Sibylle G Schwab
Affiliation: University of Western Australia
- Investigation of linkage and association/linkage disequilibrium of HLA A-, DQA1-, DQB1-, and DRB1-alleles in 69 sib-pair- and 89 trio-families with schizophreniaSibylle G Schwab
Molecular Genetics Laboratory, Department of Psychiatry, University of Bonn, Bonn, Germany
Am J Med Genet 114:315-20. 2002..Our results are not in favor of a direct involvement of the HLA system in development of schizophrenia, but are compatible with the possible existence of a susceptibility gene in the MHC region at chromosome 6p 21.31...
- DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association studySibylle G Schwab
Western Australian Institute of Medical Research and Centre for Medical Research, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
Psychiatr Genet 18:25-30. 2008..In this study, we focused on DNA sequence variants, for which association was reported and attempted to replicate association with schizophrenia or with cognitive deficits known to be present in patients with schizophrenia...
- Update on key previously proposed candidate genes for schizophreniaSibylle G Schwab
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Nedlands, Australia
Curr Opin Psychiatry 22:147-53. 2009..This includes functional data when available. Furthermore, studies on copy number repeats and their possible implications in schizophrenia will be described...
- Research on causes for schizophrenia: are we close?Sibylle G Schwab
Western Australian Institute for Medical Research and Centre for Medical Research, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
Schizophr Res 102:29-30. 2008
- Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLC18A2) with alcohol and nicotine dependenceSibylle G Schwab
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia
Neuropsychopharmacology 30:2263-8. 2005..0044). We conclude that DNA polymorphisms located in SLC18A2 might contribute to the development of substance dependence...
- Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair familiesSibylle G Schwab
Western Australian Institute of Medical Research, University of Western Australia, Perth, Australia
Biol Psychiatry 58:446-50. 2005..In addition to impairment of protein-levels and phosphorylation levels in the pathway, association of DNA sequence variants in the AKT1 gene with schizophrenia has been detected in a family sample...
- A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian populationClarissa Ganda
Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Perth, WA, Australia
Int J Neuropsychopharmacol 12:1283-9. 2009..The results from our study provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. Further studies supporting this finding are warranted...
- No support for an association with TAAR6 and schizophrenia in a linked population of European ancestryHerbert P Ludewick
Western Australian Institute of Medical Research and Centre for Medical Research, University of Western Australia, School of Psychiatry and Clinical Neuroscience, Nedlands, WA 6009, Australia
Psychiatr Genet 18:208-10. 2008..2). We conclude that trace amine associated receptor 6 is not important for the development of schizophrenia in our family samples...
- No major schizophrenia locus detected on chromosome 1q in a large multicenter sampleDouglas F Levinson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 296:739-41. 2002..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
- Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad familiesSibylle G Schwab
Molecular Genetics Laboratory, University of Bonn, Bonn, Germany
Am J Hum Genet 72:185-90. 2003....
- Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's diseaseHeike Kolsch
Department of Psychiatry, University of Bonn, Bonn, Germany
Neurosci Lett 440:68-71. 2008..15). We found a SORL1 haplotype which was associated with CSF levels of amyloid-beta cleavage products, measured as altered levels of Abeta42. Thus our data suggest that SORL1 gene variants might influence AD pathology...
- Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphismsBoris B Quednow
Department of Psychiatry, University of Bonn, Germany
Biol Psychiatry 64:434-7. 2008..Moreover, both schizophrenia and PPI are thought to be inheritable. We investigated the impact of three 5-HT(2A)R polymorphisms (A-1438G, T102C, H452Y) on PPI in schizophrenia patients...
- Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependencePetra Franke
Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
Eur Psychiatry 18:18-22. 2003..In a modified case-control association study we tested the assumption that two polymorphisms (A(118)G in exon 1 and IVS2+31 in intron 2) of the human mu-opioid receptor gene (OPRM1) confer susceptibility to opioid dependence...
- Homozygosity of the interleukin-10 receptor 1 G330R allele is associated with schizophreniaAlexandra Schosser
Department of General Psychiatry, University Hospital for Psychiatry, Medical University Vienna, Vienna, Austria
Am J Med Genet B Neuropsychiatr Genet 144:347-50. 2007..032). No such difference was seen for S138G. Our results suggest that homozygosity of the IL-10R1 G330R allele is associated with schizophrenia and may contribute to the expression of disease phenotype in susceptible individuals...
- Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophreniaXiangning Chen
Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richimond, VA 23298, USA
Hum Mol Genet 15:3329-42. 2006..However, due to the extended high LD in this region, we were unable to distinguish whether the association signals came from one or more of these genes...
- Lack of association of alpha-1 antichymotrypsin gene polymorphism with PR3-ANCA and MPO-ANCA associated vasculitisStefan Borgmann
Department of Medical Microbiology, University of Tubingen, Tubingen, Germany
Autoimmunity 35:435-9. 2002..Therefore, we can not support the hypothesis that AACT polymorphism contributes to the pathogenesis of PR3-ANCA vasculitis. Nor is it probable that any factor, coded by the serpin gene cluster, contributes to MPO-ANCA vasculitis...
- Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populationsKe Xu
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
Arch Gen Psychiatry 61:597-606. 2004..Dopamine receptor-mediated pathways play critical roles in the mechanism of addiction. However, associations of the D(2) dopamine receptor gene (DRD2) with substance abuse are controversial...
- Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophreniaSibylle G Schwab
Department of Psychiatry, University of Bonn, Wilhelmstr 31, D 53111 Bonn, Germany
Schizophr Res 65:19-25. 2003..3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFalpha gene polymorphism with schizophrenia has been reported [Mol. Psychiatry 6 (2001) 79]...
- Genetics of complex psychiatric disorders: scientific foundationsDieter B Wildenauer
Molecular Genetics Laboratory, Department of Psychiatry, University of Bonn, Wilhelmstr 31 D 53111 Bonn, Germany
Isr J Psychiatry Relat Sci 39:232-9. 2002..We explain and discuss the association approach in conjunction with the Human Genome Project. Finally, we stress possible implications for diagnosis, prevention and new therapeutic approaches...
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: SchizophreniaCathryn M Lewis
Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
Am J Hum Genet 73:34-48. 2003..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...