Heather L Scott

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi request reprint Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease
    Heather L Scott
    Departments of Biochemistry and Physiology and Pharmacology, University of Queensland, Brisbane, Queensland, Australia, 4072
    J Neurosci 22:RC206. 2002
  2. ncbi request reprint Quantitation of NMDA receptor NR2 mRNA transcripts in human brain by competitive RT-PCR
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    Brain Res Brain Res Protoc 11:67-79. 2003
  3. ncbi request reprint Differential expression of the GABA transporters GAT-1 and GAT-3 in brains of rats, cats, monkeys and humans
    David V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, 4072, Australia
    Cell Tissue Res 320:379-92. 2005
  4. ncbi request reprint Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease
    Matthew R Hynd
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland, Australia
    J Neurochem 90:913-9. 2004
  5. ncbi request reprint Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer's disease
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Australia
    J Neurochem 89:240-7. 2004
  6. ncbi request reprint Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Brisbane 4072, Australia
    Neurochem Int 45:583-95. 2004
  7. ncbi request reprint Glial glutamate transporter expression patterns in brains from multiple mammalian species
    Susan M Williams
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    Glia 49:520-41. 2005
  8. ncbi request reprint Selective loss of synaptic proteins in Alzheimer's disease: evidence for an increased severity with APOE varepsilon4
    Rudi K Tannenberg
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane 4072, Queensland, Australia
    Neurochem Int 49:631-9. 2006
  9. ncbi request reprint The identification and characterization of excitotoxic nerve-endings in Alzheimer disease
    Rudi K Tannenberg
    Department of Biochemistry, University of Queensland, Australia
    Curr Alzheimer Res 1:11-25. 2004
  10. ncbi request reprint Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study
    Nancy E Liyou
    School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia
    J Histochem Cytochem 51:1655-64. 2003

Collaborators

  • D V Pow
  • Peter R Dodd
  • Nancy E Liyou
  • Matthew R Hynd
  • Rudi K Tannenberg
  • Vicky W W Tsai
  • Susan M Williams
  • Anthony E G Tannenberg
  • Paul B Colditz
  • David I Finkelstein
  • Richard J Lewis
  • Barbara E Lingwood
  • Robert K P Sullivan
  • Robert I Westphalen

Detail Information

Publications12

  1. ncbi request reprint Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease
    Heather L Scott
    Departments of Biochemistry and Physiology and Pharmacology, University of Queensland, Brisbane, Queensland, Australia, 4072
    J Neurosci 22:RC206. 2002
    ..This study implicates aberrant glutamate transporter expression as a mechanism involved in neurodegeneration in Alzheimer's disease...
  2. ncbi request reprint Quantitation of NMDA receptor NR2 mRNA transcripts in human brain by competitive RT-PCR
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    Brain Res Brain Res Protoc 11:67-79. 2003
    ..Used in conjunction with a method for the quantitation of hNR1 transcripts [Brain Res. Protoc., in press], a complete analysis of NMDA receptor mRNA expression can be obtained...
  3. ncbi request reprint Differential expression of the GABA transporters GAT-1 and GAT-3 in brains of rats, cats, monkeys and humans
    David V Pow
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, 4072, Australia
    Cell Tissue Res 320:379-92. 2005
    ..We suggest that differences in GAT distribution, especially the expression of GAT-3 by oligodendrocytes in humans, must be accommodated in extrapolating rodent models of GABA homeostasis to humans...
  4. ncbi request reprint Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease
    Matthew R Hynd
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland, Australia
    J Neurochem 90:913-9. 2004
    ..The results suggest that NR2 subunit composition may modulate NMDA receptor-mediated excitotoxicity. NMDA receptor dysfunction might give rise to the regionally selective pattern of neuronal loss that is characteristic of AD...
  5. ncbi request reprint Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer's disease
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Australia
    J Neurochem 89:240-7. 2004
    ..Cells that express NR1 subunits with the N-terminal cassette may be selectively vulnerable to toxicity in AD...
  6. ncbi request reprint Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Brisbane 4072, Australia
    Neurochem Int 45:583-95. 2004
    ..This review discusses mechanisms for the involvement of the NMDA receptor complex and its interaction with polyamines in the pathogenesis of AD. NMDA receptor antagonists have potential for the therapeutic amelioration of AD...
  7. ncbi request reprint Glial glutamate transporter expression patterns in brains from multiple mammalian species
    Susan M Williams
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    Glia 49:520-41. 2005
    ..Collectively our data suggest that assumptions as to the roles of glutamate transporters in any species may need to be tested empirically...
  8. ncbi request reprint Selective loss of synaptic proteins in Alzheimer's disease: evidence for an increased severity with APOE varepsilon4
    Rudi K Tannenberg
    School of Molecular and Microbial Sciences, University of Queensland, Brisbane 4072, Queensland, Australia
    Neurochem Int 49:631-9. 2006
    ....
  9. ncbi request reprint The identification and characterization of excitotoxic nerve-endings in Alzheimer disease
    Rudi K Tannenberg
    Department of Biochemistry, University of Queensland, Australia
    Curr Alzheimer Res 1:11-25. 2004
    ..We discuss experimental methods to quantitate synapses, which are crucial for deciding between the various possibilities...
  10. ncbi request reprint Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study
    Nancy E Liyou
    School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia
    J Histochem Cytochem 51:1655-64. 2003
    ..The findings from this study may assist in determining the physiological role of this SULT isoform...
  11. ncbi request reprint Quantitation of alternatively spliced NMDA receptor NR1 isoform mRNA transcripts in human brain by competitive RT-PCR
    Matthew R Hynd
    Department of Biochemistry, University of Queensland, Brisbane 4072, Australia
    Brain Res Brain Res Protoc 11:52-66. 2003
    ..Neurochem. 78 (2001) 175]. Furthermore, alterations in hNR1 mRNA expression may be reflected at the translational level, resulting in functional changes in the NMDA receptor...
  12. ncbi request reprint The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer's disease
    Vicky W W Tsai
    School of Molecular and Microbial Sciences and Institute for Molecular Bioscience, University of Queensland, Brisbane 4072 Australia
    Neurotox Res 7:125-41. 2005
    ..They represent a pharmacological path to a relatively subtle amelioration of neurotoxicity because they serve a modulatory rather than a direct role in excitatory glutamatergic transmission...