R Saint

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. ncbi request reprint Pictures in cell biology. A functional marker for Drosophila chromosomes in vivo
    R Saint
    Centre for the Molecular Genetics of Development and Dept of Molecular Biosciences, University of Adelaide, SA 5005, Adelaide, Australia
    Trends Cell Biol 10:553. 2000
  2. ncbi request reprint A His2AvDGFP fusion gene complements a lethal His2AvD mutant allele and provides an in vivo marker for Drosophila chromosome behavior
    M Clarkson
    Department of Biochemistry, University of Adelaide, SA, Australia
    DNA Cell Biol 18:457-62. 1999
  3. ncbi request reprint Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein
    S O'Connell
    Centre for the Molecular Genetics of Development and Department of Genetics, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Biol Chem 276:43065-73. 2001
  4. ncbi request reprint Tissue-specific regulation of cyclin E transcription during Drosophila melanogaster embryogenesis
    L Jones
    Centre for the Molecular Genetics of Development and Department of Molecular Biosciences, University of Adelaide, South Australia, Australia
    Development 127:4619-30. 2000
  5. ncbi request reprint The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome
    R D Kortschak
    Department of Genetics, University of Adelaide, South Australia, Australia
    Genomics 51:288-92. 1998
  6. pmc The three rows gene of Drosophila melanogaster encodes a novel protein that is required for chromosome disjunction during mitosis
    R J D'Andrea
    Department of Biochemistry, University of Adelaide, Australia
    Mol Biol Cell 4:1161-74. 1993
  7. pmc Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development
    J Secombe
    Department of Genetics, University of Adelaide, South Australia, Australia, 5005
    Genetics 149:1867-82. 1998
  8. ncbi request reprint The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster
    M Coulson
    Department of Genetics, University of Adelaide, Australia
    Genomics 48:381-3. 1998
  9. ncbi request reprint ARID proteins come in from the desert
    R D Kortschak
    Centre for Molecular Genetics of Development and Dept of Genetics, University of Adelaide, Adelaide, SA 5005, Australia
    Trends Biochem Sci 25:294-9. 2000
  10. ncbi request reprint Genetic analysis of chromosomal region 97D2-9 of Drosophila melanogaster
    W R Knibb
    Department of Biochemistry, University of Adelaide, Australia
    Mol Gen Genet 239:109-14. 1993

Collaborators

  • L Wang
  • B Patterson
  • L Jones
  • J Pispa
  • M Zimmer
  • Paul J Smith
  • A Tomlinson
  • D E Jenne
  • R D Kortschak
  • T Shandala
  • W G Somers
  • S O'Connell
  • R T Williams
  • T Hader
  • S Robert
  • M J Clarkson
  • M Clarkson
  • S N Prokopenko
  • J Secombe
  • M Coulson
  • S A Valentine
  • H J Eyre
  • P Kylsten
  • L Prior
  • G Hime
  • S L Gregory
  • H Richardson
  • R S Jones
  • L Van Stekelenburg
  • J S Kazenwadel
  • M S Hancock
  • A Harley
  • J P Eid
  • M A Dziadek
  • S S Manji
  • C A Jones
  • P V Senior
  • N J Parker
  • T J Lockett
  • G Bronner
  • H Jackle
  • H Taubert
  • P W Tucker
  • D Wainwright
  • H J Bellen
  • Y He
  • F Gibson
  • D J Tremethick
  • J R Wells
  • A Brumby
  • L O'Keefe
  • S Mische
  • J A Knoblich
  • G Chen
  • H Reimann
  • J Fernandez
  • A Lonie
  • R Tearle
  • A J Courey
  • C F Lehner
  • B Kalionis
  • R J D'Andrea
  • H E Richardson
  • W R Knibb
  • R Paro
  • R D'ANDREA
  • K Sauer
  • S I Reed
  • R Stratmann
  • U P John
  • A Elizur
  • P A Moretti
  • L V O'Keefe
  • J A Lake
  • R G Tearle
  • K Medveczky
  • D Lewy
  • P Holmes

Detail Information

Publications29

  1. ncbi request reprint Pictures in cell biology. A functional marker for Drosophila chromosomes in vivo
    R Saint
    Centre for the Molecular Genetics of Development and Dept of Molecular Biosciences, University of Adelaide, SA 5005, Adelaide, Australia
    Trends Cell Biol 10:553. 2000
  2. ncbi request reprint A His2AvDGFP fusion gene complements a lethal His2AvD mutant allele and provides an in vivo marker for Drosophila chromosome behavior
    M Clarkson
    Department of Biochemistry, University of Adelaide, SA, Australia
    DNA Cell Biol 18:457-62. 1999
    ..The very high level of conservation of the H2A.F/Z family of variant histones suggests that the equivalent fusion protein construct should function equally well in a wide range of organisms...
  3. ncbi request reprint Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein
    S O'Connell
    Centre for the Molecular Genetics of Development and Department of Genetics, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Biol Chem 276:43065-73. 2001
    ..We discuss the implications of PCL association with ESC.E(Z) complexes and the possibility that PCL may either be a subunit of a subset of ESC.E(Z) complexes or a subunit of a separate complex that interacts with ESC.E(Z) complexes...
  4. ncbi request reprint Tissue-specific regulation of cyclin E transcription during Drosophila melanogaster embryogenesis
    L Jones
    Centre for the Molecular Genetics of Development and Department of Molecular Biosciences, University of Adelaide, South Australia, Australia
    Development 127:4619-30. 2000
    ..Rather, our study demonstrates that tissue-specific transcriptional regulatory mechanisms are important components of the control of cyclin E transcription and thus of cell proliferation in metazoans...
  5. ncbi request reprint The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome
    R D Kortschak
    Department of Genetics, University of Adelaide, South Australia, Australia
    Genomics 51:288-92. 1998
    ..3. As this marker is intimately linked to the Peutz-Jeghers syndrome in several large pedigrees, human dri (DRIL1) is a candidate gene for this disorder...
  6. pmc The three rows gene of Drosophila melanogaster encodes a novel protein that is required for chromosome disjunction during mitosis
    R J D'Andrea
    Department of Biochemistry, University of Adelaide, Australia
    Mol Biol Cell 4:1161-74. 1993
    ..Our results indicate that the novel thr product is required specifically for chromosome disjunction during all mitoses...
  7. pmc Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development
    J Secombe
    Department of Genetics, University of Adelaide, South Australia, Australia, 5005
    Genetics 149:1867-82. 1998
    ..In addition, this analysis has identified cyclin A and string as DmcycEJP interactors, suggesting a novel role for cyclin E in the regulation of Cyclin A and String function during eye development...
  8. ncbi request reprint The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster
    M Coulson
    Department of Genetics, University of Adelaide, Australia
    Genomics 48:381-3. 1998
    ..PHF1 was mapped to 6p21.3 by fluorescence in situ hybridization. While several genetic diseases that are likely to result from developmental abnormalities map to this region, PHF1 is not a clear candidate gene for any of them...
  9. ncbi request reprint ARID proteins come in from the desert
    R D Kortschak
    Centre for Molecular Genetics of Development and Dept of Genetics, University of Adelaide, Adelaide, SA 5005, Australia
    Trends Biochem Sci 25:294-9. 2000
    ....
  10. ncbi request reprint Genetic analysis of chromosomal region 97D2-9 of Drosophila melanogaster
    W R Knibb
    Department of Biochemistry, University of Adelaide, Australia
    Mol Gen Genet 239:109-14. 1993
    ..In addition to rough, one other locus within this region, 1(3)97De, was shown to be required for formation of the normal pattern of photoreceptor cells in the compound eye...
  11. ncbi request reprint A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesis
    H E Richardson
    Department of Biochemistry, University of Adelaide, Australia
    Development 119:673-90. 1993
    ....
  12. ncbi request reprint Zygotic transcription and cell proliferation during Drosophila embryogenesis
    R Saint
    Department of Biochemistry, University of Adelaide, Australia
    Genetica 90:157-63. 1993
    ..Genes that comprise the first class are involved in the developmental control of the cell cycle, while those of the second class identify components of the cell cycle machinery...
  13. ncbi request reprint Regions of variant histone His2AvD required for Drosophila development
    M J Clarkson
    The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory
    Nature 399:694-7. 1999
    ..We show that the unique feature of His2AvD does not reside in its histone fold but in its carboxy-terminal domain. This C-terminal region maps to a short alpha-helix in H2A that is buried deep inside the nucleosome core...
  14. pmc A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila
    S N Prokopenko
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030 USA
    Genes Dev 13:2301-14. 1999
    ..Our results identify Pbl as a RhoGEF specifically required for cytokinesis and linked through Rho1 activity to the reorganization of the actin cytoskeleton at the cleavage furrow...
  15. pmc Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer
    S A Valentine
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095 1569, USA
    Mol Cell Biol 18:6584-94. 1998
    ..By showing how binding site context can dramatically alter transcription factor function, these findings help clarify the mechanisms responsible for the regulatory specificity of transcription factors...
  16. ncbi request reprint Receptor tyrosine kinase signaling regulates different modes of Groucho-dependent control of Dorsal
    T Hader
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
    Curr Biol 10:51-4. 2000
    ..RTK signaling provides a way of modulating DI function by interfering either with Gro activity or with Dri-dependent recruitment of Gro to the enhancer...
  17. pmc Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins
    R T Williams
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria 3052, Australia
    Biochem J 357:673-85. 2001
    ..This association into oligomers in vivo indicates a possible functional interaction between STIM1 and STIM2. The structural similarities between STIM1, STIM2 and D-STIM suggest conserved biological functions...
  18. ncbi request reprint Developmental regulation of the cell cycle
    R Saint
    Department of Biochemistry, University of Adelaide, Australia
    Curr Opin Genet Dev 2:614-20. 1992
    ..Surprisingly, developmental regulation is mediated at a variety of cell-cycle stages. Highly conserved cell-cycle control mechanisms provide a focus for studying the regulatory processes involved...
  19. ncbi request reprint Imaginal tissues of Drosophila melanogaster exhibit different modes of cell proliferation control
    P Kylsten
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, Sweden
    Dev Biol 192:509-22. 1997
    ..melanogaster development, but also reveals that at least one additional mechanism is utilized to control G2-phase length and thus cell proliferation in different developmental contexts...
  20. ncbi request reprint Zygotic expression of the pebble locus is required for cytokinesis during the postblastoderm mitoses of Drosophila
    G Hime
    Department of Biochemistry, University of Adelaide, South Australia
    Development 114:165-71. 1992
    ..We postulate that developmental regulation of zygotic transcription of the pebble gene is a consequence of the transition from syncytial to cellular mitoses during cycle 14 of embryogenesis...
  21. ncbi request reprint The rough (ro+) gene as a dominant P-element marker in germ line transformation of Drosophila melanogaster
    T J Lockett
    CSIRO, Division of Biomolecular Engineering, North Ryde, NSW, Australia
    Gene 114:187-93. 1992
    ..Single insertions of this element, whether in the hemizygous or homozygous condition, completely rescued the ro- mutation and directed heat-inducible synthesis of Luc mRNA and enzyme...
  22. ncbi request reprint Pattern formation in the developing eye of Drosophila melanogaster is regulated by the homoeo-box gene, rough
    R Saint
    CSIRO Division of Entomology, Canberra, ACT, Australia
    Nature 334:151-4. 1988
    ..We have found no genetic or molecular evidence of a role for this gene in other aspects of fly development...
  23. ncbi request reprint The Drosophila melanogaster genome contains a member of the Rh/T2/S-glycoprotein family of ribonuclease-encoding genes
    G Hime
    Department of Biochemistry, University of Adelaide, Australia
    Gene 158:203-7. 1995
    ..The discovery of members of this family of genes in an insect genome indicates that these RNases are widely conserved and play important roles in the animal, as well as the plant and prokaryotic kingdoms...
  24. ncbi request reprint Molecular characterisation of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expression
    A Lonie
    Department of Biochemistry, University of Adelaide, Australia
    Development 120:2629-36. 1994
    ..These data add further support for a model in which Polycomb Group proteins form multimeric protein complexes at specific chromosomal loci to repress transcription at those loci...
  25. ncbi request reprint The dominant Drop eye mutations of Drosophila melanogaster define two loci implicated in normal eye development
    R Tearle
    Department of Biochemistry, Adelaide University, Australia
    Mol Gen Genet 244:426-34. 1994
    ....
  26. ncbi request reprint Rough genes with Deformed homeobox substitutions exhibit rough regulatory specificity during Drosophila eye development
    T J Lockett
    Laboratory for Molecular Biology, CSIRO Division of Biomolecular Engineering, North Ryde, NSW, Australia
    Mech Dev 41:57-68. 1993
    ..These results suggest that factors other than the DNA binding specificity of the homeodomain play crucial roles in determining the target, and thus the regulatory specificity, of such proteins...
  27. ncbi request reprint Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation
    J A Knoblich
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
    Cell 77:107-20. 1994
    ..Therefore, Drosophila cyclin E, which forms a complex with the Dmcdc2c kinase, controls progression through S phase and its down-regulation limits embryonic proliferation...
  28. pmc Characterization of the dead ringer gene identifies a novel, highly conserved family of sequence-specific DNA-binding proteins
    S L Gregory
    Department of Genetics, University of Adelaide, South Australia
    Mol Cell Biol 16:792-9. 1996
    ..The discovery of this new, conserved DNA-binding domain offers an explanation for the regulatory activity of several important members of this class and predicts significant regulatory roles for the others...
  29. ncbi request reprint The pebble GTP exchange factor and the control of cytokinesis
    W G Somers
    Centre for the Molecular Genetics of Development and Dept. of Molecular Biosciences, Adelaide University, SA, Australia
    Cell Struct Funct 26:619-26. 2001
    ..We summarise the evidence that the primary target of PBL is Rho1 and describe genetic approaches to elucidating the function of PBL and identifying other components of the PBL-activated Rho signalling pathway...