Kieran M Short

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. pmc MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders
    Kieran M Short
    Department of Molecular Biosciences and ARC Special Research Centre for the Molecular Genetics of Development, University of Adelaide, Adelaide, South Australia, Australia 5005
    BMC Cell Biol 3:1. 2002
  2. ncbi request reprint Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding
    Kieran M Short
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Biol Chem 281:8970-80. 2006
  3. ncbi request reprint Solution structure of the RBCC/TRIM B-box1 domain of human MID1: B-box with a RING
    Michael A Massiah
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74075 USA
    J Mol Biol 358:532-45. 2006
  4. ncbi request reprint Solution structure of the MID1 B-box2 CHC(D/C)C(2)H(2) zinc-binding domain: insights into an evolutionarily conserved RING fold
    Michael A Massiah
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA
    J Mol Biol 369:1-10. 2007
  5. doi request reprint Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular ring heterodimers
    Hu Tao
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Biochemistry 47:2450-7. 2008
  6. ncbi request reprint A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13
    John M Graham
    Medical Genetics Birth Defects Center, Ahmanson Department of Pediatrics, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    Am J Med Genet A 123:37-44. 2003

Collaborators

Detail Information

Publications6

  1. pmc MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders
    Kieran M Short
    Department of Molecular Biosciences and ARC Special Research Centre for the Molecular Genetics of Development, University of Adelaide, Adelaide, South Australia, Australia 5005
    BMC Cell Biol 3:1. 2002
    ..A protein highly related to MID1, called MID2, has also been described that similarly associates with microtubules...
  2. ncbi request reprint Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding
    Kieran M Short
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Biol Chem 281:8970-80. 2006
    ..This classification schema may aid the understanding of the molecular function of members of each subgroup and their potential involvement in both basic cellular processes and human disease...
  3. ncbi request reprint Solution structure of the RBCC/TRIM B-box1 domain of human MID1: B-box with a RING
    Michael A Massiah
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74075 USA
    J Mol Biol 358:532-45. 2006
    ..One of these is likely to provide the binding interface for Alpha 4 that is required for the localized turnover of the catalytic subunit of PP2A, the major Ser/Thr phosphatase...
  4. ncbi request reprint Solution structure of the MID1 B-box2 CHC(D/C)C(2)H(2) zinc-binding domain: insights into an evolutionarily conserved RING fold
    Michael A Massiah
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74078, USA
    J Mol Biol 369:1-10. 2007
    ..Finally, the similarity in tertiary structures of the B-box2, B-box1 and RING domains suggests these domains have evolved from a common ancestor...
  5. doi request reprint Structure of the MID1 tandem B-boxes reveals an interaction reminiscent of intermolecular ring heterodimers
    Hu Tao
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    Biochemistry 47:2450-7. 2008
    ..Notably, the interaction is reminiscent of the interaction of recently determined RING dimers, suggesting the possibility of an evolutionarily conserved role for B-box2 domains in regulating functional RING-type folds...
  6. ncbi request reprint A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13
    John M Graham
    Medical Genetics Birth Defects Center, Ahmanson Department of Pediatrics, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    Am J Med Genet A 123:37-44. 2003
    ..Altered expression of Alpha 4, through either a change in translational efficiency, mRNA stability or splicing, could explain the clinical phenotype in these boys and the phenotypic overlap with Opitz GBBB syndrome...