P S Sachdev

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. pmc Differential brain effects of laser and needle acupuncture at LR8 using functional MRI
    Im Quah-Smith
    School of Psychiatry, University of New South Wales and Neuropsychiatric Institute NPI, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Acupunct Med 31:282-9. 2013
  2. pmc The brain effects of laser acupuncture in healthy individuals: an FMRI investigation
    Im Quah-Smith
    School of Psychiatry, Faculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia
    PLoS ONE 5:e12619. 2010
  3. pmc Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals
    Fei Song
    Brain and Aging Research Program, University of New South Wales, Sydney, Australia
    PLoS ONE 7:e34078. 2012
  4. pmc Risk factors for late-life cognitive decline and variation with age and sex in the Sydney Memory and Ageing Study
    Darren M Lipnicki
    Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Australia
    PLoS ONE 8:e65841. 2013
  5. pmc Neuropsychiatry: where are we and where do we go from here?
    Perminder S Sachdev
    Centre for Healthy Brain Ageing CHeBA, School of Psychiatry, UNSW Medicine, University of New South Wales NSW 2052, Australia Neuropsychiatric Institute, Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia
    Mens Sana Monogr 11:4-15. 2013
  6. pmc COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups
    Perminder S Sachdev
    Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia
    BMC Neurol 13:165. 2013
  7. doi request reprint The Sydney Centenarian Study: methodology and profile of centenarians and near-centenarians
    Perminder S Sachdev
    Brain and Ageing Research Program, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Kensington, NSW 2052, Australia
    Int Psychogeriatr 25:993-1005. 2013
  8. pmc Factors predicting reversion from mild cognitive impairment to normal cognitive functioning: a population-based study
    Perminder S Sachdev
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Medicine, Sydney, New South Wales, Australia
    PLoS ONE 8:e59649. 2013
  9. doi request reprint Is Alzheimer's a disease of the white matter?
    Perminder S Sachdev
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales bNeuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Randwick, New South Wales, Australia
    Curr Opin Psychiatry 26:244-51. 2013
  10. pmc Cognitive and memory training in adults at risk of dementia: a systematic review
    Nicola J Gates
    School of Psychiatry, University of New South Wales, RandwickNSW 2031, Australia
    BMC Geriatr 11:55. 2011

Detail Information

Publications121 found, 100 shown here

  1. pmc Differential brain effects of laser and needle acupuncture at LR8 using functional MRI
    Im Quah-Smith
    School of Psychiatry, University of New South Wales and Neuropsychiatric Institute NPI, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Acupunct Med 31:282-9. 2013
    ..The differential effects of the two techniques are of interest. We examine this in relation to brain effects of activation of LR8, a putative acupuncture point for depression, using functional MRI (fMRI)...
  2. pmc The brain effects of laser acupuncture in healthy individuals: an FMRI investigation
    Im Quah-Smith
    School of Psychiatry, Faculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia
    PLoS ONE 5:e12619. 2010
    ....
  3. pmc Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals
    Fei Song
    Brain and Aging Research Program, University of New South Wales, Sydney, Australia
    PLoS ONE 7:e34078. 2012
    ..We examined a group of apolipoproteins, including ApoA1, ApoA2, ApoB, ApoC3, ApoE, ApoH and ApoJ, in the plasma of a longitudinal community based cohort...
  4. pmc Risk factors for late-life cognitive decline and variation with age and sex in the Sydney Memory and Ageing Study
    Darren M Lipnicki
    Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Australia
    PLoS ONE 8:e65841. 2013
    ..An aging population brings increasing burdens and costs to individuals and society arising from late-life cognitive decline, the causes of which are unclear. We aimed to identify factors predicting late-life cognitive decline...
  5. pmc Neuropsychiatry: where are we and where do we go from here?
    Perminder S Sachdev
    Centre for Healthy Brain Ageing CHeBA, School of Psychiatry, UNSW Medicine, University of New South Wales NSW 2052, Australia Neuropsychiatric Institute, Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia
    Mens Sana Monogr 11:4-15. 2013
    ..Neuropsychiatry has generally been regarded as a hybrid discipline that lies in the borderland between the disciplines of psychiatry and neurology. There is much debate on its current and future identity and status as a discipline...
  6. pmc COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups
    Perminder S Sachdev
    Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia
    BMC Neurol 13:165. 2013
    ....
  7. doi request reprint The Sydney Centenarian Study: methodology and profile of centenarians and near-centenarians
    Perminder S Sachdev
    Brain and Ageing Research Program, Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Kensington, NSW 2052, Australia
    Int Psychogeriatr 25:993-1005. 2013
    ..The study of exceptionally long-living individuals can inform us about the determinants of successful aging. There are few population-based studies of centenarians and near-centenarians internationally, but none in Australia...
  8. pmc Factors predicting reversion from mild cognitive impairment to normal cognitive functioning: a population-based study
    Perminder S Sachdev
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Medicine, Sydney, New South Wales, Australia
    PLoS ONE 8:e59649. 2013
    ..However, many individuals diagnosed with MCI are found to have reverted to normal cognition on follow-up. This study investigated factors predicting or associated with reversion from MCI to normal cognition...
  9. doi request reprint Is Alzheimer's a disease of the white matter?
    Perminder S Sachdev
    Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales bNeuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Randwick, New South Wales, Australia
    Curr Opin Psychiatry 26:244-51. 2013
    ..In doing so, we aim to provide a renewed insight into white matter changes in Alzheimer's disease and related dementias...
  10. pmc Cognitive and memory training in adults at risk of dementia: a systematic review
    Nicola J Gates
    School of Psychiatry, University of New South Wales, RandwickNSW 2031, Australia
    BMC Geriatr 11:55. 2011
    ....
  11. pmc Study of Mental Activity and Regular Training (SMART) in at risk individuals: a randomised double blind, sham controlled, longitudinal trial
    Nicola J Gates
    School of Psychiatry, University of New South Wales, and Neuropsychiatric Institute, Prince of Wales Hospital, Randwick NSW 2031, Australia
    BMC Geriatr 11:19. 2011
    ....
  12. pmc The association of APOE genotype and cognitive decline in interaction with risk factors in a 65-69 year old community sample
    Helen Christensen
    The Australian National University, Canberra, Australia
    BMC Geriatr 8:14. 2008
    ..A cross-sectional study on the lifespan effects of the *E4 allele 1 failed to find any effect of the *E4 allele on cognitive performance at ages 20-24, 40-44 or 60-64 years...
  13. ncbi request reprint Is deep brain stimulation a form of psychosurgery?
    Perminder Sachdev
    School of Psychiatry, University of New South Wales, Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
    Australas Psychiatry 15:97-9. 2007
    ..To examine the potential for the experimental treatment of deep brain stimulation for neuropsychiatric disorders, and to debate the argument that it should be considered another form of psychosurgery...
  14. ncbi request reprint Progression of white matter hyperintensities in elderly individuals over 3 years
    Perminder Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Neurology 68:214-22. 2007
    ..The aims of this study were to examine white matter hyperintensities (WMHs) in the brains of elderly individuals, the rate of progression, the anatomic regions most vulnerable, and the predictors of change...
  15. ncbi request reprint Prevalence, incidence, and risk factors of lacunar infarcts in a community sample
    Xiaohua Chen
    Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia
    Neurology 73:266-72. 2009
    ..The prevalence and risk factor profile of lacunar infarction has been variously reported, but the incidence data are scarce for large community-based data...
  16. pmc Alternating and postictal psychoses: review and a unifying hypothesis
    Perminder S Sachdev
    Neuropsychiatric Institute, The Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia
    Schizophr Bull 33:1029-37. 2007
    ..Brief postictal and alternating psychoses provide an opportunity to understand the complex relationships between epilepsy and schizophrenia-like brief psychotic episodes, and this understanding can assist in their management...
  17. ncbi request reprint Pulmonary function, cognitive impairment and brain atrophy in a middle-aged community sample
    P S Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Dement Geriatr Cogn Disord 21:300-8. 2006
    ..To determine the relationship of lung function to brain anatomical parameters and cognitive function and to examine the mediating factors for any relationships...
  18. ncbi request reprint Clinical determinants of dementia and mild cognitive impairment following ischaemic stroke: the Sydney Stroke Study
    P S Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Dement Geriatr Cogn Disord 21:275-83. 2006
    ..Dementia following stroke is common but its determinants are still incompletely understood...
  19. ncbi request reprint Long-term outcome of neurosurgery for the treatment of resistant depression
    Perminder S Sachdev
    Neuropsychiatric Institute, Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia
    J Neuropsychiatry Clin Neurosci 17:478-85. 2005
    ..Adverse effects were epilepsy (2 subjects), marked personality change (1), weight gain (2), and mild personality change (5). Any reported cognitive impairment was mild. No definite predictors of improvement were identified...
  20. ncbi request reprint Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation
    Perminder S Sachdev
    School of Psychiatry, University of New South Wales, Australia
    Psychol Med 37:1645-9. 2007
    ..To determine the efficacy and tolerability of repetitive transcranial magnetic stimulation (rTMS) as a treatment for obsessive compulsive disorder (OCD) in a double-blind placebo-controlled study...
  21. ncbi request reprint Obsessive-compulsive behaviour: a disorder of decision-making
    Perminder S Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Aust N Z J Psychiatry 39:757-63. 2005
    ..With the increasing interest in the neurobiology of decision-making, it may be useful to conceptualize OCD as a disorder of decision-making...
  22. ncbi request reprint Homocysteine and brain atrophy
    Perminder S Sachdev
    School of Psychiatry, University of New South Wales, Sydney NSW 2052, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 29:1152-61. 2005
    ..Intervention studies are necessary to confirm its aetiological role...
  23. ncbi request reprint A rating scale for neuroleptic malignant syndrome
    Perminder S Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia, and Neuropsychiatric Institute, Prince of Wales Hospital, Barker Street, Randwick, NSW, 2031, Australia
    Psychiatry Res 135:249-56. 2005
    ..The scale may be applicable not only to NMS or suspected NMS but also to NMS-like syndromes such as lethal catatonia...
  24. ncbi request reprint Hippocampal size and dementia in stroke patients: the Sydney stroke study
    P S Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, Australia
    J Neurol Sci 260:71-7. 2007
    ..Hippocampal atrophy is an early feature of Alzheimer's disease (AD) but it has also been reported in vascular dementia (VaD). It is uncertain whether hippocampal size can help differentiate the two disorders...
  25. ncbi request reprint Amygdala in stroke/transient ischemic attack patients and its relationship to cognitive impairment and psychopathology: the Sydney Stroke Study
    Perminder S Sachdev
    School of Psychiatry, University of New South Wales, Academic Department for Old Age Psychiatry the Prince of Wales Hospital, Randwick, NSW, Australia
    Am J Geriatr Psychiatry 15:487-96. 2007
    ....
  26. doi request reprint Cognitive functioning in older twins: the Older Australian Twins Study
    Perminder S Sachdev
    Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Australas J Ageing 30:17-23. 2011
    ..To examine the concordance rates of common medical conditions and neurocognitive performance in monozygotic (MZ) and dizygotic (DZ) older twins...
  27. doi request reprint The narrative in neurology and psychiatry
    Perminder Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Curr Opin Psychiatry 24:215-8. 2011
    ..Its functions have evolved more recently from classical description and clinical education to healing and remediation, and there has been an explosion of literature on narratives by sufferers of individuals with brain disorders...
  28. doi request reprint The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 years
    Perminder S Sachdev
    Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia
    Int Psychogeriatr 22:1248-64. 2010
    ....
  29. ncbi request reprint A comprehensive neuropsychiatric study of elderly twins: the Older Australian Twins Study
    Perminder S Sachdev
    Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Australia
    Twin Res Hum Genet 12:573-82. 2009
    ..The cohort will be assessed every two years, with in-depth assessments being repeated. OATS offers an excellent opportunity for collaboration with other similar studies as well as researchers who share the same interests...
  30. doi request reprint The determinants and longitudinal course of post-stroke mild cognitive impairment
    Perminder S Sachdev
    School of Psychiatry and Brain and Ageing Program, University of New South Wales, Randwick, New South Wales
    J Int Neuropsychol Soc 15:915-23. 2009
    ..The major determinant of decline and categorical transition was impaired performance at baseline, suggesting that those with mild impairment post-stroke are more vulnerable to subsequent decline...
  31. doi request reprint Neurocognitive disorders: cluster 1 of the proposed meta-structure for DSM-V and ICD-11
    P Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Psychol Med 39:2001-12. 2009
    ..These disorders are categorized as 'Dementia, Delirium, and Amnestic and Other Cognitive Disorders' in DSM-IV and 'Organic, including Symptomatic Mental Disorders' in ICD-10...
  32. doi request reprint Neurosurgical treatment of mood disorders: traditional psychosurgery and the advent of deep brain stimulation
    Perminder S Sachdev
    School of Psychiatry, University of New South Wales, Randwick, Australia
    Curr Opin Psychiatry 22:25-31. 2009
    ..With recent developments in brain stimulation techniques, the continuing relevance of psychosurgery in the treatment of psychiatric disorders is worthy of examination...
  33. doi request reprint Light to moderate alcohol use is associated with increased cortical gray matter in middle-aged men: a voxel-based morphometric study
    Perminder S Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Psychiatry Res 163:61-9. 2008
    ..These findings are consistent with an inverse-U association between alcohol use and brain morphometry, while suggesting an increased vulnerability of white matter to alcohol-related brain damage...
  34. ncbi request reprint Brains of anorexia nervosa patients process self-images differently from non-self-images: an fMRI study
    Perminder Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Neuropsychologia 46:2161-8. 2008
    ..Such discrepant emotional and perceptual processing may underlie the distortion of self-images by AN patients...
  35. doi request reprint White matter hyperintensities in mid-adult life
    Perminder Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Curr Opin Psychiatry 21:268-74. 2008
    ..Recent studies have reported that they may also be common in middle-aged individuals, and their systematic evaluation in younger populations is necessary...
  36. ncbi request reprint Sex differences in the causes and consequences of white matter hyperintensities
    P S Sachdev
    School of Psychiatry, University of New South Wales, Australia
    Neurobiol Aging 30:946-56. 2009
    ..To examine sex differences in white matter hyperintensities (WMHs) on T2-weighted magnetic resonance imaging (MRI), reported to be more severe in older women...
  37. ncbi request reprint Transcranial magnetic stimulation for the deficit syndrome of schizophrenia: a pilot investigation
    Perminder Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Psychiatry Clin Neurosci 59:354-7. 2005
    ..Repetitive transcranial magnetic stimulation as a treatment of the deficit syndrome of schizophrenia is feasible, safe and may be beneficial. A systematic study in randomized control trials would be appropriate...
  38. ncbi request reprint Schizophrenia-like illness in velo-cardio-facial syndrome: a genetic subsyndrome of schizophrenia?
    Perminder Sachdev
    Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    J Psychosom Res 53:721-7. 2002
    ..An important example of such a genetic disorder is the velo-cardio-facial syndrome (VCFS) associated with 22q11 microdeletion...
  39. ncbi request reprint Quantitative study of signal hyperintensities on T2-weighted magnetic resonance imaging in late-onset schizophrenia
    P Sachdev
    School of Psychiatry, University of New South Wales and the Neuropsychiatric Institute, Prince Henry and Prince of Wales Hospitals, Sydney, Australia
    Am J Psychiatry 156:1958-67. 1999
    ..The authors investigated the extent and distribution of signal hyperintensities on T2-weighted magnetic resonance imaging (MRI) of the brains of subjects with late-onset schizophrenia...
  40. ncbi request reprint Homocysteine and the brain in midadult life: evidence for an increased risk of leukoaraiosis in men
    Perminder Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Arch Neurol 61:1369-76. 2004
    ..Homocysteine also has a direct neurotoxic effect and has been linked to brain atrophy and an increased risk of Alzheimer disease...
  41. ncbi request reprint Early extrapyramidal side-effects as risk factors for later tardive dyskinesia: a prospective study
    Perminder Sachdev
    School of Psychiatry, University of New South Wales, New South Wales, Australia
    Aust N Z J Psychiatry 38:445-9. 2004
    ..To determine whether acute neuroleptic-induced parkinsonism and akathisia were risk factors for the later development of tardive dyskinesia (TD) in patients on typical neuroleptics...
  42. ncbi request reprint [Homocysteine and neuropsychiatric disorders]
    Perminder Sachdev
    Faculdade de Psiquiatria, Universidade de New South Wales, Sydney, Australia
    Rev Bras Psiquiatr 26:50-6. 2004
    ..More research evidence is necessary before population screening can be recommended...
  43. ncbi request reprint Reliability and validity of ratings of signal hyperintensities on MRI by visual inspection and computerised measurement
    P Sachdev
    School of Psychiatry, University of New South Wales, Kensington, Sydney, Australia
    Psychiatry Res 92:103-15. 1999
    ..Visual ratings should therefore be considered adequate for most clinical and research purposes, but such ratings should be accompanied by adequate training and the provision of standard reference images...
  44. ncbi request reprint Animal models of acute drug-induced akathisia - a review
    P S Sachdev
    School of Psychiatry, University of New South Wales and Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, Australia
    Neurosci Biobehav Rev 24:269-77. 2000
    ..It is also necessary to consider the subtypes of akathisia in the attempts to develop these models...
  45. ncbi request reprint Schizophrenia with onset after age 50 years. 2: Neurological, neuropsychological and MRI investigation
    P Sachdev
    School of Psychiatry, University of New South Wales, Neuropsychiatric Institute, Prince of Wales Hospital, Sydney
    Br J Psychiatry 175:416-21. 1999
    ..Late-onset schizophrenia (LOS) may have a basis in age-related coarse brain disease, but empirical support for this is conflicting...
  46. ncbi request reprint The current status of tardive dyskinesia
    P S Sachdev
    University of New South Wales, Sydney, Australia
    Aust N Z J Psychiatry 34:355-69. 2000
    ..This paper aims to provide an overview of the current knowledge on neuroleptic-induced tardive dyskinesia (TD) in relation to its clinical features, risk factors, pathophysiology and management...
  47. ncbi request reprint Right versus left prefrontal transcranial magnetic stimulation for obsessive-compulsive disorder: a preliminary investigation
    P S Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    J Clin Psychiatry 62:981-4. 2001
    ....
  48. ncbi request reprint Cerebral blood volume in T2-weighted white matter hyperintensities using exogenous contrast based perfusion MRI
    Perminder Sachdev
    Department of Neuropsychiatry, University of New South Wales, Sydney, Australia
    J Neuropsychiatry Clin Neurosci 16:83-92. 2004
    ..The findings suggest hemodynamic perturbation in the microvasculature of hyperintense regions, which becomes greater as the size of the WMH increases. This is equally applicable to stroke patients and healthy older individuals...
  49. ncbi request reprint How high a dose of stimulant medication in adult attention deficit hyperactivity disorder?
    P S Sachdev
    School of Psychiatry, University of New South Wales and Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, Australia
    Aust N Z J Psychiatry 34:645-50. 2000
    ..It attempts to arrive at a reasonable upper limit of dosage for clinical purposes...
  50. ncbi request reprint Bilateral orbitomedial leucotomy for obsessive-compulsive disorder: a single-case study using positron emission tomography
    P Sachdev
    Neuropsychiatric Institute, The Prince of Wales Hospital, Randwick, New South Wales 2031, Australia
    Aust N Z J Psychiatry 35:684-90. 2001
    ..The objective of this report is to correlate the clinical outcome of neurosurgery for obsessive-compulsive disorder (OCD) with regional cerebral glucose metabolic changes...
  51. ncbi request reprint Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals
    P S Sachdev
    School of Psychiatry, University of New South Wales, Australia
    Neurology 58:1539-41. 2002
    ..34) after controlling for age, folate, B12, creatinine, and white matter disease (OR = 2.3; CI, 1.03-5.09)...
  52. ncbi request reprint Homocysteine as a risk factor for cognitive impairment in stroke patients
    Perminder S Sachdev
    School of Psychiatry, University of New South Wales, Prince of Wales Hospital, Sydney, Australia
    Dement Geriatr Cogn Disord 15:155-62. 2003
    ..Elevated total homocysteine (tHcy) levels are associated with an increased risk of cerebrovascular disease. It is uncertain whether tHcy is also an independent risk factor for cognitive impairment...
  53. ncbi request reprint Progression of cognitive impairment in stroke patients
    P S Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Neurology 63:1618-23. 2004
    ..To examine the progression of neuropsychological deficits in stroke patients with and without cognitive impairment...
  54. ncbi request reprint Homocysteine, cerebrovascular disease and brain atrophy
    Perminder Sachdev
    School of Psychiatry, University of New South Wales, Neuropsychiatric Institute, The Prince of Wales Hospital, Barker Street, Randwick, Sydney NSW 2031, Australia
    J Neurol Sci 226:25-9. 2004
    ..Hcy increases the risk of micro- and macrovascular disease as well as brain atrophy, and thereby impaired cognition. Remediation of high Hcy levels should begin early in life...
  55. ncbi request reprint Sixty years of psychosurgery: its present status and its future
    P Sachdev
    Neuropsychiatric Institute, Prince Henry Hospital, Little Bay, New South Wales, Australia
    Aust N Z J Psychiatry 31:457-64. 1997
    ..The profession is urged to keep the interest in psychosurgery alive until further theoretical and empirical developments can either announce its death or lead to a resurgence of psychiatric neurosurgery in its present or modified form...
  56. ncbi request reprint The effects of beta-adrenoceptor antagonists on a rat model of neuroleptic-induced akathisia
    P S Sachdev
    School of Psychiatry, University of New South Wales, and Neuropsychiatric Institute, The Prince Henry Hospital, Sydney, Australia
    Psychiatry Res 72:133-40. 1997
    ..The B-antagonist drugs significantly reduced the cataleptic effect of haloperidol and this effect warrants further examination...
  57. pmc White matter hyperintensities are related to physical disability and poor motor function
    P S Sachdev
    NPI, Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia
    J Neurol Neurosurg Psychiatry 76:362-7. 2005
    ..To determine the impact of white matter hyperintensities (WMHs) on physical health and cognitive function in 60-64 year old individuals residing in the community...
  58. ncbi request reprint Effects of specific dopamine D1 and D2 receptor antagonists and agonists and neuroleptic drugs on emotional defecation in a rat model of akathisia
    P S Sachdev
    School of Psychiatry, University of New South Wales, and Neuropsychiatric Institute, The Prince Henry Hospital, Sydney, Little Bay, Australia
    Psychiatry Res 81:323-32. 1998
    ..It is unlikely to be due to actions of neuroleptics on 5HT2 or alpha1 receptors as has sometimes been suggested. The results have implications for our understanding of the pathogenesis of akathisia...
  59. ncbi request reprint Neuroleptic-induced movement disorders: an overview
    Perminder S Sachdev
    School of Psychiatry, University of New South Wales, Sydney NSW 2052, Australia
    Psychiatr Clin North Am 28:255-74, x. 2005
  60. ncbi request reprint An electroencephalographic investigation of late-onset schizophrenia
    P Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Int Psychogeriatr 11:421-9. 1999
    ..Our study does not suggest the presence of underlying dementia in schizophrenia of late onset...
  61. ncbi request reprint Hippocampus and amygdala volumes in elderly schizophrenic patients as assessed by magnetic resonance imaging
    P Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Psychiatry Clin Neurosci 54:105-12. 2000
    ..This pilot analysis in LOS subjects argues against the condition being secondary to Alzheimer's disease...
  62. ncbi request reprint Case-control study of neuroleptic malignant syndrome
    P Sachdev
    School of Psychiatry, University of New South Wales, Australia
    Am J Psychiatry 154:1156-8. 1997
    ..The authors performed a case-control study of neuroleptic malignant syndrome to identify potential risk factors...
  63. ncbi request reprint Vascular dementia: diagnosis, management and possible prevention
    P S Sachdev
    School of Psychiatry, University of New South Wales
    Med J Aust 170:81-5. 1999
    ..We discuss these features and risk factors and the main intervention strategies, both for treatment and prevention...
  64. ncbi request reprint Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample
    Perminder S Sachdev
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Psychol Med 35:529-38. 2005
    ..The results from epidemiological studies are mixed and largely from elderly populations...
  65. ncbi request reprint Impairment in instrumental activities of daily living with high cognitive demand is an early marker of mild cognitive impairment: the Sydney memory and ageing study
    S Reppermund
    Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia
    Psychol Med 43:2437-45. 2013
    ....
  66. ncbi request reprint The neuropsychological profile of vascular cognitive impairment in stroke and TIA patients
    P S Sachdev
    Schools of Psychiatry and Medicine, University of New South Wales, Australia
    Neurology 62:912-9. 2004
    ..To characterize the neuropsychological profile of vascular cognitive impairment (VCI) and vascular dementia (VaD)...
  67. doi request reprint The relationship of current depressive symptoms and past depression with cognitive impairment and instrumental activities of daily living in an elderly population: the Sydney Memory and Ageing Study
    S Reppermund
    Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Randwick Campus, Building R1f, UNSW, NSW 2052, Sydney, Australia
    J Psychiatr Res 45:1600-7. 2011
    ..These results support the view that current and past depressive episodes are associated with poorer cognitive performance but not with functional abilities...
  68. ncbi request reprint High (15 Hz) and low (1 Hz) frequency transcranial magnetic stimulation have different acute effects on regional cerebral blood flow in depressed patients
    C K Loo
    School of Psychiatry, University of New South Wales, Australia
    Psychol Med 33:997-1006. 2003
    ..This study aimed to understand further the mechanisms of action of high and low frequency rTMS by examining their acute effects on regional cerebral blood flow (rCBF) in depressed patients...
  69. ncbi request reprint Diffusion tensor imaging of the posterior cingulate is a useful biomarker of mild cognitive impairment
    Terence C Chua
    School of Psychiatry, University of New South Wales, NSW, Australia
    Am J Geriatr Psychiatry 17:602-13. 2009
    ..Biomarkers may help identify individuals at greatest risk of progressive decline. The authors examine a novel neuroimaging technique, diffusion tensor imaging (DTI) as a potential biomarker of MCI...
  70. doi request reprint Prevalence and characteristics of depression in mild cognitive impairment: the Sydney Memory and Ageing Study
    Z Shahnawaz
    Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    Acta Psychiatr Scand 127:394-402. 2013
    ..Depression might be a risk factor for dementia. However, little is known about the prevalence of depressive symptoms in mild cognitive impairment (MCI) and whether mood or motivation-related symptoms are predominant...
  71. ncbi request reprint 1H MRS in stroke patients with and without cognitive impairment
    A J Ross
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Neurobiol Aging 26:873-82. 2005
    ..Moreover, cortical regions not obviously infarcted may have dysfunctional neurons, the pathophysiological basis for which needs further study...
  72. ncbi request reprint Double-blind controlled investigation of bilateral prefrontal transcranial magnetic stimulation for the treatment of resistant major depression
    C K Loo
    Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales, Randwick, Australia
    Psychol Med 33:33-40. 2003
    ..The efficacy and safety of bilateral prefrontal repetitive transcranial magnetic stimulation (rTMS) for treating resistant major depression were examined in a double-blind, placebo-controlled study...
  73. ncbi request reprint Prediction of cognitive decline after stroke using proton magnetic resonance spectroscopy
    Amy J Ross
    Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Barker Street, Randwick, NSW, Australia
    J Neurol Sci 251:62-9. 2006
    ..In stroke/TIA patients, the (1)H-MRS measures were better predictors of cognitive decline than structural measures. (1)H-MRS may be useful in assessing early cognitive impairment after stroke/TIA and in normal ageing...
  74. ncbi request reprint Gray matter reduction is correlated with white matter hyperintensity volume: a voxel-based morphometric study in a large epidemiological sample
    Wei Wen
    School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia
    Neuroimage 29:1031-9. 2006
    ..Further delineation of this relationship needs a longitudinal study of the changes in both WMH and indices of brain atrophy...
  75. doi request reprint Functional alterations in brain activation and deactivation in mild cognitive impairment in response to a graded working memory challenge
    N A Kochan
    Brain and Ageing Research Program, School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia
    Dement Geriatr Cogn Disord 30:553-68. 2010
    ..To investigate dynamic changes in functional brain activity in mild cognitive impairment (MCI) in response to a graded working memory (WM) challenge with increasing memory load...
  76. ncbi request reprint Neuropsychological functioning of adults with attention deficit hyperactivity disorder
    A J Walker
    Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
    J Clin Exp Neuropsychol 22:115-24. 2000
    ..The predictive power of the tests was poor in discriminating ADHD from psychiatric disorder. Implications for the clinical diagnosis of ADHD are discussed...
  77. ncbi request reprint The differentiation of mild frontotemporal dementia from Alzheimer's disease and healthy aging by neuropsychological tests
    Alexandra J Walker
    Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
    Int Psychogeriatr 17:57-68. 2005
    ..This study aimed to investigate neuropsychological function in FTD of mild severity and compare it to that of mild AD and healthy control participants...
  78. doi request reprint Relationships between serum vitamin D levels, neuromuscular and neuropsychological function and falls in older men and women
    J C Menant
    Falls and Balance Research Group, Neuroscience Research Australia, University of New South Wales, Barker Street, Randwick, NSW 2031, Sydney, Australia
    Osteoporos Int 23:981-9. 2012
    ..In men, vitamin D insufficiency was associated with an increased risk of falling...
  79. doi request reprint The Falls Efficacy Scale International (FES-I). A comprehensive longitudinal validation study
    Kim Delbaere
    Falls and Balance Research Group, Prince of Wales Medical Research Institute, University of New South Wales, Randwick, Sydney, Australia
    Age Ageing 39:210-6. 2010
    ....
  80. ncbi request reprint Longitudinal changes during aging using proton magnetic resonance spectroscopy
    Amy J Ross
    School of Psychiatry, University of New South Wales, Sydney, Australia
    J Gerontol A Biol Sci Med Sci 61:291-8. 2006
    ....
  81. doi request reprint A sham-controlled trial of left and right temporal rTMS for the treatment of auditory hallucinations
    C K Loo
    School of Psychiatry, University of NSW and Black Dog Institute, Sydney, Australia
    Psychol Med 40:541-6. 2010
    ..Several studies have reported reduction of auditory hallucinations (AH) after repetitive transcranial magnetic stimulation (rTMS) to the left temporal cortex. This study explored the effects of rTMS to the left and right temporal cortex...
  82. ncbi request reprint An emotional Stroop functional MRI study of euthymic bipolar disorder
    Gin S Malhi
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Bipolar Disord 7:58-69. 2005
    ..To identify the brain regions associated with emotional processing in euthymic bipolar patients...
  83. doi request reprint Grey matter atrophy of basal forebrain and hippocampus in mild cognitive impairment
    Haobo Zhang
    Brain and Ageing Research Program, School of Psychiatry, University of New South Wales, Sydney, Australia
    J Neurol Neurosurg Psychiatry 82:487-93. 2011
    ..In addition, a slight but statistically significant difference was found in the left hippocampal volume between APOE ε4 allele carriers and non-carriers, consistent with prior studies...
  84. ncbi request reprint Effect of different impairment criteria on prevalence of “objective” mild cognitive impairment in a community sample
    Nicole A Kochan
    Brain and Ageing Research Program, School of Psychiatry, The University of New South Wales, Sydney, Australia
    Am J Geriatr Psychiatry 18:711-22. 2010
    ..The aims of this study were to investigate the effect of varying the criteria used to determine cognitive impairment (CI) on prevalence and case definition and to examine comparability of different criteria...
  85. ncbi request reprint Who does well after a stroke? The Sydney stroke study
    Adrienne Withall
    School of Psychiatry, University of New South Wales, Randwick, NSW, Australia
    Aging Ment Health 13:693-8. 2009
    ..We conclude that people can have good outcomes in the year after stroke except if they experience further cerebrovascular events and/or have risk factors for cerebrovascular disease. Brain reserve appears to be protective...
  86. ncbi request reprint Prevalence and predictors of “subjective cognitive complaints” in the Sydney Memory and Ageing Study
    Melissa J Slavin
    Brain and Ageing Research Program, School of Psychiatry, The University of New South Wales, Sydney, Australia
    Am J Geriatr Psychiatry 18:701-10. 2010
    ....
  87. ncbi request reprint Prevalence of mental disorders in the elderly: the Australian National Mental Health and Well-Being Survey
    Julian N Trollor
    Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia
    Am J Geriatr Psychiatry 15:455-66. 2007
    ....
  88. doi request reprint Neuroleptic malignant syndrome associated with atypical antipsychotic drugs
    Julian N Trollor
    School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia
    CNS Drugs 23:477-92. 2009
    ..Both these issues have relevance for the identification of atypical or milder forms of NMS, which are sometimes seen with atypical antipsychotic drugs...
  89. doi request reprint DSM-IV Major Depressive Episode in the elderly: the relationship between the number and the type of depressive symptoms and impairment
    Tracy M Anderson
    School of Psychiatry, University of New South Wales, Black Dog Institute Building, Prince of Wales Hospital, Randwick NSW, Australia
    J Affect Disord 117:55-62. 2009
    ....
  90. ncbi request reprint Rates of depression at 3 and 15 months poststroke and their relationship with cognitive decline: the Sydney Stroke Study
    Henry Brodaty
    School of Psychiatry, University of New South Wales, Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Randwick, NSW, Australia
    Am J Geriatr Psychiatry 15:477-86. 2007
    ..To investigate the frequency and correlates of depression at 3 and 15 months after stroke...
  91. ncbi request reprint Effects of sociodemographic and health variables on Mini-Mental State Exam scores in older Australians
    Tracy M Anderson
    School of Psychiatry, University of New South Wales, the Clinical Research Unit for Anxiety and Depression, Darlinghurst, New South Wales, Australia
    Am J Geriatr Psychiatry 15:467-76. 2007
    ....
  92. ncbi request reprint Sex differences in regional gray matter in healthy individuals aged 44-48 years: a voxel-based morphometric study
    Xiaohua Chen
    School of Psychiatry, University of New South Wales, Australia
    Neuroimage 36:691-9. 2007
    ..These differences may provide the structural brain basis for sex differences in certain cognitive functions...
  93. ncbi request reprint Regional gray matter changes in bipolar disorder: a voxel-based morphometric study
    Xiaohua Chen
    Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Randwick, New South Wales, Australia
    Aust N Z J Psychiatry 41:327-36. 2007
    ....
  94. ncbi request reprint A sham-controlled trial of the efficacy and safety of twice-daily rTMS in major depression
    Colleen K Loo
    School of Psychiatry, University of NSW and Black Dog Institute, Sydney, Australia
    Psychol Med 37:341-9. 2007
    ..Studies of repetitive transcranial magnetic stimulation (rTMS) in depression have mostly involved once-daily treatment, with positive but modest clinical results. This study tested the efficacy and safety of twice-daily rTMS over 2 weeks...
  95. ncbi request reprint Effects of cerebrovascular risk factors on gray matter volume in adults aged 60-64 years: a voxel-based morphometric study
    Xiaohua Chen
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Psychiatry Res 147:105-14. 2006
    ..Our results suggest that there are different patterns of regional effects in gray matter volume in relation to different cerebrovascular risk factors, and sex differences for the same risk factors...
  96. ncbi request reprint Combined cerebral blood flow effects of a cholinergic agonist (milameline) and a verbal recognition task in early Alzheimer's disease
    Julian N Trollor
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Psychiatry Clin Neurosci 60:616-25. 2006
    ....
  97. ncbi request reprint A high-resolution single photon emission computed tomography study of verbal recognition memory in Alzheimer's disease
    Julian N Trollor
    School of Psychiatry, University of New South Wales, Randwick, Australia
    Dement Geriatr Cogn Disord 21:267-74. 2006
    ..In view of the recent technological advances and its ease of availability, we used single photon emission computed tomography (SPECT) to examine the performance of early Alzheimer's disease (AD) subjects on a verbal recognition memory task...
  98. ncbi request reprint Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke - the Sydney Stroke Study
    Henry Brodaty
    School of Psychiatry, University of New South Wales, Randwick, Australia
    Psychol Med 35:1707-16. 2005
    ..The frequency and clinical, neuropsychological and neuroimaging correlates of apathy in patients who have had a stroke are inadequately defined...
  99. ncbi request reprint Cognitive correlates of 1H MRS measures in the healthy elderly brain
    Amy J Ross
    School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
    Brain Res Bull 66:9-16. 2005
    ..This research highlights the importance of the relationship between regional brain changes and cognitive function in the ageing brain, and suggests that MRS may be a sensitive marker of subclinical change in cognition...
  100. ncbi request reprint Magnetic resonance spectroscopy in cognitive research
    Amy J Ross
    School of Psychiatry, University of New South Wales, Kensington, New South Wales 2033, Australia
    Brain Res Brain Res Rev 44:83-102. 2004
    ....