Research Topics
| P S SachdevSummaryAffiliation: University of New South Wales Country: Australia Publications
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Detail Information
Publications
Factors predicting reversion from mild cognitive impairment to normal cognitive functioning: a population-based studyPerminder S Sachdev
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Medicine, Sydney, New South Wales, Australia
PLoS ONE 8:e59649. 2013..However, many individuals diagnosed with MCI are found to have reverted to normal cognition on follow-up. This study investigated factors predicting or associated with reversion from MCI to normal cognition...
Is Alzheimer's a disease of the white matter?Perminder S Sachdev
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales bNeuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Randwick, New South Wales, Australia
Curr Opin Psychiatry 26:244-51. 2013..In doing so, we aim to provide a renewed insight into white matter changes in Alzheimer's disease and related dementias...- Cognitive and memory training in adults at risk of dementia: a systematic reviewNicola J Gates
School of Psychiatry, University of New South Wales, RandwickNSW 2031, Australia
BMC Geriatr 11:55. 2011.... - Study of Mental Activity and Regular Training (SMART) in at risk individuals: a randomised double blind, sham controlled, longitudinal trialNicola J Gates
School of Psychiatry, University of New South Wales, and Neuropsychiatric Institute, Prince of Wales Hospital, Randwick NSW 2031, Australia
BMC Geriatr 11:19. 2011.... - The association of APOE genotype and cognitive decline in interaction with risk factors in a 65-69 year old community sampleHelen Christensen
The Australian National University, Canberra, Australia
BMC Geriatr 8:14. 2008..A cross-sectional study on the lifespan effects of the *E4 allele 1 failed to find any effect of the *E4 allele on cognitive performance at ages 20-24, 40-44 or 60-64 years... 
Progression of white matter hyperintensities in elderly individuals over 3 yearsPerminder Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Neurology 68:214-22. 2007..The aims of this study were to examine white matter hyperintensities (WMHs) in the brains of elderly individuals, the rate of progression, the anatomic regions most vulnerable, and the predictors of change...- Pulmonary function, cognitive impairment and brain atrophy in a middle-aged community sampleP S Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Dement Geriatr Cogn Disord 21:300-8. 2006..To determine the relationship of lung function to brain anatomical parameters and cognitive function and to examine the mediating factors for any relationships... - Clinical determinants of dementia and mild cognitive impairment following ischaemic stroke: the Sydney Stroke StudyP S Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Dement Geriatr Cogn Disord 21:275-83. 2006..Dementia following stroke is common but its determinants are still incompletely understood... - Alternating and postictal psychoses: review and a unifying hypothesisPerminder S Sachdev
Neuropsychiatric Institute, The Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia
Schizophr Bull 33:1029-37. 2007..Brief postictal and alternating psychoses provide an opportunity to understand the complex relationships between epilepsy and schizophrenia-like brief psychotic episodes, and this understanding can assist in their management... - The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70-90 yearsPerminder S Sachdev
Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia
Int Psychogeriatr 22:1248-64. 2010.... - Long-term outcome of neurosurgery for the treatment of resistant depressionPerminder S Sachdev
Neuropsychiatric Institute, Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia
J Neuropsychiatry Clin Neurosci 17:478-85. 2005..Adverse effects were epilepsy (2 subjects), marked personality change (1), weight gain (2), and mild personality change (5). Any reported cognitive impairment was mild. No definite predictors of improvement were identified... - Obsessive-compulsive behaviour: a disorder of decision-makingPerminder S Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Aust N Z J Psychiatry 39:757-63. 2005..With the increasing interest in the neurobiology of decision-making, it may be useful to conceptualize OCD as a disorder of decision-making... - Homocysteine and brain atrophyPerminder S Sachdev
School of Psychiatry, University of New South Wales, Sydney NSW 2052, Australia
Prog Neuropsychopharmacol Biol Psychiatry 29:1152-61. 2005..Intervention studies are necessary to confirm its aetiological role... - A rating scale for neuroleptic malignant syndromePerminder S Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia, and Neuropsychiatric Institute, Prince of Wales Hospital, Barker Street, Randwick, NSW, 2031, Australia
Psychiatry Res 135:249-56. 2005..The scale may be applicable not only to NMS or suspected NMS but also to NMS-like syndromes such as lethal catatonia... - Transcranial magnetic stimulation for the deficit syndrome of schizophrenia: a pilot investigationPerminder Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Psychiatry Clin Neurosci 59:354-7. 2005..Repetitive transcranial magnetic stimulation as a treatment of the deficit syndrome of schizophrenia is feasible, safe and may be beneficial. A systematic study in randomized control trials would be appropriate... - Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community samplePerminder S Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Psychol Med 35:529-38. 2005..The results from epidemiological studies are mixed and largely from elderly populations... - Neuroleptic-induced movement disorders: an overviewPerminder S Sachdev
School of Psychiatry, University of New South Wales, Sydney NSW 2052, Australia
Psychiatr Clin North Am 28:255-74, x. 2005 - Is deep brain stimulation a form of psychosurgery?Perminder Sachdev
School of Psychiatry, University of New South Wales, Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
Australas Psychiatry 15:97-9. 2007..This will prevent legislative restrictions on the development of brain stimulation techniques and not tar them with the lobotomy brush... - Hippocampal size and dementia in stroke patients: the Sydney stroke studyP S Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, Australia
J Neurol Sci 260:71-7. 2007..Hippocampal atrophy is an early feature of Alzheimer's disease (AD) but it has also been reported in vascular dementia (VaD). It is uncertain whether hippocampal size can help differentiate the two disorders... - Amygdala in stroke/transient ischemic attack patients and its relationship to cognitive impairment and psychopathology: the Sydney Stroke StudyPerminder S Sachdev
School of Psychiatry, University of New South Wales, Academic Department for Old Age Psychiatry the Prince of Wales Hospital, Randwick, NSW, Australia
Am J Geriatr Psychiatry 15:487-96. 2007.... - Cognitive functioning in older twins: the Older Australian Twins StudyPerminder S Sachdev
Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, and Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, New South Wales, Australia
Australas J Ageing 30:17-23. 2011..To examine the concordance rates of common medical conditions and neurocognitive performance in monozygotic (MZ) and dizygotic (DZ) older twins... - The narrative in neurology and psychiatryPerminder Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Curr Opin Psychiatry 24:215-8. 2011..Its functions have evolved more recently from classical description and clinical education to healing and remediation, and there has been an explosion of literature on narratives by sufferers of individuals with brain disorders... - A comprehensive neuropsychiatric study of elderly twins: the Older Australian Twins StudyPerminder S Sachdev
Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Australia
Twin Res Hum Genet 12:573-82. 2009..The cohort will be assessed every two years, with in-depth assessments being repeated. OATS offers an excellent opportunity for collaboration with other similar studies as well as researchers who share the same interests... - The determinants and longitudinal course of post-stroke mild cognitive impairmentPerminder S Sachdev
School of Psychiatry and Brain and Ageing Program, University of New South Wales, Randwick, New South Wales
J Int Neuropsychol Soc 15:915-23. 2009..The major determinant of decline and categorical transition was impaired performance at baseline, suggesting that those with mild impairment post-stroke are more vulnerable to subsequent decline... - Neurocognitive disorders: cluster 1 of the proposed meta-structure for DSM-V and ICD-11P Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Psychol Med 39:2001-12. 2009..These disorders are categorized as 'Dementia, Delirium, and Amnestic and Other Cognitive Disorders' in DSM-IV and 'Organic, including Symptomatic Mental Disorders' in ICD-10... - Prevalence, incidence, and risk factors of lacunar infarcts in a community sampleXiaohua Chen
Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia
Neurology 73:266-72. 2009..The prevalence and risk factor profile of lacunar infarction has been variously reported, but the incidence data are scarce for large community-based data... - Neurosurgical treatment of mood disorders: traditional psychosurgery and the advent of deep brain stimulationPerminder S Sachdev
School of Psychiatry, University of New South Wales, Randwick, Australia
Curr Opin Psychiatry 22:25-31. 2009..With recent developments in brain stimulation techniques, the continuing relevance of psychosurgery in the treatment of psychiatric disorders is worthy of examination... - Light to moderate alcohol use is associated with increased cortical gray matter in middle-aged men: a voxel-based morphometric studyPerminder S Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Psychiatry Res 163:61-9. 2008..These findings are consistent with an inverse-U association between alcohol use and brain morphometry, while suggesting an increased vulnerability of white matter to alcohol-related brain damage... - Brains of anorexia nervosa patients process self-images differently from non-self-images: an fMRI studyPerminder Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Neuropsychologia 46:2161-8. 2008..Such discrepant emotional and perceptual processing may underlie the distortion of self-images by AN patients... - White matter hyperintensities in mid-adult lifePerminder Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Curr Opin Psychiatry 21:268-74. 2008..Recent studies have reported that they may also be common in middle-aged individuals, and their systematic evaluation in younger populations is necessary... - Sex differences in the causes and consequences of white matter hyperintensitiesP S Sachdev
School of Psychiatry, University of New South Wales, Australia
Neurobiol Aging 30:946-56. 2009..To examine sex differences in white matter hyperintensities (WMHs) on T2-weighted magnetic resonance imaging (MRI), reported to be more severe in older women... - Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigationPerminder S Sachdev
School of Psychiatry, University of New South Wales, Australia
Psychol Med 37:1645-9. 2007..To determine the efficacy and tolerability of repetitive transcranial magnetic stimulation (rTMS) as a treatment for obsessive compulsive disorder (OCD) in a double-blind placebo-controlled study... - White matter hyperintensities are related to physical disability and poor motor functionP S Sachdev
NPI, Prince of Wales Hospital, Barker Street, Randwick NSW 2031, Australia
J Neurol Neurosurg Psychiatry 76:362-7. 2005..To determine the impact of white matter hyperintensities (WMHs) on physical health and cognitive function in 60-64 year old individuals residing in the community... - Homocysteine and the brain in midadult life: evidence for an increased risk of leukoaraiosis in menPerminder Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Arch Neurol 61:1369-76. 2004..Homocysteine also has a direct neurotoxic effect and has been linked to brain atrophy and an increased risk of Alzheimer disease... - An electroencephalographic investigation of late-onset schizophreniaP Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Int Psychogeriatr 11:421-9. 1999..Our study does not suggest the presence of underlying dementia in schizophrenia of late onset... - Reliability and validity of ratings of signal hyperintensities on MRI by visual inspection and computerised measurementP Sachdev
School of Psychiatry, University of New South Wales, Kensington, Sydney, Australia
Psychiatry Res 92:103-15. 1999..Visual ratings should therefore be considered adequate for most clinical and research purposes, but such ratings should be accompanied by adequate training and the provision of standard reference images... - Animal models of acute drug-induced akathisia - a reviewP S Sachdev
School of Psychiatry, University of New South Wales and Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, Australia
Neurosci Biobehav Rev 24:269-77. 2000..It is also necessary to consider the subtypes of akathisia in the attempts to develop these models... - Schizophrenia with onset after age 50 years. 2: Neurological, neuropsychological and MRI investigationP Sachdev
School of Psychiatry, University of New South Wales, Neuropsychiatric Institute, Prince of Wales Hospital, Sydney
Br J Psychiatry 175:416-21. 1999..Late-onset schizophrenia (LOS) may have a basis in age-related coarse brain disease, but empirical support for this is conflicting... - How high a dose of stimulant medication in adult attention deficit hyperactivity disorder?P S Sachdev
School of Psychiatry, University of New South Wales and Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, Australia
Aust N Z J Psychiatry 34:645-50. 2000..It attempts to arrive at a reasonable upper limit of dosage for clinical purposes... - Bilateral orbitomedial leucotomy for obsessive-compulsive disorder: a single-case study using positron emission tomographyP Sachdev
Neuropsychiatric Institute, The Prince of Wales Hospital, Randwick, New South Wales 2031, Australia
Aust N Z J Psychiatry 35:684-90. 2001..The objective of this report is to correlate the clinical outcome of neurosurgery for obsessive-compulsive disorder (OCD) with regional cerebral glucose metabolic changes... - Right versus left prefrontal transcranial magnetic stimulation for obsessive-compulsive disorder: a preliminary investigationP S Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
J Clin Psychiatry 62:981-4. 2001.... - Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individualsP S Sachdev
School of Psychiatry, University of New South Wales, Australia
Neurology 58:1539-41. 2002..34) after controlling for age, folate, B12, creatinine, and white matter disease (OR = 2.3; CI, 1.03-5.09)... - Cerebral blood volume in T2-weighted white matter hyperintensities using exogenous contrast based perfusion MRIPerminder Sachdev
Department of Neuropsychiatry, University of New South Wales, Sydney, Australia
J Neuropsychiatry Clin Neurosci 16:83-92. 2004..The findings suggest hemodynamic perturbation in the microvasculature of hyperintense regions, which becomes greater as the size of the WMH increases. This is equally applicable to stroke patients and healthy older individuals... - Homocysteine as a risk factor for cognitive impairment in stroke patientsPerminder S Sachdev
School of Psychiatry, University of New South Wales, Prince of Wales Hospital, Sydney, Australia
Dement Geriatr Cogn Disord 15:155-62. 2003..Elevated total homocysteine (tHcy) levels are associated with an increased risk of cerebrovascular disease. It is uncertain whether tHcy is also an independent risk factor for cognitive impairment... - Quantitative study of signal hyperintensities on T2-weighted magnetic resonance imaging in late-onset schizophreniaP Sachdev
School of Psychiatry, University of New South Wales and the Neuropsychiatric Institute, Prince Henry and Prince of Wales Hospitals, Sydney, Australia
Am J Psychiatry 156:1958-67. 1999..The authors investigated the extent and distribution of signal hyperintensities on T2-weighted magnetic resonance imaging (MRI) of the brains of subjects with late-onset schizophrenia... - [Homocysteine and neuropsychiatric disorders]Perminder Sachdev
Faculdade de Psiquiatria, Universidade de New South Wales, Sydney, Australia
Rev Bras Psiquiatr 26:50-6. 2004..More research evidence is necessary before population screening can be recommended... - Hippocampus and amygdala volumes in elderly schizophrenic patients as assessed by magnetic resonance imagingP Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Psychiatry Clin Neurosci 54:105-12. 2000..This pilot analysis in LOS subjects argues against the condition being secondary to Alzheimer's disease... - Case-control study of neuroleptic malignant syndromeP Sachdev
School of Psychiatry, University of New South Wales, Australia
Am J Psychiatry 154:1156-8. 1997..The authors performed a case-control study of neuroleptic malignant syndrome to identify potential risk factors... - Homocysteine, cerebrovascular disease and brain atrophyPerminder Sachdev
School of Psychiatry, University of New South Wales, Neuropsychiatric Institute, The Prince of Wales Hospital, Barker Street, Randwick, Sydney NSW 2031, Australia
J Neurol Sci 226:25-9. 2004..Hcy increases the risk of micro- and macrovascular disease as well as brain atrophy, and thereby impaired cognition. Remediation of high Hcy levels should begin early in life... - Progression of cognitive impairment in stroke patientsP S Sachdev
School of Psychiatry, University of New South Wales, Sydney, Australia
Neurology 63:1618-23. 2004..To examine the progression of neuropsychological deficits in stroke patients with and without cognitive impairment... - Sixty years of psychosurgery: its present status and its futureP Sachdev
Neuropsychiatric Institute, Prince Henry Hospital, Little Bay, New South Wales, Australia
Aust N Z J Psychiatry 31:457-64. 1997..The profession is urged to keep the interest in psychosurgery alive until further theoretical and empirical developments can either announce its death or lead to a resurgence of psychiatric neurosurgery in its present or modified form... - The effects of beta-adrenoceptor antagonists on a rat model of neuroleptic-induced akathisiaP S Sachdev
School of Psychiatry, University of New South Wales, and Neuropsychiatric Institute, The Prince Henry Hospital, Sydney, Australia
Psychiatry Res 72:133-40. 1997..The B-antagonist drugs significantly reduced the cataleptic effect of haloperidol and this effect warrants further examination... - Effects of specific dopamine D1 and D2 receptor antagonists and agonists and neuroleptic drugs on emotional defecation in a rat model of akathisiaP S Sachdev
School of Psychiatry, University of New South Wales, and Neuropsychiatric Institute, The Prince Henry Hospital, Sydney, Little Bay, Australia
Psychiatry Res 81:323-32. 1998..It is unlikely to be due to actions of neuroleptics on 5HT2 or alpha1 receptors as has sometimes been suggested. The results have implications for our understanding of the pathogenesis of akathisia... - Vascular dementia: diagnosis, management and possible preventionP S Sachdev
School of Psychiatry, University of New South Wales
Med J Aust 170:81-5. 1999..We discuss these features and risk factors and the main intervention strategies, both for treatment and prevention... - Schizophrenia-like illness in velo-cardio-facial syndrome: a genetic subsyndrome of schizophrenia?Perminder Sachdev
Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Randwick, NSW 2031, Australia
J Psychosom Res 53:721-7. 2002..An important example of such a genetic disorder is the velo-cardio-facial syndrome (VCFS) associated with 22q11 microdeletion... - Early extrapyramidal side-effects as risk factors for later tardive dyskinesia: a prospective studyPerminder Sachdev
School of Psychiatry, University of New South Wales, New South Wales, Australia
Aust N Z J Psychiatry 38:445-9. 2004..To determine whether acute neuroleptic-induced parkinsonism and akathisia were risk factors for the later development of tardive dyskinesia (TD) in patients on typical neuroleptics... - The current status of tardive dyskinesiaP S Sachdev
University of New South Wales, Sydney, Australia
Aust N Z J Psychiatry 34:355-69. 2000..This paper aims to provide an overview of the current knowledge on neuroleptic-induced tardive dyskinesia (TD) in relation to its clinical features, risk factors, pathophysiology and management... - The neuropsychological profile of vascular cognitive impairment in stroke and TIA patientsP S Sachdev
Schools of Psychiatry and Medicine, University of New South Wales, Australia
Neurology 62:912-9. 2004..The picture of VaD/VCI presented shows subcortical deficits embellished by cognitive deficits from cortical infarctions... - The relationship of current depressive symptoms and past depression with cognitive impairment and instrumental activities of daily living in an elderly population: the Sydney Memory and Ageing StudyS Reppermund
Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Randwick Campus, Building R1f, UNSW, NSW 2052, Sydney, Australia
J Psychiatr Res 45:1600-7. 2011..These results support the view that current and past depressive episodes are associated with poorer cognitive performance but not with functional abilities... - High (15 Hz) and low (1 Hz) frequency transcranial magnetic stimulation have different acute effects on regional cerebral blood flow in depressed patientsC K Loo
School of Psychiatry, University of New South Wales, Australia
Psychol Med 33:997-1006. 2003..CONCLUSIONS: High (15 Hz) and low (1 Hz) frequency rTMS led to different frontal and remote relative rCBF changes, which suggests different neurophysiological and possibly neuropsychiatric consequences of a change in frequency of rTMS... - Diffusion tensor imaging of the posterior cingulate is a useful biomarker of mild cognitive impairmentTerence C Chua
School of Psychiatry, University of New South Wales, NSW, Australia
Am J Geriatr Psychiatry 17:602-13. 2009..Biomarkers may help identify individuals at greatest risk of progressive decline. The authors examine a novel neuroimaging technique, diffusion tensor imaging (DTI) as a potential biomarker of MCI... - 1H MRS in stroke patients with and without cognitive impairmentA J Ross
School of Psychiatry, University of New South Wales, Sydney, Australia
Neurobiol Aging 26:873-82. 2005..Moreover, cortical regions not obviously infarcted may have dysfunctional neurons, the pathophysiological basis for which needs further study... - Double-blind controlled investigation of bilateral prefrontal transcranial magnetic stimulation for the treatment of resistant major depressionC K Loo
Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales, Randwick, Australia
Psychol Med 33:33-40. 2003..There were no significant neuropsychological effects. CONCLUSIONS: Bilateral rTMS was not superior to sham in treating resistant depression in this pilot study, but caused no neuropsychological impairment... - Prediction of cognitive decline after stroke using proton magnetic resonance spectroscopyAmy J Ross
Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Barker Street, Randwick, NSW, Australia
J Neurol Sci 251:62-9. 2006..In stroke/TIA patients, the (1)H-MRS measures were better predictors of cognitive decline than structural measures. (1)H-MRS may be useful in assessing early cognitive impairment after stroke/TIA and in normal ageing... - Gray matter reduction is correlated with white matter hyperintensity volume: a voxel-based morphometric study in a large epidemiological sampleWei Wen
School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia
Neuroimage 29:1031-9. 2006..Further delineation of this relationship needs a longitudinal study of the changes in both WMH and indices of brain atrophy... - Neuropsychological functioning of adults with attention deficit hyperactivity disorderA J Walker
Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
J Clin Exp Neuropsychol 22:115-24. 2000..The predictive power of the tests was poor in discriminating ADHD from psychiatric disorder. Implications for the clinical diagnosis of ADHD are discussed... - Functional alterations in brain activation and deactivation in mild cognitive impairment in response to a graded working memory challengeN A Kochan
Brain and Ageing Research Program, School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia
Dement Geriatr Cogn Disord 30:553-68. 2010..To investigate dynamic changes in functional brain activity in mild cognitive impairment (MCI) in response to a graded working memory (WM) challenge with increasing memory load... - The differentiation of mild frontotemporal dementia from Alzheimer's disease and healthy aging by neuropsychological testsAlexandra J Walker
Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
Int Psychogeriatr 17:57-68. 2005..This study aimed to investigate neuropsychological function in FTD of mild severity and compare it to that of mild AD and healthy control participants... - Relationships between serum vitamin D levels, neuromuscular and neuropsychological function and falls in older men and womenJ C Menant
Falls and Balance Research Group, Neuroscience Research Australia, University of New South Wales, Barker Street, Randwick, NSW 2031, Sydney, Australia
Osteoporos Int 23:981-9. 2012..In men, vitamin D insufficiency was associated with an increased risk of falling... - The Falls Efficacy Scale International (FES-I). A comprehensive longitudinal validation studyKim Delbaere
Falls and Balance Research Group, Prince of Wales Medical Research Institute, University of New South Wales, Randwick, Sydney, Australia
Age Ageing 39:210-6. 2010.... - Longitudinal changes during aging using proton magnetic resonance spectroscopyAmy J Ross
School of Psychiatry, University of New South Wales, Sydney, Australia
J Gerontol A Biol Sci Med Sci 61:291-8. 2006..Increasing mI may be a marker of aging or a preclinical neurodegenerative process. MRS changes do not correlate with change in neurocognitive function during aging... - Prevalence and characteristics of depression in mild cognitive impairment: the Sydney Memory and Ageing StudyZ Shahnawaz
Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales Dementia Collaborative Research Centre, School of Psychiatry, Faculty of Medicine, University of New South Wales Academic Department for Old Age Psychiatry, Prince of Wales Hospital Department of Developmental Disability Neuropsychiatry, School of Psychiatry, Faculty of Medicine, University of New South Wales Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia
Acta Psychiatr Scand 127:394-402. 2013..Conclusion: Individuals with MCI, especially aMCI, endorse more depressive symptoms when compared with cognitively intact individuals. These findings highlight the importance of assessing and treating depressive symptoms in MCI... - A sham-controlled trial of left and right temporal rTMS for the treatment of auditory hallucinationsC K Loo
School of Psychiatry, University of NSW and Black Dog Institute, Sydney, Australia
Psychol Med 40:541-6. 2010..Several studies have reported reduction of auditory hallucinations (AH) after repetitive transcranial magnetic stimulation (rTMS) to the left temporal cortex. This study explored the effects of rTMS to the left and right temporal cortex... - DSM-IV Major Depressive Episode in the elderly: the relationship between the number and the type of depressive symptoms and impairmentTracy M Anderson
School of Psychiatry, University of New South Wales, Black Dog Institute Building, Prince of Wales Hospital, Randwick NSW, Australia
J Affect Disord 117:55-62. 2009.... - Grey matter atrophy of basal forebrain and hippocampus in mild cognitive impairmentHaobo Zhang
Brain and Ageing Research Program, School of Psychiatry, University of New South Wales, Sydney, Australia
J Neurol Neurosurg Psychiatry 82:487-93. 2011..In addition, a slight but statistically significant difference was found in the left hippocampal volume between APOE ε4 allele carriers and non-carriers, consistent with prior studies... - Neuroleptic malignant syndrome associated with atypical antipsychotic drugsJulian N Trollor
School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia
CNS Drugs 23:477-92. 2009..Both these issues have relevance for the identification of atypical or milder forms of NMS, which are sometimes seen with atypical antipsychotic drugs... - An emotional Stroop functional MRI study of euthymic bipolar disorderGin S Malhi
School of Psychiatry, University of New South Wales, Sydney, Australia
Bipolar Disord 7:58-69. 2005..To identify the brain regions associated with emotional processing in euthymic bipolar patients... - Who does well after a stroke? The Sydney stroke studyAdrienne Withall
School of Psychiatry, University of New South Wales, Randwick, NSW, Australia
Aging Ment Health 13:693-8. 2009..We conclude that people can have good outcomes in the year after stroke except if they experience further cerebrovascular events and/or have risk factors for cerebrovascular disease. Brain reserve appears to be protective... - Regional cerebral blood flow deficits in mild Alzheimer's disease using high resolution single photon emission computerized tomographyJulian N Trollor
School of Psychiatry, University of New South Wales, Sydney, Australia
Psychiatry Clin Neurosci 59:280-90. 2005..Discriminant function analysis indicated that rCBF in the prefrontal polar regions achieved the best classification of cases. SPECT has utility in the diagnostic assessment of AD if standardized and semiquantitative techniques are used... - Prevalence and predictors of “subjective cognitive complaints” in the Sydney Memory and Ageing StudyMelissa J Slavin
Brain and Ageing Research Program, School of Psychiatry, The University of New South Wales, Sydney, Australia
Am J Geriatr Psychiatry 18:701-10. 2010.... - Cognitive correlates of 1H MRS measures in the healthy elderly brainAmy J Ross
School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
Brain Res Bull 66:9-16. 2005..This research highlights the importance of the relationship between regional brain changes and cognitive function in the ageing brain, and suggests that MRS may be a sensitive marker of subclinical change in cognition... - Effect of different impairment criteria on prevalence of “objective” mild cognitive impairment in a community sampleNicole A Kochan
Brain and Ageing Research Program, School of Psychiatry, The University of New South Wales, Sydney, Australia
Am J Geriatr Psychiatry 18:711-22. 2010..The aims of this study were to investigate the effect of varying the criteria used to determine cognitive impairment (CI) on prevalence and case definition and to examine comparability of different criteria... - White matter hyperintensities in the forties: their prevalence and topography in an epidemiological sample aged 44-48Wei Wen
Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, New South Wales, Australia
Hum Brain Mapp 30:1155-67. 2009..The study suggests that small punctate or focal WMHs are common in the brains of individuals in their 40s, and may represent an early stage of development of these lesions... - Rates of depression at 3 and 15 months poststroke and their relationship with cognitive decline: the Sydney Stroke StudyHenry Brodaty
School of Psychiatry, University of New South Wales, Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Randwick, NSW, Australia
Am J Geriatr Psychiatry 15:477-86. 2007..To investigate the frequency and correlates of depression at 3 and 15 months after stroke... - Sex differences in regional gray matter in healthy individuals aged 44-48 years: a voxel-based morphometric studyXiaohua Chen
School of Psychiatry, University of New South Wales, Australia
Neuroimage 36:691-9. 2007..These differences may provide the structural brain basis for sex differences in certain cognitive functions... - Disruption of the neural correlates of working memory using high- and low-frequency repetitive transcranial magnetic stimulation: a negative studyEva A Feredoes
School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia
Suppl Clin Neurophysiol 56:187-97. 2003 - Prevalence of mental disorders in the elderly: the Australian National Mental Health and Well-Being SurveyJulian N Trollor
Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW, Australia
Am J Geriatr Psychiatry 15:455-66. 2007.... - Effects of sociodemographic and health variables on Mini-Mental State Exam scores in older AustraliansTracy M Anderson
School of Psychiatry, University of New South Wales, the Clinical Research Unit for Anxiety and Depression, Darlinghurst, New South Wales, Australia
Am J Geriatr Psychiatry 15:467-76. 2007.... - Magnetic resonance spectroscopy in cognitive researchAmy J Ross
School of Psychiatry, University of New South Wales, Kensington, New South Wales 2033, Australia
Brain Res Brain Res Rev 44:83-102. 2004.... - Regional gray matter changes in bipolar disorder: a voxel-based morphometric studyXiaohua Chen
Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Randwick, New South Wales, Australia
Aust N Z J Psychiatry 41:327-36. 2007.... - A sham-controlled trial of the efficacy and safety of twice-daily rTMS in major depressionColleen K Loo
School of Psychiatry, University of NSW and Black Dog Institute, Sydney, Australia
Psychol Med 37:341-9. 2007..Studies of repetitive transcranial magnetic stimulation (rTMS) in depression have mostly involved once-daily treatment, with positive but modest clinical results. This study tested the efficacy and safety of twice-daily rTMS over 2 weeks... - Age shall not weary them: mental health in the middle-aged and the elderlyJulian N Trollor
School of Psychiatry, University of New South Wales and Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Randwick, NSW, Australia
Aust N Z J Psychiatry 41:581-9. 2007..The aim of the present paper was to provide the first direct comparison of the prevalence and demographic correlates of ICD-10 anxiety and affective disorders in the middle-aged and the elderly... - Diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease: a reviewTerence C Chua
Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Randwick, NSW, Australia
Curr Opin Neurol 21:83-92. 2008..To provide a comprehensive review of diffusion tensor imaging in evaluating microstructural changes in the spectrum of cognitive decline from ageing to Alzheimer's disease, in particular focusing on mild cognitive impairment... - Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke - the Sydney Stroke StudyHenry Brodaty
School of Psychiatry, University of New South Wales, Randwick, Australia
Psychol Med 35:1707-16. 2005..The frequency and clinical, neuropsychological and neuroimaging correlates of apathy in patients who have had a stroke are inadequately defined... - Genetic and environmental influences on obsessive-compulsive disorderJessica R Grisham
School of Psychology, University of New South Wales, Sydney, NSW, Australia
Eur Arch Psychiatry Clin Neurosci 258:107-16. 2008..We also describe innovative study designs that may be used in future research to explore the interaction between genetic vulnerability and environmental risk factors for OCD... - Effects of cerebrovascular risk factors on gray matter volume in adults aged 60-64 years: a voxel-based morphometric studyXiaohua Chen
School of Psychiatry, University of New South Wales, Sydney, Australia
Psychiatry Res 147:105-14. 2006..Our results suggest that there are different patterns of regional effects in gray matter volume in relation to different cerebrovascular risk factors, and sex differences for the same risk factors... - A high-resolution single photon emission computed tomography study of verbal recognition memory in Alzheimer's diseaseJulian N Trollor
School of Psychiatry, University of New South Wales, Randwick, Australia
Dement Geriatr Cogn Disord 21:267-74. 2006..In view of the recent technological advances and its ease of availability, we used single photon emission computed tomography (SPECT) to examine the performance of early Alzheimer's disease (AD) subjects on a verbal recognition memory task... - Combined cerebral blood flow effects of a cholinergic agonist (milameline) and a verbal recognition task in early Alzheimer's diseaseJulian N Trollor
School of Psychiatry, University of New South Wales, Sydney, Australia
Psychiatry Clin Neurosci 60:616-25. 2006.... - A longitudinal study examining the independence of apathy and depression after stroke: the Sydney Stroke StudyAdrienne Withall
School of Psychiatry, University of New South Wales, Randwick, Australia
Int Psychogeriatr 23:264-73. 2011..This is the first study to investigate the relationship of apathy and depression longitudinally following stroke and to examine the association with dementia... - Electroconvulsive treatment of neuroleptic malignant syndrome: a review and report of casesJ N Trollor
Neuropsychiatric Institute, The Prince of Wales Hospital, Randwick, New South Wales, Australia
Aust N Z J Psychiatry 33:650-9. 1999..We review 45 published case reports of ECT for NMS and describe nine new cases, to examine its effectiveness, the likelihood of adverse reactions, and the theoretical implications of such treatment... - Genetic influences on cognitive functions in the elderly: a selective review of twin studiesTeresa Lee
Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, NSW, Australia
Brain Res Rev 64:1-13. 2010..It highlights the need for more research, with consistent and appropriate cognitive measures, with data obtained from larger and more geographically and culturally diverse twin samples...