C T Roberts

Summary

Affiliation: University of Adelaide
Country: Australia

Publications

  1. Wilson R, Leviton A, Leemaqz S, Anderson P, Grieger J, Grzeskowiak L, et al. Vitamin D levels in an Australian and New Zealand cohort and the association with pregnancy outcome. BMC Pregnancy Childbirth. 2018;18:251 pubmed publisher
    ..A possible association between fetal sex, vitamin D status and GDM provides further questions and encourages continual research and discussion into the role of vitamin D in pregnancy, particularly in vitamin D replete populations. ..
  2. Gatford K, Heinemann G, Thompson S, Zhang J, Buckberry S, Owens J, et al. Circulating IGF1 and IGF2 and SNP genotypes in men and pregnant and non-pregnant women. Endocr Connect. 2014;3:138-49 pubmed publisher
    ..As IGF1 in early pregnancy promotes placental differentiation and function, lower IGF1 concentrations in pregnant women carrying IGF2 rs680 A alleles may affect placental development and/or risk of pregnancy complications. ..
  3. Roberts C. IFPA Award in Placentology Lecture: Complicated interactions between genes and the environment in placentation, pregnancy outcome and long term health. Placenta. 2010;31 Suppl:S47-53 pubmed publisher
    ..Placentologists and clinicians may usefully collaborate to identify factors that predict risk for pregnancy complications and poor health later in life. ..
  4. Standen P, Sferruzzi Perri A, Taylor R, Heinemann G, Zhang J, Highet A, et al. Maternal insulin-like growth factor 1 and 2 differentially affect the renin-angiotensin system during pregnancy in the guinea pig. Growth Horm IGF Res. 2015;25:141-7 pubmed publisher
    ..The sustained effects on placental differentiation and function after IGF2 treatment suggest therapeutic potential for exogenous administration of IGFs in improving pregnancy outcomes. ..
  5. Andraweera P, Gatford K, Dekker G, Leemaqz S, Russell D, Thompson S, et al. Insulin family polymorphisms in pregnancies complicated by small for gestational age infants. Mol Hum Reprod. 2015;21:745-52 pubmed publisher
    ..The INSR rs2059806 SNP previously associated with adult vascular and metabolic diseases is also associated with SGA pregnancies. This polymorphism may associate with the risk of vascular and metabolic disorders across the life course. ..
  6. van der Graaf A, Zeeman G, Groen H, Roberts C, Dekker G. Non-invasive assessment of maternal hemodynamics in early pregnancy. Pregnancy Hypertens. 2013;3:261-9 pubmed publisher
    ..Obtaining a comprehensive hemodynamic profile using these modalities may offer insight in maternal (mal)adaptation to pregnancy. Future work needs to be done relating such measures to pregnancy outcome. ..
  7. Verburg P, Dekker G, Tucker G, Scheil W, Erwich J, Roberts C. Seasonality of hypertensive disorders of pregnancy - A South Australian population study. Pregnancy Hypertens. 2018;12:118-123 pubmed publisher
    ..Nutrient intake, in particular vitamin D, sunlight exposure and physical activity may affect maternal, fetal and placental adaptation to pregnancy and are potential contributors to the seasonal variation of HDP. ..
  8. Zhang S, Regnault T, Barker P, Botting K, McMillen I, McMillan C, et al. Placental adaptations in growth restriction. Nutrients. 2015;7:360-89 pubmed publisher
    ..While no model system completely recapitulates human IUGR, these animal models allow us to carefully dissect cellular and molecular mechanisms to improve our understanding and facilitate development of therapeutic interventions. ..
  9. Leemaqz S, Dekker G, McCowan L, Kenny L, Myers J, Simpson N, et al. Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications. Reprod Toxicol. 2016;62:77-86 pubmed publisher
    ..44 (95% CI 2.44-12.11)]. Our data indicate that increasing use of marijuana among young women of reproductive age is a major public health concern. ..

More Information

Publications16

  1. Wilson R, Grieger J, Bianco Miotto T, Roberts C. Association between Maternal Zinc Status, Dietary Zinc Intake and Pregnancy Complications: A Systematic Review. Nutrients. 2016;8: pubmed
    ..Future studies should focus on those vulnerable to zinc deficiency and include dietary zinc intake as a measure of zinc status. ..
  2. Hodyl N, Roberts C, Bianco Miotto T. Cord Blood DNA Methylation Biomarkers for Predicting Neurodevelopmental Outcomes. Genes (Basel). 2016;7: pubmed
  3. Highet A, Bianco Miotto T, Pringle K, Peura A, Bent S, Zhang J, et al. A novel embryo culture media supplement that improves pregnancy rates in mice. Reproduction. 2017;153:327-340 pubmed publisher
    ..For embryos susceptible to detrimental effects of in vitro culture, IGF2, uPA and plasminogen supplementation of culture media can improve pregnancy success, but the effect of treatment is dependent on the mouse strain. ..
  4. Buckberry S, Bianco Miotto T, Bent S, Clifton V, Shoubridge C, Shankar K, et al. Placental transcriptome co-expression analysis reveals conserved regulatory programs across gestation. BMC Genomics. 2017;18:10 pubmed publisher
    ..This study represents a comprehensive characterisation of placental co-expression and provides insight into potential transcriptional regulators that govern conserved molecular programs fundamental to placental development. ..
  5. request reprint
    Roberts C, White C, Wiemer N, Ramsay A, Robertson S. Altered placental development in interleukin-10 null mutant mice. Placenta. 2003;24 Suppl A:S94-9 pubmed
    ..Since previous studies have paradoxically shown that postnatal growth is impaired in IL-10 null mutants, these observations are consistent with a role for IL-10 in regulating placental development and foetal programming. ..
  6. McAninch D, Roberts C, Bianco Miotto T. Mechanistic Insight into Long Noncoding RNAs and the Placenta. Int J Mol Sci. 2017;18: pubmed publisher
    ..Here, we review the current literature surrounding the involvement of lncRNAs in the development and function of trophoblasts and the human placenta. ..
  7. Wilson R, Leemaqz S, Goh Z, McAninch D, Jankovic Karasoulos T, Leghi G, et al. Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice. Sci Rep. 2017;7:15137 pubmed publisher