Craig A Smith

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo
    Craig A Smith
    Murdoch Childrens Research Institute and Department of Paediatrics, The University of Melbourne, Melbourne, Victoria 3052, Australia
    Dev Dyn 233:188-93. 2005
  2. ncbi request reprint Gene expression during gonadogenesis in the chicken embryo
    C A Smith
    Department of Paediatrics and Centre for Hormone Research, The University of Melbourne, Royal Children s Hospital, Melbourne, VIC 3052, Australia
    Gene 234:395-402. 1999
  3. ncbi request reprint Cloning and expression of a DAX1 homologue in the chicken embryo
    C A Smith
    Department of Paediatrics and Centre for Hormone Research, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    J Mol Endocrinol 24:23-32. 2000
  4. ncbi request reprint Sex determination in the chicken embryo
    C A Smith
    Department of Paediatrics and Centre for Hormone Research, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria, 3052, Australia
    J Exp Zool 290:691-9. 2001
  5. ncbi request reprint DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryos
    Craig A Smith
    Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Biol Reprod 68:560-70. 2003
  6. ncbi request reprint Restricted expression of DMRT3 in chicken and mouse embryos
    Craig A Smith
    Murdoch Children s Research Institute, The University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Gene Expr Patterns 2:69-72. 2002
  7. ncbi request reprint Restricted expression of DMRT3 in chicken and mouse embryos
    Craig A Smith
    Murdoch Children s Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Mech Dev 119:S73-6. 2002
  8. ncbi request reprint Male-specific cell migration into the developing gonad is a conserved process involving PDGF signalling
    Craig A Smith
    Department of Paediatrics and Murdoch Children s Research Institute, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Dev Biol 284:337-50. 2005
  9. doi request reprint The avian Z-linked gene DMRT1 is required for male sex determination in the chicken
    Craig A Smith
    Murdoch Children s Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Nature 461:267-71. 2009
  10. doi request reprint Manipulation of estrogen synthesis alters MIR202* expression in embryonic chicken gonads
    Stephanie C Bannister
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    Biol Reprod 85:22-30. 2011

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo
    Craig A Smith
    Murdoch Childrens Research Institute and Department of Paediatrics, The University of Melbourne, Melbourne, Victoria 3052, Australia
    Dev Dyn 233:188-93. 2005
    ..In the developing testis, its expression profile suggests that Alex2 has a role in specification or development of the interstitial cell lineage...
  2. ncbi request reprint Gene expression during gonadogenesis in the chicken embryo
    C A Smith
    Department of Paediatrics and Centre for Hormone Research, The University of Melbourne, Royal Children s Hospital, Melbourne, VIC 3052, Australia
    Gene 234:395-402. 1999
    ..DAX1 transcripts were observed in both sexes at all stages examined, but expression appeared somewhat higher in developing ovaries. These expression profiles are analysed in terms of current theories of vertebrate sex determination...
  3. ncbi request reprint Cloning and expression of a DAX1 homologue in the chicken embryo
    C A Smith
    Department of Paediatrics and Centre for Hormone Research, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    J Mol Endocrinol 24:23-32. 2000
    ..Expression increased in both sexes during gonadogenesis, but was higher in females than in males. This is the first description of a DAX1 homologue in a non-mammalian vertebrate...
  4. ncbi request reprint Sex determination in the chicken embryo
    C A Smith
    Department of Paediatrics and Centre for Hormone Research, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria, 3052, Australia
    J Exp Zool 290:691-9. 2001
    ..However, expression is not down-regulated at the onset of testicular differentiation in chicken embryos, as occurs in mice. These comparative data shed light on vertebrate sex determination in general...
  5. ncbi request reprint DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryos
    Craig A Smith
    Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Biol Reprod 68:560-70. 2003
    ..Higher levels of DMRT1 expression during testis differentiation therefore do not simply reflect a gene dosage difference between the two sexes but imply active involvement in male development...
  6. ncbi request reprint Restricted expression of DMRT3 in chicken and mouse embryos
    Craig A Smith
    Murdoch Children s Research Institute, The University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Gene Expr Patterns 2:69-72. 2002
    ..In the chicken, DMRT3 is also expressed in newly forming tail somites at early developmental stages and, later, in the Müllerian ducts of the urogenital system...
  7. ncbi request reprint Restricted expression of DMRT3 in chicken and mouse embryos
    Craig A Smith
    Murdoch Children s Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Mech Dev 119:S73-6. 2002
    ..In the chicken, DMRT3 is also expressed in newly forming tail somites at early developmental stages and, later, in the Müllerian ducts of the urogenital system...
  8. ncbi request reprint Male-specific cell migration into the developing gonad is a conserved process involving PDGF signalling
    Craig A Smith
    Department of Paediatrics and Murdoch Children s Research Institute, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Dev Biol 284:337-50. 2005
    ..Taken together, these studies indicate that a key cellular event in gonadal sex differentiation is conserved among higher vertebrates, that it involves PDGF signalling, and that in mammals is an indirect effect of Sry expression...
  9. doi request reprint The avian Z-linked gene DMRT1 is required for male sex determination in the chicken
    Craig A Smith
    Murdoch Children s Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    Nature 461:267-71. 2009
    ..These results indicate that DMRT1 is required for testis determination in the chicken. Our data support the Z dosage hypothesis for avian sex determination...
  10. doi request reprint Manipulation of estrogen synthesis alters MIR202* expression in embryonic chicken gonads
    Stephanie C Bannister
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    Biol Reprod 85:22-30. 2011
    ..These results confirm that up-regulation of MIR202* coincides with testicular differentiation in embryonic chicken gonads...
  11. doi request reprint The potential role of microRNAs in regulating gonadal sex differentiation in the chicken embryo
    Andrew D Cutting
    CSIRO Australian Animal Health Laboratories, Portarlington Road, Geelong, Victoria, Australia
    Chromosome Res 20:201-13. 2012
    ..We validated a subset of miRNAs by qRT-PCR, and prediction algorithms were used to identify potential targets. We discuss the possible roles for these miRNAs in gonadal development and how these roles might be tested in the avian model...
  12. pmc Sexually dimorphic microRNA expression during chicken embryonic gonadal development
    Stephanie C Bannister
    Commonwealth Scientific and Industrial Research Organisation Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    Biol Reprod 81:165-76. 2009
    ..These findings provide the first evidence of sexually dimorphic miRNA expression during vertebrate gonadal sex differentiation and suggest that MIR202* may function in regulating testicular development...
  13. doi request reprint The molecular genetics of avian sex determination and its manipulation
    Katie L Ayers
    Comparative Development, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
    Genesis 51:325-36. 2013
    ..Finally, we review the methods currently used to investigate the role of genes and signaling pathways during sexual differentiation, and discuss how these methods may contribute to further understanding of vertebrate gonadogenesis...
  14. pmc Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development
    Craig A Smith
    The University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria, 3052, Australia
    BMC Dev Biol 8:72. 2008
    ..Evidence is presented that this gene is an ancient component of the vertebrate ovary-determining pathway...
  15. ncbi request reprint Expression profile of the RNA-binding protein gene hermes during chicken embryonic development
    Helen P Wilmore
    Murdoch Children s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Melbourne, VIC 3052, Australia
    Dev Dyn 233:1045-51. 2005
    ..In addition, cHermes expression was seen in the mesoderm of the gut and in the notochord...
  16. doi request reprint Robust and ubiquitous GFP expression in a single generation of chicken embryos using the avian retroviral vector, RCASBP
    Craig A Smith
    Murdoch Childrens Research Institute, University of Melbourne, Department of Paediatrics, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia
    Differentiation 77:473-82. 2009
    ..This transgenic chicken model is of value in developmental studies, and for the isolation and study of avian primordial germ cells...
  17. doi request reprint Genetic evidence against a role for W-linked histidine triad nucleotide binding protein (HINTW) in avian sex determination
    Craig A Smith
    Murdoch Childrens Research Institute and the Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
    Int J Dev Biol 53:59-67. 2009
    ..Female (ZW) gonads over-expressing HINTW also developed normally, with normal ovarian structure and left/right asymmetry. These results provide genetic evidence against a dominant role for HINTW in avian sex determination...
  18. pmc Onset of meiosis in the chicken embryo; evidence of a role for retinoic acid
    Craig A Smith
    Murdoch Childrens Research Institute and University of Melbourne Department of Paediatrics, Royal Children s Hospital, Melbourne, 3052, Australia
    BMC Dev Biol 8:85. 2008
    ..Here we report the molecular analysis of meiosis onset in the chicken model and provide evidence for conserved regulation by retinoic acid...
  19. ncbi request reprint Sex determination: insights from the chicken
    Craig A Smith
    Murdoch Childrens Research Institute and Department of Paediatrics, Royal Childrens Hospital, Parkville, Victoria, Australia
    Bioessays 26:120-32. 2004
    ..The Z-linked gene, DMRT1, supports the Z-dosage model of avian sex determination. Two novel W-linked genes, ASW and FET1, represent candidate female determinants...
  20. ncbi request reprint Aromatase inhibition reduces expression of FOXL2 in the embryonic chicken ovary
    Quanah J Hudson
    Murdoch Children s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Vic, Australia
    Dev Dyn 233:1052-5. 2005
    ..The reduction in FOXL2 expression may be accounted for by interruption of a positive feedback loop by means of estrogen, or the influence of testis promoting factors such as SOX9 and DMRT1 in the masculinized gonads...
  21. ncbi request reprint Conserved expression of a novel gene during gonadal development
    Quanah J Hudson
    Murdoch Children s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Melbourne, Vic, Australia
    Dev Dyn 233:1083-90. 2005
    ..Expression of GET in the müllerian duct, wolffian duct, metanephric kidney, and external genitalia, suggests that GET may play a wider role in the development of the urogenital system...
  22. doi request reprint Just how conserved is vertebrate sex determination?
    Andrew Cutting
    Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, Australia
    Dev Dyn 242:380-7. 2013
    ..At the gonadal level, key genes required for proper sexual differentiation are conserved among vertebrates, but their relative positions in the ovarian and testicular cascades differ...
  23. doi request reprint The long non-coding RNA, MHM, plays a role in chicken embryonic development, including gonadogenesis
    Kelly N Roeszler
    Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Dev Biol 366:317-26. 2012
    ..These results indicate that MHM has a role in chicken normal embryonic development, including gonadal sex differentiation...
  24. pmc Overexpression of aromatase alone is sufficient for ovarian development in genetically male chicken embryos
    Luke S Lambeth
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    PLoS ONE 8:e68362. 2013
    ....
  25. doi request reprint Sex determination and sexual differentiation in the avian model
    Justin Chue
    Department of Paediatrics, Murdoch Children s Research Institute and University of Melbourne, Parkville, Victoria, Australia
    FEBS J 278:1027-34. 2011
    ..Female development in the avian model appears to be shared with mammals; both the FOXL2 and RSPO1/WNT4 pathways are implicated in ovarian differentiation...
  26. ncbi request reprint Conservation of a sex-determining gene
    C A Smith
    Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children s Hospital, Victoria, Australia
    Nature 402:601-2. 1999
  27. ncbi request reprint Avian sex determination: what, when and where?
    C A Smith
    Murdoch Childrens Research Institute and University of Melbourne, Department of Paediatrics, Royal Childrens Hospital, Parkville, Australia
    Cytogenet Genome Res 117:165-73. 2007
    ....
  28. doi request reprint Short hairpin RNA-mediated gene silencing
    Luke S Lambeth
    Murdoch Childrens Research Institute, Royal Childrens Hospital, Melbourne, Vic, Australia
    Methods Mol Biol 942:205-32. 2013
    ..This chapter reviews the history, cellular processing, and various applications of shRNAs in mammalian systems, including options for effector molecule design, vector and promoter types, and methods for multiple shRNA delivery...
  29. doi request reprint Sex determination in birds: HINTs from the W sex chromosome?
    C A Smith
    University of Melbourne, Department of Paediatrics and Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    Sex Dev 1:279-85. 2007
    ..However, a differentiated HINTW gene appears to be absent in the flightless ratites. This review examines the evidence for and against a role for HINTW in avian sex determination...
  30. pmc Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue
    Joanne Fanelli Panus
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 99:8348-53. 2002
    ..Viral inhibition of CD30 also lends support to the potential therapeutic value of targeting CD30 in human inflammatory and autoimmune diseases...