Sarah A Robertson

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. Prins J, Zhang B, Schjenken J, Guerin L, Barry S, Robertson S. Unstable Foxp3+ regulatory T cells and altered dendritic cells are associated with lipopolysaccharide-induced fetal loss in pregnant interleukin 10-deficient mice. Biol Reprod. 2015;93:95 pubmed publisher
  2. Robertson S, Chin P, Schjenken J, Thompson J. Female tract cytokines and developmental programming in embryos. Adv Exp Med Biol. 2015;843:173-213 pubmed publisher
    ..Defining a clear understanding of the biology of cytokine networks influencing the embryo is essential to support optimal outcomes in natural and assisted conception. ..
  3. Sharkey D, Schjenken J, Mottershead D, Robertson S. Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells. Mol Cell Endocrinol. 2015;417:178-90 pubmed publisher
    ..INHBA and FST induced by seminal fluid in cervical tissues may thus contribute to regulation of the post-coital response in women. ..
  4. Robertson S, Jin M, Yu D, Moldenhauer L, Davies M, Hull M, et al. Corticosteroid therapy in assisted reproduction - immune suppression is a faulty premise. Hum Reprod. 2016;31:2164-73 pubmed publisher
  5. Moran L, Spencer L, Russell D, Hull M, Robertson S, Varcoe T, et al. Research Priorities for Fertility and Conception Research as Identified by Multidisciplinary Health Care Practitioners and Researchers. Nutrients. 2016;8: pubmed publisher
  6. Robertson S, Guerin L, Bromfield J, Branson K, Ahlström A, Care A. Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biol Reprod. 2009;80:1036-45 pubmed publisher
    ..Both seminal plasma and sperm components of the seminal fluid are necessary to confer full tolerance and elicit the Treg cell response, potentially through provision of immune-deviating cytokines and antigens, respectively. ..
  7. Schjenken J, Glynn D, Sharkey D, Robertson S. TLR4 Signaling Is a Major Mediator of the Female Tract Response to Seminal Fluid in Mice. Biol Reprod. 2015;93:68 pubmed publisher
    ..Activation of TLR4 signaling by microbial or endogenous components of seminal fluid is thus implicated as a key element of the female tract response to seminal fluid at the outset of pregnancy in mice. ..
  8. Lane M, Robker R, Robertson S. Parenting from before conception. Science. 2014;345:756-60 pubmed publisher
    ..These insights compel us to revise generally held notions to accommodate the prospect that biological parenting commences well before birth, even prior to conception. ..
  9. Robertson S, Chin P, Femia J, Brown H. Embryotoxic cytokines-Potential roles in embryo loss and fetal programming. J Reprod Immunol. 2017;125:80-88 pubmed publisher
    ..Studies are therefore warranted to investigate whether excessive embryotoxic cytokines contribute to infertility and recurrent implantation failure in women, and compromised reproductive performance in livestock animals. ..

More Information

Publications18

  1. Sharkey D, Tremellen K, Briggs N, Dekker G, Robertson S. Seminal plasma transforming growth factor-?, activin A and follistatin fluctuate within men over time. Hum Reprod. 2016;31:2183-91 pubmed publisher
    ..This study was supported by grants from the National Health and Medical Research Council of Australia, ID453556 and APP1041332. The authors have no competing interests to disclose. ..
  2. Care A, Ingman W, Moldenhauer L, Jasper M, Robertson S. Ovarian steroid hormone-regulated uterine remodeling occurs independently of macrophages in mice. Biol Reprod. 2014;91:60 pubmed publisher
  3. Robertson S, Christiaens I, Dorian C, Zaragoza D, Care A, Banks A, et al. Interleukin-6 is an essential determinant of on-time parturition in the mouse. Endocrinology. 2010;151:3996-4006 pubmed publisher
  4. request reprint
    Robertson S. GM-CSF regulation of embryo development and pregnancy. Cytokine Growth Factor Rev. 2007;18:287-98 pubmed
  5. request reprint
    Robertson S, Care A, Skinner R. Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice. Biol Reprod. 2007;76:738-48 pubmed
  6. Robertson S, Sharkey D. Seminal fluid and fertility in women. Fertil Steril. 2016;106:511-9 pubmed publisher
    ..It will be important to define the mechanisms through which seminal fluid interacts with female reproductive tissues, to provide knowledge that may assist in preconception planning and infertility treatment. ..
  7. request reprint
    Robertson S, Skinner R, Care A. Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice. J Immunol. 2006;177:4888-96 pubmed
    ..Abundance of endogenous IL-10 in gestational tissues is therefore identified as a critical determinant of resistance to preterm labor, and IL-10 may provide a useful therapeutic agent in this common condition. ..
  8. request reprint
    Robertson S, Roberts C, van Beijering E, Pensa K, Sheng Y, Shi T, et al. Effect of beta2-glycoprotein I null mutation on reproductive outcome and antiphospholipid antibody-mediated pregnancy pathology in mice. Mol Hum Reprod. 2004;10:409-16 pubmed
    ..Together these data are consistent with pathogenic mechanisms in antiphospholipid syndrome involving both neutralization of beta(2)GPI function and beta(2)GPI-immunoglobulin complex formation. ..
  9. request reprint
    Robertson S, Sjoblom C, Jasper M, Norman R, Seamark R. Granulocyte-macrophage colony-stimulating factor promotes glucose transport and blastomere viability in murine preimplantation embryos. Biol Reprod. 2001;64:1206-15 pubmed