R SaintSummaryAffiliation: University of Adelaide Country: Australia Publications
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Pictures in cell biology. A functional marker for Drosophila chromosomes in vivoR Saint
Centre for the Molecular Genetics of Development and Dept of Molecular Biosciences, University of Adelaide, SA 5005, Adelaide, Australia
Trends Cell Biol 10:553. 2000- Regions of variant histone His2AvD required for Drosophila developmentM J Clarkson
The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory
Nature 399:694-7. 1999..We show that the unique feature of His2AvD does not reside in its histone fold but in its carboxy-terminal domain. This C-terminal region maps to a short alpha-helix in H2A that is buried deep inside the nucleosome core... 
The three rows gene of Drosophila melanogaster encodes a novel protein that is required for chromosome disjunction during mitosisR J D'Andrea
Department of Biochemistry, University of Adelaide, Australia
Mol Biol Cell 4:1161-74. 1993..Our results indicate that the novel thr product is required specifically for chromosome disjunction during all mitoses...- A His2AvDGFP fusion gene complements a lethal His2AvD mutant allele and provides an in vivo marker for Drosophila chromosome behaviorM Clarkson
Department of Biochemistry, University of Adelaide, SA, Australia
DNA Cell Biol 18:457-62. 1999..The very high level of conservation of the H2A.F/Z family of variant histones suggests that the equivalent fusion protein construct should function equally well in a wide range of organisms... - Genetic analysis of chromosomal region 97D2-9 of Drosophila melanogasterW R Knibb
Department of Biochemistry, University of Adelaide, Australia
Mol Gen Genet 239:109-14. 1993..In addition to rough, one other locus within this region, 1(3)97De, was shown to be required for formation of the normal pattern of photoreceptor cells in the compound eye... - The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogasterM Coulson
Department of Genetics, University of Adelaide, Australia
Genomics 48:381-3. 1998..PHF1 was mapped to 6p21.3 by fluorescence in situ hybridization. While several genetic diseases that are likely to result from developmental abnormalities map to this region, PHF1 is not a clear candidate gene for any of them... - Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc developmentJ Secombe
Department of Genetics, University of Adelaide, South Australia, Australia, 5005
Genetics 149:1867-82. 1998..In addition, this analysis has identified cyclin A and string as DmcycEJP interactors, suggesting a novel role for cyclin E in the regulation of Cyclin A and String function during eye development... - Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencerS A Valentine
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095 1569, USA
Mol Cell Biol 18:6584-94. 1998..By showing how binding site context can dramatically alter transcription factor function, these findings help clarify the mechanisms responsible for the regulatory specificity of transcription factors... - Developmental regulation of the cell cycleR Saint
Department of Biochemistry, University of Adelaide, Australia
Curr Opin Genet Dev 2:614-20. 1992..Surprisingly, developmental regulation is mediated at a variety of cell-cycle stages. Highly conserved cell-cycle control mechanisms provide a focus for studying the regulatory processes involved... - A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in DrosophilaS N Prokopenko
Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030 USA
Genes Dev 13:2301-14. 1999..Our results identify Pbl as a RhoGEF specifically required for cytokinesis and linked through Rho1 activity to the reorganization of the actin cytoskeleton at the cleavage furrow... - Receptor tyrosine kinase signaling regulates different modes of Groucho-dependent control of DorsalT Hader
Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
Curr Biol 10:51-4. 2000..RTK signaling provides a way of modulating DI function by interfering either with Gro activity or with Dri-dependent recruitment of Gro to the enhancer... - Tissue-specific regulation of cyclin E transcription during Drosophila melanogaster embryogenesisL Jones
Centre for the Molecular Genetics of Development and Department of Molecular Biosciences, University of Adelaide, South Australia, Australia
Development 127:4619-30. 2000..Rather, our study demonstrates that tissue-specific transcriptional regulatory mechanisms are important components of the control of cyclin E transcription and thus of cell proliferation in metazoans... - Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteinsR T Williams
Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria 3052, Australia
Biochem J 357:673-85. 2001..This association into oligomers in vivo indicates a possible functional interaction between STIM1 and STIM2. The structural similarities between STIM1, STIM2 and D-STIM suggest conserved biological functions... - Imaginal tissues of Drosophila melanogaster exhibit different modes of cell proliferation controlP Kylsten
Department of Developmental Biology, Wenner Gren Institute, Stockholm University, Sweden
Dev Biol 192:509-22. 1997..melanogaster development, but also reveals that at least one additional mechanism is utilized to control G2-phase length and thus cell proliferation in different developmental contexts... - Characterization of the dead ringer gene identifies a novel, highly conserved family of sequence-specific DNA-binding proteinsS L Gregory
Department of Genetics, University of Adelaide, South Australia
Mol Cell Biol 16:792-9. 1996..The discovery of this new, conserved DNA-binding domain offers an explanation for the regulatory activity of several important members of this class and predicts significant regulatory roles for the others... - Zygotic expression of the pebble locus is required for cytokinesis during the postblastoderm mitoses of DrosophilaG Hime
Department of Biochemistry, University of Adelaide, South Australia
Development 114:165-71. 1992..We postulate that developmental regulation of zygotic transcription of the pebble gene is a consequence of the transition from syncytial to cellular mitoses during cycle 14 of embryogenesis... - The rough (ro+) gene as a dominant P-element marker in germ line transformation of Drosophila melanogasterT J Lockett
CSIRO, Division of Biomolecular Engineering, North Ryde, NSW, Australia
Gene 114:187-93. 1992..Single insertions of this element, whether in the hemizygous or homozygous condition, completely rescued the ro- mutation and directed heat-inducible synthesis of Luc mRNA and enzyme... - Pattern formation in the developing eye of Drosophila melanogaster is regulated by the homoeo-box gene, roughR Saint
CSIRO Division of Entomology, Canberra, ACT, Australia
Nature 334:151-4. 1988..We have found no genetic or molecular evidence of a role for this gene in other aspects of fly development... - The Drosophila melanogaster genome contains a member of the Rh/T2/S-glycoprotein family of ribonuclease-encoding genesG Hime
Department of Biochemistry, University of Adelaide, Australia
Gene 158:203-7. 1995..The discovery of members of this family of genes in an insect genome indicates that these RNases are widely conserved and play important roles in the animal, as well as the plant and prokaryotic kingdoms... - Molecular characterisation of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expressionA Lonie
Department of Biochemistry, University of Adelaide, Australia
Development 120:2629-36. 1994..These data add further support for a model in which Polycomb Group proteins form multimeric protein complexes at specific chromosomal loci to repress transcription at those loci... - The dominant Drop eye mutations of Drosophila melanogaster define two loci implicated in normal eye developmentR Tearle
Department of Biochemistry, Adelaide University, Australia
Mol Gen Genet 244:426-34. 1994.... - Rough genes with Deformed homeobox substitutions exhibit rough regulatory specificity during Drosophila eye developmentT J Lockett
Laboratory for Molecular Biology, CSIRO Division of Biomolecular Engineering, North Ryde, NSW, Australia
Mech Dev 41:57-68. 1993..These results suggest that factors other than the DNA binding specificity of the homeodomain play crucial roles in determining the target, and thus the regulatory specificity, of such proteins... - Zygotic transcription and cell proliferation during Drosophila embryogenesisR Saint
Department of Biochemistry, University of Adelaide, Australia
Genetica 90:157-63. 1993..Genes that comprise the first class are involved in the developmental control of the cell cycle, while those of the second class identify components of the cell cycle machinery... - Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferationJ A Knoblich
Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
Cell 77:107-20. 1994..Therefore, Drosophila cyclin E, which forms a complex with the Dmcdc2c kinase, controls progression through S phase and its down-regulation limits embryonic proliferation... - A Drosophila G1-specific cyclin E homolog exhibits different modes of expression during embryogenesisH E Richardson
Department of Biochemistry, University of Adelaide, Australia
Development 119:673-90. 1993.... - The pebble GTP exchange factor and the control of cytokinesisW G Somers
Centre for the Molecular Genetics of Development and Dept. of Molecular Biosciences, Adelaide University, SA, Australia
Cell Struct Funct 26:619-26. 2001..We summarise the evidence that the primary target of PBL is Rho1 and describe genetic approaches to elucidating the function of PBL and identifying other components of the PBL-activated Rho signalling pathway...