Ego Seeman

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi Bone modeling and remodeling
    Ego Seeman
    Department of Endocrinology, Repatriation Campus, Austin Health, Melbourne, Australia
    Crit Rev Eukaryot Gene Expr 19:219-33. 2009
  2. doi Age- and menopause-related bone loss compromise cortical and trabecular microstructure
    Ego Seeman
    Department of Endocrinology, Level 2, Centaur Building, Repatriation Campus, Austin Health, Waterdale Road, West Heidelberg, VIC 3081, Australia
    J Gerontol A Biol Sci Med Sci 68:1218-25. 2013
  3. ncbi Pathogenesis of bone fragility in women and men
    Ego Seeman
    Department of Endocrinology, Austin and Repatriation Medical Centre, Heidelberg 3084, Victoria, Australia
    Lancet 359:1841-50. 2002
  4. ncbi The periosteum--a surface for all seasons
    E Seeman
    Austin Health, University of Melbourne, Melbourne, Australia
    Osteoporos Int 18:123-8. 2007
  5. ncbi Bone fragility in men--where are we?
    E Seeman
    Austin Health, Centaur Building, Repatriation Campus, Heidelberg, 3082, Melbourne, Australia
    Osteoporos Int 17:1577-83. 2006
  6. ncbi Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older
    Ego Seeman
    Austin Hospital, University of Melbourne, Australia
    J Bone Miner Res 21:1113-20. 2006
  7. ncbi Bone quality--the material and structural basis of bone strength and fragility
    Ego Seeman
    Department of Endocrinology, Austin Health, University of Melbourne, Melbourne, Australia
    N Engl J Med 354:2250-61. 2006
  8. ncbi The structural and biomechanical basis of the gain and loss of bone strength in women and men
    Ego Seeman
    Department of Endocrinology and Medicine, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, Melbourne 3084, Australia
    Endocrinol Metab Clin North Am 32:25-38. 2003
  9. ncbi Hot stuff--can't get enough
    E Seeman
    Austin Health, Centure Building, Repatriation Campus, Heidelberg, 3082, Melbourne, Australia
    Osteoporos Int 17:791-4. 2006
  10. ncbi Estrogen, androgen, and the pathogenesis of bone fragility in women and men
    Ego Seeman
    Department of Endocrinology, Austin Hospital, Heidelberg 3084, Melbourne, Australia
    Curr Osteoporos Rep 2:90-6. 2004

Detail Information

Publications105 found, 100 shown here

  1. ncbi Bone modeling and remodeling
    Ego Seeman
    Department of Endocrinology, Repatriation Campus, Austin Health, Melbourne, Australia
    Crit Rev Eukaryot Gene Expr 19:219-33. 2009
    ..A better understanding of the mechanisms responsible for structural decay is likely to reveal new approaches to the prevention and reversal of bone fragility...
  2. doi Age- and menopause-related bone loss compromise cortical and trabecular microstructure
    Ego Seeman
    Department of Endocrinology, Level 2, Centaur Building, Repatriation Campus, Austin Health, Waterdale Road, West Heidelberg, VIC 3081, Australia
    J Gerontol A Biol Sci Med Sci 68:1218-25. 2013
    ..Of all fractures occurring, 80% are nonvertebral and 20% are vertebral. The notion of osteoporosis as a disease of trabecular bone loss and vertebral fractures needs to be revised. ..
  3. ncbi Pathogenesis of bone fragility in women and men
    Ego Seeman
    Department of Endocrinology, Austin and Repatriation Medical Centre, Heidelberg 3084, Victoria, Australia
    Lancet 359:1841-50. 2002
    ..The structural basis of bone fragility is determined before birth, takes root during growth, and gains full expression during ageing in both sexes...
  4. ncbi The periosteum--a surface for all seasons
    E Seeman
    Austin Health, University of Melbourne, Melbourne, Australia
    Osteoporos Int 18:123-8. 2007
  5. ncbi Bone fragility in men--where are we?
    E Seeman
    Austin Health, Centaur Building, Repatriation Campus, Heidelberg, 3082, Melbourne, Australia
    Osteoporos Int 17:1577-83. 2006
    ..Advances in the study of bone fragility in men have taken place, but many challenges remain...
  6. ncbi Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older
    Ego Seeman
    Austin Hospital, University of Melbourne, Australia
    J Bone Miner Res 21:1113-20. 2006
    ..Strontium ranelate produces an early and sustained reduction of both vertebral and nonvertebral fractures in patients > or = 80 years of age...
  7. ncbi Bone quality--the material and structural basis of bone strength and fragility
    Ego Seeman
    Department of Endocrinology, Austin Health, University of Melbourne, Melbourne, Australia
    N Engl J Med 354:2250-61. 2006
  8. ncbi The structural and biomechanical basis of the gain and loss of bone strength in women and men
    Ego Seeman
    Department of Endocrinology and Medicine, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, Melbourne 3084, Australia
    Endocrinol Metab Clin North Am 32:25-38. 2003
    ..The quest to eliminate fragility fractures is a distant horizon seen through a glass darkly at this time...
  9. ncbi Hot stuff--can't get enough
    E Seeman
    Austin Health, Centure Building, Repatriation Campus, Heidelberg, 3082, Melbourne, Australia
    Osteoporos Int 17:791-4. 2006
  10. ncbi Estrogen, androgen, and the pathogenesis of bone fragility in women and men
    Ego Seeman
    Department of Endocrinology, Austin Hospital, Heidelberg 3084, Melbourne, Australia
    Curr Osteoporos Rep 2:90-6. 2004
    ..More women than men fracture because their smaller skeleton incurs greater architectural damage and adapts less by periosteal apposition. Sex hormone deficiency during growth and aging is pivotal in the pathogenesis of bone fragility...
  11. ncbi Loading and bone fragility
    Ego Seeman
    Endocrine Unit, Department of Medicine, Austin Hospital, University of Melbourne, Melbourne, Australia
    J Bone Miner Metab 23:23-9. 2005
    ..Proof requires demonstration of a reduction in spine and hip fractures in well-designed and well-executed prospective randomized studies; none exists. Blinded studies cannot be done, but open trials can and should be done...
  12. ncbi Diet and exercise during growth have site-specific skeletal effects: a co-twin control study
    Sandra Iuliano-Burns
    Department of Endocrinology, Austin Health, University of Melbourne, Studley Road, 3084 Heidelberg, Victoria, Australia
    Osteoporos Int 16:1225-32. 2005
    ..Exercise during growth appears to have greater skeletal benefits than variations in protein or calcium intakes, with the site-specific effects evident in more mature twins...
  13. ncbi The growth and age-related origins of bone fragility in men
    E Seeman
    Austin Hospital, Heidelberg 3084, Melbourne, Australia
    Calcif Tissue Int 75:100-9. 2004
  14. ncbi Anti-vertebral fracture efficacy of raloxifene: a meta-analysis
    Ego Seeman
    Department of Endocrinology, University of Melbourne, Austin Hospital, Heidelberg, 3084, Melbourne, Victoria, Australia
    Osteoporos Int 17:313-6. 2006
    ..Odds ratio estimates (95% CI) were 0.60 (0.49, 0.74) for RLX60 and 0.51 (0.41, 0.64) for RLX120/150. From these data we infer that raloxifene consistently reduces the risk of vertebral fracture in postmenopausal women...
  15. ncbi Non-compliance: the Achilles' heel of anti-fracture efficacy
    E Seeman
    Department of Medicine and Endocrinology, Austin Health, University of Melbourne, Melbourne, Australia
    Osteoporos Int 18:711-9. 2007
    ..How this is best achieved has yet to be established, but poor persistence occurs as early as 3 months of starting treatment, indicating the need for early monitoring...
  16. ncbi Microarchitectural deterioration of cortical and trabecular bone: differing effects of denosumab and alendronate
    Ego Seeman
    Austin Health, University of Melbourne, Melbourne, Australia
    J Bone Miner Res 25:1886-94. 2010
    ..001). Adverse events did not differ by group. These data suggest that structural decay owing to bone remodeling and progression of bone fragility may be prevented more effectively with denosumab...
  17. ncbi Evidence that calcium supplements reduce fracture risk is lacking
    Ego Seeman
    Department of Endocrinology, Centaur Building, Repatriation Campus, Austin Health, Heidelberg 3081, Melbourne, Australia
    Clin J Am Soc Nephrol 5:S3-11. 2010
    ....
  18. doi Five years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of age
    Ego Seeman
    Austin Health, University of Melbourne, Melbourne, Australia
    Bone 46:1038-42. 2010
    ..Despite this, few studies have examined antifracture efficacy of treatments in this high-risk group and none has provided evidence for benefits beyond 3 years...
  19. ncbi 7: Treatment of osteoporosis: why, whom, when and how to treat. The single most important consideration is the individual's absolute risk of fracture
    Ego Seeman
    Endocrine Unit, Austin and Repatriation Medical Centre, Studley Road, Heidelberg, VIC 3084, Australia
    Med J Aust 180:298-303. 2004
    ....
  20. doi To stop or not to stop, that is the question
    Ego Seeman
    Department of Endocrinology, Austin Health, University of Melbourne, Australia
    Osteoporos Int 20:187-95. 2009
    ..Thus, within the constraints of limited evidence, I infer that stopping therapy is more likely to do net harm than continuing therapy - treatment should be continued in the majority of individuals...
  21. pmc Structural basis of growth-related gain and age-related loss of bone strength
    E Seeman
    Department of Endocrinology and Medicine, Austin Health, University ofMelbourne, Melbourne, Australia
    Rheumatology (Oxford) 47:iv2-8. 2008
    ..These changes produce the material and structural abnormalities responsible for bone fragility...
  22. ncbi Bone quality: the material and structural basis of bone strength
    Ego Seeman
    Department of Endocrinology and Medicine, Austin Hospital, Austin Health, Heidelberg 3084, Melbourne, Australia
    J Bone Miner Metab 26:1-8. 2008
    ..An understanding of the mechanisms of adaptation and failed adaptation provides rational approaches to interventions that can prevent or restore bone fragility...
  23. ncbi Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia
    Ego Seeman
    Austin Health, University of Melbourne, Melbourne, Australia
    J Bone Miner Res 23:433-8. 2008
    ..Vertebral fracture risk reduction of 41-59% was shown depending on the site and fracture status at baseline. This is the first report of antivertebral fracture efficacy in women with vertebral osteopenia...
  24. ncbi Is a change in bone mineral density a sensitive and specific surrogate of anti-fracture efficacy?
    E Seeman
    Departments of Medicine and Endocrinology, Austin Health, University of Melbourne, Melbourne, Australia
    Bone 41:308-17. 2007
    ..Therefore, a small increase in BMD does not mean treatment has failed and a large increase in BMD is not indicative of a greater fracture risk reduction...
  25. ncbi Structural and biomechanical basis of racial and sex differences in vertebral fragility in Chinese and Caucasians
    Yunbo Duan
    Departments of Medicine and Endocrinology, Austin Health, The University of Melbourne, Heidelberg, Melbourne 3084, Australia
    Bone 36:987-98. 2005
    ..The structural basis of bone fragility differs by race and sex. Periosteal apposition plays a pivotal role in determining racial and sex differences in net bone loss, geometry, and strength...
  26. ncbi DNA-binding-dependent androgen receptor signaling contributes to gender differences and has physiological actions in males and females
    Helen E MacLean
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    J Endocrinol 206:93-103. 2010
    ....
  27. ncbi Varying contributions of growth and ageing to racial and sex differences in femoral neck structure and strength in old age
    Xiao Fang Wang
    Department of Endocrinology, Austin Health, The University of Melbourne, Heidelberg, Victoria 3084, Australia
    Bone 36:978-86. 2005
    ....
  28. ncbi Femoral neck fragility in women has its structural and biomechanical basis established by periosteal modeling during growth and endocortical remodeling during aging
    Silvana Filardi
    Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, 3084, Melbourne, Australia
    Osteoporos Int 15:103-7. 2004
    ..The structural basis of bone fragility has some features originating during growth and others during aging...
  29. doi The age of puberty determines sexual dimorphism in bone structure: a male/female co-twin control study
    Sandra Iuliano-Burns
    Austin Health, University of Melbourne, West Heidelberg, Australia 3081
    J Clin Endocrinol Metab 94:1638-43. 2009
    ..However, comparing sexes of the same age mismatches by pubertal stage, so males will be less mature than females. Comparing sexes of the same pubertal stage mismatches by age, so males will be older than females...
  30. ncbi Construction of the femoral neck during growth determines its strength in old age
    Roger M D Zebaze
    Departments of Medicine and Endocrinology, Austin Health, University of Melbourne, Melbourne, Australia
    J Bone Miner Res 22:1055-61. 2007
    ....
  31. doi Trabecular bone of growth plate origin influences both trabecular and cortical morphology in adulthood
    Qingju Wang
    Endocrine Centre, Heidelberg Repatriation Hospital, Austin Health, Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
    J Bone Miner Res 26:1577-83. 2011
    ..Abnormalities in the development of metaphyseal trabecular bone are likely to influence fragility in both trabecular and cortical bone of this region in adulthood...
  32. ncbi The fracture risk index and bone mineral density as predictors of vertebral structural failure
    Yunbo Duan
    Department of Endocrinology, Austin Health, The University of Melbourne, 3084, Melbourne, Australia
    Osteoporos Int 17:54-60. 2006
    ..The FRI may not predict incident vertebral fractures...
  33. ncbi Structural and biomechanical basis of sexual dimorphism in femoral neck fragility has its origins in growth and aging
    Yunbo Duan
    Department of Endocrinology, Austin and Repatriation Medical Centre, University of Melbourne, Melbourne, Victoria, Australia
    J Bone Miner Res 18:1766-74. 2003
    ....
  34. doi Differences in macro- and microarchitecture of the appendicular skeleton in young Chinese and white women
    Xiao Fang Wang
    Endocrine Centre, Austin Health, University of Melbourne, Melbourne, Australia
    J Bone Miner Res 24:1946-52. 2009
    ..01). Similar results were found at the distal tibia. Lower fracture risk in Chinese women may be partly caused by thicker cortices and trabeculae in a smaller bone-more bone within the bone than in whites...
  35. ncbi Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study
    Roger M D Zebaze
    Department of Medicine, Austin Health, University of Melbourne, Melbourne, Vic, Australia
    Lancet 375:1729-36. 2010
    ..We aimed to re-examine cortical bone as a source of bone loss in the appendicular skeleton...
  36. doi Mineralization and bone resorption are regulated by the androgen receptor in male mice
    Cherie Chiang
    Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    J Bone Miner Res 24:621-31. 2009
    ....
  37. ncbi The varying distribution of intra- and inter-vertebral height ratios determines the prevalence of vertebral fractures
    Roger Martin Djoumessi Zebaze
    Department of Endocrinology, Austin Hospital and Repartriation Medical Centre, University of Melbourne, Melbourne, Australia
    Bone 35:348-56. 2004
    ..Improved criteria to define VF are needed before credible inferences can be made regarding the burden of VFs in women and men, and between sexes, races, countries, decades, and placebo arms of clinical trials...
  38. doi New insights into the effects of primary hyperparathyroidism on the cortical and trabecular compartments of bone
    Thuy D T Vu
    Department of Medicine and Endocrinology, Austin Health, University of Melbourne, Heidelberg, Australia
    Bone 55:57-63. 2013
    ..The results were similar in the distal radius. In PHPT, chronically elevated endogenous PTH does not spare trabecular bone; it causes bone loss and microarchitectural deterioration in both cortical and trabecular compartments of bone...
  39. ncbi Reduced bone formation and increased bone resorption: rational targets for the treatment of osteoporosis
    Ego Seeman
    Department of Endocrinology, Austin and Repatriation Medical Centre, 3084, Heidelberg, Melbourne, Australia
    Osteoporos Int 14:S2-8. 2003
    ....
  40. ncbi Periosteal bone formation--a neglected determinant of bone strength
    Ego Seeman
    Austin Hospital, University of Melbourne, Melbourne, Australia
    N Engl J Med 349:320-3. 2003
  41. ncbi Body segment lengths and arm span in healthy men and women and patients with vertebral fractures
    Xiao Fang Wang
    Department of Endocrinology, Austin and Repatriation Medical Centre, The University of Melbourne, Melbourne, 3084, Australia
    Osteoporos Int 15:43-8. 2004
    ..We concluded that women, not men, with vertebral fractures may come from a population with short stature. The difference between arm span and standing or sitting height cannot be used to predict vertebral fracture risk...
  42. ncbi The structural and hormonal basis of sex differences in peak appendicular bone strength in rats
    Bom Taeck Kim
    Department of Endocrinology, Austin and Repatriation Medical Center, University of Melbourne, Melbourne, Australia
    J Bone Miner Res 18:150-5. 2003
    ..The hormonal regulation of bone surfaces establishes the amount and spatial distribution of bone and so the sexual dimorphism in its strength...
  43. ncbi Strontium ranelate: vertebral and non-vertebral fracture risk reduction
    Ego Seeman
    Austin Health, University of Melbourne, Melbourne, Australia
    Curr Opin Rheumatol 18:S17-20. 2006
    ..Strontium ranelate, a new anti-osteoporosis agent, has a broad range of antifracture efficacy...
  44. ncbi Familial resemblance and diversity in bone mass and strength in the population are established during the first year of postnatal life
    Qingju Wang
    Endocrine Centre, Austin Health, University of Melbourne, Melbourne, Australia
    J Bone Miner Res 25:1512-20. 2010
    ..Thus susceptibility to bone fragility late in life has its antecedents established early in life...
  45. ncbi Femoral neck shape and the spatial distribution of its mineral mass varies with its size: Clinical and biomechanical implications
    Roger M D Zebaze
    Austin Hospital, University of Melbourne, Heidelberg 3084, Melbourne, Australia
    Bone 37:243-52. 2005
    ..Studies are needed to determine the effects of age, sex, and race on FN size and shape in health and disease...
  46. doi Architecture of cortical bone determines in part its remodelling and structural decay
    Minh Bui
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia
    Bone 55:353-8. 2013
    ..001) after, adjusting for her own remodelling PC (22% higher; p = 0.7). The structure of bone, its surface area to bone matrix volume configuration, might contribute in part to its own remodelling and deterioration, but not vice versa...
  47. doi Skeletal growth and peak bone strength
    Qingju Wang
    Endocrine Centre, Centaur Building, Heidelberg Repatriation Hospital Austin Health, Heidelberg, Victoria, Australia
    Best Pract Res Clin Endocrinol Metab 22:687-700. 2008
    ..The machinery has enormous capacity during growth, as can be seen in the bone structure of the elite athlete, but not during advancing age because of changes in the cellular machinery itself and in systemic hormonal regulatory factors...
  48. doi Bone's structural diversity in adult females is established before puberty
    Qingju Wang
    Austin Health, University of Melbourne, Heidelberg 3081, Melbourne, Australia
    J Clin Endocrinol Metab 94:1555-61. 2009
    ..Bone must be rigid for leverage yet light for mobility. We studied how bone modeling and remodeling fashioned differences in bone size, shape, and mass during growth to achieve these properties in adulthood...
  49. ncbi Seasonal periodicity of serum vitamin D and parathyroid hormone, bone resorption, and fractures: the Geelong Osteoporosis Study
    Julie A Pasco
    Department of Clinical and Biomedical Sciences Barwon Health, The University of Melbourne, Geelong, Victoria, Australia
    J Bone Miner Res 19:752-8. 2004
    ..This was associated with an increased proportion of falls resulting in fracture and an increased risk of wrist and hip fractures...
  50. ncbi Third metacarpal condylar fatigue fractures in equine athletes occur within previously modelled subchondral bone
    R Christopher Whitton
    Faculty of Veterinary Science, Equine Centre, University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
    Bone 47:826-31. 2010
    ....
  51. ncbi During aging, men lose less bone than women because they gain more periosteal bone, not because they resorb less endosteal bone
    E Seeman
    Austin and Repatriation Medical Centre, The University of Melbourne, Victoria, Australia
    Calcif Tissue Int 69:205-8. 2001
    ..Fewer men than women are at risk for fracture because fewer men than women have these structural determinants of bone strength below a level at which the loads exceed the bone's ability to tolerate them...
  52. doi Women and men with hip fractures have a longer femoral neck moment arm and greater impact load in a sideways fall
    Q Wang
    Endocrine Centre, Department of Medicine Austin Health, The University of Melbourne, Victoria, Australia
    Osteoporos Int 20:1151-6. 2009
    ..We hypothesized that the hip geometry in elderly with hip fractures produces a greater impact on the hip during a sideways fall...
  53. doi The heterogeneity in femoral neck structure and strength
    Mariana E Kersh
    Department of Mechanical Engineering, University of Melbourne, Parkville, Australia
    J Bone Miner Res 28:1022-8. 2013
    ..001). Heterogeneity in the structure of the femoral neck determines the diversity of its strength. The median cortical thickness best predicted peak femoral neck stress and is likely to be a relevant predictor of femoral neck fragility...
  54. doi Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy
    Cherie Ying Chiang
    Department of Endocrinology, Austin Health, University of Melbourne, Melbourne, Australia
    Bone 52:360-5. 2013
    ..Teriparatide may assist in healing of atypical fractures and restoration of bone quality...
  55. doi Bone remodelling: its local regulation and the emergence of bone fragility
    T John Martin
    University of Melbourne, Melbourne, Australia
    Best Pract Res Clin Endocrinol Metab 22:701-22. 2008
    ....
  56. ncbi Depression in anorexia nervosa: a risk factor for osteoporosis
    Jerzy Konstantynowicz
    Department of Pediatrics and Auxology, Medical University of Bialystok, University Children s Hospital Dr Ludwik Zamenhof, 15 274 Bialystok, Poland
    J Clin Endocrinol Metab 90:5382-5. 2005
    ..Both anorexia nervosa (AN) and depression are associated with osteoporosis. We hypothesized that adolescent girls with AN and depression will have lower bone mineral density (BMD) than anorexic girls without depression...
  57. ncbi The characteristics of fractures in Polish adolescents aged 16-20 years
    Jerzy Konstantynowicz
    Department of Pediatrics and Auxology, Children s Hospital Dr L Zamenhof, Medical University of Bialystok, Bialystok, Poland
    Osteoporos Int 16:1397-403. 2005
    ..Fractures, particularly multiple fractures, are common in childhood and adolescence. Familial clustering of fractures suggests shared genetic and environmental factors are responsible...
  58. ncbi Bone fragility in Asian and Caucasian men
    Y Duan
    Department of Endocrinology and Medicine, Austin and Repatriation Medical Centre, University of Melbourne, Australia
    Ann Acad Med Singapore 31:54-66. 2002
    ..The results of this work will provide important insights into the pathophysiology of bone fragility in both groups...
  59. ncbi The contribution of reduced peak accrual of bone and age-related bone loss to osteoporosis at the spine and hip: insights from the daughters of women with vertebral or hip fractures
    A Tabensky
    Department of Endocrinology, Austin and Repatriation Medical Center, University of Melbourne, Heidelberg, Australia
    J Bone Miner Res 16:1101-7. 2001
    ..The pathogenesis of bone fragility at the axial and appendicular skeleton is heterogeneous and has its origins in growth and aging...
  60. ncbi Reconstructing the skeleton with intermittent parathyroid hormone
    E Seeman
    Austin and Repatriation Medical Centre, University of Melbourne, Vic, Australia
    Trends Endocrinol Metab 12:281-3. 2001
    ....
  61. ncbi Osteoporosis in men--consensus is premature
    E Seeman
    Austin Hospital, Heidelberg, 3084, Melbourne, Victoria, Australia
    Calcif Tissue Int 75:120-2. 2004
  62. doi Skeletal and hormonal responses to sunlight deprivation in Antarctic expeditioners
    S Iuliano-Burns
    Austin Health, University of Melbourne, West Heidelberg, Australia
    Osteoporos Int 20:1523-8. 2009
    ..With emerging vitamin D insufficiency, serum calcium decreased, PTH increased, and bone loss at the proximal femur was observed. Baseline serum 25(OH)D levels >100 nmol/L prevented vitamin D insufficiency...
  63. ncbi Sexual dimorphism in vertebral fragility is more the result of gender differences in age-related bone gain than bone loss
    Y Duan
    Department of Endocrinology, Austin and Repatriation Medical Center, University of Melbourne, Heidelberg, Australia
    J Bone Miner Res 16:2267-75. 2001
    ..Sexual dimorphism in vertebral fragility is more the result of gender differences in age-related bone gain than age-related bone loss...
  64. ncbi Skeletal benefits from calcium supplementation are limited in children with calcium intakes near 800 mg daily
    S Iuliano-Burns
    Department of Endocrinology, Austin Health, University of Melbourne, Waterdale Rd, West Heidelberg 3081, Australia
    Osteoporos Int 17:1794-800. 2006
    ..We tested the hypothesis that calcium from milk minerals but not calcium carbonate will be sustained after supplementation was discontinued...
  65. ncbi Osteocytes--martyrs for integrity of bone strength
    E Seeman
    Austin Health, University of Melbourne, Melbourne, Australia
    Osteoporos Int 17:1443-8. 2006
  66. doi Structural decay of bone microarchitecture in men with prostate cancer treated with androgen deprivation therapy
    E J Hamilton
    Department of Medicine, Austin Health Northern Health, University of Melbourne, Studley Road, Heidelberg, Victoria 3084, Australia
    J Clin Endocrinol Metab 95:E456-63. 2010
    ..Androgen deprivation therapy (ADT) used in the treatment of prostate cancer reduces bone mineral density (BMD) and predisposes to fractures. The structural basis of the BMD deficit and bone fragility is uncertain...
  67. ncbi The structural basis of bone fragility in men
    E Seeman
    Austin and Repatriation Medical Centre, The University of Melbourne, Australia
    Bone 25:143-7. 1999
    ..Reasonable approaches to treatment include the use of testosterone in hypogonadal men, and vitamin D if vitamin D deficiency is present. Calcium supplements may slow endocortical bone loss. Bisphosphonates may increase BMD...
  68. ncbi Differing effects of denosumab and alendronate on cortical and trabecular bone
    Roger M Zebaze
    Austin Health, University of Melbourne, Melbourne, Australia Electronic address
    Bone 59:173-9. 2014
    ..The greater reduction in cortical porosity by denosumab may be due to greater inhibition of intracortical remodeling. Head to head studies are needed to determine whether differences in porosity result in differing fracture outcomes. ..
  69. ncbi Hypocalcemia induced by raloxifene
    Thuy D T Vu
    Endocrinology Department, Austin Health, Victoria, Australia
    Curr Drug Saf 7:176-8. 2012
    ..Since vitamin D deficiency is widely prevalent in the community, screening for vitamin D deficiency and its correction is advisable before the initiation of anti-resorptive therapy...
  70. ncbi Epidemiology of hip and wrist fractures in Cameroon, Africa
    Roger Martin Djoumessi Zebaze
    Department of Endocrinology, Austin and Repatriation Medical Centre, University of Melbourne, 3084, Heidelberg, Melbourne, Australia
    Osteoporos Int 14:301-5. 2003
    ..The low incidence of fragility fractures is confirmed and is likely to be, in part, the result of reduced longevity as only 1.1% of women and 0.7% of men survive beyond 65 years of age...
  71. ncbi Fracture site-specific deficits in bone size and volumetric density in men with spine or hip fractures
    E Seeman
    Department of Endocrinology, Austin and Repatriation Medical Center, University of Melbourne, Victoria, Australia
    J Bone Miner Res 16:120-7. 2001
    ..Bone fragility leading to spine or hip fractures in men may be the result of fracture site-specific deficits in bone size and vBMD that have their origins in growth, aging, or both...
  72. ncbi Loss of regularity in the curvature of the thoracolumbar spine: a measure of structural failure
    Roger M D Zebaze
    Department of Endocrinology, Austin and Repatriation Medical Centre, University of Melbourne, Melbourne, Australia
    J Bone Miner Res 19:1099-104. 2004
    ..Departure from regularity (smoothness) in the curvature of the spine was quantified and correlated with the number of fractures, deficits in height, BMD, and identified women with vertebral fractures...
  73. doi Differences in the degree of bone tissue mineralization account for little of the differences in tissue elastic properties
    Roger M D Zebaze
    Departments of Endocrinology and Medicine, Austin Health, University of Melbourne, Melbourne, Australia
    Bone 48:1246-51. 2011
    ..Other material properties need to be taken into account to more fully predict variation in tissue elastic modulus...
  74. ncbi Invited Review: Pathogenesis of osteoporosis
    Ego Seeman
    Dept of Endocrinology, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, Melbourne 3084, Australia
    J Appl Physiol 95:2142-51. 2003
    ..More women than men experience fractures because their smaller skeleton incurs greater architectural damage and adapts less by periosteal apposition...
  75. ncbi Calcitriol does not prevent bone loss in patients with asthma receiving corticosteroid therapy: a double-blind placebo-controlled trial
    C F McDonald
    Department of Respiratory and Sleep Medicine, Austin Hospital, Heidelberg, Victoria, 3084, Australia
    Osteoporos Int 17:1546-51. 2006
    ..Patients with asthma receiving inhalational plus intermittent oral glucocorticoids lose bone, and treatment with 0.5 microg/day of calcitriol will prevent bone loss...
  76. ncbi Risedronate slows or partly reverses cortical and trabecular microarchitectural deterioration in postmenopausal women
    Yohann Bala
    Endocrine Center, Austin Health, University of Melbourne, Melbourne, Australia
    J Bone Miner Res 29:380-8. 2014
    ..005). Risedronate slows microstructural deterioration in younger and partly reverses it in older postmenopausal women, features likely to contribute to antifracture efficacy. © 2014 American Society for Bone and Mineral Research. ..
  77. pmc Seizures after alendronate
    Richard J Maclsaac
    Endocrinology Unit and Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Studley Road, Heidelberg, Victoria, 3084, Australia
    J R Soc Med 95:615-6. 2002
  78. ncbi Bone mass during growth: the effects of exercise. Exercise and mineral accrual
    S Bass
    Department of Medicine, Austin Hospital, University of Melbourne, Victorian Institute of Sport, Australia
    Acta Univ Carol Med (Praha) 40:3-6. 1994
    ..In gymnasts, BMD was 10-15 percent (or 1 SD) higher than the bone age-predicted mean. Exercise may not offset the effects of amenorrhea. Bone loss may continue but from a higher level, perhaps attained prior puberty...
  79. ncbi Unresolved issues in osteoporosis in men
    E Seeman
    Austin and Repatriation Medical Center, University of Melbourne, Melbourne, Australia
    Rev Endocr Metab Disord 2:45-64. 2001
    ..The gaps in our knowledge remain large...
  80. ncbi The effect of mechanical loading on the size and shape of bone in pre-, peri-, and postpubertal girls: a study in tennis players
    S L Bass
    School of Health Sciences, Deakin University, Melbourne, Australia
    J Bone Miner Res 17:2274-80. 2002
    ..Increasing the bone's resistance to torsion is achieved by modifying bone shape and mass, not necessarily bone density...
  81. ncbi Comparison of sequential cyproterone acetate/estrogen versus spironolactone/oral contraceptive in the treatment of hirsutism
    R C O'Brien
    Department of Endocrinology, Austin Hospital, Heidelberg, Victoria, Australia
    J Clin Endocrinol Metab 72:1008-13. 1991
    ..We conclude that spironolactone and CPA, in the dosages used in this study, are effective and well tolerated agents for the treatment of hirsutism, and that neither drug demonstrates a particular advantage over the other...
  82. ncbi The biomechanical basis of vertebral body fragility in men and women
    Y Duan
    Department of Endocrinology, Austin and Repatriation Medical Center, University of Melbourne, Australia
    J Bone Miner Res 16:2276-83. 2001
    ..The results show that a fracture threshold for vertebrae can be defined using established biomechanical principles; whether this approach has greater sensitivity and specificity than the current BMD T score of -2.5 SD is unknown...
  83. ncbi Structural adaptations to bone loss in aging men and women
    Cosimo Roberto Russo
    Laboratory of Clinical Epidemiology, INRCA Geriatric Department, Florence, Italy
    Bone 38:112-8. 2006
    ..Th) and the distance the cortex is placed from the neutral axis of a long bone, all determinants of bone strength. We tested the hypothesis that sex-related differences in these processes produces a sexual dimorphism in tibial fragility...
  84. ncbi Alendronate and vertebral fracture risk
    Ego Seeman
    Mayo Clin Proc 80:1236, 1238; author reply 1238, 1240. 2005
  85. ncbi Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study
    Julie A Pasco
    Department of Clinical and Biomedical Sciences Barwon Health, The University of Melbourne, Geelong, Australia
    J Bone Miner Res 19:19-24. 2004
    ..49-0.96). Beta-blockers were associated with higher BMD at the total hip (2.5%) and UD forearm (3.6%) after adjusting for age, anthropometry, and thiazide use. Beta-blocker use is associated with reduced fracture risk and higher BMD...
  86. ncbi Hormone therapy and risk of non-vertebral fracture: Geelong osteoporosis study
    Julie A Pasco
    Department of Clinical and Biomedical Sciences Barwon Health, The University of Melbourne, P O Box 281, 3220 Geelong, Australia
    Osteoporos Int 15:434-8. 2004
    ..53 (95% CI 0.31-0.92). HT use was associated with 2.6-7.5% higher BMD at axial and appendicular sites. HT use is associated with a halving of risk for non-vertebral fractures and higher BMD...
  87. ncbi Bone quality
    Ego Seeman
    Osteoporos Int 14:S3-7. 2003
  88. ncbi Efficacy of risedronate on clinical vertebral fractures within six months
    Christian Roux
    Cochin Hospital, Rene Descartes University, Paris, France
    Curr Med Res Opin 20:433-9. 2004
    ..Risedronate has been shown to reduce the incidence of radiographically-defined vertebral fractures by approximately two-thirds within 1 year...
  89. ncbi A comparison of the effects of raloxifene and conjugated equine estrogen on bone and lipids in healthy postmenopausal women
    Ian R Reid
    Department of Medicine, University of Auckland, PB 92019, Auckland, New Zealand
    Arch Intern Med 164:871-9. 2004
    ..Although many studies have assessed the effects of estrogen and raloxifene hydrochloride on bone mineral density and serum lipid concentrations, there are few direct comparative data...
  90. ncbi Changes in bone mineral density explain little of the reduction in vertebral or nonvertebral fracture risk with anti-resorptive therapy
    Pierre D Delmas
    Claude Bernard University of Lyon and INSERM Research Unit 403, Lyon, France
    Bone 34:599-604. 2004
    ..Further studies are needed to define the structural basis of the fracture risk reduction...
  91. ncbi The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    Pierre J Meunier
    Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyons, France
    N Engl J Med 350:459-68. 2004
    ....
  92. ncbi Half the burden of fragility fractures in the community occur in women without osteoporosis. When is fracture prevention cost-effective?
    Kerrie M Sanders
    Department of Clinical and Biomedical Sciences, Barwon Health, The University of Melbourne, PO Box 281, Geelong 3220, Australia
    Bone 38:694-700. 2006
    ....
  93. ncbi Bone fragility: failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women
    Pawel Szulc
    INSERM 403 Research Unit and Université Claude Bernard Lyon, Lyon, France
    J Bone Miner Res 21:1856-63. 2006
    ..Women with highest remodeling had greatest loss of bone mass and estimated bone strength, whereas those with low remodeling lost less bone and maintained estimated bone strength...
  94. ncbi New mechanisms and targets in the treatment of bone fragility
    T John Martin
    St Vincent s Institute of Medical Research, University of Melbourne Department of Medicine, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    Clin Sci (Lond) 112:77-91. 2007
    ..The recent discovery through mouse genetics that PTHrP (PTH-related protein) is a crucial bone-derived paracrine regulator of remodelling offers new and interesting therapeutic targets...
  95. ncbi Additive effects of raloxifene and alendronate on bone density and biochemical markers of bone remodeling in postmenopausal women with osteoporosis
    Olof Johnell
    Department of Orthopaedics, Universiteitssjukhuset MAS, Malmø, Sweden
    J Clin Endocrinol Metab 87:985-92. 2002
    ..RLX+ALN reduced bone turnover more than either drug alone, resulting in greater BMD increment, but whether this difference reflects better fracture risk reduction was not assessed in this study...
  96. ncbi An exercise in geometry
    Ego Seeman
    J Bone Miner Res 17:373-80. 2002
  97. ncbi Circulating sex steroids, sex hormone-binding globulin, and longitudinal changes in forearm bone mineral density in postmenopausal women and men: the Tromsø study
    Ashild Bjørnerem
    Institute of Community Medicine, University of Tromsø, N 9037, Tromsø, Norway
    Calcif Tissue Int 81:65-72. 2007
    ..We therefore conclude that the relations between sex steroids and bone loss are weak and measurements of sex steroids are unlikely to assist in clinical decision making...
  98. ncbi Compliance with osteoporosis therapy is the weakest link
    Juliet E Compston
    Department of Medicine, University of Cambridge Clinical School, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Lancet 368:973-4. 2006
  99. ncbi Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes
    Anne Marie Sims
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Brisbane, Australia
    J Bone Miner Res 23:499-506. 2008
    ..This confirms that extreme truncate selection is a powerful design for quantitative trait association studies of bone phenotypes...
  100. ncbi Osteoporosis and the global competition for health care resources
    L Joseph Melton
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 19:1055-8. 2004
    ..To better compete for these resources, efforts should be made to lower the cost of osteoporosis interventions. Additionally, evidence is needed that these interventions are really effective in reducing fractures in the community...
  101. ncbi A prospective study of sex steroids, sex hormone-binding globulin, and non-vertebral fractures in women and men: the Tromso Study
    Ashild Bjørnerem
    Institute of Community Medicine, University of Tromsø, N 9037 Tromsø, Norway
    Eur J Endocrinol 157:119-25. 2007
    ..As bone fragility is partly the result of sex hormone deficiency, we sought to determine whether circulating sex steroids or sex hormone-binding globulin (SHBG) predicts non-vertebral fractures...