Fiona Simpson

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi A novel hook-related protein family and the characterization of hook-related protein 1
    Fiona Simpson
    Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Traffic 6:442-58. 2005
  2. ncbi Murine embryonic expression of the gene for the UV-responsive protein p15(PAF)
    Kelly Lammerts van Bueren
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Gene Expr Patterns 7:47-50. 2007
  3. ncbi Identification and analysis of novel genes expressed in the mouse embryonic facial primordia
    Jennifer S Bennetts
    Institute for Molecular Bioscience, The University of Queensland, QLD 4072, Australia
    Front Biosci 11:2631-46. 2006
  4. ncbi Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP)
    Jennifer S Bennetts
    Institute for Molecular Bioscience, The University of Queensland, St Lucia 4072, QLD 4072, Australia
    Gene 374:153-65. 2006
  5. ncbi Visualisation of macropinosome maturation by the recruitment of sorting nexins
    Markus C Kerr
    Institute for Molecular Bioscience and ARC Centre in Bioinformatics, University of Queensland, St Lucia, QLD 4072, Australia
    J Cell Sci 119:3967-80. 2006
  6. ncbi The coding region of TP53INP2, a gene expressed in the developing nervous system, is not altered in a family with autosomal recessive non-progressive infantile ataxia on chromosome 20q11-q13
    Jennifer S Bennetts
    Institute for Molecular Bioscience, The University of Queensland, Australia
    Dev Dyn 236:843-52. 2007
  7. pmc Co-regulation of cell polarization and migration by caveolar proteins PTRF/Cavin-1 and caveolin-1
    Michelle M Hill
    The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 7:e43041. 2012
  8. ncbi The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b
    Fiona Simpson
    Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    Exp Cell Res 312:73-85. 2006
  9. ncbi A novel mammalian retromer component, Vps26B
    Markus C Kerr
    Institute for Molecular Bioscience and ARC Centre in Bioinformatics, University of Queensland, St Lucia, Queensland 4072, Australia
    Traffic 6:991-1001. 2005
  10. doi ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling
    Hayley K Charlton
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Biochem Biophys Res Commun 392:234-9. 2010

Collaborators

Detail Information

Publications20

  1. ncbi A novel hook-related protein family and the characterization of hook-related protein 1
    Fiona Simpson
    Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Traffic 6:442-58. 2005
    ..We propose that HkRP1 is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains...
  2. ncbi Murine embryonic expression of the gene for the UV-responsive protein p15(PAF)
    Kelly Lammerts van Bueren
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Gene Expr Patterns 7:47-50. 2007
    ..Our data also suggest a role in embryonic development, consistent with findings that a wide range of tumours result from aberrant activity of key developmental pathways...
  3. ncbi Identification and analysis of novel genes expressed in the mouse embryonic facial primordia
    Jennifer S Bennetts
    Institute for Molecular Bioscience, The University of Queensland, QLD 4072, Australia
    Front Biosci 11:2631-46. 2006
    ..Where a human orthologue of these genes was detected, chromosomal localisation was determined relative to known loci for human congenital disease...
  4. ncbi Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP)
    Jennifer S Bennetts
    Institute for Molecular Bioscience, The University of Queensland, St Lucia 4072, QLD 4072, Australia
    Gene 374:153-65. 2006
    ..Immunolocalisation of transiently and stably transfected epitope-tagged CDCA4 protein in mammalian cells suggests that it resides predominantly in the nucleus throughout all stages of the cell cycle...
  5. ncbi Visualisation of macropinosome maturation by the recruitment of sorting nexins
    Markus C Kerr
    Institute for Molecular Bioscience and ARC Centre in Bioinformatics, University of Queensland, St Lucia, QLD 4072, Australia
    J Cell Sci 119:3967-80. 2006
    ..Collectively these findings provide a detailed real-time characterisation of the maturation process of the macropinocytic endosome...
  6. ncbi The coding region of TP53INP2, a gene expressed in the developing nervous system, is not altered in a family with autosomal recessive non-progressive infantile ataxia on chromosome 20q11-q13
    Jennifer S Bennetts
    Institute for Molecular Bioscience, The University of Queensland, Australia
    Dev Dyn 236:843-52. 2007
    ..Our failure to detect causative mutations suggests that alterations in the coding region of TP53INP2 are not responsible for ataxia in this family, although we cannot rule out changes in non-coding elements of this gene...
  7. pmc Co-regulation of cell polarization and migration by caveolar proteins PTRF/Cavin-1 and caveolin-1
    Michelle M Hill
    The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 7:e43041. 2012
    ..By selectively manipulating PTRF/cavin-1 and caveolin-1 expression (and therefore caveola formation) in multiple cell systems, we unveil caveola-independent functions for both proteins in cell migration...
  8. ncbi The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b
    Fiona Simpson
    Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
    Exp Cell Res 312:73-85. 2006
    ..This suggests that p15(PAF) forms part of a larger protein complex potentially involved in the regulation of DNA repair, apoptosis and cell cycle progression...
  9. ncbi A novel mammalian retromer component, Vps26B
    Markus C Kerr
    Institute for Molecular Bioscience and ARC Centre in Bioinformatics, University of Queensland, St Lucia, Queensland 4072, Australia
    Traffic 6:991-1001. 2005
    ..Based on these observations, we propose that the mammalian retromer complex is located at both endosomes and the plasma membrane in some cell types...
  10. doi ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling
    Hayley K Charlton
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Biochem Biophys Res Commun 392:234-9. 2010
    ..Collectively these results establish ERp46 as the first AdipoR1-specific interacting protein and suggest a role for ERp46 in adiponectin receptor biology and adiponectin signalling...
  11. pmc Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells
    Mark T Howes
    The Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Cell Biol 190:675-91. 2010
    ..These studies provide the first quantitative ultrastructural analysis and molecular characterization of the major endocytic pathway in fibroblasts, a pathway that provides rapid membrane turnover at the leading edge of migrating cells...
  12. ncbi Insulin and oleate promote translocation of inosine-5' monophosphate dehydrogenase to lipid bodies
    Jonathan P Whitehead
    Department of Diabetes and Obesity, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Traffic 5:739-49. 2004
    ..These data support a role for IMPDH in the dynamic regulation of lipid bodies and fatty acid metabolism and regulation of its activity by subcellular redistribution in response to extracellular factors that modify lipid metabolism...
  13. doi Adiponectin--it's all about the modifications
    Fiona Simpson
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    Int J Biochem Cell Biol 42:785-8. 2010
    ..Strategies that modulate processes governing PTM of adiponectin represent attractive therapeutic approaches...
  14. doi Trafficking, development and hedgehog
    Fiona Simpson
    The University of Queensland, Institute for Molecular Bioscience, QLD, Australia
    Mech Dev 126:279-88. 2009
    ..Here we review the regulation of hedgehog signaling by intracellular trafficking, including the role of the primary cilium and lipids in mediating pathway activity...
  15. pmc A rapidly evolving secretome builds and patterns a sea shell
    Daniel J Jackson
    School of Integrative Biology, University of Queensland, Brisbane QLD 4072, Australia
    BMC Biol 4:40. 2006
    ..The recent sequencing of a wide range of metazoan genomes coupled with the analysis of gene expression in non-model animals has allowed us to investigate the evolution and process of biomineralization in gastropod mollusks...
  16. pmc Role of intratumoural heterogeneity in cancer drug resistance: molecular and clinical perspectives
    Nicholas A Saunders
    Epithelial Cancer Program, University of Queensland, Diamantine Institute, Princess Alexandra Hospital, Queensland, Australia
    EMBO Mol Med 4:675-84. 2012
    ..Each of these factors impacts on drug sensitivity. To deliver curative therapies to patients, modification of current therapeutic strategies to include methods that estimate intratumoural heterogeneity and plasticity will be essential...
  17. doi Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation
    Ayanthi A Richards
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Brisbane, Queensland, Australia
    Mol Endocrinol 24:229-39. 2010
    ..These data suggest an important role for sialic acid content in the regulation of circulating adiponectin levels and highlight the importance of understanding mechanisms regulating adiponectin sialylation/desialylation...
  18. ncbi Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
    Mark Larance
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia
    J Biol Chem 280:37803-13. 2005
    ..These findings support an important role for AS160 in the insulin regulated trafficking of GLUT4...
  19. ncbi Aortic smooth muscle and endothelial plasma membrane Ca2+ pump isoforms are inhibited differently by the extracellular inhibitor caloxin 1b1
    Jyoti Pande
    Department of Medicine, HSC 4N41, McMaster University, 1200 Main St West, Hamilton, Ontario L8N 3Z5, Canada
    Am J Physiol Cell Physiol 290:C1341-9. 2006
    ..Thus caloxin 1b1 is the first highly selective extracellular PMCA inhibitor that works better on vascular smooth muscle than on endothelium...
  20. ncbi Characterization of Rab23, a negative regulator of sonic hedgehog signaling
    Timothy M Evans
    Methods Enzymol 403:759-77. 2005
    ..We describe the methods used to design and make the Rab23 expression constructs, and to assess their localization relative to key hedgehog pathways and endocytic markers in both transiently and stably transfected cell cultures...