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Jennifer J Smith
Affiliation: University of Queensland
Smith J, Undheim E. True Lies: Using Proteomics to Assess the Accuracy of Transcriptome-Based Venomics in Centipedes Uncovers False Positives and Reveals Startling Intraspecific Variation in Scolopendra Subspinipes. Toxins (Basel). 2018;10: pubmed publisher
..Our results highlight the importance of proteomic data in studies of even comparably well-characterized venoms and warrants caution when sourcing venom from centipedes of unknown origin. ..
Smith J, Herzig V, Ikonomopoulou M, Dziemborowicz S, Bosmans F, Nicholson G, et al. Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri. Toxins (Basel). 2017;9: pubmed publisher
..Comparison of the NaV channel sequences of the tested insect species revealed that variations in the S1-S2 loops in the voltage sensor domains might underlie the differences in activity between different phyla. ..
Wilson D, Boyle G, McIntyre L, Nolan M, Parsons P, Smith J, et al. The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells. Toxins (Basel). 2017;9: pubmed publisher
..Our results suggest that the ring structure plays a role in the cytotoxicity and that modification to the polyamine head group might lead to more potent and selective compounds with potential as novel cancer treatments. ..