Sarah A Robertson

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. doi request reprint Seminal fluid and the generation of regulatory T cells for embryo implantation
    Sarah A Robertson
    Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA, Australia
    Am J Reprod Immunol 69:315-30. 2013
  2. doi request reprint Regulatory T cells in the corpus luteum--new players in fertility control?
    Sarah A Robertson
    Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, South Australia, Australia
    Biol Reprod 86:26. 2012
  3. ncbi request reprint Seminal 'priming' for protection from pre-eclampsia-a unifying hypothesis
    Sarah A Robertson
    Department of Obstetrics and Gynaecology, Adelaide University, SA 5005 Adelaide, Australia
    J Reprod Immunol 59:253-65. 2003
  4. ncbi request reprint GM-CSF regulation of embryo development and pregnancy
    Sarah A Robertson
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, SA, Australia
    Cytokine Growth Factor Rev 18:287-98. 2007
  5. ncbi request reprint Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice
    Sarah A Robertson
    Research Centre for Reproductive Health and Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide, South Australia 5005, Australia
    Biol Reprod 76:738-48. 2007
  6. ncbi request reprint Seminal fluid signaling in the female reproductive tract: lessons from rodents and pigs
    S A Robertson
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, SA 5005, Australia
    J Anim Sci 85:E36-44. 2007
  7. ncbi request reprint Immune modulators of implantation and placental development--a workshop report
    S A Robertson
    The University of Adelaide, Australia
    Placenta 24:S16-20. 2003
  8. ncbi request reprint Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice
    Sarah A Robertson
    Research Centre for Reproductive Health and Department of Obstetrics and Gynecology, University of Adelaide, Adelaide, SA 5005, Australia
    J Immunol 177:4888-96. 2006
  9. ncbi request reprint Influence of semen on inflammatory modulators of embryo implantation
    S A Robertson
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, SA 5005, Australia
    Soc Reprod Fertil Suppl 62:231-45. 2006
  10. ncbi request reprint Seminal plasma and male factor signalling in the female reproductive tract
    Sarah A Robertson
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide 5005, Australia
    Cell Tissue Res 322:43-52. 2005

Collaborators

Detail Information

Publications74

  1. doi request reprint Seminal fluid and the generation of regulatory T cells for embryo implantation
    Sarah A Robertson
    Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA, Australia
    Am J Reprod Immunol 69:315-30. 2013
    ..Improved understanding of how seminal fluid influences Treg cells in women should ultimately assist in the development of new therapies for immune-mediated pathologies of pregnancy...
  2. doi request reprint Regulatory T cells in the corpus luteum--new players in fertility control?
    Sarah A Robertson
    Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, South Australia, Australia
    Biol Reprod 86:26. 2012
    ..The discovery of dynamic populations of regulatory T cells in the corpus luteum opens new possibilities for immune regulation of early pregnancy...
  3. ncbi request reprint Seminal 'priming' for protection from pre-eclampsia-a unifying hypothesis
    Sarah A Robertson
    Department of Obstetrics and Gynaecology, Adelaide University, SA 5005 Adelaide, Australia
    J Reprod Immunol 59:253-65. 2003
    ....
  4. ncbi request reprint GM-CSF regulation of embryo development and pregnancy
    Sarah A Robertson
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, SA, Australia
    Cytokine Growth Factor Rev 18:287-98. 2007
    ....
  5. ncbi request reprint Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice
    Sarah A Robertson
    Research Centre for Reproductive Health and Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide, South Australia 5005, Australia
    Biol Reprod 76:738-48. 2007
    ....
  6. ncbi request reprint Seminal fluid signaling in the female reproductive tract: lessons from rodents and pigs
    S A Robertson
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, SA 5005, Australia
    J Anim Sci 85:E36-44. 2007
    ....
  7. ncbi request reprint Immune modulators of implantation and placental development--a workshop report
    S A Robertson
    The University of Adelaide, Australia
    Placenta 24:S16-20. 2003
  8. ncbi request reprint Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice
    Sarah A Robertson
    Research Centre for Reproductive Health and Department of Obstetrics and Gynecology, University of Adelaide, Adelaide, SA 5005, Australia
    J Immunol 177:4888-96. 2006
    ..Abundance of endogenous IL-10 in gestational tissues is therefore identified as a critical determinant of resistance to preterm labor, and IL-10 may provide a useful therapeutic agent in this common condition...
  9. ncbi request reprint Influence of semen on inflammatory modulators of embryo implantation
    S A Robertson
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, SA 5005, Australia
    Soc Reprod Fertil Suppl 62:231-45. 2006
    ..Dissecting the actions of seminal plasma may facilitate development of strategies to ensure maximal fertility and reduce embryo mortality in the pig...
  10. ncbi request reprint Seminal plasma and male factor signalling in the female reproductive tract
    Sarah A Robertson
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide 5005, Australia
    Cell Tissue Res 322:43-52. 2005
    ....
  11. ncbi request reprint Transforming growth factor beta--a mediator of immune deviation in seminal plasma
    Sarah A Robertson
    Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, Adelaide University, South Australia, Australia
    J Reprod Immunol 57:109-28. 2002
    ..A better understanding of the significance and role of TGFbeta in semen will facilitate development of novel therapies for immune-based infertility disorders...
  12. pmc Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice
    Sarah A Robertson
    Research Centre for Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 80:1036-45. 2009
    ..Both seminal plasma and sperm components of the seminal fluid are necessary to confer full tolerance and elicit the Treg cell response, potentially through provision of immune-deviating cytokines and antigens, respectively...
  13. doi request reprint Peri-conceptual cytokines--setting the trajectory for embryo implantation, pregnancy and beyond
    Sarah A Robertson
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA, Australia
    Am J Reprod Immunol 66:2-10. 2011
    ..The peri-conceptual environment influences the early embryo to impart long-term consequences for the fetus and neonate; however, the underlying mechanisms are not well defined...
  14. doi request reprint Interleukin-6 is an essential determinant of on-time parturition in the mouse
    Sarah A Robertson
    Robinson Institute, School of Pediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia
    Endocrinology 151:3996-4006. 2010
    ....
  15. doi request reprint Immune regulation of conception and embryo implantation-all about quality control?
    Sarah A Robertson
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA 5005 Australia
    J Reprod Immunol 85:51-7. 2010
    ....
  16. doi request reprint Activating T regulatory cells for tolerance in early pregnancy - the contribution of seminal fluid
    Sarah A Robertson
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA, Australia
    J Reprod Immunol 83:109-16. 2009
    ..Defining the mechanisms controlling tolerance induction will be helpful for developing new therapies for immune-mediated pathologies of pregnancy such as miscarriage and pre-eclampsia...
  17. ncbi request reprint Granulocyte-macrophage colony-stimulating factor promotes glucose transport and blastomere viability in murine preimplantation embryos
    S A Robertson
    Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide 5005, Australia
    Biol Reprod 64:1206-15. 2001
    ....
  18. ncbi request reprint The role of semen in induction of maternal immune tolerance to pregnancy
    S A Robertson
    Reproductive Medicine Unit and Department of Obstetrics and Gynaecology, Adelaide University, Adelaide, SA 5005, Australia
    Semin Immunol 13:243-54. 2001
    ..This review examines existing evidence for a role for semen in the immunology of pregnancy, highlighting the limitations of our existing knowledge and the prospects for future research and its clinical application...
  19. ncbi request reprint Effect of beta2-glycoprotein I null mutation on reproductive outcome and antiphospholipid antibody-mediated pregnancy pathology in mice
    Sarah A Robertson
    Department of Obstetrics and Gynaecology and Reproductive Medicine Unit, University of Adelaide, Adelaide, SA 5005, Australia
    Mol Hum Reprod 10:409-16. 2004
    ..Together these data are consistent with pathogenic mechanisms in antiphospholipid syndrome involving both neutralization of beta(2)GPI function and beta(2)GPI-immunoglobulin complex formation...
  20. ncbi request reprint Effect of interleukin-10 null mutation on maternal immune response and reproductive outcome in mice
    Christine A White
    Department of Obstetrics and Gynaecology and Reproductive Medicine Unit, University of Adelaide, Adelaide 5005, Australia
    Biol Reprod 70:123-31. 2004
    ....
  21. doi request reprint Stress response genes are suppressed in mouse preimplantation embryos by granulocyte-macrophage colony-stimulating factor (GM-CSF)
    Peck Y Chin
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA 5005, Australia
    Hum Reprod 24:2997-3009. 2009
    ..Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known to promote the development and survival of human and mouse preimplantation embryos; however, the mechanism of action of GM-CSF in embryos is not defined...
  22. pmc Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?
    Leigh R Guerin
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, SA 5005, Australia
    Hum Reprod Update 15:517-35. 2009
    ..T regulatory (Treg) cells are a recently discovered subset of T-lymphocytes with potent suppressive activity and pivotal roles in curtailing destructive immune responses and preventing autoimmune disease...
  23. doi request reprint TGF-β mediates proinflammatory seminal fluid signaling in human cervical epithelial cells
    David J Sharkey
    University of Adelaide, Adelaide, South Australia, Australia
    J Immunol 189:1024-35. 2012
    ..Our findings suggest that TGF-β in the male partner's seminal fluid may influence cervical immune function after coitus in women, and potentially be a determinant of fertility, as well as defense from infection...
  24. pmc Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice
    Amanda N Sferruzzi-Perri
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 81:207-21. 2009
    ..We conclude that CSF2 is a regulator of trophoblast differentiation and placental development, which potentially influences the functional capacity of the placenta to support optimal fetal growth in pregnancy...
  25. doi request reprint Immunization with recombinant murine cytomegalovirus expressing murine zona pellucida 3 causes permanent infertility in BALB/c mice due to follicle depletion and ovulation failure
    Seán O'Leary
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, South Australia, Australia 5005
    Biol Reprod 79:849-60. 2008
    ..These data indicate that vaccination with rMCMV-mZP3 causes permanent infertility in BALB/c mice principally due to induction of ovarian autoimmune pathology leading to progressive oocyte depletion and eventual ovulation failure...
  26. pmc Semen activates the female immune response during early pregnancy in mice
    Martina Johansson
    Department of Obstetrics and Gynaecology and Reproductive Medicine Unit, University of Adelaide, Adelaide, South Australia, Australia
    Immunology 112:290-300. 2004
    ..Moreover, lymphocytes activated at insemination may help mediate maternal tolerance of the conceptus in the implantation site...
  27. pmc Macrophages regulate corpus luteum development during embryo implantation in mice
    Alison S Care
    Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia
    J Clin Invest 123:3472-87. 2013
    ..Our findings raise the prospect that disruption of macrophage-endothelial cell interactions underpinning corpus luteum development contributes to infertility in women in whom luteal insufficiency is implicated. ..
  28. doi request reprint Macrophages regulate expression of α1,2-fucosyltransferase genes in human endometrial epithelial cells
    Hitomi Nakamura
    Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Mol Hum Reprod 18:204-15. 2012
    ..Abnormal phenotypes or altered abundance of uterine macrophages could contribute to the pathophysiology of primary unexplained infertility in women...
  29. ncbi request reprint Seminal plasma regulates corpora lutea macrophage populations during early pregnancy in mice
    Samantha Gangnuss
    Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, The University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
    Biol Reprod 71:1135-41. 2004
    ....
  30. doi request reprint Exogenous transforming growth factor beta1 replacement and fertility in male Tgfb1 null mutant mice
    Leanne J McGrath
    Discipline of Obstetrics and Gynaecology and Research Centre for Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Reprod Fertil Dev 21:561-70. 2009
    ....
  31. doi request reprint Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects
    Wendy V Ingman
    Discipline of Obstetrics and Gynaecology and Research Centre for Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    Biol Reprod 79:711-7. 2008
    ..These results reveal two opposing actions of TGFB1 during pubertal mammary gland morphogenesis: autocrine inhibition of epithelial ductal growth, and endocrine or paracrine stimulation of epithelial ductal growth...
  32. doi request reprint Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus
    David J Sharkey
    The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    J Immunol 188:2445-54. 2012
    ..This response is also relevant to transmission of sexually transmitted pathogens and potentially, susceptibility to cervical metaplasia...
  33. doi request reprint Dual roles for macrophages in ovarian cycle-associated development and remodelling of the mammary gland epithelium
    Angela C L Chua
    The Robinson Institute, Research Centre for Reproductive Health, and School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide 5005, Australia
    Development 137:4229-38. 2010
    ....
  34. ncbi request reprint Null mutation in transforming growth factor beta1 disrupts ovarian function and causes oocyte incompetence and early embryo arrest
    Wendy V Ingman
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, South Australia
    Endocrinology 147:835-45. 2006
    ..This study demonstrates that TGFbeta1 is a critical determinant of normal ovarian function, operating through regulation of LH activity and generation of oocytes competent for embryonic development and successful initiation of pregnancy...
  35. ncbi request reprint Ovarian steroid hormones regulate granulocyte-macrophage colony-stimulating factor synthesis by uterine epithelial cells in the mouse
    S A Robertson
    Department of Obstetrics and Gynaecology, University of Adelaide, South Australia
    Biol Reprod 54:183-96. 1996
    ..These findings implicate GM-CSF as a local mediator of steroid-driven remodeling events in the cycling and preimplantation endometrium, possibly acting through the recruitment and behavioral regulation of granulocytes and macrophages...
  36. doi request reprint Macrophage phenotype in the mammary gland fluctuates over the course of the estrous cycle and is regulated by ovarian steroid hormones
    Leigh J Hodson
    School of Medicine, University of Adelaide at the Basil Hetzel Institute, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
    Biol Reprod 89:65. 2013
    ....
  37. doi request reprint Regulation of epithelial cell turnover and macrophage phenotype by epithelial cell-derived transforming growth factor beta1 in the mammary gland
    Xuan Sun
    School of Paediatrics and Reproductive Health, University of Adelaide, Australia
    Cytokine 61:377-88. 2013
    ..These findings shed new light on the diversity of roles of TGFB1 in the mammary gland which are likely to impact on breast cancer risk...
  38. doi request reprint Seminal fluid regulates accumulation of FOXP3+ regulatory T cells in the preimplantation mouse uterus through expanding the FOXP3+ cell pool and CCL19-mediated recruitment
    Leigh R Guerin
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 85:397-408. 2011
    ....
  39. ncbi request reprint Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue
    Melinda J Jasper
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, The University of Adelaide, Adelaide, Australia
    Mol Hum Reprod 12:301-8. 2006
    ..The factors underpinning this aberration in the immune response remain to be identified...
  40. ncbi request reprint The influence of seminal plasma on ovarian function in pigs--a novel inflammatory mechanism?
    Seán O'Leary
    Reproductive Medicine Unit and Department of Obstetrics and Gynaecology, Adelaide University, SA, Australia
    J Reprod Immunol 57:225-38. 2002
    ..A better understanding of these events may facilitate development of strategies to ensure maximal fertility and reduce embryo mortality in the pig and other polyovular species...
  41. doi request reprint Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy
    Lachlan M Moldenhauer
    Research Centre for Reproductive Health, School of Paediatric and Reproductive Health, University of Adelaide, Adelaide, Australia
    J Immunol 182:8080-93. 2009
    ..Delivery of paternal Ags and immune-deviating cytokines by seminal fluid at conception may activate Ag-dependent CD4(+) and CD8(+) regulatory T cells mediating tolerance of pregnancy...
  42. doi request reprint GM-CSF is an essential regulator of T cell activation competence in uterine dendritic cells during early pregnancy in mice
    Lachlan M Moldenhauer
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia
    J Immunol 185:7085-96. 2010
    ....
  43. doi request reprint Utilising T cell receptor transgenic mice to define mechanisms of maternal T cell tolerance in pregnancy
    Lachlan M Moldenhauer
    Research Centre for Reproductive Health, School of Paediatric and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    J Reprod Immunol 87:1-13. 2010
    ..The benefits, limitations and caveats of these models, and their impact upon data interpretation, are discussed...
  44. doi request reprint Transforming growth factor-β (TGFβ) in porcine seminal plasma
    Seán O'Leary
    School of Paediatrics and Reproductive Health, The Robinson Institute, The University of Adelaide, SA 5005, Australia
    Reprod Fertil Dev 23:748-58. 2011
    ..It is concluded that TGFβ is abundant in boar seminal plasma, leading to the speculation that, in pigs, TGFβ may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by seminal fluid...
  45. ncbi request reprint Effect of granulocyte-macrophage colony-stimulating factor deficiency on ovarian follicular cell function
    R B Gilchrist
    The Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, The University of Adelaide, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia
    J Reprod Fertil 120:283-92. 2000
    ....
  46. ncbi request reprint Characterization of ovarian function in granulocyte-macrophage colony-stimulating factor-deficient mice
    M J Jasper
    Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, The University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
    Biol Reprod 62:704-13. 2000
    ..Aberrant activation of these cells appears to compromise the luteinization process and the steroidogenic capacity of the corpus luteum during early pregnancy in GM-CSF-deficient mice...
  47. doi request reprint Host-derived TGFB1 deficiency suppresses lesion development in a mouse model of endometriosis
    M Louise Hull
    The Robinson Institute, Research Centre for Reproductive Health, and School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia
    Am J Pathol 180:880-7. 2012
    ....
  48. ncbi request reprint Reduced expression of IL-6 and IL-1alpha mRNAs in secretory phase endometrium of women with recurrent miscarriage
    Melinda J Jasper
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, SA 5005, Australia
    J Reprod Immunol 73:74-84. 2007
    ..Quantitative RT-PCR assays for these cytokines in endometrial biopsies may be a realistic strategy for development of novel diagnostics for predisposition to recurrent miscarriage...
  49. ncbi request reprint Uterine eosinophils and reproductive performance in interleukin 5-deficient mice
    S A Robertson
    Department of Obstetrics and Gynaecology and Reproductive Medicine Unit, University of Adelaide, Adelaide, SA 5005, Australia
    J Reprod Fertil 120:423-32. 2000
    ....
  50. doi request reprint Interleukin-6 in pregnancy and gestational disorders
    Jelmer R Prins
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia
    J Reprod Immunol 95:1-14. 2012
    ....
  51. ncbi request reprint Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction
    Wendy V Ingman
    Discipline of Obstetrics and Gynaecology, Research Centre for Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    Endocrinology 148:4032-43. 2007
    ....
  52. doi request reprint Macrophage-derived LIF and IL1B regulate alpha(1,2)fucosyltransferase 2 (Fut2) expression in mouse uterine epithelial cells during early pregnancy
    Melinda J Jasper
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 84:179-88. 2011
    ....
  53. ncbi request reprint Interleukin-5 transgene expression and eosinophilia are associated with retarded mammary gland development in mice
    Amanda N Sferruzzi-Perri
    School of Molecular and Biomedical Science, University of Adelaide, Adelaide 5005, Australia
    Biol Reprod 69:224-33. 2003
    ....
  54. doi request reprint The essential roles of TGFB1 in reproduction
    Wendy V Ingman
    Discipline Obstetrics and Gynaecology and Research Centre for Reproductive Health, University of Adelaide, South Australia 5005, Australia
    Cytokine Growth Factor Rev 20:233-9. 2009
    ..These studies demonstrate the profound significance of TGFB1 in male and female reproductive physiology, and provide a foundation for exploring the significance of this cytokine in human infertility and sexual dysfunction...
  55. ncbi request reprint Diversity in phenotype and steroid hormone dependence in dendritic cells and macrophages in the mouse uterus
    Sarah N Hudson Keenihan
    Department of Obstetrics and Gynaecology and Reproductive Medicine Unit, Adelaide University, Adelaide, South Australia, 5005, Australia
    Biol Reprod 70:1562-72. 2004
    ..Plasticity in the ontogenetic and functional relationships between uterine dendritic cells and macrophages likely is critical in regulating immune responses conducive to reproductive success...
  56. ncbi request reprint Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cells
    David J Sharkey
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide SA 5005, Australia
    Mol Hum Reprod 13:491-501. 2007
    ..Seminal factor regulation of inflammatory cytokines in the cervical epithelium is implicated in controlling the immune response to seminal antigens, and defence against infectious agents introduced at intercourse...
  57. ncbi request reprint Defining the actions of transforming growth factor beta in reproduction
    Wendy V Ingman
    Department of Obstetrics and Gynaecology and Reproductive Medicine Unit, University of Adelaide, Australia
    Bioessays 24:904-14. 2002
    ..This review examines existing evidence for TGFbeta1, TGFbeta2 and TGFbeta3 regulation of male and female reproductive biology, and highlights prospects for future research...
  58. doi request reprint Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring
    John J Bromfield
    The Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Proc Natl Acad Sci U S A 111:2200-5. 2014
    ....
  59. ncbi request reprint Epigenetic risks related to assisted reproductive technologies: short- and long-term consequences for the health of children conceived through assisted reproduction technology: more reason for caution?
    Jeremy G Thompson
    Department of Obstetrics and Gynaecology, University of Adelaide, SA 5005, Australia
    Hum Reprod 17:2783-6. 2002
    ..Here we widen the debate to propose that environment-induced cellular stress also acts to modify fetal and placental gene expression, potentially also contributing to phenotype skewing after ART...
  60. doi request reprint MicroRNA-regulated pathways associated with endometriosis
    E Maria C Ohlsson Teague
    Research Centre for Reproductive Health, University of Adelaide, South Australia 5005, Australia
    Mol Endocrinol 23:265-75. 2009
    ..Accordingly, miRNAs are potential therapeutic targets for treating this disease...
  61. pmc Antigen-specific T-cell responses to a recombinant fowlpox virus are dependent on MyD88 and interleukin-18 and independent of Toll-like receptor 7 (TLR7)- and TLR9-mediated innate immune recognition
    Erin L Lousberg
    Hanson Institute, Adelaide, SA 5000, Australia
    J Virol 85:3385-96. 2011
    ....
  62. ncbi request reprint Leptin and leptin receptor expression in the rat ovary
    Natalie K Ryan
    Reproductive Medicine Unit, Department of Obstetrics and Gynecology, University of Adelaide, Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia
    Endocrinology 144:5006-13. 2003
    ....
  63. ncbi request reprint Seminal plasma regulates ovarian progesterone production, leukocyte recruitment and follicular cell responses in the pig
    S O'Leary
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, Frome Road, Adelaide, SA 5005, Australia
    Reproduction 132:147-58. 2006
    ..The effects of SP on ovarian function potentially contribute to reproductive success in the pig...
  64. ncbi request reprint Fertility impairment in granulocyte-macrophage colony-stimulating factor-deficient mice
    S A Robertson
    Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide, South Australia 5005, Australia
    Biol Reprod 60:251-61. 1999
    ..The detrimental effects are most clearly evident when the conceptus is also GM-CSF deficient, suggesting that GM-CSF of either maternal or fetal origin is required for optimal growth and survival of the fetus in mice...
  65. ncbi request reprint Seminal plasma regulates endometrial cytokine expression, leukocyte recruitment and embryo development in the pig
    S O'Leary
    Department of Obstetrics and Gynaecology and Centre for Reproductive Health, The University of Adelaide, Adelaide, South Australia 5005, Australia
    Reproduction 128:237-47. 2004
    ..Together, these findings implicate factors in seminal plasma in programming the trajectory of uterine cytokine expression and leukocyte trafficking during early pregnancy and in regulating pre-implantation embryo development in the pig...
  66. ncbi request reprint Altered placental development in interleukin-10 null mutant mice
    C T Roberts
    Department of Obstetrics and Gynaecology, University of Adelaide, South Australia 5005, Australia
    Placenta 24:S94-9. 2003
    ..Since previous studies have paradoxically shown that postnatal growth is impaired in IL-10 null mutants, these observations are consistent with a role for IL-10 in regulating placental development and foetal programming...
  67. ncbi request reprint The effect of restricted nutrition on uterine macrophage populations in mice
    S N Hudson
    Department of Obstetrics and Gynaecology, University of Adelaide, SA, Australia
    J Reprod Immunol 45:31-48. 1999
    ....
  68. ncbi request reprint The effect of intercourse on pregnancy rates during assisted human reproduction
    K P Tremellen
    Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, University of Adelaide, South Australia, Australia
    Hum Reprod 15:2653-8. 2000
    ..036, odds ratio 1.48, 95% confidence interval 1.01-2.19). Hence exposure to semen around the time of embryo transfer increases the likelihood of successful early embryo implantation and development...
  69. ncbi request reprint Granulocyte-macrophage colony-stimulating factor (GM-CSF) targets myeloid leukocytes in the uterus during the post-mating inflammatory response in mice
    S A Robertson
    Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia
    J Reprod Immunol 46:131-54. 2000
    ..Together, these data indicate a role for epithelial cell-derived GM-CSF in mediating the recruitment and potentially in modifying the behaviour of uterine leukocytes during the post-mating inflammatory response in mice...
  70. doi request reprint The mechanistic basis for sexual dysfunction in male transforming growth factor beta1 null mutant mice
    W V Ingman
    Research Centre for Reproductive Health and Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA 5005, Australia
    J Androl 31:95-107. 2010
    ..These studies suggest that Tgfb1 null mutation may adversely influence copulatory behavior through effects on both altered structural integrity of the penile skin and impaired tissue compliance leading to erectile dysfunction...
  71. doi request reprint Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment
    Yue Wu
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, SA, Australia
    Brain Behav Immun 25:S155-64. 2011
    ..Collectively these data suggest that alcohol is capable of rapid modification of proinflammatory immune signaling in the brain and this contributes significantly to the pharmacology of alcohol...
  72. ncbi request reprint Granulocyte-macrophage colony-stimulating factor alleviates adverse consequences of embryo culture on fetal growth trajectory and placental morphogenesis
    Cecilia Sjoblom
    Fertilitetscentrum AB and University of Göteborg, Sweden
    Endocrinology 146:2142-53. 2005
    ..This demonstrates that embryonic exposure to GM-CSF is essential for normal placental development and fetal growth...
  73. ncbi request reprint Beta-2 glycoprotein I and its role in antiphospholipid syndrome-lessons from knockout mice
    Spiros Miyakis
    Department of Immunology, Allergy and Infectious Disease, St George Hospital, University of New South Wales, Kogarah, NSW 2217, Australia
    Clin Immunol 112:136-43. 2004
    ..Furthermore, although mice lacking beta2GPI are fertile, the success of early pregnancy is moderately compromised and functional beta2GPI is believed necessary for optimal implantation and placental morphogenesis...
  74. ncbi request reprint Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts independently of the beta common subunit of the GM-CSF receptor to prevent inner cell mass apoptosis in human embryos
    Cecilia Sjoblom
    Fertilitetscentrum AB, 402 29 Göteborg, Sweden
    Biol Reprod 67:1817-23. 2002
    ..Together, these data indicate that GM-CSF regulates cell viability in human embryos and that this potentially occurs through a novel receptor mechanism that is independent of betac...