Christophe Rosty

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. doi Should the grading of colorectal adenocarcinoma include microsatellite instability status?
    Christophe Rosty
    Envoi Pathology, Brisbane, QLD 4059, Australia University of Queensland, School of Medicine, Brisbane, QLD, 4029 Australia Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Carlton 3010, Vic, Australia Electronic address
    Hum Pathol 45:2077-84. 2014
  2. pmc PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival
    Christophe Rosty
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, Australia
    PLoS ONE 8:e65479. 2013
  3. doi Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features
    Christophe Rosty
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Mod Pathol 26:825-34. 2013
  4. pmc Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management
    Christophe Rosty
    Envoi Pathology, 1 49 Butterfield Street, Herston, Brisbane, QLD, 4006, Australia
    J Gastroenterol 48:287-302. 2013
  5. pmc Multiplicity and molecular heterogeneity of colorectal carcinomas in individuals with serrated polyposis
    Christophe Rosty
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Bancroft Centre, Herston, QLD, Australia
    Am J Surg Pathol 37:434-42. 2013
  6. doi Hyperplastic polyp of the duodenum: a report of 9 cases with immunohistochemical and molecular findings
    Christophe Rosty
    Anatomical Pathology, Pathology Queensland, Royal Brisbane and Women s Hospital, Herston QLD 4006, Australia
    Hum Pathol 42:1953-9. 2011
  7. pmc Phenotype and polyp landscape in serrated polyposis syndrome: a series of 100 patients from genetics clinics
    Christophe Rosty
    Pathology Queensland, Royal Brisbane and Women s Hospital, Herston, QLD 4006, Australia
    Am J Surg Pathol 36:876-82. 2012
  8. doi Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype
    Michael D Walsh
    1 Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, QLD, Australia 2 Department of Histopathology, Sullivan Nicolaides Pathology, Taringa, QLD, Australia
    Mod Pathol 26:1642-56. 2013
  9. pmc Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer
    Aung Ko Win
    Centre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria, Australia
    Gastroenterology 146:1208-11.e1-5. 2014
  10. pmc Immunohistochemical testing of conventional adenomas for loss of expression of mismatch repair proteins in Lynch syndrome mutation carriers: a case series from the Australasian site of the colon cancer family registry
    Michael D Walsh
    Familial Cancer Laboratory, QIMR, Herston, QLD, Australia
    Mod Pathol 25:722-30. 2012

Collaborators

Detail Information

Publications28

  1. doi Should the grading of colorectal adenocarcinoma include microsatellite instability status?
    Christophe Rosty
    Envoi Pathology, Brisbane, QLD 4059, Australia University of Queensland, School of Medicine, Brisbane, QLD, 4029 Australia Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Carlton 3010, Vic, Australia Electronic address
    Hum Pathol 45:2077-84. 2014
    ....
  2. pmc PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival
    Christophe Rosty
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, Australia
    PLoS ONE 8:e65479. 2013
    ..PIK3CA mutation also contributes to significantly decreased survival for patients with wild-type BRAF tumors...
  3. doi Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features
    Christophe Rosty
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, Queensland, Australia
    Mod Pathol 26:825-34. 2013
    ..In summary, KRAS-mutated carcinomas frequently develop in contiguity with a residual polyp and show molecular features distinct from other colorectal carcinomas, in particular from tumors with neither BRAF nor KRAS mutation...
  4. pmc Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management
    Christophe Rosty
    Envoi Pathology, 1 49 Butterfield Street, Herston, Brisbane, QLD, 4006, Australia
    J Gastroenterol 48:287-302. 2013
    ..Patient management guidelines have been recently updated although high-level evidence to support them is still required...
  5. pmc Multiplicity and molecular heterogeneity of colorectal carcinomas in individuals with serrated polyposis
    Christophe Rosty
    Cancer and Population Studies Group, Queensland Institute of Medical Research, Bancroft Centre, Herston, QLD, Australia
    Am J Surg Pathol 37:434-42. 2013
    ..The high proportion of multiple CRCs suggests that individuals with SP would benefit from frequent colonoscopic surveillance and from a consideration of a more extensive colectomy at the time of CRC diagnosis...
  6. doi Hyperplastic polyp of the duodenum: a report of 9 cases with immunohistochemical and molecular findings
    Christophe Rosty
    Anatomical Pathology, Pathology Queensland, Royal Brisbane and Women s Hospital, Herston QLD 4006, Australia
    Hum Pathol 42:1953-9. 2011
    ..However, no patient met the criteria for serrated polyposis. Although probably rare and of uncertain malignant potential, hyperplastic polyp should be considered in the differential diagnosis of benign duodenal polyp...
  7. pmc Phenotype and polyp landscape in serrated polyposis syndrome: a series of 100 patients from genetics clinics
    Christophe Rosty
    Pathology Queensland, Royal Brisbane and Women s Hospital, Herston, QLD 4006, Australia
    Am J Surg Pathol 36:876-82. 2012
    ..003). Patients with SPS referred to genetics clinics had a pancolonic disease with a high polyp burden and a high rate of BRAF mutation. The occurrence of CRC was associated with the presence of conventional adenoma...
  8. doi Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype
    Michael D Walsh
    1 Cancer and Population Studies Group, Queensland Institute of Medical Research, Herston, QLD, Australia 2 Department of Histopathology, Sullivan Nicolaides Pathology, Taringa, QLD, Australia
    Mod Pathol 26:1642-56. 2013
    ..Our results suggest that, in methylator-positive tumors, mucin genes on chromosome 11p15.5 region undergo increased expression via mechanisms other than direct regulation by CDX2. ..
  9. pmc Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer
    Aung Ko Win
    Centre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria, Australia
    Gastroenterology 146:1208-11.e1-5. 2014
    ..6%-17.7%) and 10% for women (95% CI, 6.7%-14.4%). Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population...
  10. pmc Immunohistochemical testing of conventional adenomas for loss of expression of mismatch repair proteins in Lynch syndrome mutation carriers: a case series from the Australasian site of the colon cancer family registry
    Michael D Walsh
    Familial Cancer Laboratory, QIMR, Herston, QLD, Australia
    Mod Pathol 25:722-30. 2012
    ..The overwhelming majority of conventional adenomas from mutation carriers show loss of mismatch repair protein expression concordant with the underlying germline mutation...
  11. pmc Family history of colorectal cancer in BRAF p.V600E-mutated colorectal cancer cases
    Daniel D Buchanan
    Cancer and Population Studies Group, Queensland Institute of Medical Research, 300 Herston Rd, Herston QLD 4006, Australia
    Cancer Epidemiol Biomarkers Prev 22:917-26. 2013
    ..V600E mutation are at an increased risk of CRC and extracolonic cancers (ECC). In this study, we estimated the association between a family history of either CRC or ECC and risk of CRC with a BRAF p.V600E mutation...
  12. pmc Role of tumour molecular and pathology features to estimate colorectal cancer risk for first-degree relatives
    Aung Ko Win
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia
    Gut 64:101-10. 2015
    ..To estimate risk of colorectal cancer (CRC) for first-degree relatives of CRC cases based on CRC molecular subtypes and tumour pathology features...
  13. doi Mutation deep within an intron of MSH2 causes Lynch syndrome
    Mark Clendenning
    Familial Cancer Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, QLD, Australia
    Fam Cancer 10:297-301. 2011
    ....
  14. pmc Risk factors for colorectal cancer in patients with multiple serrated polyps: a cross-sectional case series from genetics clinics
    Daniel D Buchanan
    Familial Cancer Laboratory, QIMR, Herston, Queensland, Australia
    PLoS ONE 5:e11636. 2010
    ..The aim of this work therefore was to investigate the association between smoking and the risk of CRC in high-risk genetics clinic patients presenting with multiple serrated polyps...
  15. doi Tubular adenomas with minor villous changes show molecular features characteristic of tubulovillous adenomas
    Tatsuhiro Ishii
    Royal Brisbane and Women s Hospital Research Foundation Clinical Research Centre, Brisbane, Australia
    Am J Surg Pathol 35:212-20. 2011
    ..These data support the concept that any villous change may indicate increased malignant potential and may be useful to consider when assigning surveillance guidelines...
  16. pmc Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome
    Aung Ko Win
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, Level 3, 207 Bouverie Street, The University of Melbourne, VIC 3010, Australia
    J Natl Cancer Inst 104:1363-72. 2012
    ..We estimated the risks of primary cancers other than colorectal cancer following a diagnosis of colorectal cancer in mutation carriers...
  17. doi The challenging diagnosis of Cronkhite-Canada syndrome in the upper gastrointestinal tract: a series of 7 cases with clinical follow-up
    Mark Bettington
    Envoi Specialist Pathologists The Conjoint Gastroenterology Laboratory Cancer and Population Studies Group, Queensland Institute of Medical Research, Bancroft Centre School of Medicine, University of Queensland Anatomical Pathology, Pathology Queensland, Royal Brisbane and Women s Hospital, Herston Sullivan Nicolaides Pathology, Taringa, QLD Department of Anatomical Pathology, PathWest, QE II Medical Centre School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA, Australia
    Am J Surg Pathol 38:215-23. 2014
    ....
  18. pmc Linkage to chromosome 2q32.2-q33.3 in familial serrated neoplasia (Jass syndrome)
    Aedan Roberts
    Familial Cancer Laboratory, Queensland Institute of Medical Research, Herston, QLD 4006, Australia
    Fam Cancer 10:245-54. 2011
    ..36 (P = 0.004). Five primary candidate genes (CFLAR, CASP10, CASP8, FZD7 and BMPR2) were sequenced and no segregating variants identified. There was no evidence of linkage to previously reported loci on chromosomes 3, 7 and 9...
  19. doi Tropical sprue: revisiting an underrecognized disease
    Ian S Brown
    Envoi Specialist Pathologists Anatomical Pathology, Pathology Queensland, Royal Brisbane and Women s Hospital The Conjoint Gastroenterology Laboratory Cancer and Population Studies Group, Queensland Institute of Medical Research, Bancroft Centre School of Medicine, University of Queensland, Herston Sullivan Nicolaides Pathology, Taringa, QLD, Australia
    Am J Surg Pathol 38:666-72. 2014
    ..With the expansion of tourism and increasing employment opportunities in tropical regions, pathologists in the West are increasingly likely to encounter cases of tropical sprue and should be aware of this diagnosis. ..
  20. doi A clinicopathological and molecular analysis of 200 traditional serrated adenomas
    Mark L Bettington
    1 The Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia 2 The School of Medicine, The University of Queensland, Brisbane, QLD, Australia 3 Envoi Specialist Pathologists, Brisbane, QLD, Australia
    Mod Pathol 28:414-27. 2015
    ..Thus, the BRAF mutant traditional serrated adenoma represents an important precursor of the aggressive BRAF mutant, microsatellite-stable subtype of colorectal carcinoma. ..
  21. doi Do serrated neoplasms of the small intestine represent a distinct entity? Pathological findings and molecular alterations in a series of 13 cases
    Christophe Rosty
    Envoi Pathology, Brisbane, QLD, Australia School of Medicine, University of Queensland, Brisbane, QLD, Australia Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Carlton, Vic, Australia
    Histopathology 66:333-42. 2015
    ..To characterize pathological, immunohistochemical and molecular features of small intestinal serrated neoplasms...
  22. pmc High prevalence of mismatch repair deficiency in prostate cancers diagnosed in mismatch repair gene mutation carriers from the colon cancer family registry
    Christophe Rosty
    Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology and Centre for Epidemiology and Biostatistics, University of Melbourne, Parkville, Vic, 3010, Australia
    Fam Cancer 13:573-82. 2014
    ..MMR IHC screening of prostate cancers will aid in identifying MMR gene mutation carriers...
  23. pmc Detection of large scale 3' deletions in the PMS2 gene amongst Colon-CFR participants: have we been missing anything?
    Mark Clendenning
    Cancer and Population Studies, Queensland Institute of Medical Research, 300 Herston Road, Herston, QLD, 4006, Australia
    Fam Cancer 12:563-6. 2013
    ..No deletions encompassing any or all of exons 12 through 15 were identified; therefore, our results suggest that 3' deletions in PMS2 are not a frequent occurrence in such families...
  24. doi Critical appraisal of the diagnosis of the sessile serrated adenoma
    Mark Bettington
    The Conjoint Gastroenterology Laboratory Cancer and Population Studies Group The Statistics Unit, QIMR Berghofer Medical Research Institute School of Medicine, The University of Queensland Envoi Specialist Pathologists Departments of Anatomical Pathology Chemical Pathology, Central Laboratory, Pathology Queensland The Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia
    Am J Surg Pathol 38:158-66. 2014
    ..7%. In summary, we believe that SSAs continue to be underdiagnosed in pathologic practice and that this may result in inadequate surveillance and thus contribute to interval colorectal carcinomas. ..
  25. pmc Serrated polyposis: an enigmatic model of colorectal cancer predisposition
    Christophe Rosty
    Pathology Queensland and UQ Centre for Clinical Research, Royal Brisbane and Women s Hospital, Herston, QLD 4029, Australia
    Patholog Res Int 2011:157073. 2011
    ....
  26. pmc BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch syndrome
    Christopher W Toon
    Department of Anatomical Pathology Northern Cancer Translational Research Unit Familial Cancer Clinic, Royal North Shore Hospital Department of Pathology, SydPath, St Vincents Hospital, Darlinghurst Faculty of Medicine, University of NSW Sydney Medical School, University of Sydney, Sydney, NSW Department of Molecular and Cellular Pathology Department of Pathology, School of Medicine, University of Queensland Envoi Specialist Pathologists, Herston Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, QLD Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Carlton, Vic, Australia Department of Neuropathology, Institute of Pathology, Ruprecht Karls University Clinical Cooperation Unit Neuropathology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Am J Surg Pathol 37:1592-602. 2013
    ..Reflex BRAFV600E and MMR IHC are simple cheap tests that facilitate universal LS screening and identify the poor prognosis of the BRAFV600E-mutant MSS CRC phenotype. ..
  27. doi Colonic mucosubmucosal elongated polyp: a clinicopathologic study of 13 cases and review of the literature
    Michelle Marie Christine Alizart
    Anatomical Pathology, Pathology Queensland, Royal Brisbane and Women s Hospital, The University of Queensland School of Medicine, UQ Centre for Clinical Research, Herston, Australia
    Am J Surg Pathol 35:1818-22. 2011
    ..Despite the occasional large size, CMSEP is a benign lesion seldom leading to clinical complications...
  28. doi Gastrointestinal pathology in celiac disease: a case series of 150 consecutive newly diagnosed patients
    Ian S Brown
    Anatomical Pathology, Pathology Queensland, Royal Brisbane and Women s Hospital, Herston QLD 4006, Australia
    Am J Clin Pathol 138:42-9. 2012
    ..4% of patients. We demonstrated that these underrecognized features, which can be misleading, are not uncommon in celiac disease and were positively associated with more advanced stages of the disease (P < .0001)...