Philip Sambrook

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi Bisphosphonates and glucocorticoid osteoporosis in men: results of a randomized controlled trial comparing zoledronic acid with risedronate
    Philip N Sambrook
    University of Sydney, Sydney, NSW, Australia
    Bone 50:289-95. 2012
  2. ncbi Association between a variation in the phosphodiesterase 4D gene and bone mineral density
    Richard H Reneland
    Sequenom, Inc, San Diego, California, USA
    BMC Med Genet 6:9. 2005
  3. ncbi Tumour necrosis factor blockade and the risk of osteoporosis: back to the future
    Philip Sambrook
    Arthritis Res Ther 9:107. 2007
  4. ncbi Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population
    P N Sambrook
    Institute of Bone and Joint Research, Department of Public Health, ANZAC Research Institute, University of Sydney, Prince of Wales Medical Research Institute, Sydney, New South Wales 2065, Australia
    J Clin Endocrinol Metab 89:1572-6. 2004
  5. ncbi Risk reduction of non-vertebral fractures with intravenous ibandronate: post-hoc analysis from DIVA
    Philip Sambrook
    Kolling Institute, Royal North Shore Hospital, St Leonards, Sydney, Australia
    Curr Med Res Opin 26:599-604. 2010
  6. ncbi Alendronate produces greater effects than raloxifene on bone density and bone turnover in postmenopausal women with low bone density: results of EFFECT (Efficacy of FOSAMAX versus EVISTA Comparison Trial) International
    P N Sambrook
    Institue of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, St Leonards NSW, Australia
    J Intern Med 255:503-11. 2004
  7. ncbi Impact of adverse news media on prescriptions for osteoporosis: effect on fractures and mortality
    Philip N Sambrook
    Royal North Shore Hospital, Sydney, NSW, Australia
    Med J Aust 193:154-6. 2010
  8. ncbi Osteocyte viability with glucocorticoid treatment: relation to histomorphometry
    P N Sambrook
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Australia
    Ann Rheum Dis 62:1215-7. 2003
  9. ncbi Oral bisphosphonates are associated with reduced mortality in frail older people: a prospective five-year study
    P N Sambrook
    Institute of Bone and Joint Research, University of Sydney, Level 4, Building 35, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Osteoporos Int 22:2551-6. 2011
  10. ncbi Once weekly alendronate
    Philip Sambrook
    Professor of Rheumatology, University of Sydney, Sydney, Australia
    Drugs Today (Barc) 39:339-46. 2003

Collaborators

Detail Information

Publications83

  1. ncbi Bisphosphonates and glucocorticoid osteoporosis in men: results of a randomized controlled trial comparing zoledronic acid with risedronate
    Philip N Sambrook
    University of Sydney, Sydney, NSW, Australia
    Bone 50:289-95. 2012
    ..5 mg/day or equivalent) (prevention arm, n=88) or continuing glucocorticoid therapy (treatment arm, n=177)...
  2. ncbi Association between a variation in the phosphodiesterase 4D gene and bone mineral density
    Richard H Reneland
    Sequenom, Inc, San Diego, California, USA
    BMC Med Genet 6:9. 2005
    ..Bone mineral density (BMD) is a useful surrogate marker for risk of fracture and is a highly heritable trait. The genetic variants underlying this genetic contribution are largely unknown...
  3. ncbi Tumour necrosis factor blockade and the risk of osteoporosis: back to the future
    Philip Sambrook
    Arthritis Res Ther 9:107. 2007
    ....
  4. ncbi Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population
    P N Sambrook
    Institute of Bone and Joint Research, Department of Public Health, ANZAC Research Institute, University of Sydney, Prince of Wales Medical Research Institute, Sydney, New South Wales 2065, Australia
    J Clin Endocrinol Metab 89:1572-6. 2004
    ..Serum PTH is a predictor of time to first fall in the frail elderly independent of vitamin D status and measures of general health...
  5. ncbi Risk reduction of non-vertebral fractures with intravenous ibandronate: post-hoc analysis from DIVA
    Philip Sambrook
    Kolling Institute, Royal North Shore Hospital, St Leonards, Sydney, Australia
    Curr Med Res Opin 26:599-604. 2010
    ..v. regimen (3 mg q3mo). To evaluate this, a post-hoc analysis of non-vertebral fracture incidence was performed using DIVA study individual patient data...
  6. ncbi Alendronate produces greater effects than raloxifene on bone density and bone turnover in postmenopausal women with low bone density: results of EFFECT (Efficacy of FOSAMAX versus EVISTA Comparison Trial) International
    P N Sambrook
    Institue of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, St Leonards NSW, Australia
    J Intern Med 255:503-11. 2004
    ..This study was undertaken to compare the efficacy and tolerability of alendronate to raloxifene in postmenopausal women with low-bone density...
  7. ncbi Impact of adverse news media on prescriptions for osteoporosis: effect on fractures and mortality
    Philip N Sambrook
    Royal North Shore Hospital, Sydney, NSW, Australia
    Med J Aust 193:154-6. 2010
    ..To examine the impact of a national current affairs television program about the association between osteonecrosis of the jaw and bisphosphonates on subsequent prescription use, fractures and deaths...
  8. ncbi Osteocyte viability with glucocorticoid treatment: relation to histomorphometry
    P N Sambrook
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Australia
    Ann Rheum Dis 62:1215-7. 2003
    ..Glucocorticoid induced osteoporosis is a common clinical problem...
  9. ncbi Oral bisphosphonates are associated with reduced mortality in frail older people: a prospective five-year study
    P N Sambrook
    Institute of Bone and Joint Research, University of Sydney, Level 4, Building 35, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Osteoporos Int 22:2551-6. 2011
    ..In a study of 2005 institutionalized older people, use of oral bisphosphonates was associated with a 27% reduction in risk of death compared to non-users after adjusting for potential confounders...
  10. ncbi Once weekly alendronate
    Philip Sambrook
    Professor of Rheumatology, University of Sydney, Sydney, Australia
    Drugs Today (Barc) 39:339-46. 2003
    ..This review examines published data addressing the safety and efficacy of once-weekly alendronate administration...
  11. ncbi Osteoporosis
    Philip Sambrook
    Institute of Bone and Joint Research, University of Sydney, Sydney 2065, NSW, Australia
    Lancet 367:2010-8. 2006
    ..At the same time, other diagnostic and therapeutic approaches, including biological agents, are likely to become more widespread...
  12. ncbi Alendronate in the prevention of osteoporosis: 7-year follow-up
    P N Sambrook
    Institute of Bone and Joint Research, University of Sydney, Royal North Shore Hospital, St Leonards, Level 4, Block 4, 2065 Sydney, Australia
    Osteoporos Int 15:483-8. 2004
    ..Early postmenopausal women who discontinue ALN after 2 years of treatment experience significant bone loss at all skeletal sites despite the higher (20 mg) initial dosing. The ALN was generally well tolerated during 7 years of treatment...
  13. ncbi Serum parathyroid hormone is associated with increased mortality independent of 25-hydroxy vitamin d status, bone mass, and renal function in the frail and very old: a cohort study
    P N Sambrook
    Institute of Bone and Joint Research, Department of Public Health, ANZAC Research Institute, University of Sydney, Prince of Wales Medical Research Institute, New South Wales 2065, Australia
    J Clin Endocrinol Metab 89:5477-81. 2004
    ..Serum PTH appears to be associated with increased mortality in the frail elderly independent of vitamin D status, renal function, bone mass, and measures of general health. The mechanism of this effect requires further investigation...
  14. ncbi Vitamin D and fractures: quo vadis?
    Philip Sambrook
    Institute of Bone and Joint Research, Royal North Shore Hospital, St Leonards, Sydney, NSW 2065, Australia
    Lancet 365:1599-600. 2005
  15. ncbi D-hormones for prevention of bone loss after organ transplant
    Philip N Sambrook
    Institute of Bone and Joint Research, University of Sydney, Sydney, Australia
    J Rheumatol Suppl 76:41-3. 2005
    ..Based upon available evidence, prophylaxis should involve a bisphosphonate, with D-hormone considered as adjunctive or alternative therapy...
  16. ncbi Compliance with treatment in osteoporosis patients--an ongoing problem
    Philip Sambrook
    Institute of Bone and Joint Research, University of Sydney, New South Wales
    Aust Fam Physician 35:135-7. 2006
    ..However, compliance with therapy in the 'real world' setting has generally been less than that seen in clinical trials...
  17. ncbi Osteonecrosis of the jaw
    Philip N Sambrook
    Kolling Institute of Medical Research, University of Sydney E25, Royal North Shore Hospital, Saint Leonards NSW 2065, Sydney, Australia
    Curr Rheumatol Rep 10:97-101. 2008
    ..Still, in a very small number of patients taking bisphosphonates, intractable, painful, nonhealing exposed bone may occur following dental extractions or denture irritation...
  18. ncbi Quarterly intravenous injection of ibandronate to treat osteoporosis in postmenopausal women
    Philip Sambrook
    University of Sydney, Sydney, Australia
    Clin Interv Aging 2:65-72. 2007
    ..This paper will review the role of intravenous ibandronate in the treatment of postmenopausal osteoporosis...
  19. ncbi Influence of fall related factors and bone strength on fracture risk in the frail elderly
    P N Sambrook
    Institute of Bone and Joint Research, University of Sydney, Sydney, Australia
    Osteoporos Int 18:603-10. 2007
    ..In a prospective study of elderly subjects at high risk of falls, we investigated the influence of bone strength and fall risk on fracture...
  20. ncbi Does increased sunlight exposure work as a strategy to improve vitamin D status in the elderly: a cluster randomised controlled trial
    P N Sambrook
    Institute of Bone and Joint Research, University of Sydney, Sydney, Australia
    Osteoporos Int 23:615-24. 2012
    ..In a randomised controlled trial, adherence to sunlight exposure was low (median adherence, 26%) and no effect of increased UV exposure on falls risk was observed (incidence rate ratio (IRR) 1.06, P = 0.73)...
  21. ncbi Postmenopausal osteoporosis treatment guidelines
    P Sambrook
    Royal North Shore Hospital, New South Wales
    Aust Fam Physician 29:751-3, 756-8. 2000
    ..Since then significant advances in our understanding of the treatment of osteoporosis have been published. The importance of this is heightened as early diagnosis is now possible with precise methods of bone density measurement...
  22. ncbi Corticosteroid osteoporosis
    P N Sambrook
    Sydney University Dept of Rheumatology, Royal North Shore Hospital, Australia
    Z Rheumatol 59:45-7. 2000
    ..In postmenopausal women, concomitant use of estrogen replacement therapy is also appropriate. It is important in a patient on long-term therapy to review the need for continuing treatment or the possibility of dosage reduction...
  23. ncbi Osteoporosis prevention and treatment
    P N Sambrook
    Institute of Bone and Joint Research, University of Sydney, Royal North Shore Hospital, NSW
    Med J Aust 172:226-9. 2000
    ..Supplementation with simple vitamin D should be considered in elderly patients who are housebound or live in institutions, as they are at risk of vitamin D deficiency and osteomalacia...
  24. ncbi Predicting fractures in an international cohort using risk factor algorithms without BMD
    Philip N Sambrook
    University of Sydney Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia
    J Bone Miner Res 26:2770-7. 2011
    ..However, more sophisticated models incorporating multiple clinical risk factors including falls were not superior to more parsimonious models in predicting future fracture in this population...
  25. ncbi Carpal tunnel syndrome and its relationship to occupation: a meta-analysis
    Annica Barcenilla
    Department of Rheumatology, Institute of Bone and Joint Research, University of Sydney, Level 4, Building 35, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Rheumatology (Oxford) 51:250-61. 2012
    ..To examine the association between work place exposure and CTS by meta-analysis, including analyses with respect to exposure to hand force, repetition, vibration and wrist posture...
  26. ncbi Prevention and treatment of glucocorticoid-induced osteoporosis: a comparison of calcitriol, vitamin D plus calcium, and alendronate plus calcium
    Philip N Sambrook
    Institute of Bone and Joint Research, University of Sydney, Sydney, Australia
    J Bone Miner Res 18:919-24. 2003
    ..These data do not suggest any difference between simple vitamin D and calcitriol but do show that alendronate was superior to either treatment for glucocorticoid induced bone loss...
  27. ncbi Health-related quality of life and treatment of postmenopausal osteoporosis: results from the HORIZON-PFT
    Philip N Sambrook
    University of Sydney, Sydney, Australia
    Bone 48:1298-304. 2011
    ..HRQL is reduced in patients with vertebral fractures. Treatment with ZOL over 3years was associated with improvements in specific domains of quality of life vs. placebo, particularly in patients sustaining incident fractures...
  28. ncbi Steroid-induced osteoporosis
    P N Sambrook
    Institute of Bone and Joint Research, University of Sydney, Sydney, Australia
    Ann Acad Med Singapore 31:48-53. 2002
    ..Corticosteroids have major effects on calcium metabolism, leading to accelerated osteoporosis and fracture...
  29. ncbi Gender differences in plasma ghrelin and its relations to body composition and bone - an opposite-sex twin study
    Joanna Makovey
    Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    Clin Endocrinol (Oxf) 66:530-7. 2007
    ..Ghrelin, a peptide hormone that plays a role in the regulation of appetite and body adiposity, may also play a role in bone metabolism...
  30. ncbi Gender differences in relationships between body composition components, their distribution and bone mineral density: a cross-sectional opposite sex twin study
    Joanna Makovey
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    Osteoporos Int 16:1495-505. 2005
    ..Fat mass (FM) and lean mass (LM) and their distribution in the body have different relationships with regional BMD in men and women that differ by age...
  31. ncbi Calcaneal ultrasound but not bone turnover predicts fractures in vitamin D deficient frail elderly at high risk of falls
    J S Chen
    Institute of Bone and Joint Research, University of Sydney, Royal North Shore Hospital, St Leonards, Sydney, NSW 2065, Australia
    Calcif Tissue Int 79:37-42. 2006
    ..7 vs 0.9 falls respectively; P < 0.001) during the follow-up period. CONCLUSION: In the frail elderly with vitamin D deficiency and high falls risk, calcaneal ultrasound but not markers of bone turnover were associated with fractures...
  32. ncbi Gender differences in volumetric bone density: a study of opposite-sex twins
    Vasi Naganathan
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    Osteoporos Int 14:564-9. 2003
    ..A comparison of vBMD between men and women shows only small differences in bone density between the sexes...
  33. ncbi Who will benefit from treatment with selective estrogen receptor modulators (SERMs)?
    Philip Sambrook
    Institute of Bone and Joint Research, Building 36, Royal North Shore Hospital, St Leonards, Sydney 2065, Australia
    Best Pract Res Clin Rheumatol 19:975-81. 2005
    ..Because of its quicker offset, use of raloxifene may have advantages over potent bisphosphonates if use of anabolic agents are contemplated in an individual patient...
  34. ncbi Quantitative ultrasound of the calcaneus and falls risk in the institutionalized elderly: sex differences and relationship to vitamin D status
    J Zochling
    Institute of Bone and Joint Research, University of Sydney, Australia
    Osteoporos Int 13:882-7. 2002
    ..Quadriceps strength and weight but not serum 25(OH)D were significantly associated with BUA. These data suggest only minor loss occurs at the calcaneal site in BUA and VOS with very old age in either sex...
  35. ncbi Gender differences in the genetic factors responsible for variation in bone density and ultrasound
    Vasi Naganathan
    Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, Sydney, Australia
    J Bone Miner Res 17:725-33. 2002
    ..However, at some regions there is evidence to suggest a gender-specific genetic component to the overall genetic variance...
  36. ncbi New therapeutic applications for the anticoagulant, activated protein C
    Chris Jackson
    Institute of Bone and Joint Research, Kolling Institute, Sutton Arthritis Research Laboratories, Department of Rheumatology, University of Sydney at Royal North Shore Hospital, 2065 Australia
    Expert Opin Biol Ther 8:1109-22. 2008
    ..Originally thought to be synthesised exclusively by the liver, recent reports have shown that PC is also produced by endothelial cells, smooth muscle cells, keratinocytes and some leukocytes...
  37. ncbi Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing
    Christopher J Jackson
    The Sutton Arthritis Research Laboratories, Institute of Bone and Joint Research, University of Sydney, Sydney, New South Wales, Australia
    Wound Repair Regen 13:284-94. 2005
    ..These unique properties of APC make it an attractive therapeutic agent to promote the healing of chronic wounds...
  38. ncbi Management of osteoporosis in primary care in Australia
    J S Chen
    Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia
    Osteoporos Int 20:491-6. 2009
    ..Only 29.7% of patients with a prior fracture were currently on specific medication for osteoporosis. The results highlight the need for further exploration of barriers to osteoporosis management...
  39. ncbi Role of quantitative ultrasound to predict fracture among institutionalised older people with a history of fracture
    J S Chen
    Institute of Bone and Joint Research, University of Sydney, Sydney, Australia
    Osteoporos Int 20:105-12. 2009
    ..These findings suggest that QUS measurements for frail older people might be more useful in those without a fracture history...
  40. ncbi A multivariate regression model predicted falls in residents living in intermediate hostel care
    J S Chen
    Institute of Bone and Joint Research, Department of Medicine, Level 4, Block 4, Royal North Shore Hospital, University of Sydney, St Leonards, NSW 2065, Australia
    J Clin Epidemiol 58:503-8. 2005
    ..To evaluate whether individual falls risk could be predicted in a frail elderly population...
  41. ncbi Vertebral fracture risk with long-term corticosteroid therapy: prevalence and relation to age, bone density, and corticosteroid use
    V Naganathan
    Department of Rheumatology, Institute of Bone and Joint Research, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    Arch Intern Med 160:2917-22. 2000
    ..The aim of this study was to determine the prevalence and the role of risk factors such as age, bone mineral density (BMD), and corticosteroid use for vertebral deformity in patients receiving long-term corticosteroid therapy...
  42. ncbi How to prevent steroid induced osteoporosis
    P N Sambrook
    Royal North Shore Hospital, St Leonards, Sydney, Australia 2065
    Ann Rheum Dis 64:176-8. 2005
    ..For patients receiving chronic low dose corticosteroids treatment with calcium and vitamin D may prevent further bone loss. Use of parathyroid hormone is promising...
  43. ncbi Risk factors for proximal humerus, forearm, and wrist fractures in elderly men and women: the Dubbo Osteoporosis Epidemiology Study
    T V Nguyen
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Am J Epidemiol 153:587-95. 2001
    ..0, 3.6) and a history of falls (women: RR = 1.9, 95% CI: 1.4, 2.6) were also significant. These data suggest that elderly men and women largely share common risk factors for upper limb fractures and that FNBMD is the primary risk factor...
  44. ncbi Peak bone mass is increased in the hip in daughters of women with osteoarthritis
    V Naganathan
    Institute of Bone and Joint Research, University of Sydney, Royal North Shore Hospital, Sydney, NSW, Australia
    Bone 30:287-92. 2002
    ..These findings suggest that the observation of higher BMD in older patients with OA may be due in part to achievement of a higher peak bone mass at some sites...
  45. ncbi Knee osteoarthritis: the influence of environmental factors
    D J Hunter
    Institution Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia
    Clin Exp Rheumatol 20:93-100. 2002
    ..Since they are modifiable, this has important implications for public health recommendations and treatment by health professionals...
  46. ncbi Quantitative heel ultrasound as a predictor for osteoporosis
    V Naganathan
    Department of Rheumatology, Royal North Shore Hospital, Sydney, NSW
    Med J Aust 171:297-300. 1999
    ..To determine the diagnostic value of quantitative ultrasound (QUS) to predict bone mineral density (BMD) categories as defined by dual-energy x-ray absorptiometry...
  47. ncbi Intrusive pain and worry about health in older men: the CHAMP study
    F M Blyth
    Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, NSW, Australia
    Pain 152:447-52. 2011
    ..In older community-dwelling men, pain was robustly associated with worry about health, highlighting the potential importance of subthreshold anxiety-related psychological factors...
  48. ncbi Determinants of health-related quality of life in institutionalised older persons in northern Sydney
    Y Y Sitoh
    Institute of Bone and Joint Research, University of Sydney, Sydney, Australia
    Intern Med J 35:131-4. 2005
    ..Some of these conditions may be amenable to intervention...
  49. ncbi Quantitative ultrasound measurements of bone: measurement error, discordance, and their effects on longitudinal studies
    J Zochling
    Institute of Bone and Joint Research, University of Sydney, Australia
    Osteoporos Int 15:619-24. 2004
    ..However, diagnosis by T-score criteria was instrument specific, and such criteria should be interpreted with caution in the assessment of fracture risk...
  50. ncbi Cartilage defects are associated with physical disability in obese adults
    Ananthila Anandacoomarasamy
    Department of Rheumatology, Institute of Bone and Joint Research, Kolling Institute, Sydney, NSW 2065, Australia
    Rheumatology (Oxford) 48:1290-3. 2009
    ..To describe the associations between physical disability measures and knee cartilage defects in obese adults...
  51. ncbi Femoral neck axis length, height loss and risk of hip fracture in males and females
    J R Center
    Bone and Mineral Research Division, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Osteoporos Int 8:75-81. 1998
    ..Moreover, FNAL appears to have limited utility in the prediction of hip fracture risk and any role of HAL in the prediction of hip fracture does not relate to its major component of femoral neck length...
  52. ncbi Physical functioning measures and risk of falling in older people living in residential aged care facilities
    Nicholas Wilson
    University of Sydney, Departments of Clinical Pharmacology and Aged Care, Sydney, Australia
    Ther Adv Musculoskelet Dis 3:9-15. 2011
    ..In residents of RACFs, we aimed to produce sex-specific means and empirical norms of objective physical function measures to ascertain whether these measures are predictors of falls...
  53. ncbi Activated protein C mediates a healing phenotype in cultured tenocytes
    Meilang Xue
    Institute of Bone and Joint Research, Kolling Institute of Medical Research, The University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia
    J Cell Mol Med 13:749-57. 2009
    ..Furthermore, EPCR is expressed by tenocytes and mediates the actions of APC, at least partly by signalling through selective MAP kinases. These data implicate APC as a potential healing agent for injured tendons...
  54. ncbi Hormonal and biochemical parameters in the determination of osteoporosis in elderly men
    J R Center
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, New South Wales
    J Clin Endocrinol Metab 84:3626-35. 1999
    ....
  55. ncbi Mortality after all major types of osteoporotic fracture in men and women: an observational study
    J R Center
    Bone and Mineral Research Division, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Lancet 353:878-82. 1999
    ..Mortality increases after hip fractures in women and more so in men. Little is known, however, about mortality after other fractures. We investigated the mortality associated with all fracture types in elderly women and men...
  56. ncbi Quality of life in osteoporosis: reliability, consistency, and validity of the Osteoporosis Assessment Questionnaire
    A G Randell
    Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, NSW, Australia
    J Rheumatol 25:1171-9. 1998
    ..To determine the reliability, consistency, and clinical utility of the Osteoporosis Assessment Questionnaire (OPAQ), an AIMS2 based self-assessment questionnaire...
  57. ncbi Secondary osteoporosis in patients with an osteoporotic fracture
    C Kok
    Kolling Institute, University of Sydney, St Leonards, Sydney 2065, Australia
    Best Pract Res Clin Rheumatol 23:769-79. 2009
    ..With appropriate consideration of secondary causes and relevant investigations, many of these conditions are preventable with newer therapies...
  58. ncbi The association of cartilage volume with knee pain
    D J Hunter
    Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia
    Osteoarthritis Cartilage 11:725-9. 2003
    ..The aim of this study was to examine the association between knee symptoms and MRI cartilage volume...
  59. ncbi The role of gene-environment interaction in determining bone mineral density in a twin population
    Vasi Naganathan
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Australia
    Twin Res Hum Genet 10:191-7. 2007
  60. ncbi Calcium metabolism in the frail elderly
    Jane Zochling
    Institute of Bone and Joint Research, University of Sydney, Australia
    Clin Rheumatol 24:576-82. 2005
    ..Vitamin D deficiency remains a significant public health problem in the institutionalized frail elderly. Currently available supplements are not adequate or utilized frequently enough to address this problem...
  61. ncbi Development and validation of fall risk screening tools for use in residential aged care facilities
    Kim Delbaere
    Falls and Balance Research Group, Prince of Wales Medical Research Institute, University of New South Wales, Sydney, NSW
    Med J Aust 189:193-6. 2008
    ..To develop screening tools for predicting falls in nursing home and intermediate-care hostel residents who can and cannot stand unaided...
  62. ncbi Atypical antipsychotic medications and risk of falls in residents of aged care facilities
    Le T T Hien
    School of Public Health, University of Sydney, Sydney, Australia
    J Am Geriatr Soc 53:1290-5. 2005
    ..45, 95% CI=1.09-1.93). CONCLUSION: Despite fewer extrapyramidal side effects, atypical antipsychotic medications are not associated with fewer falls than the older, more-established antipsychotics...
  63. ncbi Vitamin D in Australia. Issues and recommendations
    Caryl A Nowson
    School of Health Sciences, Deakin University, Victoria
    Aust Fam Physician 33:133-8. 2004
    ..Increased availability of larger dose preparations of cholecalciferol would be a useful therapy in the case of severe deficiencies...
  64. ncbi Differing risk factors for falls in nursing home and intermediate-care residents who can and cannot stand unaided
    Stephen R Lord
    Prince of Wales Medical Research Institute, University of New South Wales, New South Wales, Australia
    J Am Geriatr Soc 51:1645-50. 2003
    ..To determine fall risk factors in nursing home and intermediate-care residents who can and cannot stand unaided...
  65. ncbi Reduction of immunosuppressant therapy requirement in heart transplantation by calcitriol
    N Kathryn Briffa
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    Transplantation 75:2133-4. 2003
    ....
  66. ncbi Glucocorticoid osteoporosis
    Philip N Sambrook
    Institute of Bone and Joint Research, University of Sydney, Sydney, Australia
    Curr Pharm Des 8:1877-83. 2002
    ....
  67. ncbi Vitamin D deficiency is common in frail institutionalised older people in northern Sydney
    Philip N Sambrook
    Med J Aust 176:560. 2002
  68. ncbi Introduction. D-hormones alfacalcidol and calcitriol for prevention and treatment of glucocorticoid/inflammation-induced osteoporosis
    Philip N Sambrook
    Institute of Bone and Joint Research, University of Sydney, Sydney, Australia
    J Rheumatol Suppl 76:1-3. 2005
  69. ncbi Fracture risk assessment in frail older people using clinical risk factors
    Jian Sheng Chen
    Institute of Bone and Joint Research, University of Sydney, St Leonards, NSW 2065, Australia
    Age Ageing 37:536-41. 2008
    ..this study aims to develop and evaluate a simple fracture risk index for use in frail older people...
  70. ncbi Genetic effects on bone loss in peri- and postmenopausal women: a longitudinal twin study
    Joanna Makovey
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    J Bone Miner Res 22:1773-80. 2007
    ..Results of genetic model-fitting analysis indicated genetic effects on bone loss account for approximately 40% of the between-individual variation in bone loss at the lumbar spine, forearm, and whole body...
  71. ncbi Differential regulation of matrix metalloproteinase 2 and matrix metalloproteinase 9 by activated protein C: relevance to inflammation in rheumatoid arthritis
    Meilang Xue
    Institute of Bone and Joint Research, University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Arthritis Rheum 56:2864-74. 2007
    ..To investigate the in vitro effect of activated protein C (APC), a natural anticoagulant and novel antiinflammatory agent, on the regulation of the gelatinases matrix metalloproteinase 2 (MMP-2) and MMP-9...
  72. ncbi Endothelial protein C receptor is overexpressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes
    Meilang Xue
    Sutton Arthritis Research Laboratories, Level 1, Block 4, University of Sydney at Royal North Shore Hospital, St Leonards NSW, 2065 Australia
    Ann Rheum Dis 66:1574-80. 2007
    ....
  73. ncbi Anabolic therapy in glucocorticoid-induced osteoporosis
    Philip N Sambrook
    N Engl J Med 357:2084-6. 2007
  74. ncbi Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort
    Scott G Wilson
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia
    Eur J Hum Genet 14:340-8. 2006
    ..0067) and P2RX4 (P = 0.017). These data provide replication and refinement of the 12q24 obesity locus and suggest that genes involved in phospholipase and purinoreceptor pathways may regulate fat accumulation and distribution...
  75. ncbi Effect of age-related chronic immobility on markers of bone turnover
    Jian Sheng Chen
    Institute of Bone and Joint Research, University of Sydney, Sydney, Australia
    J Bone Miner Res 21:324-31. 2006
    ..CONCLUSIONS: Our findings suggest that poor mobility contributes to the state of accelerated bone turnover usually seen in the elderly. The effect of chronic relative immobility may be more marked on bone formation than bone resorption...
  76. ncbi High bone turnover is an independent predictor of mortality in the frail elderly
    Philip N Sambrook
    Institute of Bone and Joint Research, Royal North Shore Hospital, The University of Sydney, Sydney, Australia
    J Bone Miner Res 21:549-55. 2006
    ..The mechanism of the effect of bone turnover on mortality seems to be mainly manifested in deaths from cardiovascular causes...
  77. ncbi Preventing osteoporosis: outcomes of the Australian Fracture Prevention Summit
    Philip N Sambrook
    Med J Aust 176:S1-16. 2002
  78. ncbi Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents
    Meilang Xue
    Sutton Arthritis Research Laboratories, Institute of Bone and Joint Research, University of Sydney, NSW, Australia
    Clin Hemorheol Microcirc 34:153-61. 2006
    ..In summary, our results demonstrate that APC promotes cutaneous wound healing at least partly by stimulation of angiogenesis...
  79. ncbi Genetic contribution to cartilage volume in women: a classical twin study
    David J Hunter
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Australia
    Rheumatology (Oxford) 42:1495-500. 2003
    ..A classical twin study was performed to assess the relative contribution of genetic and environmental factors to cartilage volume...
  80. ncbi Proxy assessment of health-related quality of life in the frail elderly
    Yih Yiow Sitoh
    Age Ageing 32:459-61. 2003
  81. ncbi Drug Insight: choosing a drug treatment strategy for women with osteoporosis-an evidence--based clinical perspective
    Piet P Geusens
    Department of Internal Medicine, Division of Rheumatology, University Hospital, P Debyelaan 25, Box 5800, 6202 AZ Maastricht, The Netherlands
    Nat Clin Pract Rheumatol 4:240-8. 2008
    ..Other determinants include the potential extraskeletal benefits and safety concerns of the drug, patient preferences and reimbursement issues...
  82. ncbi Structural, psychological, and genetic influences on low back and neck pain: a study of adult female twins
    Alexander J MacGregor
    St Thomas Hospital, London, UK
    Arthritis Rheum 51:160-7. 2004
    ....
  83. ncbi Predictors of clinical response to intraarticular Hylan injections -- a prospective study using synovial fluid measures, clinical outcomes, and magnetic resonance imaging
    Ananthila Anandacoomarasamy
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    J Rheumatol 35:685-90. 2008
    ..To evaluate synovial fluid (SF) and clinical and imaging predictors of clinical response in patients receiving intraarticular Hylan GF-20 injections...