Fernando Santiago

Summary

Affiliation: Centre for Vascular Research
Location: , Australia
Summary:
cardiovascular diseases, oncology, molecular biology

Publications

  1. ncbi request reprint Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling, and inhibits proliferation
    Douglas J Francis
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Circ Res 92:e70-7. 2003
  2. ncbi request reprint Regulation of inducible heparanase gene transcription in activated T cells by early growth response 1
    Amanda M de Mestre
    Cancer and Vascular Biology Group, John Curtin School of Medical Research, Australian National University, Acton ACT 2601
    J Biol Chem 278:50377-85. 2003
  3. ncbi request reprint Ets-1 stimulates platelet-derived growth factor A-chain gene transcription and vascular smooth muscle cell growth via cooperative interactions with Sp1
    Fernando S Santiago
    Centre for Vascular Research, The University of New South Wales, and the Department of Haematology, The Prince of Wales Hospital, Sydney, Australia
    Circ Res 95:479-87. 2004
  4. ncbi request reprint Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1
    Mary Yanxia Liu
    Centre for Vascular Research, Department of Pathology, University of New South Wales, Sydney NSW 2052 Australia
    Blood 107:2322-9. 2006
  5. ncbi request reprint Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-cyclin D1 assembly
    Fernando S Santiago
    Centre for Vascular Research, Department of Pathology, University of New South Wales, and Department of Haematology, The Prince of Wales Hospital, Sydney, NSW, Australia
    Circ Res 101:146-55. 2007
  6. doi request reprint Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1
    Nicole Y Tan
    Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Circ Res 102:e38-51. 2008
  7. doi request reprint Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription
    Bo Wang
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Arterioscler Thromb Vasc Biol 30:536-45. 2010
  8. doi request reprint Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules
    Qiang Cheng
    Department of Medicine, Monash Medical Centre, Centre for Inflammatory Diseases, Monash University, Clayton, Victoria, Australia
    J Immunol 185:1238-47. 2010
  9. doi request reprint Interplay between heme oxygenase-1 and the multifunctional transcription factor yin yang 1 in the inhibition of intimal hyperplasia
    Konstanze Beck
    Centre for Vascular Research, School of Medical Sciences and Bosch Institute, Medical Foundation Building K25, University of Sydney, 92 94 Parramatta Rd, Camperdown, NSW 2006, Australia
    Circ Res 107:1490-7. 2010
  10. doi request reprint Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1
    Hideto Ishii
    Centre for Vascular Research, University of New South Wales, Sydney, Australia
    Int J Oncol 40:1575-80. 2012

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling, and inhibits proliferation
    Douglas J Francis
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Circ Res 92:e70-7. 2003
    ..As such, this study demonstrates a new role for PI-88 as an inhibitor of intimal thickening after balloon angioplasty. The full text of this article is available online at http://www.circresaha.org...
  2. ncbi request reprint Regulation of inducible heparanase gene transcription in activated T cells by early growth response 1
    Amanda M de Mestre
    Cancer and Vascular Biology Group, John Curtin School of Medical Research, Australian National University, Acton ACT 2601
    J Biol Chem 278:50377-85. 2003
    ..These findings provide the first insight into the mechanisms controlling inducible transcription of the HPSE gene, and could represent an important lead into understanding how HPSE expression is deregulated in metastatic tumor cells...
  3. ncbi request reprint Ets-1 stimulates platelet-derived growth factor A-chain gene transcription and vascular smooth muscle cell growth via cooperative interactions with Sp1
    Fernando S Santiago
    Centre for Vascular Research, The University of New South Wales, and the Department of Haematology, The Prince of Wales Hospital, Sydney, Australia
    Circ Res 95:479-87. 2004
    ..These findings identify a functional cis-acting element for Ets-1 in the PDGF-A promoter and demonstrate that Sp1 and Ets-1 cooperatively activate PDGF-A transcription in vascular SMCs...
  4. ncbi request reprint Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1
    Mary Yanxia Liu
    Centre for Vascular Research, Department of Pathology, University of New South Wales, Sydney NSW 2052 Australia
    Blood 107:2322-9. 2006
    ..Thus, 2 separate trans-acting factors regulate PDGF-D transcription, alone and in response to oxidative stress...
  5. ncbi request reprint Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-cyclin D1 assembly
    Fernando S Santiago
    Centre for Vascular Research, Department of Pathology, University of New South Wales, and Department of Haematology, The Prince of Wales Hospital, Sydney, NSW, Australia
    Circ Res 101:146-55. 2007
    ..These findings define a new role for YY1 as both an inducer of p53 instability in smooth muscle cells, and an indirect repressor of p21(WAF1/Cip1) transcription, p21(WAF1/Cip1)-cdk4-cyclin D1 assembly and intimal thickening...
  6. doi request reprint Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1
    Nicole Y Tan
    Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Circ Res 102:e38-51. 2008
    ..This study provides new insights into the regulatory mechanisms controlling the PKC-zeta-phospho-Sp1 axis and angiotensin II-inducible gene expression...
  7. doi request reprint Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription
    Bo Wang
    Centre for Vascular Research, University of New South Wales, Sydney NSW 2052, Australia
    Arterioscler Thromb Vasc Biol 30:536-45. 2010
    ..EGR-1 autoregulation, and histone modification in the EGR-1 promoter, represent key mechanisms in EGR-1 control, but have not been explored...
  8. doi request reprint Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules
    Qiang Cheng
    Department of Medicine, Monash Medical Centre, Centre for Inflammatory Diseases, Monash University, Clayton, Victoria, Australia
    J Immunol 185:1238-47. 2010
    ....
  9. doi request reprint Interplay between heme oxygenase-1 and the multifunctional transcription factor yin yang 1 in the inhibition of intimal hyperplasia
    Konstanze Beck
    Centre for Vascular Research, School of Medical Sciences and Bosch Institute, Medical Foundation Building K25, University of Sydney, 92 94 Parramatta Rd, Camperdown, NSW 2006, Australia
    Circ Res 107:1490-7. 2010
    ....
  10. doi request reprint Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1
    Hideto Ishii
    Centre for Vascular Research, University of New South Wales, Sydney, Australia
    Int J Oncol 40:1575-80. 2012
    ..Moreover, YY1 inhibited p21WAF1/Cip1 complex formation with cdk4 and cyclin D1. These findings demonstrate that YY1 can negatively regulate the growth of multiple malignant cell types...
  11. ncbi request reprint Nucleic acid based strategies as potential therapeutic tools: mechanistic considerations and implications to restenosis
    F S Santiago
    Centre for Thrombosis and Vascular Research, School of Pathology, University of New South Wales, Sydney NSW 2052, Australia
    J Mol Med 79:695-706. 2001
    ..This review describes the evolution of these gene-specific agents and summarizes recent efforts to inhibit smooth muscle cell growth with these molecules as candidate therapeutic tools in restenosis...
  12. pmc NF1/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter
    Louise A Rafty
    Centre for Thrombosis and Vascular Research, Department of Pathology, The University of New South Wales, Sydney, Australia
    EMBO J 21:334-43. 2002
    ..These findings demonstrate that repression of PDGF-A gene transcription is governed by interplay between NF1/X and Sp1...
  13. pmc In vitro activity of minimised hammerhead ribozymes
    P Hendry
    CSIRO, Division of Biomolecular Engineering, North Ryde, NSW, Australia
    Nucleic Acids Res 23:3922-7. 1995
    ..The minizymes are significantly less active than comparable, full-size ribozymes when cleaving short substrates. However, at a particular site in a transcribed TAT gene from HIV-1, minizymes are more effective than ribozymes...
  14. pmc Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2
    F S Santiago
    Centre for Thrombosis and Vascular Research, School of Pathology, The University of New South Wales, Sydney, Australia
    Am J Pathol 154:937-44. 1999
    ..These findings demonstrate that inducible Egr-1 expression after injury is contingent on the release and paracrine action of FGF-2...
  15. ncbi request reprint GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury
    L M Khachigian
    Centre for Thrombosis and Vascular Research, The University of New South Wales, Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    Circ Res 84:1258-67. 1999
    ..These findings demonstrate negative regulation of PDGF-A expression by GCF2. This is the first report of the induction of an endogenous transcriptional repressor in the rat vessel wall...
  16. ncbi request reprint Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement
    M M Kavurma
    Centre for Thrombosis and Vascular Research, The University of New South Wales, Sydney NSW 2052, Australia
    J Biol Chem 276:4964-71. 2001
    ..Thus, Sp1 phosphorylation is a proapoptotic transcriptional event in vascular SMC and, given the wide distribution of this housekeeping transcription factor, may be a common regulatory theme in apoptotic signal transduction...
  17. ncbi request reprint Induction of the transcriptional repressor Yin Yang-1 by vascular cell injury. Autocrine/paracrine role of endogenous fibroblast growth factor-2
    F S Santiago
    Center for Thrombosis and Vascular Research, The University of New South Wales, Sydney, New South Wales 2052, Australia
    J Biol Chem 276:41143-9. 2001
    ....
  18. doi request reprint DNAzyme targeting c-jun suppresses skin cancer growth
    Hong Cai
    Centre for Vascular Research, University of New South Wales, Sydney, New South Wales 2052, Australia
    Sci Transl Med 4:139ra82. 2012
    ..If these findings hold true in clinical trials, Dz13 may provide a safe, effective therapy for human skin cancer...