Research Topics
Species | Ego SeemanSummaryAffiliation: University of Melbourne Country: Australia Publications
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Publications
The structural basis of bone fragility in menE Seeman
Austin and Repatriation Medical Centre, The University of Melbourne, Australia
Bone 25:143-7. 1999..Reasonable approaches to treatment include the use of testosterone in hypogonadal men, and vitamin D if vitamin D deficiency is present. Calcium supplements may slow endocortical bone loss. Bisphosphonates may increase BMD...- Osteocytes--martyrs for integrity of bone strengthE Seeman
Austin Health, University of Melbourne, Melbourne, Australia
Osteoporos Int 17:1443-8. 2006 - Reduced bone formation and increased bone resorption: rational targets for the treatment of osteoporosisEgo Seeman
Department of Endocrinology, Austin and Repatriation Medical Centre, 3084, Heidelberg, Melbourne, Australia
Osteoporos Int 14:S2-8. 2003.... - Reconstructing the skeleton with intermittent parathyroid hormoneE Seeman
Austin and Repatriation Medical Centre, University of Melbourne, Vic, Australia
Trends Endocrinol Metab 12:281-3. 2001.... - Structural and biomechanical basis of racial and sex differences in vertebral fragility in Chinese and CaucasiansYunbo Duan
Departments of Medicine and Endocrinology, Austin Health, The University of Melbourne, Heidelberg, Melbourne 3084, Australia
Bone 36:987-98. 2005..The structural basis of bone fragility differs by race and sex. Periosteal apposition plays a pivotal role in determining racial and sex differences in net bone loss, geometry, and strength... 
DNA-binding-dependent androgen receptor signaling contributes to gender differences and has physiological actions in males and femalesHelen E MacLean
Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
J Endocrinol 206:93-103. 2010....- Five years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of ageEgo Seeman
Austin Health, University of Melbourne, Melbourne, Australia
Bone 46:1038-42. 2010..Despite this, few studies have examined antifracture efficacy of treatments in this high-risk group and none has provided evidence for benefits beyond 3 years... - Varying contributions of growth and ageing to racial and sex differences in femoral neck structure and strength in old ageXiao-Fang Wang
Department of Endocrinology, Austin Health, The University of Melbourne, Heidelberg, Victoria 3084, Australia
Bone 36:978-86. 2005.... - Estrogen, androgen, and the pathogenesis of bone fragility in women and menEgo Seeman
Department of Endocrinology, Austin Hospital, Heidelberg 3084, Melbourne, Australia
Curr Osteoporos Rep 2:90-6. 2004..More women than men fracture because their smaller skeleton incurs greater architectural damage and adapts less by periosteal apposition. Sex hormone deficiency during growth and aging is pivotal in the pathogenesis of bone fragility... - The age of puberty determines sexual dimorphism in bone structure: a male/female co-twin control studySandra Iuliano-Burns
Austin Health, University of Melbourne, West Heidelberg, Australia 3081
J Clin Endocrinol Metab 94:1638-43. 2009..However, comparing sexes of the same age mismatches by pubertal stage, so males will be less mature than females. Comparing sexes of the same pubertal stage mismatches by age, so males will be older than females... - Trabecular bone of growth plate origin influences both trabecular and cortical morphology in adulthoodQingju Wang
Endocrine Centre, Heidelberg Repatriation Hospital, Austin Health, Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
J Bone Miner Res 26:1577-83. 2011..Abnormalities in the development of metaphyseal trabecular bone are likely to influence fragility in both trabecular and cortical bone of this region in adulthood... - Bone modeling and remodelingEgo Seeman
Department of Endocrinology, Repatriation Campus, Austin Health, Melbourne, Australia
Crit Rev Eukaryot Gene Expr 19:219-33. 2009..A better understanding of the mechanisms responsible for structural decay is likely to reveal new approaches to the prevention and reversal of bone fragility... - Femoral neck fragility in women has its structural and biomechanical basis established by periosteal modeling during growth and endocortical remodeling during agingSilvana Filardi
Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, 3084, Melbourne, Australia
Osteoporos Int 15:103-7. 2004..The structural basis of bone fragility has some features originating during growth and others during aging... - Seasonal periodicity of serum vitamin D and parathyroid hormone, bone resorption, and fractures: the Geelong Osteoporosis StudyJulie A Pasco
Department of Clinical and Biomedical Sciences: Barwon Health, The University of Melbourne, Geelong, Victoria, Australia
J Bone Miner Res 19:752-8. 2004..Whether vitamin D supplementation in winter can reduce the population burden of fractures requires further investigation... - Half the burden of fragility fractures in the community occur in women without osteoporosis. When is fracture prevention cost-effective?Kerrie M Sanders
Department of Clinical and Biomedical Sciences, Barwon Health, The University of Melbourne, PO Box 281, Geelong 3220, Australia
Bone 38:694-700. 2006..Using osteoporosis and age (>60 years) as criteria for intervention reduces the population burden of fractures by 28% and is cost-effective but solutions to the prevention of the remaining 72% of fragility fractures remain unavailable... - The fracture risk index and bone mineral density as predictors of vertebral structural failureYunbo Duan
Department of Endocrinology, Austin Health, The University of Melbourne, 3084, Melbourne, Australia
Osteoporos Int 17:54-60. 2006..The FRI may not predict incident vertebral fractures... - Construction of the femoral neck during growth determines its strength in old ageRoger M D Zebaze
Departments of Medicine and Endocrinology, Austin Health, University of Melbourne, Melbourne, Australia
J Bone Miner Res 22:1055-61. 2007.... - Hormone therapy and risk of non-vertebral fracture: Geelong osteoporosis studyJulie A Pasco
Department of Clinical and Biomedical Sciences Barwon Health, The University of Melbourne, P O Box 281, 3220 Geelong, Australia
Osteoporos Int 15:434-8. 2004..53 (95% CI 0.31-0.92). HT use was associated with 2.6-7.5% higher BMD at axial and appendicular sites. HT use is associated with a halving of risk for non-vertebral fractures and higher BMD... - Structural and biomechanical basis of sexual dimorphism in femoral neck fragility has its origins in growth and agingYunbo Duan
Department of Endocrinology, Austin and Repatriation Medical Centre, University of Melbourne, Melbourne, Victoria, Australia
J Bone Miner Res 18:1766-74. 2003.... - Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional studyRoger M D Zebaze
Department of Medicine, Austin Health, University of Melbourne, Melbourne, Vic, Australia
Lancet 375:1729-36. 2010..We aimed to re-examine cortical bone as a source of bone loss in the appendicular skeleton... - Bone quality: the material and structural basis of bone strengthEgo Seeman
Department of Endocrinology and Medicine, Austin Hospital, Austin Health, Heidelberg 3084, Melbourne, Australia
J Bone Miner Metab 26:1-8. 2008..An understanding of the mechanisms of adaptation and failed adaptation provides rational approaches to interventions that can prevent or restore bone fragility... - Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and olderEgo Seeman
Austin Hospital, University of Melbourne, Australia
J Bone Miner Res 21:1113-20. 2006..Strontium ranelate produces an early and sustained reduction of both vertebral and nonvertebral fractures in patients > or = 80 years of age... - Microarchitectural deterioration of cortical and trabecular bone: differing effects of denosumab and alendronateEgo Seeman
Austin Health, University of Melbourne, Melbourne, Australia
J Bone Miner Res 25:1886-94. 2010..001). Adverse events did not differ by group. These data suggest that structural decay owing to bone remodeling and progression of bone fragility may be prevented more effectively with denosumab... - Differences in macro- and microarchitecture of the appendicular skeleton in young Chinese and white womenXiao Fang Wang
Endocrine Centre, Austin Health, University of Melbourne, Melbourne, Australia
J Bone Miner Res 24:1946-52. 2009..01). Similar results were found at the distal tibia. Lower fracture risk in Chinese women may be partly caused by thicker cortices and trabeculae in a smaller bone-more bone within the bone than in whites... - Bone quality--the material and structural basis of bone strength and fragilityEgo Seeman
Department of Endocrinology, Austin Health, University of Melbourne, Melbourne, Australia
N Engl J Med 354:2250-61. 2006 - Strontium ranelate reduces the risk of vertebral fractures in patients with osteopeniaEgo Seeman
Austin Health, University of Melbourne, Melbourne, Australia
J Bone Miner Res 23:433-8. 2008..Vertebral fracture risk reduction of 41-59% was shown depending on the site and fracture status at baseline. This is the first report of antivertebral fracture efficacy in women with vertebral osteopenia... - Femoral neck shape and the spatial distribution of its mineral mass varies with its size: Clinical and biomechanical implicationsRoger M D Zebaze
Austin Hospital, University of Melbourne, Heidelberg 3084, Melbourne, Australia
Bone 37:243-52. 2005..Studies are needed to determine the effects of age, sex, and race on FN size and shape in health and disease... - Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis StudyJulie A Pasco
Department of Clinical and Biomedical Sciences Barwon Health, The University of Melbourne, Geelong, Australia
J Bone Miner Res 19:19-24. 2004..49-0.96). Beta-blockers were associated with higher BMD at the total hip (2.5%) and UD forearm (3.6%) after adjusting for age, anthropometry, and thiazide use. Beta-blocker use is associated with reduced fracture risk and higher BMD... - Mineralization and bone resorption are regulated by the androgen receptor in male miceCherie Chiang
Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
J Bone Miner Res 24:621-31. 2009.... - The varying distribution of intra- and inter-vertebral height ratios determines the prevalence of vertebral fracturesRoger Martin Djoumessi Zebaze
Department of Endocrinology, Austin Hospital and Repartriation Medical Centre, University of Melbourne, Melbourne, Australia
Bone 35:348-56. 2004..Improved criteria to define VF are needed before credible inferences can be made regarding the burden of VFs in women and men, and between sexes, races, countries, decades, and placebo arms of clinical trials... - Body segment lengths and arm span in healthy men and women and patients with vertebral fracturesXiao-Fang Wang
Department of Endocrinology, Austin and Repatriation Medical Centre, The University of Melbourne, Melbourne, 3084, Australia
Osteoporos Int 15:43-8. 2004..We concluded that women, not men, with vertebral fractures may come from a population with short stature. The difference between arm span and standing or sitting height cannot be used to predict vertebral fracture risk... - Familial resemblance and diversity in bone mass and strength in the population are established during the first year of postnatal lifeQingju Wang
Endocrine Centre, Austin Health, University of Melbourne, Melbourne, Australia
J Bone Miner Res 25:1512-20. 2010..Thus susceptibility to bone fragility late in life has its antecedents established early in life... - Periosteal bone formation--a neglected determinant of bone strengthEgo Seeman
Austin Hospital, University of Melbourne, Melbourne, Australia
N Engl J Med 349:320-3. 2003 - Skeletal growth and peak bone strengthQingju Wang
Endocrine Centre, Centaur Building, Heidelberg Repatriation Hospital Austin Health, Heidelberg, Victoria, Australia
Best Pract Res Clin Endocrinol Metab 22:687-700. 2008..The machinery has enormous capacity during growth, as can be seen in the bone structure of the elite athlete, but not during advancing age because of changes in the cellular machinery itself and in systemic hormonal regulatory factors... - Bone's structural diversity in adult females is established before pubertyQingju Wang
Austin Health, University of Melbourne, Heidelberg 3081, Melbourne, Australia
J Clin Endocrinol Metab 94:1555-61. 2009..Bone must be rigid for leverage yet light for mobility. We studied how bone modeling and remodeling fashioned differences in bone size, shape, and mass during growth to achieve these properties in adulthood... - Pathogenesis of bone fragility in women and menEgo Seeman
Department of Endocrinology, Austin and Repatriation Medical Centre, Heidelberg 3084, Victoria, Australia
Lancet 359:1841-50. 2002..The structural basis of bone fragility is determined before birth, takes root during growth, and gains full expression during ageing in both sexes... - Third metacarpal condylar fatigue fractures in equine athletes occur within previously modelled subchondral boneR Christopher Whitton
Faculty of Veterinary Science, Equine Centre, University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
Bone 47:826-31. 2010.... - Diet and exercise during growth have site-specific skeletal effects: a co-twin control studySandra Iuliano-Burns
Department of Endocrinology, Austin Health, University of Melbourne, Studley Road, 3084 Heidelberg, Victoria, Australia
Osteoporos Int 16:1225-32. 2005..Exercise during growth appears to have greater skeletal benefits than variations in protein or calcium intakes, with the site-specific effects evident in more mature twins... - Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapyCherie Ying Chiang
Department of Endocrinology, Austin Health, University of Melbourne, Melbourne, Australia
Bone 52:360-5. 2013..Teriparatide may assist in healing of atypical fractures and restoration of bone quality... - Loading and bone fragilityEgo Seeman
Endocrine Unit, Department of Medicine, Austin Hospital, University of Melbourne, Melbourne, Australia
J Bone Miner Metab 23:23-9. 2005..Proof requires demonstration of a reduction in spine and hip fractures in well-designed and well-executed prospective randomized studies; none exists. Blinded studies cannot be done, but open trials can and should be done... - To stop or not to stop, that is the questionEgo Seeman
Department of Endocrinology, Austin Health, University of Melbourne, Australia
Osteoporos Int 20:187-95. 2009..Thus, within the constraints of limited evidence, I infer that stopping therapy is more likely to do net harm than continuing therapy - treatment should be continued in the majority of individuals... - Bone remodelling: its local regulation and the emergence of bone fragilityT John Martin
University of Melbourne, Melbourne, Australia
Best Pract Res Clin Endocrinol Metab 22:701-22. 2008.... - Evidence that calcium supplements reduce fracture risk is lackingEgo Seeman
Department of Endocrinology, Centaur Building, Repatriation Campus, Austin Health, Heidelberg 3081, Melbourne, Australia
Clin J Am Soc Nephrol 5:S3-11. 2010.... - The structural and hormonal basis of sex differences in peak appendicular bone strength in ratsBom-Taeck Kim
Department of Endocrinology, Austin and Repatriation Medical Center, University of Melbourne, Melbourne, Australia
J Bone Miner Res 18:150-5. 2003..The hormonal regulation of bone surfaces establishes the amount and spatial distribution of bone and so the sexual dimorphism in its strength... - Strontium ranelate: vertebral and non-vertebral fracture risk reductionEgo Seeman
Austin Health, University of Melbourne, Melbourne, Australia
Curr Opin Rheumatol 18:S17-20. 2006..Strontium ranelate, a new anti-osteoporosis agent, has a broad range of antifracture efficacy... - Anti-vertebral fracture efficacy of raloxifene: a meta-analysisEgo Seeman
Department of Endocrinology, University of Melbourne, Austin Hospital, Heidelberg, 3084, Melbourne, Victoria, Australia
Osteoporos Int 17:313-6. 2006..Odds ratio estimates (95% CI) were 0.60 (0.49, 0.74) for RLX60 and 0.51 (0.41, 0.64) for RLX120/150. From these data we infer that raloxifene consistently reduces the risk of vertebral fracture in postmenopausal women... - The structural and biomechanical basis of the gain and loss of bone strength in women and menEgo Seeman
Department of Endocrinology and Medicine, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, Melbourne 3084, Australia
Endocrinol Metab Clin North Am 32:25-38. 2003..The quest to eliminate fragility fractures is a distant horizon seen through a glass darkly at this time... - The characteristics of fractures in Polish adolescents aged 16-20 yearsJerzy Konstantynowicz
Department of Pediatrics and Auxology, Children s Hospital Dr L Zamenhof, Medical University of Bialystok, Bialystok, Poland
Osteoporos Int 16:1397-403. 2005..Fractures, particularly multiple fractures, are common in childhood and adolescence. Familial clustering of fractures suggests shared genetic and environmental factors are responsible... - Depression in anorexia nervosa: a risk factor for osteoporosisJerzy Konstantynowicz
Department of Pediatrics and Auxology, Medical University of Bialystok, University Children s Hospital Dr Ludwik Zamenhof, 15 274 Bialystok, Poland
J Clin Endocrinol Metab 90:5382-5. 2005..Both anorexia nervosa (AN) and depression are associated with osteoporosis. We hypothesized that adolescent girls with AN and depression will have lower bone mineral density (BMD) than anorexic girls without depression... - Hypocalcemia induced by raloxifeneThuy D T Vu
Endocrinology Department, Austin Health, Victoria, Australia
Curr Drug Saf 7:176-8. 2012..Since vitamin D deficiency is widely prevalent in the community, screening for vitamin D deficiency and its correction is advisable before the initiation of anti-resorptive therapy... - Loss of regularity in the curvature of the thoracolumbar spine: a measure of structural failureRoger M D Zebaze
Department of Endocrinology, Austin and Repatriation Medical Centre, University of Melbourne, Melbourne, Australia
J Bone Miner Res 19:1099-104. 2004..01 SD), and 2- to 4-fold greater height deficits (-0.5 SD) than women with deformities (by QVM). The SCII is a robust method of identifying structural failure that is easy to compute and does not require controls... - 7: Treatment of osteoporosis: why, whom, when and how to treat. The single most important consideration is the individual's absolute risk of fractureEgo Seeman
Endocrine Unit, Austin and Repatriation Medical Centre, Studley Road, Heidelberg, VIC 3084, Australia
Med J Aust 180:298-303. 2004.... - Epidemiology of hip and wrist fractures in Cameroon, AfricaRoger Martin Djoumessi Zebaze
Department of Endocrinology, Austin and Repatriation Medical Centre, University of Melbourne, 3084, Heidelberg, Melbourne, Australia
Osteoporos Int 14:301-5. 2003..The low incidence of fragility fractures is confirmed and is likely to be, in part, the result of reduced longevity as only 1.1% of women and 0.7% of men survive beyond 65 years of age... - Differences in the degree of bone tissue mineralization account for little of the differences in tissue elastic propertiesRoger M D Zebaze
Departments of Endocrinology and Medicine, Austin Health, University of Melbourne, Melbourne, Australia
Bone 48:1246-51. 2011..Other material properties need to be taken into account to more fully predict variation in tissue elastic modulus... - Invited Review: Pathogenesis of osteoporosisEgo Seeman
Dept. of Endocrinology, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, Melbourne 3084, Australia
J Appl Physiol 95:2142-51. 2003..More women than men experience fractures because their smaller skeleton incurs greater architectural damage and adapts less by periosteal apposition... 
Seizures after alendronateRichard J Maclsaac
Endocrinology Unit and Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Studley Road, Heidelberg, Victoria, 3084, Australia
J R Soc Med 95:615-6. 2002- The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosisPierre J Meunier
Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyons, France
N Engl J Med 350:459-68. 2004.... - A comparison of the effects of raloxifene and conjugated equine estrogen on bone and lipids in healthy postmenopausal womenIan R Reid
Department of Medicine, University of Auckland, PB 92019, Auckland, New Zealand
Arch Intern Med 164:871-9. 2004..Although many studies have assessed the effects of estrogen and raloxifene hydrochloride on bone mineral density and serum lipid concentrations, there are few direct comparative data... - Additive effects of raloxifene and alendronate on bone density and biochemical markers of bone remodeling in postmenopausal women with osteoporosisOlof Johnell
Department of Orthopaedics, Universiteitssjukhuset MAS, Malm, Sweden
J Clin Endocrinol Metab 87:985-92. 2002..RLX+ALN reduced bone turnover more than either drug alone, resulting in greater BMD increment, but whether this difference reflects better fracture risk reduction was not assessed in this study... - Efficacy of risedronate on clinical vertebral fractures within six monthsChristian Roux
Cochin Hospital, Rene Descartes University, Paris, France
Curr Med Res Opin 20:433-9. 2004..Risedronate has been shown to reduce the incidence of radiographically-defined vertebral fractures by approximately two-thirds within 1 year... - Changes in bone mineral density explain little of the reduction in vertebral or nonvertebral fracture risk with anti-resorptive therapyPierre D Delmas
Claude Bernard University of Lyon and INSERM Research Unit 403, Lyon, France
Bone 34:599-604. 2004..Further studies are needed to define the structural basis of the fracture risk reduction... - Alendronate and vertebral fracture riskEgo Seeman
Mayo Clin Proc 80:1236, 1238; author reply 1238, 1240. 2005 - New mechanisms and targets in the treatment of bone fragilityT John Martin
St Vincent s Institute of Medical Research, University of Melbourne Department of Medicine, 9 Princes Street, Fitzroy, Victoria 3065, Australia
Clin Sci (Lond) 112:77-91. 2007..The recent discovery through mouse genetics that PTHrP (PTH-related protein) is a crucial bone-derived paracrine regulator of remodelling offers new and interesting therapeutic targets... - Structural adaptations to bone loss in aging men and womenCosimo Roberto Russo
Laboratory of Clinical Epidemiology, INRCA Geriatric Department, Florence, Italy
Bone 38:112-8. 2006..Th) and the distance the cortex is placed from the neutral axis of a long bone, all determinants of bone strength. We tested the hypothesis that sex-related differences in these processes produces a sexual dimorphism in tibial fragility... - An exercise in geometryEgo Seeman
J Bone Miner Res 17:373-80. 2002 - Bone qualityEgo Seeman
Osteoporos Int 14:S3-7. 2003 - Circulating sex steroids, sex hormone-binding globulin, and longitudinal changes in forearm bone mineral density in postmenopausal women and men: the Tromsø studyAshild Bjørnerem
Institute of Community Medicine, University of Tromsø, N 9037, Tromsø, Norway
Calcif Tissue Int 81:65-72. 2007..We therefore conclude that the relations between sex steroids and bone loss are weak and measurements of sex steroids are unlikely to assist in clinical decision making... - The perspective of the international osteoporosis foundation on the official positions of the international society for clinical densitometryJohn A Kanis
WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, S10 2DU, Sheffield, UK
J Clin Densitom 8:145-7. 2005 - Preventing osteoporosis: outcomes of the Australian Fracture Prevention SummitPhilip N Sambrook
Med J Aust 176:S1-16. 2002 - Compliance with osteoporosis therapy is the weakest linkJuliet E Compston
Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
Lancet 368:973-4. 2006 - Bone fragility: failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal womenPawel Szulc
INSERM 403 Research Unit and Université Claude Bernard Lyon, Lyon, France
J Bone Miner Res 21:1856-63. 2006..Women with highest remodeling had greatest loss of bone mass and estimated bone strength, whereas those with low remodeling lost less bone and maintained estimated bone strength... - Bone remodeling rate and remodeling balance are not co-regulated in adulthood: implications for the use of activation frequency as an index of remodeling rateJuliet E Compston
Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
J Bone Miner Res 22:1031-6. 2007..In iliac crest biopsy specimens from 57 healthy subjects 19-80 yr of age, no correlations were shown between these variables, an observation that challenges the use of activation frequency as an estimate of remodeling rate... - Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genesAnne Marie Sims
Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Brisbane, Australia
J Bone Miner Res 23:499-506. 2008..This confirms that extreme truncate selection is a powerful design for quantitative trait association studies of bone phenotypes... - The perspective of the International Osteoporosis Foundation on the official positions of the International Society for Clinical DensitometryJohn A Kanis
WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield S10 2DU, UK
Osteoporos Int 16:456-9, discussion 579-80. 2005 - Osteoporosis and the global competition for health care resourcesL Joseph Melton
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Bone Miner Res 19:1055-8. 2004..To better compete for these resources, efforts should be made to lower the cost of osteoporosis interventions. Additionally, evidence is needed that these interventions are really effective in reducing fractures in the community...