R K Shepherd

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. pmc Cochlear implants and brain plasticity
    James B Fallon
    Bionic Ear Institute, 384 388 Albert Street, East Melbourne, VIC 3002, Australia
    Hear Res 238:110-7. 2008
  2. ncbi request reprint A multichannel scala tympani electrode array incorporating a drug delivery system for chronic intracochlear infusion
    Robert K Shepherd
    Department of Otolaryngology, The University of Melbourne, 32 Gisborne Street, 3002, East Melbourne, Vic, Australia
    Hear Res 172:92-8. 2002
  3. ncbi request reprint Electrical stimulation of the auditory nerve: single neuron strength-duration functions in deafened animals
    R K Shepherd
    Human Communications Research Centre, Department of Otolaryngology, The University of Melbourne, Parkville, Victoria, Australia
    Ann Biomed Eng 29:195-201. 2001
  4. ncbi request reprint Chronic electrical stimulation of the auditory nerve using non-charge-balanced stimuli
    R K Shepherd
    Human Communication Research Centre, Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria, Australia
    Acta Otolaryngol 119:674-84. 1999
  5. ncbi request reprint Electrical stimulation of the auditory nerve: II. Effect of stimulus waveshape on single fibre response properties
    R K Shepherd
    Department of Otolaryngology, University of Melbourne, Parkville, Vic, Australia
    Hear Res 130:171-88. 1999
  6. ncbi request reprint Reduction in excitability of the auditory nerve following electrical stimulation at high stimulus rates
    M Tykocinski
    Department of Otolaryngology, University of Melbourne, Victoria, Australia
    Hear Res 88:124-42. 1995
  7. ncbi request reprint Electrical stimulation of the auditory nerve. I. Correlation of physiological responses with cochlear status
    R K Shepherd
    Department of Otolaryngology, University of Melbourne, Parkville, Victoria, Australia
    Hear Res 108:112-44. 1997
  8. ncbi request reprint Onset of ototoxicity in the cat is related to onset of auditory function
    R K Shepherd
    Co operative Research Centre for Cochlear Implant, Speech, and Hearing Research, East Melbourne, Victoria, Australia
    Hear Res 92:131-42. 1995
  9. ncbi request reprint Cochlear histopathologic characteristics following long-term implantation. Safety studies in the young monkey
    M J Burton
    Department of Otolaryngology, University of Melbourne, Australia
    Arch Otolaryngol Head Neck Surg 122:1097-104. 1996
  10. ncbi request reprint Long-term sensorineural hearing loss induces functional changes in the rat auditory nerve
    Robert K Shepherd
    The Bionic Ear Institute, Department of Otolaryngology, The University of Melbourne, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia
    Eur J Neurosci 20:3131-40. 2004

Collaborators

Detail Information

Publications46

  1. pmc Cochlear implants and brain plasticity
    James B Fallon
    Bionic Ear Institute, 384 388 Albert Street, East Melbourne, VIC 3002, Australia
    Hear Res 238:110-7. 2008
    ....
  2. ncbi request reprint A multichannel scala tympani electrode array incorporating a drug delivery system for chronic intracochlear infusion
    Robert K Shepherd
    Department of Otolaryngology, The University of Melbourne, 32 Gisborne Street, 3002, East Melbourne, Vic, Australia
    Hear Res 172:92-8. 2002
    ..The design of the electrode array is described in detail. Experimental studies performed in guinea pigs confirm that this array can successfully deliver various drugs to the cochlea while chronically stimulating the auditory nerve...
  3. ncbi request reprint Electrical stimulation of the auditory nerve: single neuron strength-duration functions in deafened animals
    R K Shepherd
    Human Communications Research Centre, Department of Otolaryngology, The University of Melbourne, Parkville, Victoria, Australia
    Ann Biomed Eng 29:195-201. 2001
    ..These changes in the site of action potential generation have implications for the delivery of charge to ANFs via cochlear implants...
  4. ncbi request reprint Chronic electrical stimulation of the auditory nerve using non-charge-balanced stimuli
    R K Shepherd
    Human Communication Research Centre, Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria, Australia
    Acta Otolaryngol 119:674-84. 1999
    ..In conclusion, the present study highlights the potential for neural damage following stimulation using poorly charge-balanced stimuli...
  5. ncbi request reprint Electrical stimulation of the auditory nerve: II. Effect of stimulus waveshape on single fibre response properties
    R K Shepherd
    Department of Otolaryngology, University of Melbourne, Parkville, Vic, Australia
    Hear Res 130:171-88. 1999
    ..These findings provide insight into the mechanisms underlying the generation of action potentials using electrical stimuli. Moreover, a number of these novel stimuli may have potential clinical application...
  6. ncbi request reprint Reduction in excitability of the auditory nerve following electrical stimulation at high stimulus rates
    M Tykocinski
    Department of Otolaryngology, University of Melbourne, Victoria, Australia
    Hear Res 88:124-42. 1995
    ..The present findings have implications for the design of safe speech-processing strategies for use in multichannel cochlear implants...
  7. ncbi request reprint Electrical stimulation of the auditory nerve. I. Correlation of physiological responses with cochlear status
    R K Shepherd
    Department of Otolaryngology, University of Melbourne, Parkville, Victoria, Australia
    Hear Res 108:112-44. 1997
    ..Knowledge of the extent of these changes have important implications for the clinical application of cochlear implants...
  8. ncbi request reprint Onset of ototoxicity in the cat is related to onset of auditory function
    R K Shepherd
    Co operative Research Centre for Cochlear Implant, Speech, and Hearing Research, East Melbourne, Victoria, Australia
    Hear Res 92:131-42. 1995
    ..The rapid onset of deafness following this procedure makes it a useful technique in the study of both ototoxicity and cochlear development...
  9. ncbi request reprint Cochlear histopathologic characteristics following long-term implantation. Safety studies in the young monkey
    M J Burton
    Department of Otolaryngology, University of Melbourne, Australia
    Arch Otolaryngol Head Neck Surg 122:1097-104. 1996
    ..To evaluate the safety of cochlear implantation in children 2 years of age or younger using a non-human primate model...
  10. ncbi request reprint Long-term sensorineural hearing loss induces functional changes in the rat auditory nerve
    Robert K Shepherd
    The Bionic Ear Institute, Department of Otolaryngology, The University of Melbourne, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia
    Eur J Neurosci 20:3131-40. 2004
    ..001). These functional changes have implications for recipients of cochlear implants and potential therapies directed toward halting or reversing AN pathology...
  11. ncbi request reprint The central auditory system and auditory deprivation: experience with cochlear implants in the congenitally deaf
    R K Shepherd
    Human Communication Research Centre, University of Melbourne, Australia
    Acta Otolaryngol Suppl 532:28-33. 1997
    ..These findings suggest that functional reorganisation within the central auditory pathway can at least partially account for improvements in clinical performance over time...
  12. ncbi request reprint Chronic placental insufficiency has long-term effects on auditory function in the guinea pig
    Alexandra E Rehn
    Department of Anatomy and Cell Biology, The University of Melbourne, Parkville, VIC 3010, Australia
    Hear Res 166:159-65. 2002
    ..The results suggest subtle deficits in neural conduction in the PC guinea pig at maturity, and may have implications for speech perception abilities of low birth weight or prenatally affected infants...
  13. pmc A fully implantable stimulator for use in small laboratory animals
    Rodney E Millard
    Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria 3002, Australia
    J Neurosci Methods 166:168-77. 2007
    ..Circuit diagrams and manufacturing details are provided as supplementary data...
  14. pmc Examining the auditory nerve fiber response to high rate cochlear implant stimulation: chronic sensorineural hearing loss and facilitation
    Leon F Heffer
    Dept of Otolaryngology, The University of Melbourne, Royal Victorian Eye and Ear Hospital, Level 2, 32 Gisborne St, East Melbourne, Vic, 3002, Australia
    J Neurophysiol 104:3124-35. 2010
    ....
  15. pmc A fully implantable rodent neural stimulator
    D W J Perry
    Bionics Institute, Victoria, Australia
    J Neural Eng 9:014001. 2012
    ....
  16. ncbi request reprint Deafness-induced changes in the auditory pathway: implications for cochlear implants
    R K Shepherd
    Department of Otolaryngology, University of Melbourne, East Melbourne, Vic, Australia
    Audiol Neurootol 6:305-18. 2001
    ..Finally, the plastic response of the deafened auditory system to electrical stimulation of the auditory nerve is reviewed in light of the clinical implications for cochlear implant recipients...
  17. pmc Cochlear implantation in rats: a new surgical approach
    Wei Lu
    Department of Otolaryngology, Royal Victorian Eye and Ear Hospital, The University of Melbourne, 32 Gisborne Street, East Melbourne, VIC 3002, Australia
    Hear Res 205:115-22. 2005
    ..The surgical approach presented in this paper presents a safe and effective procedure for acute or chronic cochlear implantation in the rat model...
  18. pmc Chronic depolarization enhances the trophic effects of brain-derived neurotrophic factor in rescuing auditory neurons following a sensorineural hearing loss
    Robert K Shepherd
    The Bionic Ear Institute, Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria 3002, Australia
    J Comp Neurol 486:145-58. 2005
    ..Cotreatment of SGNs with BDNF and ES provides a substantial functional and trophic advantage; this treatment may have important implications for neural prostheses...
  19. pmc Neurotrophins and electrical stimulation for protection and repair of spiral ganglion neurons following sensorineural hearing loss
    Robert K Shepherd
    The Bionic Ear Institute, 384 388 Albert Street, East Melbourne, Victoria 3002, Australia
    Hear Res 242:100-9. 2008
    ..This result suggests that chronic ES can prevent the rapid loss of SGNs that occurs after the withdrawal of exogenous NTs. Implications for the clinical delivery of NTs are discussed...
  20. ncbi request reprint Synergy between TGF-beta 3 and NT-3 to promote the survival of spiral ganglia neurones in vitro
    P L Marzella
    Department of Otolaryngology, Victorian Royal Eye and Ear Hospital, East Melbourne, Australia
    Neurosci Lett 240:77-80. 1998
    ..The findings from this study suggest that TGF-beta3 supports neuronal survival in a concentration-dependent manner. Moreover TGF-beta3 and NT-3-potentiated spiral ganglion neuronal survival in a synergistic fashion...
  21. pmc Does cochlear implantation and electrical stimulation affect residual hair cells and spiral ganglion neurons?
    Anne Coco
    Department of Otolaryngology, University of Melbourne, East Melbourne, VIC 3002, Australia
    Hear Res 225:60-70. 2007
    ..Moreover, while there is an increase in the soma area of SGNs close to the stimulating electrodes in severely deaf cochleae, this trophic effect does not result in increased SGN survival...
  22. ncbi request reprint Basis of electrical stimulation of the cochlea and the cochlear nucleus
    Robert K Shepherd
    The Bionic Ear Institute, East Melbourne, Victoria, Australia
    Adv Otorhinolaryngol 64:186-205. 2006
    ..This paper reviews the basis of electrical stimulation of these structures with an emphasis on pathophysiology and safety...
  23. pmc Effect of interphase gap and pulse duration on electrically evoked potentials is correlated with auditory nerve survival
    Pavel Prado-Guitierrez
    Department of Otolaryngology, The University of Melbourne, Australia
    Hear Res 215:47-55. 2006
    ..These results may provide a tool for investigating the contribution of auditory nerve survival to clinical performance among cochlear implant subjects...
  24. pmc Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss
    Michel Guipponi
    Molecular Medicine Division, The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Am J Pathol 171:608-16. 2007
    ..Hearing impairment present in Tmprss1-null mice is characterized by a combination of various structural, cellular, and molecular abnormalities that are likely to affect different cochlear processes...
  25. doi request reprint The development of encapsulated cell technologies as therapies for neurological and sensory diseases
    M P Zanin
    The Bionics Institute, 384 388 Albert Street, East Melbourne, Victoria 3002, Australia
    J Control Release 160:3-13. 2012
    ....
  26. ncbi request reprint Functional and morphological response of the stria vascularis following a sensorineural hearing loss
    W P L Hellier
    Department of Otolaryngology, University of Melbourne, 32 Gisborne Street, 3002, East Melbourne, Vic, Australia
    Hear Res 172:127-36. 2002
    ..The large reduction in the extent of the SV after deafening suggests that a reduced strial volume is capable of maintaining a normal EP under conditions of reduced K(+) leakage current...
  27. pmc Neural prostheses and brain plasticity
    James B Fallon
    Bionic Ear Institute, 384 388 Albert Street, East Melbourne, VIC 3002, Australia
    J Neural Eng 6:065008. 2009
    ..Finally, we will discuss the role of brain plasticity in neural prostheses in general...
  28. pmc A protocol for cryoembedding the adult guinea pig cochlea for fluorescence immunohistology
    Bryony Coleman
    The Department of Otolaryngology, University of Melbourne, East Melbourne 3002, Australia The Royal Victorian Eye and Ear Hospital, East Melbourne 3002, Australia
    J Neurosci Methods 176:144-51. 2009
    ....
  29. doi request reprint Promoting neurite outgrowth from spiral ganglion neuron explants using polypyrrole/BDNF-coated electrodes
    Alison J Evans
    Department of Otolaryngology, The University of Melbourne, Melbourne, Victoria, Australia
    J Biomed Mater Res A 91:241-50. 2009
    ..The versatility of Ppy to store and release neurotrophins, conduct electrical charge, and act as a substrate for nerve-electrode interactions is discussed for specialized applications such as cochlear implants...
  30. pmc Effects of localized neurotrophin gene expression on spiral ganglion neuron resprouting in the deafened cochlea
    Andrew K Wise
    Bionic Ear Institute, East Melbourne, Victoria, Australia
    Mol Ther 18:1111-22. 2010
    ..05), a first step in promoting organized resprouting of auditory peripheral fibers via gene therapy...
  31. ncbi request reprint Schwann cells revert to non-myelinating phenotypes in the deafened rat cochlea
    Patricia A Hurley
    Department of Otolaryngology, University of Melbourne, Australia
    Eur J Neurosci 26:1813-21. 2007
    ..The potential clinical significance of these findings for cochlear implants is discussed...
  32. ncbi request reprint Concise review: the potential of stem cells for auditory neuron generation and replacement
    Bryony Coleman
    Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria, Australia
    Stem Cells 25:2685-94. 2007
    ..Although still in its infancy the aim of this therapy is to restore a critical number of auditory neurons, thereby improving the benefits derived from a cochlear implant...
  33. ncbi request reprint Cochlear immunochemistry--a new technique based on gelatin embedding
    Patricia A Hurley
    Department of Otolaryngology, Royal Victorian Eye and Ear Hospital, University of Melbourne, 32, Gisborne Street, East Melbourne, Melbourne 3002, Vic, Australia
    J Neurosci Methods 129:81-6. 2003
    ..It is also likely to be adaptable for the infiltration of other heterogeneous structures prone to distortion during frozen sectioning...
  34. ncbi request reprint Surface microstructure of the perilymphatic space: implications for cochlear implants and cell- or drug-based therapies
    Robert K Shepherd
    Department of Otolaryngology, The University of Melbourne, Australia
    Arch Otolaryngol Head Neck Surg 130:518-23. 2004
    ..To study the surface microstructure of the scala tympani and scala vestibuli in humans and cats using scanning electron microscopy...
  35. pmc Pneumococcal meningitis threshold model: A potential tool to assess infectious risk of new or existing inner ear surgical interventions
    Benjamin P C Wei
    Department of Otolaryngology, University of Melbourne, Melbourne, Victoria, Australia
    Otol Neurotol 27:1152-61. 2006
    ..A minimal threshold of Streptococcus pneumoniae is required to induce meningitis in healthy animals for intraperitoneal (hematogenous), middle ear, and inner ear inoculations, and this threshold may be altered via recent inner ear surgery...
  36. pmc Auditory hair cell explant co-cultures promote the differentiation of stem cells into bipolar neurons
    B Coleman
    Department of Otolaryngology, University of Melbourne, East Melbourne, Australia
    Exp Cell Res 313:232-43. 2007
    ....
  37. pmc Protective effects of local administration of ciprofloxacin on the risk of pneumococcal meningitis after cochlear implantation
    Benjamin P C Wei
    Department of Otolaryngology, Bionic Ear Institute, University of Melbourne, Royal Victorian Eye and Eye Hospiatl, Melbourne, Victoria, Australia
    Laryngoscope 116:2138-44. 2006
    ..pneumoniae...
  38. doi request reprint Pneumococcal meningitis post-cochlear implantation: preventative measures
    Benjamin P C Wei
    Department of Otolaryngology, Bionic Ear Institute, University of Melbourne, Melbourne, Victoria, Australia
    Otolaryngol Head Neck Surg 143:S9-14. 2010
    ..Both clinical data and laboratory studies demonstrated the risk of pneumococcal meningitis post-cochlear implantation. This review examines strategies to prevent post-implant meningitis...
  39. pmc Cochlear implants stimulate activity-dependent CREB pathway in the deaf auditory cortex: implications for molecular plasticity induced by neural prosthetic devices
    Justin Tan
    The Bionic Ear Institute, East Melbourne, Victoria 3002, Australia
    Cereb Cortex 18:1799-813. 2008
    ..These findings provide insights into adaptive, molecular mechanisms recruited by the brain upon functional electrical stimulation by neural prosthetic devices...
  40. pmc Pneumococcal meningitis: development of a new animal model
    Benjamin P C Wei
    Bionic Ear Institute, Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
    Otol Neurotol 27:844-54. 2006
    ..The rat is a suitable animal to establish a model for the study of pneumococcal meningitis postcochlear implantation...
  41. ncbi request reprint Assessment of the protective effect of pneumococcal vaccination in preventing meningitis after cochlear implantation
    Benjamin P C Wei
    Bionic Ear Institute, Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, 32 Gisbourne St, East Melbourne, Victoria 3002, Australia
    Arch Otolaryngol Head Neck Surg 133:987-94. 2007
    ..To examine if a 23-valent pneumococcal capsular polysaccharide vaccine (PPV23) reduces the risk of meningitis in healthy rats after cochlear implantation...
  42. pmc Neurotrophic factors and neural prostheses: potential clinical applications based upon findings in the auditory system
    Lisa N Pettingill
    Bionic Ear Institute, East Melbourne VIC 3002, Australia
    IEEE Trans Biomed Eng 54:1138-48. 2007
    ....
  43. pmc Deafness alters auditory nerve fibre responses to cochlear implant stimulation
    David J Sly
    The Bionic Ear Institute, Melbourne, Victoria 3002, Australia
    Eur J Neurosci 26:510-22. 2007
    ....
  44. pmc Survival of partially differentiated mouse embryonic stem cells in the scala media of the guinea pig cochlea
    Michael S Hildebrand
    Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    J Assoc Res Otolaryngol 6:341-54. 2005
    ..This is the first report of the survival of partially differentiated ES cells in the scala media of the mammalian cochlea, and it provides support for the potential of cell-based therapies for sensorineural hearing impairment...
  45. doi request reprint The auditory brain--a tribute to Dexter R.F. Irvine
    David R Moore
    Hear Res 238:1-2. 2008
  46. pmc Clinical application of neurotrophic factors: the potential for primary auditory neuron protection
    Lisa N Gillespie
    The Bionic Ear Institute, 384 Albert Street, East Melbourne, Australia 3002
    Eur J Neurosci 22:2123-33. 2005
    ..This review considers these issues in view of the potential therapeutic application of neurotrophic factors within the auditory system...