Sibylle G Schwab

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1-, and DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophrenia
    Sibylle G Schwab
    Molecular Genetics Laboratory, Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 114:315-20. 2002
  2. doi request reprint DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study
    Sibylle G Schwab
    Western Australian Institute of Medical Research and Centre for Medical Research, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Psychiatr Genet 18:25-30. 2008
  3. doi request reprint Update on key previously proposed candidate genes for schizophrenia
    Sibylle G Schwab
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Nedlands, Australia
    Curr Opin Psychiatry 22:147-53. 2009
  4. ncbi request reprint Research on causes for schizophrenia: are we close?
    Sibylle G Schwab
    Western Australian Institute for Medical Research and Centre for Medical Research, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Schizophr Res 102:29-30. 2008
  5. ncbi request reprint Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence
    Sibylle G Schwab
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
    Neuropsychopharmacology 30:2263-8. 2005
  6. ncbi request reprint Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families
    Sibylle G Schwab
    Western Australian Institute of Medical Research, University of Western Australia, Perth, Australia
    Biol Psychiatry 58:446-50. 2005
  7. doi request reprint A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population
    Clarissa Ganda
    Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Perth, WA, Australia
    Int J Neuropsychopharmacol 12:1283-9. 2009
  8. doi request reprint No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry
    Herbert P Ludewick
    Western Australian Institute of Medical Research and Centre for Medical Research, University of Western Australia, School of Psychiatry and Clinical Neuroscience, Nedlands, WA 6009, Australia
    Psychiatr Genet 18:208-10. 2008
  9. ncbi request reprint No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:739-41. 2002
  10. pmc Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families
    Sibylle G Schwab
    Molecular Genetics Laboratory, University of Bonn, Bonn, Germany
    Am J Hum Genet 72:185-90. 2003

Detail Information

Publications20

  1. ncbi request reprint Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1-, and DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophrenia
    Sibylle G Schwab
    Molecular Genetics Laboratory, Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 114:315-20. 2002
    ..Our results are not in favor of a direct involvement of the HLA system in development of schizophrenia, but are compatible with the possible existence of a susceptibility gene in the MHC region at chromosome 6p 21.31...
  2. doi request reprint DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study
    Sibylle G Schwab
    Western Australian Institute of Medical Research and Centre for Medical Research, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Psychiatr Genet 18:25-30. 2008
    ..In this study, we focused on DNA sequence variants, for which association was reported and attempted to replicate association with schizophrenia or with cognitive deficits known to be present in patients with schizophrenia...
  3. doi request reprint Update on key previously proposed candidate genes for schizophrenia
    Sibylle G Schwab
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Nedlands, Australia
    Curr Opin Psychiatry 22:147-53. 2009
    ..This includes functional data when available. Furthermore, studies on copy number repeats and their possible implications in schizophrenia will be described...
  4. ncbi request reprint Research on causes for schizophrenia: are we close?
    Sibylle G Schwab
    Western Australian Institute for Medical Research and Centre for Medical Research, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
    Schizophr Res 102:29-30. 2008
  5. ncbi request reprint Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependence
    Sibylle G Schwab
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
    Neuropsychopharmacology 30:2263-8. 2005
    ..0044). We conclude that DNA polymorphisms located in SLC18A2 might contribute to the development of substance dependence...
  6. ncbi request reprint Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families
    Sibylle G Schwab
    Western Australian Institute of Medical Research, University of Western Australia, Perth, Australia
    Biol Psychiatry 58:446-50. 2005
    ..In addition to impairment of protein-levels and phosphorylation levels in the pathway, association of DNA sequence variants in the AKT1 gene with schizophrenia has been detected in a family sample...
  7. doi request reprint A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population
    Clarissa Ganda
    Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Perth, WA, Australia
    Int J Neuropsychopharmacol 12:1283-9. 2009
    ..The results from our study provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. Further studies supporting this finding are warranted...
  8. doi request reprint No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry
    Herbert P Ludewick
    Western Australian Institute of Medical Research and Centre for Medical Research, University of Western Australia, School of Psychiatry and Clinical Neuroscience, Nedlands, WA 6009, Australia
    Psychiatr Genet 18:208-10. 2008
    ..2). We conclude that trace amine associated receptor 6 is not important for the development of schizophrenia in our family samples...
  9. ncbi request reprint No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:739-41. 2002
    ..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
  10. pmc Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families
    Sibylle G Schwab
    Molecular Genetics Laboratory, University of Bonn, Bonn, Germany
    Am J Hum Genet 72:185-90. 2003
    ....
  11. doi request reprint Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neurosci Lett 440:68-71. 2008
    ..15). We found a SORL1 haplotype which was associated with CSF levels of amyloid-beta cleavage products, measured as altered levels of Abeta42. Thus our data suggest that SORL1 gene variants might influence AD pathology...
  12. doi request reprint Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 64:434-7. 2008
    ..Moreover, both schizophrenia and PPI are thought to be inheritable. We investigated the impact of three 5-HT(2A)R polymorphisms (A-1438G, T102C, H452Y) on PPI in schizophrenia patients...
  13. ncbi request reprint Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence
    Petra Franke
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Psychiatry 18:18-22. 2003
    ..In a modified case-control association study we tested the assumption that two polymorphisms (A(118)G in exon 1 and IVS2+31 in intron 2) of the human mu-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence...
  14. ncbi request reprint Homozygosity of the interleukin-10 receptor 1 G330R allele is associated with schizophrenia
    Alexandra Schosser
    Department of General Psychiatry, University Hospital for Psychiatry, Medical University Vienna, Vienna, Austria
    Am J Med Genet B Neuropsychiatr Genet 144:347-50. 2007
    ..032). No such difference was seen for S138G. Our results suggest that homozygosity of the IL-10R1 G330R allele is associated with schizophrenia and may contribute to the expression of disease phenotype in susceptible individuals...
  15. ncbi request reprint Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia
    Xiangning Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richimond, VA 23298, USA
    Hum Mol Genet 15:3329-42. 2006
    ..However, due to the extended high LD in this region, we were unable to distinguish whether the association signals came from one or more of these genes...
  16. ncbi request reprint Lack of association of alpha-1 antichymotrypsin gene polymorphism with PR3-ANCA and MPO-ANCA associated vasculitis
    Stefan Borgmann
    Department of Medical Microbiology, University of Tubingen, Tubingen, Germany
    Autoimmunity 35:435-9. 2002
    ..Therefore, we can not support the hypothesis that AACT polymorphism contributes to the pathogenesis of PR3-ANCA vasculitis. Nor is it probable that any factor, coded by the serpin gene cluster, contributes to MPO-ANCA vasculitis...
  17. ncbi request reprint Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations
    Ke Xu
    Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Arch Gen Psychiatry 61:597-606. 2004
    ..Dopamine receptor-mediated pathways play critical roles in the mechanism of addiction. However, associations of the D(2) dopamine receptor gene (DRD2) with substance abuse are controversial...
  18. ncbi request reprint Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia
    Sibylle G Schwab
    Department of Psychiatry, University of Bonn, Wilhelmstr 31, D 53111 Bonn, Germany
    Schizophr Res 65:19-25. 2003
    ..3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFalpha gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]...
  19. ncbi request reprint Genetics of complex psychiatric disorders: scientific foundations
    Dieter B Wildenauer
    Molecular Genetics Laboratory, Department of Psychiatry, University of Bonn, Wilhelmstr 31 D 53111 Bonn, Germany
    Isr J Psychiatry Relat Sci 39:232-9. 2002
    ..We explain and discuss the association approach in conjunction with the Human Genome Project. Finally, we stress possible implications for diagnosis, prevention and new therapeutic approaches...
  20. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
    Cathryn M Lewis
    Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Am J Hum Genet 73:34-48. 2003
    ..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...