Claire E Shepherd

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Relationship between neuronal loss and 'inflammatory plaques' in early onset Alzheimer's disease
    C E Shepherd
    Prince of Wales Medical Research Institute, Sydney, NSW, Australia
    Neuropathol Appl Neurobiol 33:328-33. 2007
  2. ncbi request reprint Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease
    C E Shepherd
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney 2031, Australia
    Neurobiol Aging 27:1554-63. 2006
  3. ncbi request reprint Novel 'inflammatory plaque' pathology in presenilin-1 Alzheimer's disease
    C E Shepherd
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney 2031, Australia
    Neuropathol Appl Neurobiol 31:503-11. 2005
  4. ncbi request reprint Histocompatibility antigens, aspirin use and cognitive performance in non-demented elderly subjects
    C E Shepherd
    Centre for Education and Research on Ageing, The University of Sydney, Sydney, Australia
    J Neuroimmunol 148:178-82. 2004
  5. ncbi request reprint Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques
    Claire E Shepherd
    Prince of Wales Medical Research Institute, Randwick, 2031 Sydney, Australia
    Neurobiol Dis 15:115-9. 2004
  6. ncbi request reprint Pick bodies in a family with presenilin-1 Alzheimer's disease
    Glenda M Halliday
    Prince of Wales Medical Research Institute and the University of New South Wales, Barker Street, Randwick, Sydney, 2031 NSW, Australia
    Ann Neurol 57:139-43. 2005
  7. doi request reprint Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease
    Anna Sokolova
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, Australia
    Brain Pathol 19:392-8. 2009
  8. pmc C9ORF72 repeat expansion in clinical and neuropathologic frontotemporal dementia cohorts
    Carol Dobson-Stone
    Neuroscience Research Australia, Sydney, Australia
    Neurology 79:995-1001. 2012
  9. ncbi request reprint Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease
    Glenda M Halliday
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia
    Brain 128:2654-64. 2005
  10. ncbi request reprint Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia
    Prudence M Stanford
    Garvan Institute of Medical Research, Sydney, NSW, Australia
    Brain 126:814-26. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Relationship between neuronal loss and 'inflammatory plaques' in early onset Alzheimer's disease
    C E Shepherd
    Prince of Wales Medical Research Institute, Sydney, NSW, Australia
    Neuropathol Appl Neurobiol 33:328-33. 2007
    ..7 +/- 0.8). These data demonstrate that EOAD cases exhibit greater neuronal cell loss in the superior frontal cortex than sporadic AD and that this effect is independent of the presence or absence of inflammatory plaque pathology...
  2. ncbi request reprint Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease
    C E Shepherd
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney 2031, Australia
    Neurobiol Aging 27:1554-63. 2006
    ..This study indicates a potential role for pro-inflammatory S100A9 and S100A12 in pathogenesis caused by inflammation and protein complex formation in AD...
  3. ncbi request reprint Novel 'inflammatory plaque' pathology in presenilin-1 Alzheimer's disease
    C E Shepherd
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney 2031, Australia
    Neuropathol Appl Neurobiol 31:503-11. 2005
    ..Identification of this substance may be important for the development of future therapeutic strategies...
  4. ncbi request reprint Histocompatibility antigens, aspirin use and cognitive performance in non-demented elderly subjects
    C E Shepherd
    Centre for Education and Research on Ageing, The University of Sydney, Sydney, Australia
    J Neuroimmunol 148:178-82. 2004
    ..018), respectively. HLA-DRB1*05 had a negative impact on the Boston naming test (p=0.002). Our results suggest that aspirin use and inflammatory genotype may influence cognition in non-demented subjects...
  5. ncbi request reprint Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques
    Claire E Shepherd
    Prince of Wales Medical Research Institute, Randwick, 2031 Sydney, Australia
    Neurobiol Dis 15:115-9. 2004
    ..These findings suggest that PS-1 mutations increase tau deposition while mutation-specific cellular responses determine phosphorylation events and may influence cell death mechanisms...
  6. ncbi request reprint Pick bodies in a family with presenilin-1 Alzheimer's disease
    Glenda M Halliday
    Prince of Wales Medical Research Institute and the University of New South Wales, Barker Street, Randwick, Sydney, 2031 NSW, Australia
    Ann Neurol 57:139-43. 2005
    ..M146L mutant PS-1 may predispose to both Pick's disease and AD by affecting multiple intracellular pathways involving tau phosphorylation and amyloid metabolism...
  7. doi request reprint Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease
    Anna Sokolova
    Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney, Australia
    Brain Pathol 19:392-8. 2009
    ..Our data support previous work on significant increases in IL-6 and IL-8 in AD but indicate that MCP-1 may play a more dominant role in chronic inflammation in AD...
  8. pmc C9ORF72 repeat expansion in clinical and neuropathologic frontotemporal dementia cohorts
    Carol Dobson-Stone
    Neuroscience Research Australia, Sydney, Australia
    Neurology 79:995-1001. 2012
    ....
  9. ncbi request reprint Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease
    Glenda M Halliday
    Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, Australia
    Brain 128:2654-64. 2005
    ..Overall, these changes may trigger a cascade of events leading to larger intracellular aggregates of alpha-synuclein and the dispersement of protective pigment to precipitate cell death in Parkinson's disease...
  10. ncbi request reprint Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia
    Prudence M Stanford
    Garvan Institute of Medical Research, Sydney, NSW, Australia
    Brain 126:814-26. 2003
    ..The increase in tau proteolysis was associated with increased evidence of apoptosis. This mechanism of neurodegeneration may be more applicable to the majority of FTD cases, which do not accumulate insoluble tau deposits...
  11. ncbi request reprint Insoluble alpha-synuclein in Alzheimer's disease without Lewy body formation
    Melissa Broe
    Prince of Wales Medical Research Institute, Sydney, 2031 Australia
    Neurotox Res 7:69-76. 2005
    ..This lipid-association of alpha-synuclein in mature AD plaques links this protein with other lipid changes thought to be important in disease pathogenesis...
  12. ncbi request reprint Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders
    Emma Schofield
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    Brain 126:827-40. 2003
    ..In frontotemporal lobar degeneration, a significant proportion of the activated white matter microglia were tau-2-immunoreactive, suggesting direct involvement in axonal degeneration, possibly via immune processes...
  13. ncbi request reprint Effect of anti-inflammatory medications on neuropathological findings in Alzheimer disease
    G M Halliday
    Prince of Wales Medical Research Institute, High Street, Randwick, NSW 2031, Australia
    Arch Neurol 57:831-6. 2000
    ..There has been no analysis of brain tissue from longitudinally observed, cognitively tested patients to validate whether anti-inflammatory medications protect against the pathological changes of Alzheimer disease...
  14. ncbi request reprint Neurofilament-immunoreactive neurons in Alzheimer's disease and dementia with Lewy bodies
    Claire E Shepherd
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney 2031, Australia
    Neurobiol Dis 9:249-57. 2002
    ..This increased number of cortical NF-containing neurons reveal novel widespread cortical changes, beyond those explained by Lewy body formation, that are specific for DLB...
  15. ncbi request reprint Relationship between DNA fragmentation, morphological changes and neuronal loss in Alzheimer's disease and dementia with Lewy bodies
    M Broe
    Prince of Wales Medical Research Institute, Randwick, NSW, Australia
    Acta Neuropathol 101:616-24. 2001
    ..02). Abnormal nuclei were not associated with plaque or tangle pathology. Our results suggest that nuclear abnormalities appear restricted to AD cases with substantial tau deposition and are related to the degree of neuronal degeneration...
  16. ncbi request reprint Neurofilament-immunoreactive neurons are not selectively vulnerable in Alzheimer's disease
    C E Shepherd
    Prince of Wales Medical Research Institute, High Street, Randwick, 2031, Australia
    Neurobiol Dis 8:136-46. 2001
    ..Our results challenge the theory that neurons containing 200 kDa neurofilament are selectively vulnerable in Alzheimer's disease...
  17. doi request reprint Increased apolipoprotein D dimer formation in Alzheimer's disease hippocampus is associated with lipid conjugated diene levels
    Surabhi Bhatia
    Neuroscience Research Australia, Randwick, NSW, Australia
    J Alzheimers Dis 35:475-86. 2013
    ..These results are consistent with the hypothesis that apoD acts as a lipid antioxidant in the brain...
  18. ncbi request reprint Intraneuronal advanced glycation endproducts in presenilin-1 Alzheimer's disease
    Gerald Munch
    Neuroimmunological Cell Biology IZKF, Leipzig, Germany
    Neuroreport 13:601-4. 2002
    ..These conditions of carbonyl stress may contribute to increased neuronal dysfunction and vulnerability leading to the early disease onset...