Nicole Schonrock

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. pmc Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta
    Nicole Schonrock
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 5:e11070. 2010
  2. doi request reprint Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    Neurodegener Dis 5:179-81. 2008
  3. ncbi request reprint A decade of tau transgenic animal models and beyond
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    Brain Pathol 17:91-103. 2007
  4. ncbi request reprint Alzheimer's disease selective vulnerability and modeling in transgenic mice
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    J Alzheimers Dis 18:243-51. 2009
  5. ncbi request reprint Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods?
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    J Alzheimers Dis 14:423-9. 2008
  6. doi request reprint Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β
    Nicole Schonrock
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, 2050, Camperdown, Sydney, NSW, Australia
    J Mol Neurosci 46:324-35. 2012
  7. ncbi request reprint Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy?
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    Med J Aust 185:381-4. 2006
  8. pmc An update on the toxicity of Abeta in Alzheimer's disease
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Neuropsychiatr Dis Treat 4:1033-42. 2008

Detail Information

Publications8

  1. pmc Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta
    Nicole Schonrock
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 5:e11070. 2010
    ..Taken together, our findings suggest that neuronal miRNA deregulation in response to an insult by Abeta may be an important factor contributing to the cascade of events leading to AD...
  2. doi request reprint Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    Neurodegener Dis 5:179-81. 2008
    ..Furthermore, in cell culture, Abeta(42) induces tau aggregation. While both Abeta(42) and mutant tau cause neuronal dysfunction, their modes of action are only vaguely understood...
  3. ncbi request reprint A decade of tau transgenic animal models and beyond
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    Brain Pathol 17:91-103. 2007
    ..Moreover, the existence of a number of neurodegenerative diseases with tau pathology in the absence of extracellular deposits underscores the relevance of research on tau...
  4. ncbi request reprint Alzheimer's disease selective vulnerability and modeling in transgenic mice
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    J Alzheimers Dis 18:243-51. 2009
    ..We suggest, since transgenic animal models of disease reproduce aspects of selective vulnerability, that these models offer a valuable system for future investigations into the physiological basis of selective vulnerability...
  5. ncbi request reprint Is tau aggregation toxic or protective: a sensible question in the absence of sensitive methods?
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia
    J Alzheimers Dis 14:423-9. 2008
    ..We discuss ways of how tau aggregation is monitored in these mice and what the detection limits are of these methods. We conclude that new tools are needed to measure the different stages of tau aggregation...
  6. doi request reprint Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β
    Nicole Schonrock
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, 2050, Camperdown, Sydney, NSW, Australia
    J Mol Neurosci 46:324-35. 2012
    ..Taken together, our study identifies putative target genes of miRNAs miR-9 and 181c, which may function in brain homeostasis and disease pathogenesis...
  7. ncbi request reprint Alzheimer's disease and frontotemporal dementia: prospects of a tailored therapy?
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia
    Med J Aust 185:381-4. 2006
    ..More than 50 drugs are currently in clinical trials, and novel and more effective drugs targeting both AD and FTD are expected to become available within 5-10 years...
  8. pmc An update on the toxicity of Abeta in Alzheimer's disease
    Jürgen Götz
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Neuropsychiatr Dis Treat 4:1033-42. 2008
    ..We discuss which of these conformations exert toxicity, highlight molecular pathways involved and discuss what has been learned by applying functional genomics...