Research Topics
Genomes and Genes | Craig A SmithSummaryAffiliation: University of Melbourne Country: Australia Publications
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Publications
Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryoCraig A Smith
Murdoch Childrens Research Institute and Department of Paediatrics, The University of Melbourne, Melbourne, Victoria 3052, Australia
Dev Dyn 233:188-93. 2005..In the developing testis, its expression profile suggests that Alex2 has a role in specification or development of the interstitial cell lineage...- Gene expression during gonadogenesis in the chicken embryoC A Smith
Department of Paediatrics and Centre for Hormone Research, The University of Melbourne, Royal Children s Hospital, Melbourne, VIC 3052, Australia
Gene 234:395-402. 1999..DAX1 transcripts were observed in both sexes at all stages examined, but expression appeared somewhat higher in developing ovaries. These expression profiles are analysed in terms of current theories of vertebrate sex determination... - Cloning and expression of a DAX1 homologue in the chicken embryoC A Smith
Department of Paediatrics and Centre for Hormone Research, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
J Mol Endocrinol 24:23-32. 2000..Expression increased in both sexes during gonadogenesis, but was higher in females than in males. This is the first description of a DAX1 homologue in a non-mammalian vertebrate... - Sex determination in the chicken embryoC A Smith
Department of Paediatrics and Centre for Hormone Research, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria, 3052, Australia
J Exp Zool 290:691-9. 2001..However, expression is not down-regulated at the onset of testicular differentiation in chicken embryos, as occurs in mice. These comparative data shed light on vertebrate sex determination in general... - DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryosCraig A Smith
Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
Biol Reprod 68:560-70. 2003..Higher levels of DMRT1 expression during testis differentiation therefore do not simply reflect a gene dosage difference between the two sexes but imply active involvement in male development... - Restricted expression of DMRT3 in chicken and mouse embryosCraig A Smith
Murdoch Children s Research Institute, The University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
Gene Expr Patterns 2:69-72. 2002..In the chicken, DMRT3 is also expressed in newly forming tail somites at early developmental stages and, later, in the Müllerian ducts of the urogenital system... - Restricted expression of DMRT3 in chicken and mouse embryosCraig A Smith
Murdoch Children s Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
Mech Dev 119:S73-6. 2002..In the chicken, DMRT3 is also expressed in newly forming tail somites at early developmental stages and, later, in the Müllerian ducts of the urogenital system... - Manipulation of estrogen synthesis alters MIR202* expression in embryonic chicken gonadsStephanie C Bannister
CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
Biol Reprod 85:22-30. 2011..These results confirm that up-regulation of MIR202* coincides with testicular differentiation in embryonic chicken gonads... - Male-specific cell migration into the developing gonad is a conserved process involving PDGF signallingCraig A Smith
Department of Paediatrics and Murdoch Children's Research Institute, The University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia
Dev Biol 284:337-50. 2005..Taken together, these studies indicate that a key cellular event in gonadal sex differentiation is conserved among higher vertebrates, that it involves PDGF signalling, and that in mammals is an indirect effect of Sry expression... - The potential role of microRNAs in regulating gonadal sex differentiation in the chicken embryoAndrew D Cutting
CSIRO Australian Animal Health Laboratories, Portarlington Road, Geelong, Victoria, Australia
Chromosome Res 20:201-13. 2012..We validated a subset of miRNAs by qRT-PCR, and prediction algorithms were used to identify potential targets. We discuss the possible roles for these miRNAs in gonadal development and how these roles might be tested in the avian model... - The avian Z-linked gene DMRT1 is required for male sex determination in the chickenCraig A Smith
Murdoch Children s Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
Nature 461:267-71. 2009..These results indicate that DMRT1 is required for testis determination in the chicken. Our data support the Z dosage hypothesis for avian sex determination... - Sexually dimorphic microRNA expression during chicken embryonic gonadal developmentStephanie C Bannister
Commonwealth Scientific and Industrial Research Organisation Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
Biol Reprod 81:165-76. 2009..These findings provide the first evidence of sexually dimorphic miRNA expression during vertebrate gonadal sex differentiation and suggest that MIR202* may function in regulating testicular development... - Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian developmentCraig A Smith
The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, 3052, Australia
BMC Dev Biol 8:72. 2008..Evidence is presented that this gene is an ancient component of the vertebrate ovary-determining pathway... - Expression profile of the RNA-binding protein gene hermes during chicken embryonic developmentHelen P Wilmore
Murdoch Children s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Melbourne, VIC 3052, Australia
Dev Dyn 233:1045-51. 2005..In addition, cHermes expression was seen in the mesoderm of the gut and in the notochord... - Sex determination: insights from the chickenCraig A Smith
Murdoch Childrens Research Institute and Department of Paediatrics, Royal Childrens Hospital, Parkville, Victoria, Australia
Bioessays 26:120-32. 2004..The Z-linked gene, DMRT1, supports the Z-dosage model of avian sex determination. Two novel W-linked genes, ASW and FET1, represent candidate female determinants... - Robust and ubiquitous GFP expression in a single generation of chicken embryos using the avian retroviral vector, RCASBPCraig A Smith
Murdoch Childrens Research Institute, University of Melbourne, Department of Paediatrics, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia
Differentiation 77:473-82. 2009..This transgenic chicken model is of value in developmental studies, and for the isolation and study of avian primordial germ cells... - Genetic evidence against a role for W-linked histidine triad nucleotide binding protein (HINTW) in avian sex determinationCraig A Smith
Murdoch Childrens Research Institute and the Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
Int J Dev Biol 53:59-67. 2009..Female (ZW) gonads over-expressing HINTW also developed normally, with normal ovarian structure and left/right asymmetry. These results provide genetic evidence against a dominant role for HINTW in avian sex determination... - Onset of meiosis in the chicken embryo; evidence of a role for retinoic acidCraig A Smith
Murdoch Childrens Research Institute and University of Melbourne Department of Paediatrics, Royal Children s Hospital, Melbourne, 3052, Australia
BMC Dev Biol 8:85. 2008..Here we report the molecular analysis of meiosis onset in the chicken model and provide evidence for conserved regulation by retinoic acid... - Conserved expression of a novel gene during gonadal developmentQuanah J Hudson
Murdoch Children s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Melbourne, Vic, Australia
Dev Dyn 233:1083-90. 2005..Expression of GET in the müllerian duct, wolffian duct, metanephric kidney, and external genitalia, suggests that GET may play a wider role in the development of the urogenital system... - Aromatase inhibition reduces expression of FOXL2 in the embryonic chicken ovaryQuanah J Hudson
Murdoch Children s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Vic, Australia
Dev Dyn 233:1052-5. 2005..The reduction in FOXL2 expression may be accounted for by interruption of a positive feedback loop by means of estrogen, or the influence of testis promoting factors such as SOX9 and DMRT1 in the masculinized gonads... - Sex determination and sexual differentiation in the avian modelJustin Chue
Department of Paediatrics, Murdoch Children s Research Institute and University of Melbourne, Parkville, Victoria, Australia
FEBS J 278:1027-34. 2011..Female development in the avian model appears to be shared with mammals; both the FOXL2 and RSPO1/WNT4 pathways are implicated in ovarian differentiation... - Conservation of a sex-determining geneC A Smith
Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Victoria, Australia
Nature 402:601-2. 1999 - The long non-coding RNA, MHM, plays a role in chicken embryonic development, including gonadogenesisKelly N Roeszler
Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
Dev Biol 366:317-26. 2012..These results indicate that MHM has a role in chicken normal embryonic development, including gonadal sex differentiation... - Avian sex determination: what, when and where?C A Smith
Murdoch Childrens Research Institute and University of Melbourne, Department of Paediatrics, Royal Childrens Hospital, Parkville, Australia
Cytogenet Genome Res 117:165-73. 2007.... - Sex determination in birds: HINTs from the W sex chromosome?C A Smith
University of Melbourne, Department of Paediatrics and Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
Sex Dev 1:279-85. 2007..However, a differentiated HINTW gene appears to be absent in the flightless ratites. This review examines the evidence for and against a role for HINTW in avian sex determination... - Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologueJoanne Fanelli Panus
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 99:8348-53. 2002..Viral inhibition of CD30 also lends support to the potential therapeutic value of targeting CD30 in human inflammatory and autoimmune diseases...