P S Sachdev


Affiliation: University of New South Wales
Country: Australia


  1. Revelas M, Thalamuthu A, Oldmeadow C, Evans T, Armstrong N, Riveros C, et al. Exceptional Longevity and Polygenic Risk for Cardiovascular Health. Genes (Basel). 2019;10: pubmed publisher
    ..Future work in larger cohorts is required to further explore the role of cardiovascular-related genetic variants in EL. ..
  2. Radd Vagenas S, Fiatarone Singh M, Daniel K, Noble Y, Jain N, O Leary F, et al. Validity of the Mediterranean Diet and Culinary Index (MediCul) for Online Assessment of Adherence to the 'Traditional' Diet and Aspects of Cuisine in Older Adults. Nutrients. 2018;10: pubmed publisher
    ..Online MediCul administration demonstrated good reliability and moderate validity for assessing adherence to a 'traditional' Mediterranean pattern among older Australians. ..
  3. Sachdev P, Lammel A, Trollor J, Lee T, Wright M, Ames D, et al. A comprehensive neuropsychiatric study of elderly twins: the Older Australian Twins Study. Twin Res Hum Genet. 2009;12:573-82 pubmed publisher
    ..The cohort will be assessed every two years, with in-depth assessments being repeated. OATS offers an excellent opportunity for collaboration with other similar studies as well as researchers who share the same interests. ..
  4. Sachdev P, Lipnicki D, Crawford J, Reppermund S, Kochan N, Trollor J, et al. Factors predicting reversion from mild cognitive impairment to normal cognitive functioning: a population-based study. PLoS ONE. 2013;8:e59649 pubmed publisher
    ..Assessing these factors could facilitate more accurate prognosis of individuals with MCI. Participation in cognitively enriching activities and efforts to lower blood pressure might promote reversion. ..
  5. Clement J, Wong M, Poljak A, Sachdev P, Braidy N. The Plasma NAD+ Metabolome is Dysregulated in 'normal' Ageing. Rejuvenation Res. 2018;: pubmed publisher
    ..Taken together, our data cumulatively suggests that age-related impairments may also be associated with alterations in the extracellular plasma NAD+ metabolome. ..
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    Yang Z, Wen W, Jiang J, Crawford J, Reppermund S, Levitan C, et al. Structural MRI Biomarkers of Mild Cognitive Impairment from Young Elders to Centenarians. Curr Alzheimer Res. 2016;13:256-67 pubmed
    ..The structures that best distinguish aMCI from CN differ in those <85 from those ≥85, suggesting different neuropathological underpinnings of cognitive impairment in the very old. ..
  7. Jacka F, Cherbuin N, Anstey K, Sachdev P, Butterworth P. Western diet is associated with a smaller hippocampus: a longitudinal investigation. BMC Med. 2015;13:215 pubmed publisher
    ..To our knowledge, this is the first human study to demonstrate associations between diet and hippocampal volume concordant with data previously observed in animal models. ..
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    Sachdev P. Neuroleptic-induced movement disorders: an overview. Psychiatr Clin North Am. 2005;28:255-74, x pubmed
  9. Chen X, Wen W, Anstey K, Sachdev P. Prevalence, incidence, and risk factors of lacunar infarcts in a community sample. Neurology. 2009;73:266-72 pubmed publisher
    ..Hypertension was the major treatable risk factor, and lacunar infarction was usually associated with severe white matter hyperintensities on T2-weighted imaging. ..

More Information


  1. Braidy N, Berg J, Clement J, Khorshidi F, Poljak A, Jayasena T, et al. NAD+ Precursors as Therapeutic Agents for Age-related Degenerative Diseases. Antioxid Redox Signal. 2018;: pubmed publisher
  2. Sachdev P, Chen X, Wen W. White matter hyperintensities in mid-adult life. Curr Opin Psychiatry. 2008;21:268-74 pubmed publisher
    ..Standardized methods to examine such pathology and its determinants will help inform strategies for their prevention, which is an important component of a healthy ageing agenda. ..
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    Sachdev P, Chen X, Joscelyne A, Wen W, Altendorf A, Brodaty H. Hippocampal size and dementia in stroke patients: the Sydney stroke study. J Neurol Sci. 2007;260:71-7 pubmed
    ..The hippocampus volume relates to episodic memory, especially right hippocampus and new visual learning. A longitudinal study of these subjects will determine whether hippocampal atrophy is a late development in VaD. ..
  4. Brodaty H, Woolf C, Andersen S, Barzilai N, Brayne C, Cheung K, et al. ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups. BMC Neurol. 2016;16:52 pubmed publisher
    ..A specific challenge for ICC-Dementia relates to the concept and definition of'abnormal' in this exceptional group of individuals who are rarely free of physical, sensory and/or cognitive impairments. ..
  5. Lipnicki D, Crawford J, Kochan N, Trollor J, Draper B, Reppermund S, et al. Risk Factors for Mild Cognitive Impairment, Dementia and Mortality: The Sydney Memory and Ageing Study. J Am Med Dir Assoc. 2017;18:388-395 pubmed publisher
    ..Tests for slower walking speed and poorer smelling ability may help screen for cognitive decline. Individuals with normal cognition are at greater risk of future cognitive impairment if they have a history of MCI. ..
  6. Zhang H, Sachdev P, Thalamuthu A, He Y, Xia M, Kochan N, et al. The relationship between voxel-based metrics of resting state functional connectivity and cognitive performance in cognitively healthy elderly adults. Brain Imaging Behav. 2018;12:1742-1758 pubmed publisher
  7. Chopra S, Shaw M, Shaw T, Sachdev P, Anstey K, Cherbuin N. More highly myelinated white matter tracts are associated with faster processing speed in healthy adults. Neuroimage. 2018;171:332-340 pubmed publisher
    ..The present results indicate that myelin content, estimated in vivo using a neuroimaging approach in healthy older adults, is sufficiently precise to predict variability in processing speed in behavioural measures. ..
  8. Sachdev P, Andrews G, Hobbs M, Sunderland M, Anderson T. Neurocognitive disorders: cluster 1 of the proposed meta-structure for DSM-V and ICD-11. Psychol Med. 2009;39:2001-12 pubmed publisher
    ..Further developments in the aetiopathogenesis of these disorders will enhance the clinical utility of this cluster. ..
  9. Sachdev P, Thalamuthu A, Mather K, Ames D, Wright M, Wen W. White Matter Hyperintensities Are Under Strong Genetic Influence. Stroke. 2016;47:1422-8 pubmed publisher
    ..The genetic influence is higher in women, and there is an age-related decline, most markedly for deep WMH. The data suggest some heterogeneity in the pathogenesis of WMH for different brain regions and for men and women. ..
  10. Sachdev P, Lipnicki D, Kochan N, Crawford J, Rockwood K, Xiao S, et al. COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurol. 2013;13:165 pubmed publisher
    ..COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing. ..
  11. Sachdev P, Zhuang L, Braidy N, Wen W. Is Alzheimer's a disease of the white matter?. Curr Opin Psychiatry. 2013;26:244-51 pubmed publisher
    ..White matter abnormalities not only represent an early neuropathological event in Alzheimer's disease but may also play an important role in the pathogenesis and diagnosis of Alzheimer's disease. ..
  12. Yang Z, Wen W, Jiang J, Crawford J, Reppermund S, Levitan C, et al. Age-associated differences on structural brain MRI in nondemented individuals from 71 to 103 years. Neurobiol Aging. 2016;40:86-97 pubmed publisher
    ..Our study demonstrated heterogeneous differences across brain regions between the oldest old and young old, with an emphasis on hippocampus, temporoposterior cortex, and white matter hyperintensities. ..
  13. Gates N, Sachdev P, Fiatarone Singh M, Valenzuela M. Cognitive and memory training in adults at risk of dementia: a systematic review. BMC Geriatr. 2011;11:55 pubmed publisher
    ..However, the number of high quality RCTs remains low, and so further trials must be a priority. Several suggestions for the better design of cognitive training trials are provided. ..
  14. Eramudugolla R, Mortby M, Sachdev P, Meslin C, Kumar R, Anstey K. Evaluation of a research diagnostic algorithm for DSM-5 neurocognitive disorders in a population-based cohort of older adults. Alzheimers Res Ther. 2017;9:15 pubmed publisher
    ..Expert diagnosis using DSM-5 NCD criteria captured most cases with DSM-IV dementia and MCI in our sample, but included many additional cases suggesting that DSM-5 criteria are broader in their categorization. ..
  15. Wong M, Braidy N, Poljak A, Pickford R, Thambisetty M, Sachdev P. Dysregulation of lipids in Alzheimer's disease and their role as potential biomarkers. Alzheimers Dement. 2017;13:810-827 pubmed publisher
    ..Important considerations for designing large-scale lipidomics experiments are discussed to help standardize findings across different laboratories, as well as challenges associated with moving toward clinical application. ..
  16. Muenchhoff J, Song F, Poljak A, Crawford J, Mather K, Kochan N, et al. Plasma apolipoproteins and physical and cognitive health in very old individuals. Neurobiol Aging. 2017;55:49-60 pubmed publisher
    ..Our findings suggest levels of some apolipoproteins, especially ApoE, are associated with lifespan and cognitive function in exceptionally long-lived individuals. ..
  17. Sachdev P, Mohan A. An International Curriculum for Neuropsychiatry and Behavioural Neurology. Rev Colomb Psiquiatr. 2017;46 Suppl 1:18-27 pubmed publisher
    ..The future of Neuropsychiatry (or Behavioural Neurology) as a discipline will be influenced by the successful adoption of such a unified training curriculum. ..
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    Sachdev P, Saharov T. The effects of beta-adrenoceptor antagonists on a rat model of neuroleptic-induced akathisia. Psychiatry Res. 1997;72:133-40 pubmed
    ..The B-antagonist drugs significantly reduced the cataleptic effect of haloperidol and this effect warrants further examination...
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    Sachdev P, Brune M. Animal models of acute drug-induced akathisia - a review. Neurosci Biobehav Rev. 2000;24:269-77 pubmed
    ..It is also necessary to consider the subtypes of akathisia in the attempts to develop these models...
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    Sachdev P, Saharov T. Effects of specific dopamine D1 and D2 receptor antagonists and agonists and neuroleptic drugs on emotional defecation in a rat model of akathisia. Psychiatry Res. 1998;81:323-32 pubmed
    ..It is unlikely to be due to actions of neuroleptics on 5HT2 or alpha1 receptors as has sometimes been suggested. The results have implications for our understanding of the pathogenesis of akathisia...