Helen Rizos

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition
    Helen Rizos
    Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 278:4981-9. 2003
  2. pmc p16INK4a-induced senescence is disabled by melanoma-associated mutations
    Sebastian Haferkamp
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia
    Aging Cell 7:733-45. 2008
  3. ncbi request reprint p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism
    Helen Rizos
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, Australia
    Cell Cycle 6:1741-7. 2007
  4. ncbi request reprint Physical and functional interaction of the p14ARF tumor suppressor with ribosomes
    Helen Rizos
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 281:38080-8. 2006
  5. ncbi request reprint p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners
    Helen Rizos
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, Australia
    Cell Cycle 4:597-603. 2005
  6. ncbi request reprint A melanoma-associated germline mutation in exon 1beta inactivates p14ARF
    H Rizos
    Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital, Westmead NSW 2145, Australia
    Oncogene 20:5543-7. 2001
  7. ncbi request reprint Mutations in the INK4a/ARF melanoma susceptibility locus functionally impair p14ARF
    H Rizos
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 276:41424-34. 2001
  8. ncbi request reprint Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A
    Heather A McKenzie
    Westmead Institute for Cancer Research and Melanoma Institute of Australia, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead NSW 2145, Australia
    Hum Mutat 31:692-701. 2010
  9. doi request reprint Absence of distinguishing senescence traits in human melanocytic nevi
    Sieu L Tran
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia
    J Invest Dermatol 132:2226-34. 2012
  10. pmc The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a
    Therese M Becker
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute and Westmead Hospital, Australia
    Mol Cancer 8:4. 2009

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition
    Helen Rizos
    Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 278:4981-9. 2003
    ....
  2. pmc p16INK4a-induced senescence is disabled by melanoma-associated mutations
    Sebastian Haferkamp
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia
    Aging Cell 7:733-45. 2008
    ..Our data provide the first evidence that p16(INK4a) can initiate a CDK4/6-dependent autonomous senescence programme that is disabled by inherited melanoma-associated mutations...
  3. ncbi request reprint p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism
    Helen Rizos
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, Australia
    Cell Cycle 6:1741-7. 2007
    ..Importantly, these data establish that the ARF-E2F-1 pathway is an extension of the p53-mdm2-ARF tumor suppressor network and is unlikely to constitute a p53-independent pathway for ARF function...
  4. ncbi request reprint Physical and functional interaction of the p14ARF tumor suppressor with ribosomes
    Helen Rizos
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 281:38080-8. 2006
    ..These results suggest a ribosome-dependent p14(ARF) pathway that regulates cell growth and thus complements p53-dependent p14(ARF) functions...
  5. ncbi request reprint p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners
    Helen Rizos
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, Australia
    Cell Cycle 4:597-603. 2005
    ..Furthermore, p14ARF-induced sumoylation is abrogated by a subset of melanoma-associated p14ARF mutations. These results provide a mechanism for p14ARF action through a common modification of diverse binding partners...
  6. ncbi request reprint A melanoma-associated germline mutation in exon 1beta inactivates p14ARF
    H Rizos
    Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital, Westmead NSW 2145, Australia
    Oncogene 20:5543-7. 2001
    ..This is the first example of an exon 1beta mutation that inactivates p14ARF, and thus implicates a role for this tumour suppressor in melanoma predisposition...
  7. ncbi request reprint Mutations in the INK4a/ARF melanoma susceptibility locus functionally impair p14ARF
    H Rizos
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 276:41424-34. 2001
    ..This work establishes the importance of p14(ARF) in melanoma predisposition...
  8. ncbi request reprint Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A
    Heather A McKenzie
    Westmead Institute for Cancer Research and Melanoma Institute of Australia, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead NSW 2145, Australia
    Hum Mutat 31:692-701. 2010
    ..The ability to determine variant functional activity accurately would identify disease-associated mutations and facilitate effective genetic counselling of individuals at high risk of melanoma...
  9. doi request reprint Absence of distinguishing senescence traits in human melanocytic nevi
    Sieu L Tran
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia
    J Invest Dermatol 132:2226-34. 2012
    ..We conclude that on the basis of current evidence it cannot be reasonably inferred that nevi are permanently growth arrested via senescence...
  10. pmc The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a
    Therese M Becker
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute and Westmead Hospital, Australia
    Mol Cancer 8:4. 2009
    ..To identify such functions we conducted a yeast-two-hybrid screen for novel p16INK4a binding partners...
  11. doi request reprint IGFBP7 is not required for B-RAF-induced melanocyte senescence
    Lyndee L Scurr
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales 2145, Australia
    Cell 141:717-27. 2010
    ..Therefore, we conclude that the secreted protein IGFBP7 is dispensable for B-RAF(V600E)-induced senescence in human melanocytes...
  12. doi request reprint Effects of BRAF inhibitors on human melanoma tissue before treatment, early during treatment, and on progression
    Georgina V Long
    Melanoma Institute Australia, Sydney, NSW, Australia
    Pigment Cell Melanoma Res 26:499-508. 2013
    ..The addition of therapies targeting the cell cycle machinery may improve the response and duration of BRAFi, and investigation of the mechanisms of apoptosis may provide additional therapeutic targets. ..
  13. ncbi request reprint Antiproliferative effects of continued mitogen-activated protein kinase pathway inhibition following acquired resistance to BRAF and/or MEK inhibition in melanoma
    Matteo S Carlino
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
    Mol Cancer Ther 12:1332-42. 2013
    ..These data provide a rationale for the continuation of BRAF and MEK inhibitors after disease progression and support the development of clinical trials to examine this strategy...
  14. ncbi request reprint p16(INK) (4a) deficiency promotes DNA hyper-replication and genetic instability in melanocytes
    Carina Fung
    Westmead Institute for Cancer Research, The University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia
    Pigment Cell Melanoma Res 26:236-46. 2013
    ..Thus, we propose that loss of p16(INK) (4a) facilitates tumourigenesis by promoting the proliferation of genetically unstable cells...
  15. pmc Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion
    Suzanah C Boyd
    University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia
    J Invest Dermatol 133:1269-77. 2013
    ..We propose that this B-RAF/Tbx3/E-cadherin pathway has a critical role in promoting the metastasis of B-RAF-mutant melanomas...
  16. pmc p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors
    Stuart J Gallagher
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead NSW 2145, Australia
    Neoplasia 10:1231-9. 2008
    ..This study shows that high expression of p16(INK4a) or the absence of activated B-RAF correlates with in vivo response of melanoma to cytotoxic drugs...
  17. pmc The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence
    Sebastian Haferkamp
    Westmead Institute for Cancer Research and Melanoma Institute of Australia, University of Sydney at Westmead, Westmead NSW 2145, Australia
    Aging (Albany NY) 1:542-56. 2009
    ..Thus, in melanocytes with oncogenic signalling only p16(INK4a) can fully engage the pRb pathway to alter chromatin structure and silence the genes that are required for proliferation...
  18. ncbi request reprint Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma
    Matteo S Carlino
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales 2145, Australia Department of Medical Oncology, Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
    Mol Oncol 8:544-54. 2014
    ..Our data indicate that a broader targeting strategy concurrently inhibiting ERK, rather than MEK, and PI3K/mTOR may circumvent BRAF inhibitor resistance, and should be considered during the clinical development of ERK inhibitors. ..
  19. doi request reprint Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors
    Sebastian Haferkamp
    Westmead Institute for Cancer Research, Westmead Hospital, University of Sydney at Westmead Millennium Institute, Westmead, New South Wales, Australia
    J Invest Dermatol 129:1983-91. 2009
    ..Our data are consistent with observations showing that senescent nevus cells do not always express p16(INK4a), and highlight the need to thoroughly explore INK4a/ARF-independent molecular pathways of senescence in human melanocytes...
  20. ncbi request reprint BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact
    Helen Rizos
    Authors Affiliations Westmead Institute for Cancer Research, The University of Sydney at Westmead Millennium Institute Departments of Medical Oncology and Surgical Oncology, Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead Melanoma Institute Australia Disciplines of Pathology, Medicine, and Surgery, Sydney Medical School, The University of Sydney, Sydney Departments of Melanoma and Surgical Oncology and Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Clin Cancer Res 20:1965-77. 2014
    ..Multiple BRAF inhibitor resistance mechanisms have been described, however, their relative frequency, clinical correlates, and effect on subsequent therapy have not been assessed in patients with metastatic melanoma...
  21. ncbi request reprint Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria
    Mal Irvine
    Westmead Institute for Cancer Research and Melanoma Institute of Australia, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia
    Cell Cycle 9:829-39. 2010
    ..This allows the interaction of p14(ARF) with mitochondrial proteins, including p32 and enables p53-independent cell death...
  22. pmc P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
    Kelly A Avery-Kiejda
    Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia
    BMC Cancer 11:203. 2011
    ..While mutation of the P53 tumour suppressor gene is a common feature of many types of cancer, mutational inactivation of P53 in melanoma is uncommon; however, its function often appears abnormal...
  23. pmc A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration
    Li Zhou
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW 2145, Sydney, Australia
    BMC Genomics 13:677. 2012
    ..Therefore, identifying HIV fingerprints on the host gene machinery and its regulation by microRNA holds a great promise and potential for improving our understanding of HAD pathogenesis, its diagnosis and therapy...
  24. ncbi request reprint The melanoma-associated 24 base pair duplication in p16INK4a is functionally impaired
    Therese M Becker
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, New South Wales, Australia
    Int J Cancer 117:569-73. 2005
    ..We also show that the cell cycle-regulatory defect of the p16INK4a duplication mutant was associated with decreased inhibition of pRb phosphorylation even though it retained significant binding to CDK4...
  25. doi request reprint Secondary c-Kit mutations confer acquired resistance to RTK inhibitors in c-Kit mutant melanoma cells
    Jason R Todd
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia
    Pigment Cell Melanoma Res 26:518-26. 2013
    ..Our data provide a rationale for treating patients with melanoma progressing on imatinib or nilotinib with alternative RTK inhibitors or inhibitors targeting the MAPK and PI3K signalling cascades. ..
  26. ncbi request reprint Enforced expression of p14ARF induces p53-dependent cell cycle arrest but not apoptosis
    Stuart Gallagher
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, Australia
    Cell Cycle 4:465-72. 2005
    ..Thus, loss of p14ARF would be an important step in the selection of apoptotic resistant tumour cells...
  27. doi request reprint Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition
    Kavitha Gowrishankar
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute and Melanoma Institute Australia, Westmead Hospital, Westmead, New South Wales, Australia
    J Invest Dermatol 132:1850-9. 2012
    ..These data indicate that melanoma tumors are likely to develop heterogeneous mechanisms of resistance, many of which will confer resistance to multiple MAPK inhibitory therapies...
  28. doi request reprint Ankyrin repeat domain 1, ANKRD1, a novel determinant of cisplatin sensitivity expressed in ovarian cancer
    Lyndee L Scurr
    Westmead Institute for Cancer Research, University of Sydney at the Westmead Millennium Institute, Westmead Hospital, Westmead, NSW, Australia
    Clin Cancer Res 14:6924-32. 2008
    ....
  29. ncbi request reprint Impaired inhibition of NF-kappaB activity by melanoma-associated p16INK4a mutations
    T M Becker
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute, Westmead, NSW 2145, Australia
    Biochem Biophys Res Commun 332:873-9. 2005
    ..p16INK4a does not affect NF-kappaB nuclear translocation or DNA binding, suggesting a mechanism that reduces NF-kappaB transactivation activity...
  30. ncbi request reprint Functional impairment of melanoma-associated p16(INK4a) mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding
    T M Becker
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, NSW 2145, Australia
    Clin Cancer Res 7:3282-8. 2001
    ..We examined the relationship between loss of CDK binding by mutant proteins and various measures of cellular growth in melanoma cells...
  31. ncbi request reprint Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization
    H Rizos
    Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital, Westmead NSW 2145, Australia
    Oncogene 19:2978-85. 2000
    ..The INK4a/ARF exon2-mutations could affect the function of both the p16INK4a and p14ARF tumour suppressors. Oncogene (2000)...
  32. ncbi request reprint Multiple abnormalities of the p16INK4a-pRb regulatory pathway in cultured melanoma cells
    H Rizos
    Westmead Institute for Cancer Research, University of Sydney Westmead Hospital, NSW, Australia
    Melanoma Res 9:10-9. 1999
    ..This suggests that the selective growth advantages afforded by CDKN2A inactivation and CDK4 insensitivity are distinct and may involve the mediation of other CDK inhibitors or CDKs...
  33. pmc First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia
    Li Zhou
    Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW 2145, Sydney, Australia
    Mol Neurodegener 5:27. 2010
    ..The pathogenesis of HIV-associated dementia (HAD) is poorly understood. To date, detailed proteomic fingerprinting directly from autopsied brain tissues of HAD and HIV non-dementia patients has not been performed...
  34. ncbi request reprint The ARF tumour suppressor
    Stuart J Gallagher
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, NSW 2145, Australia
    Int J Biochem Cell Biol 38:1637-41. 2006
    ..The biological functions of ARF interactions with other binding partners remain uncertain, but ARF-mediated sumoylation may represent a unifying effector pathway...
  35. ncbi request reprint Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF
    Leisl M Packer
    Oncogenomics Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    Int J Cancer 121:784-90. 2007
    ..We propose that regulation of these genes may contribute to melanoma development when p14ARF function is lost...