Jason A Roberts

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. ncbi request reprint Antibiotic resistance--what's dosing got to do with it?
    Jason A Roberts
    Burns Trauma and Critical Care Research Centre, University of Queensland, Herston, Australia
    Crit Care Med 36:2433-40. 2008
  2. ncbi request reprint Doripenem population pharmacokinetics and dosing requirements for critically ill patients receiving continuous venovenous haemodiafiltration
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Australia Royal Brisbane and Women s Hospital, Brisbane, Australia
    J Antimicrob Chemother 69:2508-16. 2014
  3. pmc Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, QLD, Australia Department of Intensive Care Medicine, Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia Electronic address
    Lancet Infect Dis 14:498-509. 2014
  4. ncbi request reprint Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: lessons from the DALI Study
    J A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia Electronic address
    Int J Antimicrob Agents 43:423-30. 2014
  5. pmc ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO
    Kiran Shekar
    Critical Care Research Group, Adult Intensive Care Services, The Prince Charles Hospital and The University of Queensland, Brisbane, Queensland, Australia
    BMC Anesthesiol 12:29. 2012
  6. doi request reprint Optimal doripenem dosing simulations in critically ill nosocomial pneumonia patients with obesity, augmented renal clearance, and decreased bacterial susceptibility
    Jason A Roberts
    Burns, Trauma, and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Crit Care Med 41:489-95. 2013
  7. doi request reprint The clinical relevance of plasma protein binding changes
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Level 3, Ned Hanlon Building, Royal Brisbane and Women s Hospital, Herston, Brisbane, QLD, 4029, Australia
    Clin Pharmacokinet 52:1-8. 2013
  8. pmc DALI: Defining Antibiotic Levels in Intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic
    Jason A Roberts
    Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    BMC Infect Dis 12:152. 2012
  9. pmc Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review
    Fekade Bruck Sime
    School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
    Ann Intensive Care 2:35. 2012
  10. doi request reprint How to optimise antimicrobial prescriptions in the Intensive Care Unit: principles of individualised dosing using pharmacokinetics and pharmacodynamics
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Int J Antimicrob Agents 39:187-92. 2012

Detail Information

Publications80

  1. ncbi request reprint Antibiotic resistance--what's dosing got to do with it?
    Jason A Roberts
    Burns Trauma and Critical Care Research Centre, University of Queensland, Herston, Australia
    Crit Care Med 36:2433-40. 2008
    ..Using this data, we seek to apply pharmacodynamic principles to assist clinical practice for suppressing the emergence of resistance. Concepts such as mutant selection window and mutant prevention concentration will be discussed...
  2. ncbi request reprint Doripenem population pharmacokinetics and dosing requirements for critically ill patients receiving continuous venovenous haemodiafiltration
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Australia Royal Brisbane and Women s Hospital, Brisbane, Australia
    J Antimicrob Chemother 69:2508-16. 2014
    ..The objective of this study was to determine the population pharmacokinetics of doripenem in critically ill patients undergoing continuous venovenous haemodiafiltration (CVVHDF) for acute kidney injury (AKI)...
  3. pmc Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, QLD, Australia Department of Intensive Care Medicine, Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia Electronic address
    Lancet Infect Dis 14:498-509. 2014
    ..Individualisation of dosing could optimise antibiotic exposure and maximise effectiveness. ..
  4. ncbi request reprint Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: lessons from the DALI Study
    J A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia Electronic address
    Int J Antimicrob Agents 43:423-30. 2014
    ..Variability in teicoplanin protein binding is very high, placing significant doubt on the validity of total concentrations for therapeutic drug monitoring in critically ill patients...
  5. pmc ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO
    Kiran Shekar
    Critical Care Research Group, Adult Intensive Care Services, The Prince Charles Hospital and The University of Queensland, Brisbane, Queensland, Australia
    BMC Anesthesiol 12:29. 2012
    ..abstract:..
  6. doi request reprint Optimal doripenem dosing simulations in critically ill nosocomial pneumonia patients with obesity, augmented renal clearance, and decreased bacterial susceptibility
    Jason A Roberts
    Burns, Trauma, and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Crit Care Med 41:489-95. 2013
    ....
  7. doi request reprint The clinical relevance of plasma protein binding changes
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Level 3, Ned Hanlon Building, Royal Brisbane and Women s Hospital, Herston, Brisbane, QLD, 4029, Australia
    Clin Pharmacokinet 52:1-8. 2013
    ..We propose that further pharmacokinetic modelling-based research is required to enable the design of robust dosing regimens for drugs affected by altered protein binding...
  8. pmc DALI: Defining Antibiotic Levels in Intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic
    Jason A Roberts
    Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    BMC Infect Dis 12:152. 2012
    ..A large-scale multi-centre study (DALI Study) is currently underway describing the clinical outcomes of patients achieving pre-defined antibiotic exposures. This report describes the protocol...
  9. pmc Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review
    Fekade Bruck Sime
    School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
    Ann Intensive Care 2:35. 2012
    ..The impact of TDM on important clinical outcomes also remains to be established. Whereas TDM may be theoretically rational, clinical studies to assess utility in the clinical setting are urgently required...
  10. doi request reprint How to optimise antimicrobial prescriptions in the Intensive Care Unit: principles of individualised dosing using pharmacokinetics and pharmacodynamics
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Int J Antimicrob Agents 39:187-92. 2012
    ..Where such data do not exist, therapeutic drug monitoring may be a useful alternative and has been associated with significant clinical benefits, although it is not currently widely available...
  11. ncbi request reprint Using PK/PD to optimize antibiotic dosing for critically ill patients
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Curr Pharm Biotechnol 12:2070-9. 2011
    ....
  12. ncbi request reprint Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Int J Antimicrob Agents 36:332-9. 2010
    ..05) were found to be predictive of mortality. In conclusion, further research is required to determine definitively whether achievement of optimal beta-lactam pharmacodynamic targets improves clinical outcomes...
  13. pmc Using population pharmacokinetics to determine gentamicin dosing during extended daily diafiltration in critically ill patients with acute kidney injury
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia
    Antimicrob Agents Chemother 54:3635-40. 2010
    ..Redosing in many patients should occur after 48 h, and we recommend the use of therapeutic drug monitoring to guide dosing to optimize achievement of the AUC(0-24) targets...
  14. pmc The pharmacokinetics of cefazolin in patients undergoing elective & semi-elective abdominal aortic aneurysm open repair surgery
    Alexandra Douglas
    Burns, Trauma and Critical Care Research Centre, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    BMC Anesthesiol 11:5. 2011
    ..abstract:..
  15. pmc Antibiotic dosing in the 'at risk' critically ill patient: Linking pathophysiology with pharmacokinetics/pharmacodynamics in sepsis and trauma patients
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    BMC Anesthesiol 11:3. 2011
    ..abstract:..
  16. pmc Vancomycin dosing in critically ill patients: robust methods for improved continuous-infusion regimens
    Jason A Roberts
    Burns Trauma and Critical Care Research Centre, The University of Queensland, Level 3, Ned Hanlon Building, Royal Brisbane and Women s Hospital, Butterfield St, Brisbane, Queensland, Australia 4029
    Antimicrob Agents Chemother 55:2704-9. 2011
    ..In conclusion, we have found that higher-than-recommended loading and daily doses of vancomycin seem to be necessary to rapidly achieve therapeutic serum concentrations in these patients...
  17. doi request reprint First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Int J Antimicrob Agents 35:156-63. 2010
    ..These data suggest that administration of piperacillin by continuous infusion, with a loading dose, both for first dose and for subsequent dosing achieves superior pharmacodynamic targets compared with conventional bolus dosing...
  18. pmc Therapeutic drug monitoring of antimicrobials
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia
    Br J Clin Pharmacol 73:27-36. 2012
    ....
  19. doi request reprint Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    J Antimicrob Chemother 64:142-50. 2009
    ....
  20. ncbi request reprint A novel way to investigate the effects of plasma exchange on antibiotic levels: use of microdialysis
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Australia
    Int J Antimicrob Agents 31:240-4. 2008
    ..In critically ill patients, we believe that administration of a beta-lactam antibiotic by continuous infusion should be considered to maintain serum and tissue concentrations of these time-dependent antibiotics...
  21. ncbi request reprint Piperacillin penetration into tissue of critically ill patients with sepsis--bolus versus continuous administration?
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Australia
    Crit Care Med 37:926-33. 2009
    ....
  22. pmc Pharmacokinetics of intraperitoneal gentamicin in peritoneal dialysis patients with peritonitis (GIPD study)
    Julie M Varghese
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Clin J Am Soc Nephrol 7:1249-56. 2012
    ..This study aimed to describe the plasma and infection site pharmacokinetics of intraperitoneal gentamicin in patients with peritonitis...
  23. doi request reprint Pharmacokinetics of meropenem and piperacillin in critically ill patients with indwelling surgical drains
    Syamhanin Adnan
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Int J Antimicrob Agents 42:90-3. 2013
    ..We propose that only when very high drain fluid output is present (>1000 mL/day) would an additional dose of antibiotic be necessary...
  24. ncbi request reprint A protocol for a multicentre randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients with severe sepsis: the BLING II study
    Joel M Dulhunty
    Department of Intensive Care Medicine, Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia
    Crit Care Resusc 15:179-85. 2013
    ..The randomised controlled trials conducted to date comparing the mode of betalactam administration have been inconclusive and limited by non-equivalent dosing, unblinded administration and small sample sizes...
  25. ncbi request reprint The impact of variation in renal replacement therapy settings on piperacillin, meropenem, and vancomycin drug clearance in the critically ill: an analysis of published literature and dosing regimens*
    Janattul Ain Jamal
    1Burns, Trauma and Critical Care Research Centre, School of Medicine, The University of Queensland, Brisbane, QLD, Australia 2Department of Intensive Care Medicine, The Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia 3Department of Pharmacy, The Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia
    Crit Care Med 42:1640-50. 2014
    ....
  26. doi request reprint β-Lactam therapeutic drug monitoring in the critically ill: optimising drug exposure in patients with fluctuating renal function and hypoalbuminaemia
    Yoshiro Hayashi
    The University of Queensland, UQ Centre for Clinical Research, Herston, QLD 4029, Australia
    Int J Antimicrob Agents 41:162-6. 2013
    ..Future studies investigating the clinical outcome benefits of β-lactam TDM in these patient groups are now warranted...
  27. doi request reprint Flucloxacillin dosing in critically ill patients with hypoalbuminaemia: special emphasis on unbound pharmacokinetics
    Marta Ulldemolins
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    J Antimicrob Chemother 65:1771-8. 2010
    ....
  28. doi request reprint Subtherapeutic initial β-lactam concentrations in select critically ill patients: association between augmented renal clearance and low trough drug concentrations
    Andrew A Udy
    Department of Intensive Care Medicine, University of Queensland, Herston, Brisbane, QLD, Australia
    Chest 142:30-9. 2012
    ..Changes in renal function in this setting can significantly impact the probability of achieving such targets...
  29. doi request reprint Can population pharmacokinetic modelling guide vancomycin dosing during continuous renal replacement therapy in critically ill patients?
    Andrew A Udy
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Int J Antimicrob Agents 41:564-8. 2013
    ..These data provide a cautionary tale of the challenges of describing pharmacokinetics in critically ill patients receiving RRT and highlights the need for a detailed, prospective, multicentre study to better inform dosing practice...
  30. doi request reprint Using pharmacokinetics and pharmacodynamics to optimise dosing of antifungal agents in critically ill patients: a systematic review
    Mahipal Sinnollareddy
    Pharmacy Department, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville, Adelaide, SA 5011, Australia
    Int J Antimicrob Agents 39:1-10. 2012
    ..Further research to confirm the appropriateness of current dosing strategies to attain the appropriate pharmacodynamic targets is recommended...
  31. pmc Plasma and tissue pharmacokinetics of cefazolin in patients undergoing elective and semielective abdominal aortic aneurysm open repair surgery
    Alexandra Douglas
    Burns Trauma and Critical Care Research Centre, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Antimicrob Agents Chemother 55:5238-42. 2011
    ..In conclusion, we found that a single 2-g dose of cefazolin administered 30 min before incision provides plasma and ISF concentrations in excess of the likely MICs for susceptible pathogens in patients undergoing AAA open repair surgery...
  32. doi request reprint Pharmacokinetic evaluation of piperacillin-tazobactam
    Yoshiro Hayashi
    University of Queensland Centre for Clinical Research, Brisbane, Australia
    Expert Opin Drug Metab Toxicol 6:1017-31. 2010
    ..However, its pharmacokinetics (PK) can be significantly altered in a variety of states...
  33. doi request reprint Therapeutic drug monitoring of beta-lactam antibiotics in burns patients--a one-year prospective study
    Bhavik M Patel
    Burns, Trauma, and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Ther Drug Monit 34:160-4. 2012
    ..This study was conducted to evaluate the utility of a beta-lactam TDM program in a cohort of burn injury patients in a ward environment...
  34. doi request reprint The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients
    Marta Ulldemolins
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Queensland, Australia
    Clin Pharmacokinet 50:99-110. 2011
    ..Further research that defines dosing regimens that account for such altered pharmacokinetics is recommended...
  35. ncbi request reprint Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study
    Darren M Roberts
    Burns, Trauma, and Critical Care Research Centre, University of Queensland, Brisbane, Queensland, Australia
    Crit Care Med 40:1523-8. 2012
    ....
  36. doi request reprint Augmented renal clearance: implications for antibacterial dosing in the critically ill
    Andrew A Udy
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Queensland, Australia
    Clin Pharmacokinet 49:1-16. 2010
    ....
  37. doi request reprint Augmented renal clearance in the Intensive Care Unit: an illustrative case series
    Andrew A Udy
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Queensland, Australia
    Int J Antimicrob Agents 35:606-8. 2010
    ..TDM, or at least a measured creatinine clearance, should be considered early in this setting to allow the optimisation of antibiotic exposure...
  38. doi request reprint Improving vancomycin prescription in critical illness through a drug use evaluation process: a weight-based dosing intervention study
    Janice Li
    School of Pharmacy, The University of Queensland, Brisbane, Australia
    Int J Antimicrob Agents 39:69-72. 2012
    ..However, subtherapeutic exposures were still prevalent and may warrant more vigilant promotion of the dosing protocol to ensure that recommended vancomycin doses are used in this population...
  39. doi request reprint Continuous infusion of beta-lactam antibiotics in severe sepsis: a multicenter double-blind, randomized controlled trial
    Joel M Dulhunty
    Department of Intensive Care Medicine, Royal Brisbane and Women s Hospital, and Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane
    Clin Infect Dis 56:236-44. 2013
    ..The aim of this trial was to determine the clinical and pharmacokinetic differences between continuous and intermittent dosing in patients with severe sepsis...
  40. ncbi request reprint Improving antibiotic dosing in special situations in the ICU: burns, renal replacement therapy and extracorporeal membrane oxygenation
    Janattul Ain Jamal
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Queensland, Australia
    Curr Opin Crit Care 18:460-71. 2012
    ..This article reviews the recently published antibiotic pharmacokinetic data associated with burns patients, those receiving continuous RRT (CRRT), sustained low-efficiency dialysis (SLED) and ECMO...
  41. pmc Population pharmacokinetics of fluconazole in critically ill patients receiving continuous venovenous hemodiafiltration: using Monte Carlo simulations to predict doses for specified pharmacodynamic targets
    Kashyap Patel
    The School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, Brisbane, Queensland, Australia
    Antimicrob Agents Chemother 55:5868-73. 2011
    ..This is the first study we are aware of that uses Monte Carlo simulations to inform dosing requirements in patients where tubular reabsorption of fluconazole is probably nonexistent...
  42. doi request reprint Characteristics of bloodstream infections in burn patients: An 11-year retrospective study
    Bhavik M Patel
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Burns 38:685-90. 2012
    ..We sought to determine the organisms that caused BSI and factors that could predict the outcome of BSI...
  43. doi request reprint Pharmacokinetics and pharmacodynamics in critically ill patients
    Julie M Varghese
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Curr Opin Anaesthesiol 23:472-8. 2010
    ..The purpose of this review is to highlight the recently published studies in the area of pharmacokinetics and pharmacodynamics in critically ill patients and ascertain the relevance to clinical practice...
  44. doi request reprint Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation
    Kiran Shekar
    Critical Care Research Group, The Prince Charles Hospital and The University of Queensland, Brisbane, Australia
    J Crit Care 27:741.e9-18. 2012
    ....
  45. doi request reprint A method for determining the free (unbound) concentration of ten beta-lactam antibiotics in human plasma using high performance liquid chromatography with ultraviolet detection
    Scott E Briscoe
    Chemical Pathology, Pathology Queensland, Brisbane, Queensland, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 907:178-84. 2012
    ....
  46. doi request reprint Pharmacokinetics of beta-lactam antibiotics in patients with intra-abdominal disease: a structured review
    Syamhanin Adnan
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Surg Infect (Larchmt) 13:9-17. 2012
    ....
  47. ncbi request reprint Ampicillin/sulbactam: its potential use in treating infections in critically ill patients
    Syamhanin Adnan
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Australia Electronic address
    Int J Antimicrob Agents 42:384-9. 2013
    ..Optimisation of therapy may be more likely with the use of higher doses, administration by 4h infusion or by combination therapy, particularly for the treatment of infections caused by MDR pathogens. ..
  48. ncbi request reprint DALI: defining antibiotic levels in intensive care unit patients: are current β-lactam antibiotic doses sufficient for critically ill patients?
    Jason A Roberts
    Burns Trauma and Critical Care Research Centre, University of Queensland
    Clin Infect Dis 58:1072-83. 2014
    ..We aimed to determine whether β-lactam antibiotic dosing in critically ill patients achieves concentrations associated with maximal activity and whether antibiotic concentrations affect patient outcome...
  49. ncbi request reprint Pharmacokinetics of piperacillin and tazobactam in plasma and subcutaneous interstitial fluid in critically ill patients receiving continuous venovenous haemodiafiltration
    Julie M Varghese
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Level 7, Block 6, Royal Brisbane and Women s Hospital, Brisbane, QLD 4029, Australia Electronic address
    Int J Antimicrob Agents 43:343-8. 2014
    ..For the CVVHDF settings used in this study, a dose of 4.5g piperacillin/tazobactam administered evry 8h resulted in piperacillin concentrations in plasma and ISF >32mg/L throughout most of the dosing interval. ..
  50. doi request reprint What is the relevance of fosfomycin pharmacokinetics in the treatment of serious infections in critically ill patients? A systematic review
    Suzanne Parker
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia Electronic address
    Int J Antimicrob Agents 42:289-93. 2013
    ..Altered dosing strategies may be required to optimise dosing given these PK changes, although the current paucity of data on fosfomycin in critically ill patients prevents accurate dosing guidance being recommended at this time. ..
  51. pmc Protein binding of β-lactam antibiotics in critically ill patients: can we successfully predict unbound concentrations?
    Gloria Wong
    Burns Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia
    Antimicrob Agents Chemother 57:6165-70. 2013
    ..However, direct measurement of unbound drug in research and clinical practice is suggested for selected beta-lactams. ..
  52. doi request reprint Pharmacodynamic profiling of intravenous antibiotics against prevalent Gram-negative organisms across the globe: the PASSPORT Program-Asia-Pacific Region
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia
    Int J Antimicrob Agents 37:225-9. 2011
    ..The safety and efficacy of these high dosing regimens will need to be confirmed in the clinical setting...
  53. doi request reprint Antibacterial therapeutic drug monitoring in cerebrospinal fluid: difficulty in achieving adequate drug concentrations
    Dagan O Lonsdale
    Department of Intensive Care Medicine, Royal Brisbane and Women s Hospital, Herston, Queenslan, Australia
    J Neurosurg 118:297-301. 2013
    ..In this respect, the authors would advocate further research using TDM in the management of CNS infection in this setting, in addition to work defining plasma and CSF concentrations associated with antibacterial efficacy and toxicity...
  54. doi request reprint Pharmacokinetic evaluation of fluconazole in critically ill patients
    Mahipal Sinnollareddy
    The Queen Elizabeth Hospital, Pharmacy Department, Adelaide, Australia
    Expert Opin Drug Metab Toxicol 7:1431-40. 2011
    ....
  55. doi request reprint Better outcomes through continuous infusion of time-dependent antibiotics to critically ill patients?
    Jason A Roberts
    Burns Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Queensland, Australia
    Curr Opin Crit Care 14:390-6. 2008
    ..The background, emerging evidence and practical considerations associated with continuous infusions are discussed...
  56. ncbi request reprint Antibacterial dosing in intensive care: pharmacokinetics, degree of disease and pharmacodynamics of sepsis
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia
    Clin Pharmacokinet 45:755-73. 2006
    ..Some patients with serum creatinine values within the normal range can have very high drug clearances, thereby producing low serum drug levels and again leading to underdosing...
  57. pmc Optimising intraperitoneal gentamicin dosing in peritoneal dialysis patients with peritonitis (GIPD) study
    Dwarakanathan Ranganathan
    Renal Medicine, Royal Brisbane and Women s Hospital, Brisbane, Queensland, 4029 Australia
    BMC Nephrol 10:42. 2009
    ..The aim of this study is to examine a model of gentamicin pharmacokinetics and to develop an intraperitoneal drug dosing regime that maximises bacterial killing and minimises toxicity...
  58. doi request reprint Monte Carlo simulations: maximizing antibiotic pharmacokinetic data to optimize clinical practice for critically ill patients
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    J Antimicrob Chemother 66:227-31. 2011
    ..In this issue of JAC, Zelenitsky et al. provide a very useful example of MCS for interpreting the optimal methods for dosing meropenem, piperacillin/tazobactam, cefepime and ceftobiprole in critically ill patients...
  59. ncbi request reprint Optimizing use of beta-lactam antibiotics in the critically ill
    Jason A Roberts
    Burns Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Australia
    Semin Respir Crit Care Med 28:579-85. 2007
    ..Suffice to say clinicians must use antibiotic regimens that optimally treat the individual patient and reduce the development of antibiotic resistance...
  60. ncbi request reprint Continuous infusion of beta-lactam antibiotics in severe infections: a review of its role
    Jason A Roberts
    Burns Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Australia
    Int J Antimicrob Agents 30:11-8. 2007
    ..Available data suggest that seriously ill patients with severe infections requiring significant antibiotic courses (>or=4 days) may be the subgroup that will achieve better outcomes with continuous infusion...
  61. doi request reprint Implications of augmented renal clearance in critically ill patients
    Andrew A Udy
    Burns, Trauma, and Critical Care Research Center, University of Queensland, Royal Brisbane and Women s Hospital, Herston, QLD 4029, Australia
    Nat Rev Nephrol 7:539-43. 2011
    ..With an increasing appreciation of this phenomenon, alternative dosing strategies will need to be investigated...
  62. pmc Continuous beta-lactam infusion in critically ill patients: the clinical evidence
    Mohd H Abdul-Aziz
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Australia
    Ann Intensive Care 2:37. 2012
    ..To further ascertain whether benefits of continuous infusion in critically ill patients do exist, a large-scale, prospective, multinational trial with a robust design is required...
  63. pmc Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy
    Fekade Bruck Sime
    School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia Therapeutics Research Centre, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Adelaide, Australia
    Antimicrob Agents Chemother 58:3533-7. 2014
    ..Antibiotic exposure did not consistently result in therapeutic targets. We conclude that alternative dosing strategies guided by therapeutic drug monitoring may be required to optimize exposure. ..
  64. ncbi request reprint How should we dose antibiotics for pneumonia in the ICU?
    Andrew A Udy
    Burns, Trauma, and Critical Care Research Centre, University of Queensland, Herston, Queensland, Australia
    Curr Opin Infect Dis 26:189-95. 2013
    ..Associated morbidity and mortality remain high, with an increasing incidence of multidrug-resistant organisms. Appropriate antibiotic therapy, both in terms of spectrum of cover and dose, remains the cornerstone of effective management...
  65. ncbi request reprint Cefepime versus ceftazidime: considerations for empirical use in critically ill patients
    Jason A Roberts
    Royal Brisbane and Women s Hospital, Butterfield Street, Herston, Brisbane, QLD 4029, Australia
    Int J Antimicrob Agents 29:117-28. 2007
    ..Such a study to determine whether apparent differences translate into clinically relevant differences in outcome is indicated...
  66. doi request reprint β-lactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: a structured review
    Mahipal G Sinnollareddy
    Pharmacy Department, The Queen Elizabeth Hospital, Adelaide, SA, Australia
    Clin Exp Pharmacol Physiol 39:489-96. 2012
    ..4. The present review describes the strategies for dose optimization of β-lactams in critically ill patients in line with the PK and PD of these drugs...
  67. doi request reprint Analysis of 12 beta-lactam antibiotics in human plasma by HPLC with ultraviolet detection
    Brett C McWhinney
    Chemical Pathology, Pathology Queensland, Brisbane, Queensland, Australia brett
    J Chromatogr B Analyt Technol Biomed Life Sci 878:2039-43. 2010
    ..Validation has demonstrated the method to be linear, accurate and precise. The method has been used in a pathology laboratory for therapeutic drug monitoring (TDM) of beta-lactams in critically ill patients...
  68. doi request reprint A systematic review on clinical benefits of continuous administration of beta-lactam antibiotics
    Jason A Roberts
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Crit Care Med 37:2071-8. 2009
    ..We systematically reviewed the literature to determine whether any clinical benefits exist for administration of beta-lactam antibiotics by extended or continuous infusion...
  69. ncbi request reprint Antimicrobial chemotherapy and lung microdialysis: a review
    Jayesh Dhanani
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Int J Antimicrob Agents 36:491-500. 2010
    ..Data emanating from these studies could inform decisions for appropriate dosing schedules of antimicrobial agents in pneumonia...
  70. ncbi request reprint Pharmacokinetic issues for antibiotics in the critically ill patient
    Jason A Roberts
    University of Queensland, Pharmacy Department, Royal Brisbane and Women s Hospital, Herston, Australia
    Crit Care Med 37:840-51; quiz 859. 2009
    ..To discuss the altered pharmacokinetic properties of selected antibiotics in critically ill patients and to develop basic dose adjustment principles for this patient population...
  71. doi request reprint Antibiotic dosing in multiple organ dysfunction syndrome
    Marta Ulldemolins
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, QLD, Australia
    Chest 139:1210-20. 2011
    ..Thereafter, maintenance dosing must be guided by drug clearance and adjusted to the degree of organ dysfunction...
  72. pmc The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation
    Kiran Shekar
    Critical Care Research Group, Adult Intensive Care Services, The Prince Charles, Hospital and The University of Queensland, Brisbane, QLD, 4032, Australia
    BMC Anesthesiol 13:7. 2013
    ..The aim of this project is to investigate each of circuit, drug and critical illness factors that affect drug PK during ECMO...
  73. ncbi request reprint The compatibility of a low concentration of hydrocortisone sodium succinate with selected drugs during a simulated Y-site administration
    Andrew J Semark
    Department of Intensive Care Medicine, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Crit Care Resusc 15:63-6. 2013
    ....
  74. doi request reprint Antimicrobial pharmacokinetic and pharmacodynamic issues in the critically ill with severe sepsis and septic shock
    Julie M Varghese
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Level 7 Block 6, Royal Brisbane and Women s Hospital, Brisbane Queensland 4029, Australia
    Crit Care Clin 27:19-34. 2011
    ..Knowledge of PK/PD properties of antimicrobials can be used to personalize dosing regimens not only to maximize antimicrobial activity but also to minimize toxicity and reduce the development of antimicrobial resistance...
  75. ncbi request reprint A survey of antibiotic prescribing practices in Australian and New Zealand intensive care units
    Joel M Dulhunty
    Department of Intensive Care Medicine, Royal Brisbane and Women s Hospital, Brisbane, QLD
    Crit Care Resusc 12:162-70. 2010
    ..To evaluate antibiotic prescribing practices in empirical and directed treatment of severe sepsis and septic shock in Australian and New Zealand intensive care units...
  76. doi request reprint Evaluation of medication-related problems in medication reviews: a comparative perspective
    Sukhpreet Kaur
    School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
    Ann Pharmacother 46:972-82. 2012
    ..The elderly population is at a high risk of medication misadventure, with many studies reporting a high number of medication-related problems (MRPs) in this group...
  77. pmc A comparison of estimates of glomerular filtration in critically ill patients with augmented renal clearance
    João Pedro Baptista
    Servico de Medicina Intensiva, Hospitais da Universidade de Coimbra, EPEPraceta Prof Mota Pinto, Av Bissaya Barreto 3000 075 Coimbra, Portugal
    Crit Care 15:R139. 2011
    ..To date, these estimates have not been rigorously validated in those with augmented clearances, resulting in potentially inaccurate drug prescription...
  78. pmc Effect of intravenous GLutamine supplementation IN Trauma patients receiving enteral nutrition study protocol (GLINT Study): a prospective, blinded, randomised, placebo-controlled clinical trial
    Ruqaiya M Al Balushi
    The University of Queensland, School of Medicine, Burns, Trauma and Critical Care Research Centre, Brisbane, Australia
    BMJ Open 1:e000334. 2011
    ..Trial registration number This trial is registered at http://www.clinicaltrials.gov. NCT01240291...
  79. ncbi request reprint Continuous infusion of beta-lactams in the intensive care unit--best way to hit the target?
    Jason A Roberts
    Crit Care Med 36:1663-4. 2008
  80. ncbi request reprint Is continuous infusion ceftriaxone better than once-a-day dosing in intensive care? A randomized controlled pilot study
    Jason A Roberts
    Royal Brisbane and Women s Hospital, Brisbane Australia
    J Antimicrob Chemother 59:285-91. 2007
    ..To compare the clinical and bacteriological outcome of critically ill patients with sepsis treated by ceftriaxone administered as a once-a-day intermittent bolus dose or by 24 h continuous infusion...