Mark A Schembri

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. Coggon C, Jiang A, Goh K, Henderson I, Schembri M, Wells T. A Novel Method of Serum Resistance by Escherichia coli That Causes Urosepsis. MBio. 2018;9: pubmed publisher
  2. Forde B, Phan M, Gawthorne J, Ashcroft M, Stanton Cook M, Sarkar S, et al. Lineage-Specific Methyltransferases Define the Methylome of the Globally Disseminated Escherichia coli ST131 Clone. MBio. 2015;6:e01602-15 pubmed publisher
    ..Overall, our analysis highlights the potential for DNA methylation to dramatically influence gene regulation at the transcriptional level within a well-defined E. coli clone. ..
  3. Ben Zakour N, Alsheikh Hussain A, Ashcroft M, Khanh Nhu N, Roberts L, Stanton Cook M, et al. Sequential Acquisition of Virulence and Fluoroquinolone Resistance Has Shaped the Evolution of Escherichia coli ST131. MBio. 2016;7:e00347-16 pubmed publisher
    ..Thus, ST131 has emerged by stealth, first acquiring genes associated with an increased capacity to cause human infection, and then gaining a resistance armory that has driven its massive population expansion across the globe. ..
  4. Moriel D, Heras B, Paxman J, Lo A, Tan L, Sullivan M, et al. Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic Protein. MBio. 2016;7:e02046 pubmed publisher
    ..Overall, this work suggests a potential novel contribution for IrmA in UPEC infection. ..
  5. Chen W, Zuo H, Rolfe B, Schembri M, Cobbold R, Zhang B, et al. Clay nanoparticles co-deliver three antigens to promote potent immune responses against pathogenic Escherichia coli. J Control Release. 2018;292:196-209 pubmed publisher
    ..The results of this study suggest that LDH and HEC offer considerable promise as effective multivalent vaccine carriers against important pathogens such as enteropathogenic E. coli. ..
  6. Nhu N, Phan M, Peters K, Lo A, Forde B, Min Chong T, et al. Discovery of New Genes Involved in Curli Production by a Uropathogenic Escherichia coli Strain from the Highly Virulent O45:K1:H7 Lineage. MBio. 2018;9: pubmed publisher
    ..In total, this study demonstrates an important role for curli as a UPEC virulence factor that promotes biofilm formation, resistance, and pathogenesis. ..
  7. Easton D, Allsopp L, Phan M, Moriel D, Goh G, Beatson S, et al. The Intimin-Like Protein FdeC Is Regulated by H-NS and Temperature in Enterohemorrhagic Escherichia coli. Appl Environ Microbiol. 2014;80:7337-47 pubmed publisher
    ..Taken together, our data suggest a role for FdeC in EHEC when it grows at temperatures above 37°C, a condition relevant to its specialized niche at the rectoanal junctions of cattle. ..
  8. Chen Z, Phan M, Bates L, Peters K, Mukerjee C, Moore K, et al. The urinary microbiome in patients with refractory urge incontinence and recurrent urinary tract infection. Int Urogynecol J. 2018;29:1775-1782 pubmed publisher
    ..Patients with refractory urge incontinence and coexistent rUTI possess a diverse urinary microbiota, suggesting that persistent bladder colonisation might augment the pathology of their chronic condition. ..
  9. Wurpel D, Totsika M, Allsopp L, Webb R, Moriel D, Schembri M. Comparative proteomics of uropathogenic Escherichia coli during growth in human urine identify UCA-like (UCL) fimbriae as an adherence factor involved in biofilm formation and binding to uroepithelial cells. J Proteomics. 2016;131:177-189 pubmed publisher
    ..Combined, this study has defined the surface proteomic profiles and core surface proteome of UPEC during growth in human urine and identified a new type of fimbriae that may contribute to UTI. ..

More Information

Publications19

  1. Schembri M, Zakour N, Phan M, Forde B, Stanton Cook M, Beatson S. Molecular Characterization of the Multidrug Resistant Escherichia coli ST131 Clone. Pathogens. 2015;4:422-30 pubmed publisher
  2. Phan M, Peters K, Sarkar S, Forde B, Lo A, Stanton Cook M, et al. Third-generation cephalosporin resistance conferred by a chromosomally encoded blaCMY-23 gene in the Escherichia coli ST131 reference strain EC958. J Antimicrob Chemother. 2015;70:1969-72 pubmed publisher
    ..This is the first known report to demonstrate the chromosomal location of blaCMY-23 in E. coli ST131. In EC958, CMY-23 plays a major role in resistance to third-generation cephalosporins and cephamycins. ..
  3. Wurpel D, Moriel D, Totsika M, Easton D, Schembri M. Comparative analysis of the uropathogenic Escherichia coli surface proteome by tandem mass-spectrometry of artificially induced outer membrane vesicles. J Proteomics. 2015;115:93-106 pubmed publisher
    ..The method enables the rapid characterisation of the E. coli surface proteome and could easily be applied to the large-scale outer membrane protein profiling of other Gram-negative bacteria. ..
  4. Nichols K, Totsika M, Moriel D, Lo A, Yang J, Wurpel D, et al. Molecular Characterization of the Vacuolating Autotransporter Toxin in Uropathogenic Escherichia coli. J Bacteriol. 2016;198:1487-98 pubmed publisher
    ..Hence, Vat is a highly conserved and tightly regulated urosepsis-associated virulence factor. ..
  5. Sarkar S, Roberts L, Phan M, Tan L, Lo A, Peters K, et al. Comprehensive analysis of type 1 fimbriae regulation in fimB-null strains from the multidrug resistant Escherichia coli ST131 clone. Mol Microbiol. 2016;101:1069-87 pubmed publisher
    ..Our results provide a comprehensive analysis of type 1 fimbriae regulation in ST131, and highlight important differences in its control compared to non-ST131 UPEC. ..
  6. Lo A, Moriel D, Phan M, Schulz B, Kidd T, Beatson S, et al. 'Omic' Approaches to Study Uropathogenic Escherichia coli Virulence. Trends Microbiol. 2017;25:729-740 pubmed publisher
    ..Here we outline this progress and present a view for future developments using these exciting forefront technologies to fully comprehend UPEC pathogenesis in the context of infection. ..
  7. Martínez Gil M, Goh K, Rackaityte E, Sakamoto C, Audrain B, Moriel D, et al. YeeJ is an inverse autotransporter from Escherichia coli that binds to peptidoglycan and promotes biofilm formation. Sci Rep. 2017;7:11326 pubmed publisher
    ..Overall, our work provides new insight into YeeJ as a member of the recently defined IAT class, and contributes to our understanding of how commensal and pathogenic E. coli colonise their environments. ..
  8. Goh K, Phan M, Forde B, Chong T, Yin W, Chan K, et al. Genome-Wide Discovery of Genes Required for Capsule Production by Uropathogenic Escherichia coli. MBio. 2017;8: pubmed publisher
    ..Our comprehensive approach uncovered new genes involved in the regulation of this key virulence determinant. ..
  9. Djoko K, Achard M, Phan M, Lo A, Miraula M, Prombhul S, et al. Copper Ions and Coordination Complexes as Novel Carbapenem Adjuvants. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..Overall, this work demonstrates the potential use of copper coordination complexes as novel carbapenemase adjuvants. ..
  10. Abraham S, Chapman T, Zhang R, Chin J, Mabbett A, Totsika M, et al. Molecular characterization of Escherichia coli strains that cause symptomatic and asymptomatic urinary tract infections. J Clin Microbiol. 2012;50:1027-30 pubmed publisher
    ..coli strains that cause UTIs. Comparative analysis identified a subgroup of strains with a high number of virulence genes (VGs) and microcins M/H47. We also identified associations between microcin genes, VGs, and specific plasmid types...