D R Shafren

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. pmc Oncolysis of malignant human melanoma tumors by Coxsackieviruses A13, A15 and A18
    Gough G Au
    The Picornaviral Research Unit, The School of Biomedical Sciences and Pharmacy, Faculty of Health, The University of Newcastle, Newcastle, New South Wales 2300, Australia
    Virol J 8:22. 2011
  2. ncbi Oncolysis of human ovarian cancers by echovirus type 1
    Darren R Shafren
    Picornaviral Research Unit, School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Newcastle, Newcastle, New South Wales, Australia
    Int J Cancer 115:320-8. 2005
  3. ncbi Cytoplasmic interactions between decay-accelerating factor and intercellular adhesion molecule-1 are not required for coxsackievirus A21 cell infection
    D R Shafren
    Picornaviral Research Unit, Discipline of Immunology and Microbiology, Faculty of Medicine and Health Sciences, The University of Newcastle, Level 3, Royal Newcastle Hospital, Newcastle, New South Wales, Australia
    J Gen Virol 81:889-94. 2000
  4. pmc Picornavirus receptor down-regulation by plasminogen activator inhibitor type 2
    D R Shafren
    Picornaviral Research Unit, Discipline of Immunology and Microbiology, Faculty of Medicine and Health Sciences, University of Newcastle, Newcastle, New South Wales 2300, Australia
    J Virol 73:7193-8. 1999
  5. pmc Viral cell entry induced by cross-linked decay-accelerating factor
    D R Shafren
    Department of Microbiology, Faculty of Medicine, The University of Newcastle, Newcastle New South Wales 2300, Australia
    J Virol 72:9407-12. 1998
  6. ncbi Antibody binding to individual short consensus repeats of decay-accelerating factor enhances enterovirus cell attachment and infectivity
    D R Shafren
    Department of Microbiology, Faculty of Medicine, The University of Newcastle, New South Wales, Australia
    J Immunol 160:2318-23. 1998
  7. pmc A decay-accelerating factor-binding strain of coxsackievirus B3 requires the coxsackievirus-adenovirus receptor protein to mediate lytic infection of rhabdomyosarcoma cells
    D R Shafren
    Department of Microbiology, Faculty of Medicine, The University of Newcastle, Australia
    J Virol 71:9844-8. 1997
  8. pmc Coxsackievirus A21 binds to decay-accelerating factor but requires intercellular adhesion molecule 1 for cell entry
    D R Shafren
    Department of Microbiology, Faculty of Medicine, The University of Newcastle, New South Wales, Australia
    J Virol 71:4736-43. 1997
  9. ncbi CD36 forms covalently associated dimers and multimers in platelets and transfected COS-7 cells
    R F Thorne
    Cancer Research Unit, Faculty of Medicine and Health Sciences, University of Newcastle, NSW, Australia
    Biochem Biophys Res Commun 240:812-8. 1997
  10. ncbi An enzyme-linked immunosorbent assay for the detection of avian encephalomyelitis virus antigens
    D R Shafren
    Faculty of Medicine, University of Newcastle, New South Wales, Australia
    Avian Dis 32:209-14. 1988

Detail Information

Publications17

  1. pmc Oncolysis of malignant human melanoma tumors by Coxsackieviruses A13, A15 and A18
    Gough G Au
    The Picornaviral Research Unit, The School of Biomedical Sciences and Pharmacy, Faculty of Health, The University of Newcastle, Newcastle, New South Wales 2300, Australia
    Virol J 8:22. 2011
    ..From these studies it can be concluded that the administration of CVA13, CVA15 or CVA18 could be employed as a potential multivalent oncolytic therapy against malignant melanoma...
  2. ncbi Oncolysis of human ovarian cancers by echovirus type 1
    Darren R Shafren
    Picornaviral Research Unit, School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Newcastle, Newcastle, New South Wales, Australia
    Int J Cancer 115:320-8. 2005
    ..These findings demonstrate an important proof of principle for employing wild-type EV1 as a potential oncolytic agent in the control of human ovarian cancers...
  3. ncbi Cytoplasmic interactions between decay-accelerating factor and intercellular adhesion molecule-1 are not required for coxsackievirus A21 cell infection
    D R Shafren
    Picornaviral Research Unit, Discipline of Immunology and Microbiology, Faculty of Medicine and Health Sciences, The University of Newcastle, Level 3, Royal Newcastle Hospital, Newcastle, New South Wales, Australia
    J Gen Virol 81:889-94. 2000
    ..Furthermore, it was shown that potential extracellular DAF/ICAM-1 interactions are likely to occur in an area on or proximal to DAF SCR3 and may influence the route of CAV-21 cell entry...
  4. pmc Picornavirus receptor down-regulation by plasminogen activator inhibitor type 2
    D R Shafren
    Picornaviral Research Unit, Discipline of Immunology and Microbiology, Faculty of Medicine and Health Sciences, University of Newcastle, Newcastle, New South Wales 2300, Australia
    J Virol 73:7193-8. 1999
    ..These findings suggest that PAI-2 and/or related serpins may form the basis of novel antiviral strategies against picornavirus infections and also therapeutic interventions against ICAM-1-mediated respiratory inflammation...
  5. pmc Viral cell entry induced by cross-linked decay-accelerating factor
    D R Shafren
    Department of Microbiology, Faculty of Medicine, The University of Newcastle, Newcastle New South Wales 2300, Australia
    J Virol 72:9407-12. 1998
    ..In contrast to the situation with ICAM-1-mediated CAV21 infection, in which high levels of A-type particles are formed, cross-linked DAF-induced CAV21 replication occurs in the absence of detectable A-particle formation...
  6. ncbi Antibody binding to individual short consensus repeats of decay-accelerating factor enhances enterovirus cell attachment and infectivity
    D R Shafren
    Department of Microbiology, Faculty of Medicine, The University of Newcastle, New South Wales, Australia
    J Immunol 160:2318-23. 1998
    ..This is the first demonstration of enhancement of viral infectivity mediated by Ab against the viral receptor...
  7. pmc A decay-accelerating factor-binding strain of coxsackievirus B3 requires the coxsackievirus-adenovirus receptor protein to mediate lytic infection of rhabdomyosarcoma cells
    D R Shafren
    Department of Microbiology, Faculty of Medicine, The University of Newcastle, Australia
    J Virol 71:9844-8. 1997
    ..R. Shafren, D. J. Dorahy, R. A. Ingham, G. F. Burns, and R. D. Barry, J. Virol. 71:4736-4743, 1997), in that DAF may act as a CVB3 sequestration site, enhancing viral presentation to the functional CAR protein...
  8. pmc Coxsackievirus A21 binds to decay-accelerating factor but requires intercellular adhesion molecule 1 for cell entry
    D R Shafren
    Department of Microbiology, Faculty of Medicine, The University of Newcastle, New South Wales, Australia
    J Virol 71:4736-43. 1997
    ..It is therefore suggested that DAF may function as a low-affinity attachment receptor either enhancing viral presentation or providing a viral sequestration site for subsequent high-affinity binding to ICAM-1...
  9. ncbi CD36 forms covalently associated dimers and multimers in platelets and transfected COS-7 cells
    R F Thorne
    Cancer Research Unit, Faculty of Medicine and Health Sciences, University of Newcastle, NSW, Australia
    Biochem Biophys Res Commun 240:812-8. 1997
    ..Mutagenesis of the cDNA for CD36 implicated the cysteines in the extracellular domain of the molecule. The potential physiological roles of CD36 multimerisation are discussed...
  10. ncbi An enzyme-linked immunosorbent assay for the detection of avian encephalomyelitis virus antigens
    D R Shafren
    Faculty of Medicine, University of Newcastle, New South Wales, Australia
    Avian Dis 32:209-14. 1988
    ..Excretion was most prolonged following oral inoculation (4-10 days), although antigen could be detected by 2 days after intracerebral inoculation. Detectable antibody was present by 10 days following infection by each route...
  11. ncbi The integrins alpha3beta1 and alpha6beta1 physically and functionally associate with CD36 in human melanoma cells. Requirement for the extracellular domain OF CD36
    R F Thorne
    Cancer Research Unit and Department of Microbiology, Faculty of Medicine and Health Sciences, University of Newcastle, New South Wales 2308, Australia
    J Biol Chem 275:35264-75. 2000
    ..These results suggest that in melanoma cells CD36 expression may induce the sequestration of certain integrins into membrane microdomains and promote cell migration...
  12. pmc Mouse cells expressing human intercellular adhesion molecule-1 are susceptible to infection by coxsackievirus A21
    D R Shafren
    Department of Microbiology, Faculty of Medicine, The University of Newcastle, New South Wales, Australia
    J Virol 71:785-9. 1997
    ..Finally, we show transfection of normally nonsusceptible mouse L cells with human ICAM-1 cDNA renders them susceptible to infection by CAV21...
  13. ncbi Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells
    M V Agrez
    Faculty of Medicine and Health Sciences, University of Newcastle, New South Wales, Australia
    Virology 239:71-7. 1997
    ..This may be essential in the conversion of asymptomatic enterovirus infection into clinically apparent disease...
  14. ncbi Development and application of an ELISA technique for the detection of antibody to avian encephalomyelitis viruses
    D R Shafren
    Department of Biological Sciences, University of Newcastle, New South Wales, Australia
    Res Vet Sci 46:95-9. 1989
    ..95 per cent) and a good correlation was observed with results obtained by neutralisation index tests (r = 0.91, P less than 0.1). The assay detects only AEV-specific antibody and allows monitoring of the spread of AEV in flocks...
  15. ncbi Development and application of an improved infectivity assay for the standardization of avian encephalomyelitis vaccines
    D R Shafren
    Faculty of Medicine, University of Newcastle, Australia
    Vaccine 8:283-5. 1990
    ..No animal handling facilities are required with the brain antigen ELISA and results of comparable sensitivity to the hatch-out assay were obtained...
  16. ncbi CD36 is spatially associated with glycoprotein IIb-IIIa (alpha IIb beta 3) on the surface of resting platelets
    D J Dorahy
    Cancer Research Unit, Faculty of Medicine and Health Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Biochem Biophys Res Commun 218:575-81. 1996
    ..By the use of immunoprecipitation of lysates of platelets that have been surface labeled and chemically crosslinked we show here that CD36 and GPIIb-IIIa are spatially associated on the surface of resting platelets...
  17. ncbi Pathogenesis of avian encephalomyelitis viruses
    D R Shafren
    Faculty of Medicine, University of Newcastle, New South Wales, Australia
    J Gen Virol 72:2713-9. 1991
    ..Primary cultures of chicken embryo brain cells supported the growth of the Van Roekel strain to a much greater extent than the field and vaccine strains...