Nitin K Saksena

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. pmc HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sites
    Nitin K Saksena
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead, NSW, Sydney, Australia
    HIV AIDS (Auckl) 2:103-22. 2010
  2. pmc Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort
    Haran Sivakumaran
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Virol J 4:107. 2007
  3. pmc Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor
    Leon Caly
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Retrovirology 5:67. 2008
  4. pmc Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS
    Jasminka Sterjovski
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:89. 2007
  5. pmc HIV-1 nef suppression by virally encoded microRNA
    Shinya Omoto
    Molecular Biology and Retroviral Genetics Group, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Retrovirology 1:44. 2004
  6. ncbi request reprint Human immunodeficiency virus interactions with CD8+ T lymphocytes
    Nitin K Saksena
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead, Australia
    Curr HIV Res 6:1-9. 2008
  7. ncbi request reprint HAART & the molecular biology of AIDS dementia complex
    Nitin K Saksena
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, Darcy Road, Westmead NSW 2145, Sydney, Australia
    Indian J Med Res 121:256-69. 2005
  8. ncbi request reprint Snapshot of HIV pathogenesis in China
    Nitin K Saksena
    Centre for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead NSW 2145 Sydney, Australia
    Cell Res 15:953-61. 2005
  9. pmc First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia
    Li Zhou
    Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW 2145, Sydney, Australia
    Mol Neurodegener 5:27. 2010
  10. ncbi request reprint Elite HIV controllers: myth or reality?
    Nitin K Saksena
    Retroviral Genetics Division, Westmead Millennium Institute, Westmead Hospital, Westmead NSW, Sydney, Australia
    AIDS Rev 9:195-207. 2007

Collaborators

Detail Information

Publications69

  1. pmc HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sites
    Nitin K Saksena
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead, NSW, Sydney, Australia
    HIV AIDS (Auckl) 2:103-22. 2010
    ..This review provides an overview of HIV reservoir sites and discusses both the virtues and problems associated with therapies/strategies targeting these reservoir sites in vivo...
  2. pmc Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort
    Haran Sivakumaran
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Virol J 4:107. 2007
    ..It supports the belief that quasispecies variation in HIV-1 is a mechanism for selection towards defining a fitter gene variant that is capable of resisting the human immune system...
  3. pmc Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor
    Leon Caly
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Retrovirology 5:67. 2008
    ..Importantly, an F72L point mutation in the LTNP was identified for the first time as being uniquely responsible for decreased Vpr nuclear import...
  4. pmc Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS
    Jasminka Sterjovski
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:89. 2007
    ....
  5. pmc HIV-1 nef suppression by virally encoded microRNA
    Shinya Omoto
    Molecular Biology and Retroviral Genetics Group, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Retrovirology 1:44. 2004
    ..Our recent study has shown that HIV-1 nef dsRNA from AIDS patients who are long-term non-progressors (LTNPs) inhibited the transcription of HIV-1...
  6. ncbi request reprint Human immunodeficiency virus interactions with CD8+ T lymphocytes
    Nitin K Saksena
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead, Australia
    Curr HIV Res 6:1-9. 2008
    ....
  7. ncbi request reprint HAART & the molecular biology of AIDS dementia complex
    Nitin K Saksena
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, Darcy Road, Westmead NSW 2145, Sydney, Australia
    Indian J Med Res 121:256-69. 2005
    ..In addition, an overview of various biological, molecular and therapeutic aspects that may influence HIV dementia (HIV-D) is provided...
  8. ncbi request reprint Snapshot of HIV pathogenesis in China
    Nitin K Saksena
    Centre for Virus Research, Westmead Millennium Institute, The University of Sydney, Westmead NSW 2145 Sydney, Australia
    Cell Res 15:953-61. 2005
    ....
  9. pmc First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia
    Li Zhou
    Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW 2145, Sydney, Australia
    Mol Neurodegener 5:27. 2010
    ..The pathogenesis of HIV-associated dementia (HAD) is poorly understood. To date, detailed proteomic fingerprinting directly from autopsied brain tissues of HAD and HIV non-dementia patients has not been performed...
  10. ncbi request reprint Elite HIV controllers: myth or reality?
    Nitin K Saksena
    Retroviral Genetics Division, Westmead Millennium Institute, Westmead Hospital, Westmead NSW, Sydney, Australia
    AIDS Rev 9:195-207. 2007
    ..Aspects dealing with cellular, humoral, innate, and adaptive immunity, which are relevant to nonprogressive HIV disease, are beyond the scope of this review...
  11. ncbi request reprint Reservoirs of HIV-1 in vivo: implications for antiretroviral therapy
    Nitin K Saksena
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, University of Sydney, Sydney, Australia
    AIDS Rev 5:3-18. 2003
    ..In addition, it addresses the effect of sub-optimal drug concentrations on reservoir establishment and outlines future therapeutic strategies to counteract these reservoirs and sanctuaries...
  12. ncbi request reprint Viral reservoirs an impediment to HAART: new strategies to eliminate HIV-1
    Nitin K Saksena
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead NSW 2145, Sydney, Australia
    Curr Drug Targets Infect Disord 3:179-206. 2003
    ..New strategies are needed for flushing hidden pockets of HIV in vivo. This review will focus mainly on novel strategies in the pipeline, along with the recent developments in the field...
  13. ncbi request reprint Drug resistance and viral evolution in plasma and peripheral blood cells during structured treatment interruption (STI) and non-interrupted HAART
    Yuan Min Wang
    Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institutes, Westmead Hospital, The University of Sydney, Sydney, Australia
    Curr HIV Res 5:235-50. 2007
    ..In addition, little remains known how viral evolutionary process may differ between cell-free and cell-associated compartments, over time, in vivo in patients receiving HAART or STI...
  14. pmc Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy
    Jing Qin Wu
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, University of Sydney, Darcy Road, Westmead, NSW 2145, Sydney, Australia
    Retrovirology 5:24. 2008
    ..Blood samples were collected over an average of 3 years and 5-8 time points were selected for microarray assay and statistical analysis...
  15. pmc Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection
    Wayne B Dyer
    Australian Red Cross Blood Service, 153 Clarence Street, Sydney, NSW 2000, Australia
    Retrovirology 5:112. 2008
    ..We examined the mechanisms that differentiated delayed progressors from LTNP in this cohort...
  16. ncbi request reprint Genetic analyses reveal structured HIV-1 populations in serially sampled T lymphocytes of patients receiving HAART
    Simon J Potter
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Darcy Road, Westmead, Sydney NSW 2145, Australia
    Virology 348:35-46. 2006
    ....
  17. ncbi request reprint Continuous crossover(s) events of HIV-1 CRF01_AE and B subtype strains in Malaysia: evidence of rapid and extensive HIV-1 evolution in the region
    Katherine A Lau
    Retroviral Genetics Division, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, Sydney, Australia
    Curr HIV Res 6:108-16. 2008
    ..This highlights the public health relevance of newly emerging second generation HIV-1 recombinant forms and their dispersal, along with their rapid and continuous evolution in the region...
  18. ncbi request reprint Evidence for possible biological advantages of the newly emerging HIV-1 circulating recombinant form from Malaysia - CRF33_01B in comparison to its progenitors - CRF01_AE and subtype B
    Katherine A Lau
    Retroviral Genetics Division, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW 2145, Sydney, Australia
    Curr HIV Res 8:259-71. 2010
    ..We therefore estimate a possible gradual replacement of the current predominance of CRF01_AE, as well as wider dissemination of CRF33_01B, together with the identification of other new CRF01_AE/B inter-subtype recombinants in Malaysia...
  19. ncbi request reprint Assessment of drug resistance mutations in plasma and peripheral blood mononuclear cells at different plasma viral loads in patients receiving HAART
    Choo Beng Chew
    Center for Infectious Diseases and Microbiology Laboratory Systems, ICPMR, Westmead Hospital, Westmead, NSW 2145, Australia
    J Clin Virol 33:206-16. 2005
    ..PBMCs harbor archival proviral DNA, are a major source of HIV and also underdo latent infection during suppressive HAART...
  20. pmc HIV-1 gp120 N-linked glycosylation differs between plasma and leukocyte compartments
    Yung Shwen Ho
    Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Westmead NSW, 2145 Sydney, Australia
    Virol J 5:14. 2008
    ..Although it is known that glycosylation changes can dramatically influence virus recognition by the host antibody, the actual contribution of compartmental differences in N-linked glycosylation patterns remains unclear...
  21. pmc Evidence for predilection of macrophage infiltration patterns in the deeper midline and mesial temporal structures of the brain uniquely in patients with HIV-associated dementia
    Li Zhou
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW, Sydney, Australia
    BMC Infect Dis 9:192. 2009
    ..HIV-1 penetrates the central nervous system, which is vital for HIV-associated dementia (HAD). But the role of cellular infiltration and activation together with HIV in the development of HAD is poorly understood...
  22. ncbi request reprint Evidence for predominance of CCR5-using HIV-1 strains during highly active antiretroviral therapy
    Yuan Min Wang
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia
    Curr HIV Res 5:221-34. 2007
    ....
  23. ncbi request reprint Sensitive detection of the K103N non-nucleoside reverse transcriptase inhibitor resistance mutation in treatment-naïve HIV-1 infected individuals by rolling circle amplification
    Bin Wang
    Center for Virus Research, Westmead Millennium Institute, University of Sydney, Sydney, NSW 2145, Australia
    J Virol Methods 161:128-35. 2009
    ..Importantly, the new RCA technology allows large-scale, sensitive detection of drug resistance mutations, including detection of minority populations with minimal equipment requirement...
  24. ncbi request reprint Obstacles to successful antiretroviral treatment of HIV-1 infection: problems & perspectives
    Simon J Potter
    Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Sydney, NSW, Australia
    Indian J Med Res 119:217-37. 2004
    ..In the present article, we discuss various obstacles to HIV therapy, and provide perspectives relating to these issues that are critical in determining the success or failure of HAART...
  25. ncbi request reprint Detection of the rapid emergence of the H275Y mutation associated with oseltamivir resistance in severe pandemic influenza virus A/H1N1 09 infections
    Bin Wang
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
    Antiviral Res 87:16-21. 2010
    ..In the light of emerging resistance, close monitoring and understanding of the nature and dynamics of resistance mutations in newly emerging strains should be a priority...
  26. ncbi request reprint Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, and University of New South Wales, Sydney, Australia
    Blood 103:2238-47. 2004
    ..Moreover, expression of CCR5 may render them particularly susceptible to cytopathic effects during progressive HIV-1 infection...
  27. ncbi request reprint Near full-length sequence analysis of a Unique CRF01_AE/B recombinant from Kuala Lumpur, Malaysia
    Katherine A Lau
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Westmead NSW 2145, Sydney, Australia
    AIDS Res Hum Retroviruses 23:1139-45. 2007
    ..Thus we suggest that 06MYKLD46 is a possible second-generation HIV-1 recombinant derived from CRF33_01B...
  28. pmc A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration
    Li Zhou
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW 2145, Sydney, Australia
    BMC Genomics 13:677. 2012
    ..Therefore, identifying HIV fingerprints on the host gene machinery and its regulation by microRNA holds a great promise and potential for improving our understanding of HAD pathogenesis, its diagnosis and therapy...
  29. pmc Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stages
    Jing Qin Wu
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Darcy Road, Westmead, NSW 2145, Sydney, Australia
    Retrovirology 4:83. 2007
    ....
  30. ncbi request reprint Full-length HIV type 1 genome analysis showing evidence for HIV type 1 transmission from a nonprogressor to two recipients who progressed to AIDS
    Meriet Mikhail
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead NSW 2145, Sydney, Australia
    AIDS Res Hum Retroviruses 21:575-9. 2005
    ..Overall, these studies highlight the utility of full genome sequencing in establishing epidemiologic linkage in a chronically infected HIV cohort after 10 years of initial infection...
  31. ncbi request reprint First demonstration of a lack of viral sequence evolution in a nonprogressor, defining replication-incompetent HIV-1 infection
    Bin Wang
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
    Virology 312:135-50. 2003
    ..Further study on the antigenic properties of this strain may assist in the development of HIV vaccines and therapeutics...
  32. pmc Independent evolution of human immunodeficiency virus (HIV) drug resistance mutations in diverse areas of the brain in HIV-infected patients, with and without dementia, on antiretroviral treatment
    Theresa K Smit
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Darcy Rd, Westmead NSW 2145, Sydney, Australia
    J Virol 78:10133-48. 2004
    ..The emergence of resistant virus in the CNS may have considerable influence on the outcome of neurologic disease and also the reseeding of HIV in the systemic circulation upon failure of therapy...
  33. pmc Genome-wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV disease
    Jing Qin Wu
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, University of Sydney, Darcy Road, Westmead, NSW 2145, Australia
    Retrovirology 8:18. 2011
    ..Therefore, this work aimed to define the genomic basis of HIV interactions with the cellular transcriptome of both CD4+ and CD8+ T cells...
  34. pmc Role of viral evolutionary rate in HIV-1 disease progression in a linked cohort
    Meriet Mikhail
    Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead NSW 2145, Sydney, Australia
    Retrovirology 2:41. 2005
    ..By conducting 15 near full-length genome (8.7 kb) analysis from longitudinally derived patient PBMC samples enabled us to investigate the extent of molecular factors, which govern HIV disease progression...
  35. ncbi request reprint HIV-1 compartmentalization in diverse leukocyte populations during antiretroviral therapy
    Simon J Potter
    Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Darcy Road, Westmead, Sydney NSW 2145, Australia
    J Leukoc Biol 76:562-70. 2004
    ....
  36. ncbi request reprint HIV-1 co-infection, superinfection and recombination
    Megan C Steain
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia
    Sex Health 1:239-50. 2004
    ..This review is aimed at providing a more thorough understanding of dual infections (both co-infection and super-infection) and the possible consequences of the emergence of recombinant HIV-1 strains...
  37. ncbi request reprint Analysis of HIV-1 sequences vertically transmitted to infants in Kisumu, Kenya
    Megan C Steain
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW 2145 Sydney, Australia
    J Clin Virol 36:298-302. 2006
    ..The risk of a seropositve mother transmitting the virus to her infant is 25-35% in developing countries, such as Kenya, where antiretroviral drugs are not readily available...
  38. doi request reprint Transcriptional profiles in CD8+ T cells from HIV+ progressors on HAART are characterized by coordinated up-regulation of oxidative phosphorylation enzymes and interferon responses
    Jing Qin Wu
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, University of Sydney, Westmead, NSW, Australia
    Virology 380:124-35. 2008
    ..These results will provide biological insights into natural control of HIV versus HIV control under HAART...
  39. pmc HIV-1 integrase polymorphisms are associated with prior antiretroviral drug exposure
    Sebastiaan J van Hal
    Centre for Infectious Diseases and Microbiology, ICPMR Westmead Hospital, University of Sydney, Westmead 2145, NSW, Australia
    Retrovirology 6:12. 2009
    ..Based on these findings, we would recommend ongoing surveillance of integrase mutations, and integrase region sequencing for patients prior to commencement of integrase inhibitors...
  40. ncbi request reprint Short communication: absence of HIV infection in the choroid plexus of two patients who died rapidly with HIV-associated dementia
    Li Zhou
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead NSW 2145, Australia
    AIDS Res Hum Retroviruses 24:839-43. 2008
    ..These data suggest that HIV entry to the CNS may be independent of the CPx. It also emphasizes that the CPx is unlikely to harbor a significant reservoir of HIV in patients who rapidly progress to dementia...
  41. ncbi request reprint Complex patterns of the HIV-1 epidemic in Kuala Lumpur, Malaysia: evidence for expansion of circulating recombinant form CRF33_01B and detection of multiple other recombinants
    Bin Wang
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead NSW, Sydney, Australia
    Virology 367:288-97. 2007
    ..The remaining 18% of samples were identified as unique recombinant forms (URFs)...
  42. doi request reprint The possible contribution of HIV-1-induced syncytia to the generation of intersubtype recombinants in vitro
    Megan C Steain
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, Sydney, New South Wales, Australia
    AIDS 22:1009-17. 2008
    ..To develop a method for single syncytia isolation and delineate the possible contribution of syncytia to intersubtype recombination...
  43. ncbi request reprint Differential cellular distribution of HIV-1 drug resistance in vivo: evidence for infection of CD8+ T cells during HAART
    Simon J Potter
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital and The University of Sydney, New South Wales 2145, Australia
    Virology 305:339-52. 2003
    ..This study is the first to demonstrate the differential distribution of HIV drug resistance in different blood cell types during HAART and provides new insights into the infection of CD8+ T cells in vivo...
  44. pmc Hierarchical kernel mixture models for the prediction of AIDS disease progression using HIV structural gp120 profiles
    Paul D Yoo
    Centre for Distributed and High Performance Computing, University of Sydney, NSW, Australia
    BMC Genomics 11:S22. 2010
    ..82% CCI, 30.21 MSE, 0.8 STD, and 2.62 TBM on the three stages of AIDS disease progression of 50 HIV+ individuals. This framework is an invaluable bioinformatics tool that will be useful to the clinical assessment of viral pathogenesis...
  45. ncbi request reprint Env gp120 sequence analysis of HIV type 1 strains from diverse areas of the brain shows preponderance of CCR5 usage
    Meet Shah
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Darcy Road, Westmead NSW 2145, Australia
    AIDS Res Hum Retroviruses 22:177-81. 2006
    ....
  46. ncbi request reprint Comprehensive analyses of a unique HIV-1-infected nonprogressor reveal a complex association of immunobiological mechanisms in the context of replication-incompetent infection
    Bin Wang
    Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Westmead, New South Wales 2145, Australia
    Virology 304:246-64. 2002
    ..Understanding how to induce these protective immune responses in other individuals could provide a major step forward in the design of effective immunotherapies or vaccines against HIV infection...
  47. doi request reprint Detection of influenza A H1N1 and H3N2 mutations conferring resistance to oseltamivir using rolling circle amplification
    Megan C Steain
    Department of Infectious Diseases and Immunology, University of Sydney, NSW 2006, Australia
    Antiviral Res 84:242-8. 2009
    ..These results were further confirmed by neuraminidase region sequencing. In conclusion, RCA technology can provide rapid (<24 h), high-throughput diagnosis of OTV resistance mutations with a high specificity and sensitivity...
  48. ncbi request reprint Mechanisms involved in non-progressive HIV disease
    Meriet Mikhail
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, Sydney NSW 2145, Australia
    AIDS Rev 5:230-44. 2003
    ....
  49. pmc Rapid and sensitive detection of severe acute respiratory syndrome coronavirus by rolling circle amplification
    Bin Wang
    Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, The University of Sydney, Darcy Rd, Westmead, Sydney, NSW 2145, Australia
    J Clin Microbiol 43:2339-44. 2005
    ..Furthermore, the RCA technology provides a faster, more sensitive, and economical option to currently available PCR-based methods...
  50. ncbi request reprint Emerging trends of HIV epidemiology in Asia
    Katherine A Lau
    Retroviral Genetics Division, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Sydney, Australia
    AIDS Rev 9:218-29. 2007
    ..This appears to be an ongoing phenomenon and has resulted in an HIV-1 epidemic shift, with the expansion and dissemination of a wide variety of HIV-1 forms within this geographic region...
  51. doi request reprint Gene array data relevant to immunological and virological monitoring of human immunodeficiency virus type 1 infection
    Nitin K Saksena
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, Sydney, New South Wales, Australia
    Curr Opin HIV AIDS 8:132-9. 2013
    ..The purpose of the review is to provide a recent update on the use or possible use of array-based data in immunomonitoring of HIV patients...
  52. pmc Synthetic long oligonucleotides to generate artificial templates for use as positive controls in molecular assays: drug resistance mutations in influenza virus as an example
    Bin Wang
    Retroviral Genetics Laboratory, Centre for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, New South Wales, Australia
    Virol J 8:405. 2011
    ..This work describes the development of a synthetic oligo-cassette for positive controls for accurate and highly sensitive diagnosis of several mutations relevant to influenza virus drug resistance...
  53. pmc Segregation of human immunodeficiency virus type 1 subtypes by risk factor in Australia
    Belinda L Herring
    Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
    J Clin Microbiol 41:4600-4. 2003
    ..Subtype B strains of group M viruses predominate in Australia in HIV-1 transmitted by homosexual or bisexual contact and IDU. However, non-B subtypes have been introduced, mostly acquired via heterosexual contact...
  54. ncbi request reprint Interaction between HIV-1 and APOBEC3 sub-family of proteins
    Maria E Arriaga
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Sydney, Australia
    Curr HIV Res 4:401-9. 2006
    ..The main purpose of this review is to provide a detailed overview on HIV-specific interaction of APOBEC3 subfamily of proteins and discuss its potential role in HIV pathogenesis...
  55. ncbi request reprint HIV type 1 sequence diversity and dual infections in Kenya
    Megan C Steain
    Retroviral Genetics Laboratory, Center for Virus Research, Westmead Millennium Institute, Westmead NSW 2145, Sydney, Australia
    AIDS Res Hum Retroviruses 21:882-5. 2005
    ..These results imply that the HIV epidemic in western Kenya is a dynamic one and is continually evolving. Therefore, continued monitoring of the epidemic in this region is necessary if a vaccine for the area is to be developed...
  56. pmc Viruses and neurodegeneration
    Li Zhou
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead NSW 2145, Sydney Australia
    Virol J 10:172. 2013
    ..This will further stimulate the birth of new concepts in the biological research, which is needed for gaining deeper insights into the treatment of human NDs and delineate mechanisms underlying neurodegeneration...
  57. pmc Why are the neurodegenerative disease-related pathways overrepresented in primary HIV-infected peripheral blood mononuclear cells: a genome-wide perspective
    Li Zhou
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, Sydney, 2145, NSW, Australia
    Virol J 9:308. 2012
    ..Moreover, these findings signify the utility of PBMC and genome-wide mapping of the host gene expression as a powerful tool in predicting possible early events in neurologic deterioration in HIV patients...
  58. ncbi request reprint Micro-RNA: new players in HIV-pathogenesis, diagnosis, prognosis and antiviral therapy
    Lauren Fowler
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, Australia
    AIDS Rev 15:3-14. 2013
    ....
  59. pmc Regulation of gene expression by microRNA in HCV infection and HCV-mediated hepatocellular carcinoma
    Priyanka Gupta
    Centre for Virus Research, Westmead Millennium Institute, Darcy Road, Sydney, Westmead NSW 2145, Australia
    Virol J 11:64. 2014
    ..Here, we review the current knowledge on the role of miRNA and gene expression on HCV infection and hepatocellular carcinoma, in addition to the possible role of miRNA as future therapeutic targets. ..
  60. pmc Transcriptome analysis of primary monocytes from HIV-positive patients with differential responses to antiretroviral therapy
    Jing Qin Wu
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Westmead, Sydney, NSW, 2145, Australia
    Virol J 10:361. 2013
    ..This study investigated the monocytic transcriptome distinctions between patients with sustained virus suppression and those with virological failure during highly active antiretroviral therapy (HAART)...
  61. ncbi request reprint Double-stranded nef RNA interferes with human immunodeficiency virus type 1 replication
    Takuya Yamamoto
    Division of Nutritional Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi 467 8603, Japan
    Microbiol Immunol 46:809-17. 2002
    ..At 48 hr, a defective nef dsRNA (556 nt) suppressed Luc activity more potently than did SF2 full-length nef dsRNA (744 nt), suggesting that approximately 500 nt-long nef dsRNA could interfere with the HIV-1 transcription...
  62. ncbi request reprint HIV-1 Nef protein in the nucleus influences adipogenesis as well as viral transcription through the peroxisome proliferator-activated receptors
    Kaori Otake
    Nagoya University Hospital, Japan
    AIDS 18:189-98. 2004
    ..Nef is known to play an important role in transcriptional events and viral replication, but the actual target of Nef in the nucleus remains to be identified...
  63. ncbi request reprint Functional conservation of HIV-1 Vpr and variability in a mother-child pair of long-term non-progressors
    Yuqi Zhao
    Children s Memorial Institute for Education and Research, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Virus Res 89:103-21. 2002
    ..Thus, Vpr activities are generally conserved in naturally occurring viruses. The functionally defective Vpr identified in the mother-child pair of LTNPs are likely to be unique and may possibly contribute to the slow disease progression...
  64. ncbi request reprint Evidence for host-driven selection of the HIV type 1 vpr gene in vivo during HIV disease progression in a transfusion-acquired cohort
    Leon Cali
    Nuclear Signalling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Monash, VIC 3800, Australia
    AIDS Res Hum Retroviruses 21:728-33. 2005
    ....
  65. ncbi request reprint Broad neutralization and complement-mediated lysis of HIV-1 by PEHRG214, a novel caprine anti-HIV-1 polyclonal antibody
    Erin E Verity
    Department of Microbiology, Monash University, Clayton, Victoria, Australia
    AIDS 20:505-15. 2006
    ..To assess the potency, breadth of action, and mechanism of action of the polyclonal goat anti-HIV antibody, PEHRG214...
  66. pmc Transitory viremic surges in a human immunodeficiency virus-positive elite controller can shift the cellular transcriptome profile: a word of caution for microarray studies
    Jing Qin Wu
    J Virol 82:10326-7. 2008
  67. ncbi request reprint Site stripping based on likelihood ratio reduction is a useful tool to evaluate the impact of non-clock-like behavior on viral phylogenetic reconstructions
    Philippe Lemey
    Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B 3000, Leuven, Belgium
    FEMS Immunol Med Microbiol 39:125-32. 2003
    ..Our method was able to rapidly recover clock-like behavior and to indicate the presence and direction of a bias when estimates of divergence times using the unstripped data were flawed...
  68. pmc Tracing the origin and history of the HIV-2 epidemic
    Philippe Lemey
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    Proc Natl Acad Sci U S A 100:6588-92. 2003
    ....
  69. pmc Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 allele
    Lachlan Gray
    Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne 3001, Victoria, Australia
    J Virol 80:3684-91. 2006
    ..The persistence of CCR5-using HIV-1 in two CCR5delta32 homozygotes suggests the conserved CCR5 binding domain of Env is highly stable and provides new mechanistic insights important for HIV-1 transmission and persistence...