S J Rogerson

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi Malaria in pregnancy: pathogenesis and immunity
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Lancet Infect Dis 7:105-17. 2007
  2. pmc Ownership and use of insecticide-treated nets during pregnancy in sub-Saharan Africa: a review
    Megha Singh
    Nossal Institute for Global Health, University of Melbourne, Carlton, Vic, Australia
    Malar J 12:268. 2013
  3. pmc Opsonization of malaria-infected erythrocytes activates the inflammasome and enhances inflammatory cytokine secretion by human macrophages
    Jingling Zhou
    Centre for Virology, Burnet Institute, PO Box 2284, Melbourne, Victoria, 3001, Australia
    Malar J 11:343. 2012
  4. pmc Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study
    Jennifer B Griffin
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, McGavran Greenberg Hall, Campus Box 7435, Chapel Hill, 27599 7435, USA
    Malar J 11:319. 2012
  5. pmc The impact of tubal ectopic pregnancy in Papua New Guinea - a retrospective case review
    Nancy N Hamura
    Department of Obstetrics and Gynaecology, Modilon General Hospital, P, O, Box 2119, Madang, 511, Papua New Guinea
    BMC Pregnancy Childbirth 13:86. 2013
  6. pmc A retrospective study of secondary bacteraemia in hospitalised adults with community acquired non-typhoidal Salmonella gastroenteritis
    Christopher M Parry
    Tropical and Infectious Disease Unit, Royal Liverpool University Hospital, Liverpool, UK
    BMC Infect Dis 13:107. 2013
  7. pmc Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line
    Francisca Yosaatmadja
    Department of Medicine, University of Melbourne RMH WH, Post Office Royal Melbourne Hospital, Parkville VIC 3050, Australia
    Malar J 7:51. 2008
  8. pmc The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia
    Jean Pierre Van Geertruyden
    Unit International Health, Epidemiology and Social Medicine, Antwerp University, Belgium
    Malar J 8:258. 2009
  9. pmc Malaria during pregnancy and foetal haematological status in Blantyre, Malawi
    Elizabeth T Abrams
    Department of Humanities and Social Sciences, California Institute of Technology, Pasadena, California, USA
    Malar J 4:39. 2005
  10. ncbi Malaria in pregnancy: linking immunity and pathogenesis to prevention
    Stephen J Rogerson
    Department of Medicine RMH WH, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Am J Trop Med Hyg 77:14-22. 2007

Detail Information

Publications76

  1. ncbi Malaria in pregnancy: pathogenesis and immunity
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Lancet Infect Dis 7:105-17. 2007
    ....
  2. pmc Ownership and use of insecticide-treated nets during pregnancy in sub-Saharan Africa: a review
    Megha Singh
    Nossal Institute for Global Health, University of Melbourne, Carlton, Vic, Australia
    Malar J 12:268. 2013
    ..These findings highlight the need for context-specific approaches and educational components to be incorporated into ITN distribution programmes to address some of the reasons why some pregnant women do not use the ITNs they own. ..
  3. pmc Opsonization of malaria-infected erythrocytes activates the inflammasome and enhances inflammatory cytokine secretion by human macrophages
    Jingling Zhou
    Centre for Virology, Burnet Institute, PO Box 2284, Melbourne, Victoria, 3001, Australia
    Malar J 11:343. 2012
    ..The effects of phagocytosis of opsonized IE on macrophage pro-inflammatory cytokine responses are poorly understood...
  4. pmc Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study
    Jennifer B Griffin
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, McGavran Greenberg Hall, Campus Box 7435, Chapel Hill, 27599 7435, USA
    Malar J 11:319. 2012
    ..The objective of this analysis was to examine the effect of malaria parasitaemia prior to 20 weeks' gestation on subsequent changes in uterine and umbilical artery blood flow and intrauterine growth restriction...
  5. pmc The impact of tubal ectopic pregnancy in Papua New Guinea - a retrospective case review
    Nancy N Hamura
    Department of Obstetrics and Gynaecology, Modilon General Hospital, P, O, Box 2119, Madang, 511, Papua New Guinea
    BMC Pregnancy Childbirth 13:86. 2013
    ..Tubal EP is well described in industrialised countries, but less is known about its impact in low-resource countries, in particular in the South Pacific Region...
  6. pmc A retrospective study of secondary bacteraemia in hospitalised adults with community acquired non-typhoidal Salmonella gastroenteritis
    Christopher M Parry
    Tropical and Infectious Disease Unit, Royal Liverpool University Hospital, Liverpool, UK
    BMC Infect Dis 13:107. 2013
    ..The clinical significance of bacteraemia secondary to non-typhoidal Salmonella (NTS) gastroenteritis in hospitalised adults is uncertain...
  7. pmc Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line
    Francisca Yosaatmadja
    Department of Medicine, University of Melbourne RMH WH, Post Office Royal Melbourne Hospital, Parkville VIC 3050, Australia
    Malar J 7:51. 2008
    ..VAR2CSA appears to be the main ligand responsible for adhesion to chondroitin sulphate A (CSA). Whether other PfEMP1 molecules can also mediate placental adhesion, independent of CSA binding, is unclear...
  8. pmc The relationship of Plasmodium falciparum humeral immunity with HIV-1 immunosuppression and treatment efficacy in Zambia
    Jean Pierre Van Geertruyden
    Unit International Health, Epidemiology and Social Medicine, Antwerp University, Belgium
    Malar J 8:258. 2009
    ..This study reports the impact of HIV-1 infection and other variables on the level of malaria humeral immunity in adults with clinical malaria and whether humeral immune suppression was a risk factor for treatment failure...
  9. pmc Malaria during pregnancy and foetal haematological status in Blantyre, Malawi
    Elizabeth T Abrams
    Department of Humanities and Social Sciences, California Institute of Technology, Pasadena, California, USA
    Malar J 4:39. 2005
    ..This study addressed this idea by examining cord haemoglobin levels in relation to maternal malaria, anaemia, and markers of foetal immune activation...
  10. ncbi Malaria in pregnancy: linking immunity and pathogenesis to prevention
    Stephen J Rogerson
    Department of Medicine RMH WH, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Am J Trop Med Hyg 77:14-22. 2007
    ..Improved understanding of the relationship between pathogenesis, immunity, and pregnancy outcome will allow better targeting of our interventions to prevent the consequences of malaria in pregnancy...
  11. ncbi HIV-1, antiretroviral therapy, and malaria
    Stephen Rogerson
    Department of Medicine RMH WH, University of Melbourne, Royal Melbourne Hospital, VIC 3050, Parkville, Australia
    Lancet 362:1008-9. 2003
  12. pmc Diagnosis of Plasmodium falciparum malaria at delivery: comparison of blood film preparation methods and of blood films with histology
    Stephen J Rogerson
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    J Clin Microbiol 41:1370-4. 2003
    ..02). Placental histology is the most sensitive method for the diagnosis of malaria in pregnancy. Methods for preparation of placental films may affect the density, but not the prevalence, of P. falciparum infection detected...
  13. ncbi New approaches to pathogenesis of malaria in pregnancy
    S J Rogerson
    Department of Medicine RMH WH, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
    Parasitology 134:1883-93. 2007
    ..Such approaches would greatly increase our knowledge on the pathogenesis of this disease and may provide new avenues for intervention strategies...
  14. ncbi Placental monocyte infiltrates in response to Plasmodium falciparum malaria infection and their association with adverse pregnancy outcomes
    Stephen J Rogerson
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Am J Trop Med Hyg 68:115-9. 2003
    ..0001), number of ANC visits (P = 0.002), and recent febrile symptoms (P = 0.0001). Pigment-containing placental monocytes are associated with anemia and LBW due to malaria, and may have a causative role in their development...
  15. pmc Placental tumor necrosis factor alpha but not gamma interferon is associated with placental malaria and low birth weight in Malawian women
    Stephen J Rogerson
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Department of Obstetrics and Gynaecology, College of Medicine, University of Malawi, Blantyre, Malawi
    Infect Immun 71:267-70. 2003
    ..Placental production of TNF-alpha, but not of IFN-gamma, may be implicated in impaired fetal growth in Malawian women...
  16. pmc Severe vivax malaria: newly recognised or rediscovered
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    PLoS Med 5:e136. 2008
  17. pmc What is the relationship between haptoglobin, malaria, and anaemia?
    Stephen Rogerson
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    PLoS Med 3:e200. 2006
  18. doi Host immunity as a determinant of treatment outcome in Plasmodium falciparum malaria
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Melbourne, Vic, Australia
    Lancet Infect Dis 10:51-9. 2010
    ..With increasing malaria control efforts worldwide, declining population immunity might alter drug response profiles. Improved methods for assessing antimalarial immunity will strengthen malaria control efforts...
  19. ncbi Treatment and prevention of malaria in pregnancy: opportunities and challenges
    Stephen J Rogerson
    University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Australia
    Expert Rev Anti Infect Ther 4:687-702. 2006
    ..Prevention of pregnancy malaria by vaccination may also become possible, but targets must be closely defined, and strategies developed to test candidates against meaningful end points...
  20. ncbi Sequestration: causes and consequences
    Stephen J Rogerson
    Department of Medicine, University of Melbourne, Post Office Royal Melbourne Hospital, Victoria, Australia
    Redox Rep 8:295-9. 2003
    ....
  21. pmc Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic properties
    J G Beeson
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria, Australia
    J Infect Dis 180:464-72. 1999
    ..The prevalence of agglutinating antibodies to pregnancy isolates was generally low, but it was highest in multigravidae who are likely to have had the greatest exposure...
  22. pmc The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1
    J C Reeder
    The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 96:5198-202. 1999
    ..falciparum erythrocyte membrane protein 1 as the parasite ligand paves the way to a more detailed understanding of the pathogenesis of placental infection and potential therapeutic strategies targeting the interaction...
  23. pmc Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria
    J G Beeson
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Med 6:86-90. 2000
    ....
  24. ncbi The age-specific prevalence of Plasmodium falciparum in migrants to Irian Jaya is not attributable to agglutinating antibody repertoire
    J C Reeder
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria
    Acta Trop 65:163-73. 1997
    ..falciparum antigens is more likely to account for the age-dependent prevalence of parasitaemia observed...
  25. pmc Plasmodium falciparum rosette formation is uncommon in isolates from pregnant women
    S J Rogerson
    Wellcome Trust Research Laboratories, College of Medicine, University of Malawi, Blantyre, Malawi
    Infect Immun 68:391-3. 2000
    ..002), and both formed fewer rosettes than isolates cultured from children (range, 0 to 56%; P < 0.0001). Rosette formation is common in infections of children but uncommon in pregnancy and rarely detected in placental isolates...
  26. ncbi Parasite adhesion and immune evasion in placental malaria
    J G Beeson
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Trends Parasitol 17:331-7. 2001
    ..falciparum-erythrocyte membrane protein 1 (PfEMP1)...
  27. ncbi Intermittent sulfadoxine-pyrimethamine in pregnancy: effectiveness against malaria morbidity in Blantyre, Malawi, in 1997-99
    S J Rogerson
    Wellcome Trust Research Laboratories and Malaria Project, College of Medicine, University of Malawi, Blantyre, Malawi
    Trans R Soc Trop Med Hyg 94:549-53. 2000
    ..Intermittent presumptive treatment with SP is having a positive impact on some, but not all indicators of malaria infection and morbidity in Malawi. Improved implementation and continued surveillance are essential...
  28. ncbi The placenta in malaria: mechanisms of infection, disease and foetal morbidity
    S J Rogerson
    Wellcome Trust Research Laboratories and Malaria Project, College of Medicine, University of Malawi, Blantyre, Malawi
    Ann Trop Med Parasitol 93:S35-42. 1999
    ..The results of recent research indicating an interaction between HIV and malaria in pregnancy are summarized. Ten questions for basic researchers are posed. The answers may help direct future efforts to control malaria in pregnancy...
  29. ncbi An alternative agglutination assay to measure antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes
    E J Mann
    Department of Medicine, University of Melbourne, 4th Floor Clinical Sciences Building, Parkville, Victoria 3050, Australia
    Trans R Soc Trop Med Hyg 97:717-9. 2003
    ..Fixed Giemsa-stained smears allow long-term storage and re-examination, without fluorescence microscopy...
  30. ncbi A novel flow cytometric phagocytosis assay of malaria-infected erythrocytes
    Emma Tippett
    AIDS Pathogenesis and Clinical Research Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    J Immunol Methods 325:42-50. 2007
    ..These assays have the advantage over other malaria phagocytosis assays in that they are rapid, simple and specific to malaria-infected cells and avoid potential bias associated with manual counting...
  31. ncbi Maternal syphilis infection is associated with increased risk of mother-to-child transmission of HIV in Malawi
    Victor Mwapasa
    Department of Community Health, College of Medicine, Blantyre, Malawi, USA
    AIDS 20:1869-77. 2006
    ..To determine the association between maternal syphilis and HIV mother-to-child transmission (MTCT)...
  32. pmc Placental hypoxia during placental malaria
    Philippe Boeuf
    Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    J Infect Dis 197:757-65. 2008
    ..We investigated whether parasite or monocyte infiltrates were associated with placental hypoxia, as a potential mechanism underlying malarial FGR...
  33. doi Differential antibody responses to Plasmodium falciparum merozoite proteins in Malawian children with severe malaria
    Carlota Dobano
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland
    J Infect Dis 197:766-74. 2008
    ..005; for MSP-2, P< .05) or SMA (for MSP-1 and MSP-2, P<.001; for AMA-1, P< .005). These distinct IgG patterns might reflect differences in age, exposure to P. falciparum, and/or genetic factors affecting immune responses...
  34. ncbi Placental malaria in women with South-East Asian ovalocytosis
    Ariadna Benet
    Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    Am J Trop Med Hyg 75:597-604. 2006
    ..Furthermore, we found that the prevalence of the SAO trait was lower among pregnant women than among non-pregnant controls...
  35. pmc Expression of merozoite surface protein markers by Plasmodium falciparum-infected erythrocytes in peripheral blood and tissues of children with fatal malaria
    Carlota Dobano
    Centre de Salut Internacional, Hospital Clinic IDIBAPS, Universitat de Barcelona, E 08036 Barcelona, Spain
    Infect Immun 75:643-52. 2007
    ..These findings do not support the hypothesis that cerebral malaria is caused by cerebral sequestration of certain virulent types...
  36. ncbi Identification of basic transcriptional elements required for rif gene transcription
    Wai Hong Tham
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Int J Parasitol 37:605-15. 2007
    ..We propose that the differential timing of binding provides a mechanism for the temporal repression of rif genes. In addition, we find that transcription profiles of upsA var genes and their neighbouring rif genes are unlinked...
  37. pmc Impact of human immunodeficiency virus infection in pregnant women on variant-specific immunity to malaria
    Edson G Dembo
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Clin Vaccine Immunol 15:617-21. 2008
    ..005) was lower in HIV-infected women than in HIV-uninfected women. HIV infection has a broad impact on variant-specific immunity, which may explain the susceptibility of infected individuals to clinical malaria episodes...
  38. pmc Inhibition of dendritic cell maturation by malaria is dose dependent and does not require Plasmodium falciparum erythrocyte membrane protein 1
    Salenna R Elliott
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 75:3621-32. 2007
    ..However, our observation that low-dose iRBCs initiate functional DC maturation warrants reevaluation and further investigation of DC interactions with blood-stage P. falciparum...
  39. pmc Serum lipoproteins promote efficient presentation of the malaria virulence protein PfEMP1 at the erythrocyte surface
    Sarah Frankland
    Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
    Eukaryot Cell 6:1584-94. 2007
    ....
  40. doi Plasmodium vivax infection during pregnancy: an important problem in need of new solutions
    Feiko O Ter Kuile
    Clin Infect Dis 46:1382-4. 2008
  41. ncbi Antibody recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adults
    Salenna R Elliott
    Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Victoria, Australia
    Am J Trop Med Hyg 76:860-4. 2007
    ..Together these data suggest that a single P. falciparum infection can be sufficient to induce antibodies reactive with several PfEMP1 variants, although the repertoire of target epitopes they recognize may still be restricted...
  42. ncbi CD16+ monocyte subset preferentially harbors HIV-1 and is expanded in pregnant Malawian women with Plasmodium falciparum malaria and HIV-1 infection
    Anthony Jaworowski
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    J Infect Dis 196:38-42. 2007
    ..These data suggest a role for CD16(+) monocytes in the pathogenesis of maternal malaria and HIV-1 infections...
  43. pmc Differential var gene expression in the organs of patients dying of falciparum malaria
    Jacqui Montgomery
    Malawi Liverpool Wellcome Programme of Clinical Tropical Research, College of Medicine, Blantyre, Malawi
    Mol Microbiol 65:959-67. 2007
    ..falciparum variant types and suggest that parasitized erythrocytes can exhibit preferential binding in the body, supporting the hypothesis of cytoadherence-linked pathogenesis...
  44. pmc Maternal-fetal DNA admixture is associated with intrapartum mother-to-child transmission of HIV-1 in Blantyre, Malawi
    Jesse J Kwiek
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    J Infect Dis 197:1378-81. 2008
    ..The mechanism of mother-to-child transmission (MTCT) of HIV-1 is not well described...
  45. pmc Transcribed var genes associated with placental malaria in Malawian women
    Michael F Duffy
    Department of Medicine RMH, University of Melbourne, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Infect Immun 74:4875-83. 2006
    ..The diversity of var2csa sequences may be important for understanding immunity and for the development of vaccines for malaria during pregnancy...
  46. ncbi Protecting pregnant women from malaria in areas of high HIV infection prevalence
    Steven R Meshnick
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    J Infect Dis 194:273-5. 2006
  47. ncbi Genetic analysis of circulating and sequestered populations of Plasmodium falciparum in fatal pediatric malaria
    Jacqui Montgomery
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, Blantyre, Malawi
    J Infect Dis 194:115-22. 2006
    ..Our findings support the notion that CM is associated with the emergence of a small number of dominant genotypes in an infected individual...
  48. ncbi HIV infection among paediatric in-patients in Blantyre, Malawi
    Sheryle R Rogerson
    Department of Paediatrics, College of Medicine, University of Malawi, Malawi
    Trans R Soc Trop Med Hyg 98:544-52. 2004
    ..Almost 30% of HIV-infected children died, compared with 8.9% of uninfected children, and HIV-infected children constituted over 40% of in-patient deaths...
  49. ncbi Impairment of humoral immunity to Plasmodium falciparum malaria in pregnancy by HIV infection
    Adele M Mount
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia
    Lancet 363:1860-7. 2004
    ..Antibodies to variant surface antigens (VSA) on infected erythrocytes might protect against malaria in pregnancy. We postulated that HIV-induced impairment of humoral immunity to VSA mediates the increased susceptibility to malaria...
  50. ncbi The effect of Plasmodium falciparum malaria on peripheral and placental HIV-1 RNA concentrations in pregnant Malawian women
    Victor Mwapasa
    Department of Community Health, College of Medicine, Blantyre, Malawi
    AIDS 18:1051-9. 2004
    ..To investigate the effect of placental Plasmodium falciparum malaria infection on peripheral and/or placental HIV-1 viral load...
  51. pmc Phenotypes of Plasmodium falciparum from the peripheral blood of pregnant women
    James G Beeson
    Infect Immun 72:1841. 2004
  52. pmc Antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes and adhesion inhibitory antibodies are associated with placental malaria and have overlapping and distinct targets
    James G Beeson
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Victoria, Australia
    J Infect Dis 189:540-51. 2004
    ..Comparisons between antibodies suggest that adhesion-inhibitory antibodies and those to PRBC variant antigens have distinct and overlapping epitopes, may be acquired independently, and have different roles in immunity...
  53. pmc Selective accumulation of mature asexual stages of Plasmodium falciparum-infected erythrocytes in the placenta
    James G Beeson
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Victoria 3050, Australia
    Infect Immun 70:5412-5. 2002
    ..These findings demonstrate prominent selective accumulation of mature asexual-stage IEs but infrequent accumulation of ring stages in the placental blood spaces, consistent with an important role for mature-stage IE adhesion...
  54. ncbi Evaluating specific adhesion of Plasmodium falciparum-infected erythrocytes to immobilised hyaluronic acid with comparison to binding of mammalian cells
    James G Beeson
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia
    Int J Parasitol 32:1245-52. 2002
    ..These findings have important implications for understanding and evaluating interactions between P. falciparum and hyaluronic acid that may be involved in disease pathogenesis...
  55. ncbi Asexual blood stages of malaria antigens: cytoadherence
    Dror I Baruch
    Laboratory of Parasitic Diseases, NIAID NIH, Bethesda, MD, USA
    Chem Immunol 80:144-62. 2002
  56. ncbi Plasmodium falciparum: PCR detection and genotyping of isolates from peripheral, placental, and cord blood of pregnant Malawian women and their infants
    Deborah D Kamwendo
    Department of Obstetrics and Gynaecology, College of Medicine, University of Malawi, Blantyre, Malawi
    Trans R Soc Trop Med Hyg 96:145-9. 2002
    ..Transplacental infection before term, and clearance of maternal infection, is postulated...
  57. ncbi Expanding the paradigms of placental malaria
    James G Beeson
    Trends Parasitol 18:145-7. 2002
  58. ncbi Identification of a conserved Plasmodium falciparum var gene implicated in malaria in pregnancy
    J Alexandra Rowe
    Institute of Cell, Animal, and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    J Infect Dis 185:1207-11. 2002
    ..These results indicate the need for reevaluation of previous assumptions of a minimal overlap between var gene repertoires from different parasite isolates...
  59. ncbi Host response to malaria during pregnancy: placental monocyte recruitment is associated with elevated beta chemokine expression
    Elizabeth T Abrams
    Department of Anthropology, University of Michigan, Ann Arbor, MI 48104, USA
    J Immunol 170:2759-64. 2003
    ..In sum, local placental production of chemokines is increased in malaria, and may be an important trigger for monocyte accumulation in the placenta...
  60. ncbi Risk factors and mechanisms of preterm delivery in Malawi
    Elizabeth T Abrams
    Department of Anthropology, University of Michigan, Ann Arbor, MI, USA
    Am J Reprod Immunol 52:174-83. 2004
    ..We examined risk factors and mechanisms of preterm delivery (PTD) in malaria-exposed pregnant women in Blantyre, Malawi...
  61. pmc Evaluation of the OptiMAL rapid antigen test and species-specific PCR to detect placental Plasmodium falciparum infection at delivery
    Limangeni Mankhambo
    College of Medicine, University of Malawi, Blantyre, Malawi
    J Clin Microbiol 40:155-8. 2002
    ..Neither OptiMAL nor PCR testing of peripheral blood is adequately sensitive to detect all placental malaria infection, but a positive result by OptiMAL testing identifies women with a high proportion of low-birth-weight babies...
  62. ncbi Are Plasmodium falciparum parasites present in peripheral blood genetically the same as those sequestered in the tissues?
    Edson G Dembo
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    Am J Trop Med Hyg 74:730-2. 2006
    ..The lack of novel genotypes emerging suggests that among children with severe malaria the dominant clones sequestered in deep organs are usually the same as those in peripheral circulation...
  63. pmc Delivery of the malaria virulence protein PfEMP1 to the erythrocyte surface requires cholesterol-rich domains
    Sarah Frankland
    Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
    Eukaryot Cell 5:849-60. 2006
    ..Although these nonhydrolyzable GTP analogs reduced erythrocyte invasion efficiency and partially retarded growth of the intracellular parasite, they appeared to have little direct effect on PfEMP1 trafficking...
  64. ncbi VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum
    Michael F Duffy
    The Department of Medicine, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Mol Biochem Parasitol 148:117-24. 2006
    ....
  65. pmc Antigenic differences and conservation among placental Plasmodium falciparum-infected erythrocytes and acquisition of variant-specific and cross-reactive antibodies
    James G Beeson
    Walter and Eliza Hall Institute of Medical Research, Parkville, and Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    J Infect Dis 193:721-30. 2006
    ..Conclusions. Immunity may be mediated by a repertoire of antibodies to diverse and common epitopes. Strategies based on vaccination with a single domain or isolate might be hindered by antigenic diversity...
  66. pmc Maternal-fetal microtransfusions and HIV-1 mother-to-child transmission in Malawi
    Jesse J Kwiek
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    PLoS Med 3:e10. 2006
    ..Between 25% and 35% of infants born to HIV-infected mothers become HIV-1 infected. One potential route of mother-to-child transmission (MTCT) could be through a breakdown in the placental barrier (i.e., maternal-fetal microtransfusions)...
  67. ncbi Targets of protective antibodies to malaria during pregnancy
    James G Beeson
    Walter and Eliza Hall Institute of Medical Research and Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Victoria, Australia
    J Infect Dis 192:1647-50. 2005
  68. pmc Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi
    Alisa P Alker
    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC 27599 7435, USA
    Antimicrob Agents Chemother 49:3919-21. 2005
    ..The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unreported mutations in dihydropteroate synthase were also found...
  69. pmc Placental malaria induces variant-specific antibodies of the cytophilic subtypes immunoglobulin G1 (IgG1) and IgG3 that correlate with adhesion inhibitory activity
    Salenna R Elliott
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Victoria, 3050, Australia
    Infect Immun 73:5903-7. 2005
    ..They may function by blocking parasite adhesion to placental CSA, but given their cytophilic nature, they might also opsonize malaria-infected erythrocytes for interaction with Fc receptors on phagocytic cells...
  70. pmc Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected erythrocytes are associated with transcription of var2csa
    Salenna R Elliott
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Victoria 3050 Australia
    Infect Immun 73:2848-56. 2005
    ..These data are consistent with the hypothesis that var2csa encodes a PfEMP1 expressed on the surface of IE, which mediates adhesion to CSA and is relatively conserved between genetically distinct strains of P. falciparum...
  71. ncbi Broad analysis reveals a consistent pattern of var gene transcription in Plasmodium falciparum repeatedly selected for a defined adhesion phenotype
    Michael F Duffy
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Mol Microbiol 56:774-88. 2005
    ..Unspliced or partial transcripts were detected for most var genes tested. These atypical var gene transcripts may have implications for the regulation of var gene transcription...
  72. ncbi The microcirculation in severe malaria
    Stephen J Rogerson
    Department of Medicine RMH, University of Melbourne, Parkville, Australia
    Microcirculation 11:559-76. 2004
    ....
  73. ncbi The burden of co-infection with human immunodeficiency virus type 1 and malaria in pregnant women in sub-saharan Africa
    Feiko O Ter Kuile
    Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    Am J Trop Med Hyg 71:41-54. 2004
    ..There is a clear need to strengthen the deployment of existing malaria and HIV prevention and intervention measures for pregnant women...
  74. ncbi Malaria in pregnancy and the endemicity spectrum: what can we learn?
    Francois Nosten
    Shoklo Malaria Research Unit, 736 2 Intarakiri Road, PO Box 46, Mae Sot, 63110 Thailand
    Trends Parasitol 20:425-32. 2004
    ..In this paper, we attempt to improve our understanding of the disease and its mechanisms from observed differences and similarities between contrasting areas of transmission, and to identify priorities for future research...
  75. ncbi Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria
    James G Kublin
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    J Infect Dis 185:380-8. 2002
    ..If this model is validated in other populations, it will finally be possible to use molecular markers for surveillance of antifolate-resistant P. falciparum malaria in Africa...
  76. pmc A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women
    Linda Kalilani
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 2:e1166. 2007
    ..We investigated the safety and efficacy of azithromycin or artesunate combined with sulfadoxine-pyrimethamine used for treatment of malaria in pregnant women in Blantyre, Malawi...