Genomes and Genes
Affiliation: Centre for Vascular Research
Location: , Australia
cardiovascular diseases, oncology, molecular biology
- Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling, and inhibits proliferationDouglas J Francis
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Circ Res 92:e70-7. 2003..As such, this study demonstrates a new role for PI-88 as an inhibitor of intimal thickening after balloon angioplasty. The full text of this article is available online at http://www.circresaha.org...
- Regulation of inducible heparanase gene transcription in activated T cells by early growth response 1Amanda M de Mestre
Cancer and Vascular Biology Group, John Curtin School of Medical Research, Australian National University, Acton ACT 2601
J Biol Chem 278:50377-85. 2003..These findings provide the first insight into the mechanisms controlling inducible transcription of the HPSE gene, and could represent an important lead into understanding how HPSE expression is deregulated in metastatic tumor cells...
- Ets-1 stimulates platelet-derived growth factor A-chain gene transcription and vascular smooth muscle cell growth via cooperative interactions with Sp1Fernando S Santiago
Centre for Vascular Research, The University of New South Wales, and the Department of Haematology, The Prince of Wales Hospital, Sydney, Australia
Circ Res 95:479-87. 2004..These findings identify a functional cis-acting element for Ets-1 in the PDGF-A promoter and demonstrate that Sp1 and Ets-1 cooperatively activate PDGF-A transcription in vascular SMCs...
- Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1Mary Yanxia Liu
Centre for Vascular Research, Department of Pathology, University of New South Wales, Sydney NSW 2052 Australia
Blood 107:2322-9. 2006..Thus, 2 separate trans-acting factors regulate PDGF-D transcription, alone and in response to oxidative stress...
- Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-cyclin D1 assemblyFernando S Santiago
Centre for Vascular Research, Department of Pathology, University of New South Wales, and Department of Haematology, The Prince of Wales Hospital, Sydney, NSW, Australia
Circ Res 101:146-55. 2007..These findings define a new role for YY1 as both an inducer of p53 instability in smooth muscle cells, and an indirect repressor of p21(WAF1/Cip1) transcription, p21(WAF1/Cip1)-cdk4-cyclin D1 assembly and intimal thickening...
- Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1Nicole Y Tan
Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, Australia
Circ Res 102:e38-51. 2008..This study provides new insights into the regulatory mechanisms controlling the PKC-zeta-phospho-Sp1 axis and angiotensin II-inducible gene expression...
- Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcriptionBo Wang
Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
Arterioscler Thromb Vasc Biol 30:536-45. 2010..EGR-1 autoregulation, and histone modification in the EGR-1 promoter, represent key mechanisms in EGR-1 control, but have not been explored...
- Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion moleculesQiang Cheng
Department of Medicine, Monash Medical Centre, Centre for Inflammatory Diseases, Monash University, Clayton, Victoria, Australia
J Immunol 185:1238-47. 2010....
- Interplay between heme oxygenase-1 and the multifunctional transcription factor yin yang 1 in the inhibition of intimal hyperplasiaKonstanze Beck
Centre for Vascular Research, School of Medical Sciences and Bosch Institute, Medical Foundation Building K25, University of Sydney, 92 94 Parramatta Rd, Camperdown, NSW 2006, Australia
Circ Res 107:1490-7. 2010....
- Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1Hideto Ishii
Centre for Vascular Research, University of New South Wales, Sydney, Australia
Int J Oncol 40:1575-80. 2012..Moreover, YY1 inhibited p21WAF1/Cip1 complex formation with cdk4 and cyclin D1. These findings demonstrate that YY1 can negatively regulate the growth of multiple malignant cell types...
- Nucleic acid based strategies as potential therapeutic tools: mechanistic considerations and implications to restenosisF S Santiago
Centre for Thrombosis and Vascular Research, School of Pathology, University of New South Wales, Sydney NSW 2052, Australia
J Mol Med 79:695-706. 2001..This review describes the evolution of these gene-specific agents and summarizes recent efforts to inhibit smooth muscle cell growth with these molecules as candidate therapeutic tools in restenosis...
- NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoterLouise A Rafty
Centre for Thrombosis and Vascular Research, Department of Pathology, The University of New South Wales, Sydney, Australia
EMBO J 21:334-43. 2002..These findings demonstrate that repression of PDGF-A gene transcription is governed by interplay between NF1/X and Sp1...
- In vitro activity of minimised hammerhead ribozymesP Hendry
CSIRO, Division of Biomolecular Engineering, North Ryde, NSW, Australia
Nucleic Acids Res 23:3922-7. 1995..The minizymes are significantly less active than comparable, full-size ribozymes when cleaving short substrates. However, at a particular site in a transcribed TAT gene from HIV-1, minizymes are more effective than ribozymes...
- Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2F S Santiago
Centre for Thrombosis and Vascular Research, School of Pathology, The University of New South Wales, Sydney, Australia
Am J Pathol 154:937-44. 1999..These findings demonstrate that inducible Egr-1 expression after injury is contingent on the release and paracrine action of FGF-2...
- GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injuryL M Khachigian
Centre for Thrombosis and Vascular Research, The University of New South Wales, Department of Haematology, Prince of Wales Hospital, Sydney, Australia
Circ Res 84:1258-67. 1999..These findings demonstrate negative regulation of PDGF-A expression by GCF2. This is the first report of the induction of an endogenous transcriptional repressor in the rat vessel wall...
- Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagementM M Kavurma
Centre for Thrombosis and Vascular Research, The University of New South Wales, Sydney NSW 2052, Australia
J Biol Chem 276:4964-71. 2001..Thus, Sp1 phosphorylation is a proapoptotic transcriptional event in vascular SMC and, given the wide distribution of this housekeeping transcription factor, may be a common regulatory theme in apoptotic signal transduction...
- Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2F S Santiago
Center for Thrombosis and Vascular Research, The University of New South Wales, Sydney, New South Wales 2052, Australia
J Biol Chem 276:41143-9. 2001....
- DNAzyme targeting c-jun suppresses skin cancer growthHong Cai
Centre for Vascular Research, University of New South Wales, Sydney, New South Wales 2052, Australia
Sci Transl Med 4:139ra82. 2012..If these findings hold true in clinical trials, Dz13 may provide a safe, effective therapy for human skin cancer...