian species...
  23. doi request reprint Sex steroid control of hypothalamic Kiss1 expression in sheep and rodents: comparative aspects
    Jeremy T Smith
    Department of Physiology, PO Box 13F, Monash University, Wellington Road Clayton, Victoria 3880, Australia
    Peptides 30:94-102. 2009
    ..There are no Kiss1 cells in the ovine AVPV, but there is a population in the preoptic area. The role these preoptic area cells play in the sex steroid feedback regulation of GnRH secretion, if any, is yet to be revealed...
  24. doi request reprint Preweaning over- and underfeeding alters onset of puberty in the rat without affecting kisspeptin
    Jeremy T Smith
    Department of Physiology, Faculty of Medicine, Monash University, Melbourne, Victoria, Australia
    Biol Reprod 86:145, 1-8. 2012
    ..Our findings show early life underfeeding in males and overfeeding in females significantly affects puberty onset, altering steroid hormone concentrations in males, but this is not related to changes in hypothalamic kisspeptin...
  25. doi request reprint Kisspeptin and energy balance in reproduction
    Julie Ann P De Bond
    School of Anatomy, Physiology and Human Biology, M309, The University of Western Australia, Hackett Entrance 2, Hackett Drive, Nedlands, Perth, Western Australia 6009, Australia
    Reproduction 147:R53-63. 2014
    ..Thus, in addition to regulating reproduction, and mediating the effect of energy balance on reproductive function, kisspeptin signaling may also be a direct regulator of metabolism. ..
  26. ncbi request reprint Plasma leptin-binding activity and hypothalamic leptin receptor expression during pregnancy and lactation in the rat
    Ruth M Seeber
    School of Anatomy and Human Biology and The Western Australian Institute for Medical Research, University of Western Australia, Crawley, Perth, Western Australia 6009, Australia
    Biol Reprod 66:1762-7. 2002
    ..The results of this study confirm that pregnancy in the rat is a state of relative leptin resistance, which is due primarily to increased plasma leptin-binding activity rather than to changes in hypothalamic Ob-Rb expression...