M B Renfree

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. pmc Promoter-specific expression and imprint status of marsupial IGF2
    Jessica M Stringer
    ARC Centre of Excellence in Kangaroo Genomics, The University of Melbourne, Victoria, Australia
    PLoS ONE 7:e41690. 2012
  2. pmc The evolution of mammalian genomic imprinting was accompanied by the acquisition of novel CpG islands
    Shunsuke Suzuki
    Australian Research Council Centre of Excellence for Kangaroo Genomics, The University of Melbourne, Victoria, Australia
    Genome Biol Evol 3:1276-83. 2011
  3. pmc Ultrasonography of wallaby prenatal development shows that the climb to the pouch begins in utero
    Barbara Drews
    Department of Reproduction Management, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany
    Sci Rep 3:1458. 2013
  4. ncbi request reprint Inducing sex reversal of the urogenital system of marsupials
    Marilyn B Renfree
    Department of Zoology, The University of Melbourne, Victoria 3010 Australia Electronic address
    Differentiation 87:23-31. 2014
  5. pmc Postnatal epigenetic reprogramming in the germline of a marsupial, the tammar wallaby
    Shunsuke Suzuki
    Department of Zoology, The University of Melbourne, Victoria, 3010, Australia
    Epigenetics Chromatin 6:14. 2013
  6. pmc Evolution of vertebrate interferon inducible transmembrane proteins
    Danielle Hickford
    ARC Centre of Excellence for Kangaroo Genomics, Department of Zoology, The University of Melbourne, Victoria, 3010, Australia
    BMC Genomics 13:155. 2012
  7. pmc The mammary gland-specific marsupial ELP and eutherian CTI share a common ancestral gene
    Elizabeth A Pharo
    Department of Zoology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
    BMC Evol Biol 12:80. 2012
  8. pmc On the origin of POU5F1
    Stephen Frankenberg
    Department of Zoology, University of Melbourne, Melbourne, VIC 3010, Australia
    BMC Biol 11:56. 2013
  9. pmc The origin and evolution of genomic imprinting and viviparity in mammals
    Marilyn B Renfree
    Department of Zoology, The University of Melbourne, Victoria 3010, Australia
    Philos Trans R Soc Lond B Biol Sci 368:20120151. 2013
  10. pmc Evolution of coding and non-coding genes in HOX clusters of a marsupial
    Hongshi Yu
    ARC Centre of Excellence in Kangaroo Genomics, The University of Melbourne, Melbourne, Victoria 3010, Australia
    BMC Genomics 13:251. 2012

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. pmc Promoter-specific expression and imprint status of marsupial IGF2
    Jessica M Stringer
    ARC Centre of Excellence in Kangaroo Genomics, The University of Melbourne, Victoria, Australia
    PLoS ONE 7:e41690. 2012
    ..The conservation of the IGF2 promoters suggests they originated before the divergence of marsupials and eutherians, and have been selectively maintained for at least 160 million years...
  2. pmc The evolution of mammalian genomic imprinting was accompanied by the acquisition of novel CpG islands
    Shunsuke Suzuki
    Australian Research Council Centre of Excellence for Kangaroo Genomics, The University of Melbourne, Victoria, Australia
    Genome Biol Evol 3:1276-83. 2011
    ..We propose that acquisition of novel CGIs was a key genomic change for the evolution of imprinting and that it usually occurred in the maternal gDMR loci...
  3. pmc Ultrasonography of wallaby prenatal development shows that the climb to the pouch begins in utero
    Barbara Drews
    Department of Reproduction Management, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany
    Sci Rep 3:1458. 2013
    ..Interestingly climbing movements by the fetus began in utero about 3 days before birth, mimicking those required to climb to the pouch...
  4. ncbi request reprint Inducing sex reversal of the urogenital system of marsupials
    Marilyn B Renfree
    Department of Zoology, The University of Melbourne, Victoria 3010 Australia Electronic address
    Differentiation 87:23-31. 2014
    ..This review discusses the control and development of the marsupial urogenital system, largely drawn from our studies in the tammar wallaby and our ability to manipulate this system to induce sex reversal. ..
  5. pmc Postnatal epigenetic reprogramming in the germline of a marsupial, the tammar wallaby
    Shunsuke Suzuki
    Department of Zoology, The University of Melbourne, Victoria, 3010, Australia
    Epigenetics Chromatin 6:14. 2013
    ....
  6. pmc Evolution of vertebrate interferon inducible transmembrane proteins
    Danielle Hickford
    ARC Centre of Excellence for Kangaroo Genomics, Department of Zoology, The University of Melbourne, Victoria, 3010, Australia
    BMC Genomics 13:155. 2012
    ..This study characterised IFITMs in two distantly related marsupial species, the Australian tammar wallaby and the South American grey short-tailed opossum, and analysed the phylogeny of the IFITM family in vertebrates...
  7. pmc The mammary gland-specific marsupial ELP and eutherian CTI share a common ancestral gene
    Elizabeth A Pharo
    Department of Zoology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
    BMC Evol Biol 12:80. 2012
    ..Although ELP and CTI both have a single bovine pancreatic trypsin inhibitor (BPTI)-Kunitz domain and are secreted only during the early lactation phases, their evolutionary history is yet to be investigated...
  8. pmc On the origin of POU5F1
    Stephen Frankenberg
    Department of Zoology, University of Melbourne, Melbourne, VIC 3010, Australia
    BMC Biol 11:56. 2013
    ..They have undergone a complex pattern of evolution which is poorly understood and controversial...
  9. pmc The origin and evolution of genomic imprinting and viviparity in mammals
    Marilyn B Renfree
    Department of Zoology, The University of Melbourne, Victoria 3010, Australia
    Philos Trans R Soc Lond B Biol Sci 368:20120151. 2013
    ..Thus, genomic imprinting could evolve from a defence mechanism against transposable elements that depended on DNA methylation established in germ cells...
  10. pmc Evolution of coding and non-coding genes in HOX clusters of a marsupial
    Hongshi Yu
    ARC Centre of Excellence in Kangaroo Genomics, The University of Melbourne, Melbourne, Victoria 3010, Australia
    BMC Genomics 13:251. 2012
    ..The sequencing of the kangaroo genome provides an opportunity to use comparative analyses to compare the HOX clusters of a mammal with a distinct body plan to those of other mammals...
  11. pmc Selected imprinting of INS in the marsupial
    Jessica M Stringer
    ARC Centre of Excellence in Kangaroo Genomics, University of Melbourne, Melbourne, Victoria, 3010, Australia
    Epigenetics Chromatin 5:14. 2012
    ..abstract:..
  12. pmc A novel MSMB-related microprotein in the postovulatory egg coats of marsupials
    Stephen Frankenberg
    ARC Centre of Excellence for Kangaroo Genomics and Department of Zoology, University of Melbourne, Parkville, Victoria, Australia
    BMC Evol Biol 11:373. 2011
    ..Additionally, in marsupials the zona pellucida is surrounded by two acellular layers, the mucoid coat and shell, which are formed from secretions from the reproductive tract...
  13. pmc Desert hedgehog is a mammal-specific gene expressed during testicular and ovarian development in a marsupial
    William A O'Hara
    Department of Molecular and Cellular Biology, The University of Connecticut, Storrs, CT 06269, USA
    BMC Dev Biol 11:72. 2011
    ....
  14. pmc HOXA13 and HOXD13 expression during development of the syndactylous digits in the marsupial Macropus eugenii
    Keng Yih Chew
    ARC Centre of Excellence in Kangaroo Genomics, The University of Melbourne, Melbourne, Victoria, 3010, Australia
    BMC Dev Biol 12:2. 2012
    ..We investigated the expression of two genes, HOXA13 and HOXD13, that are crucial for digit patterning in mice during formation of the limbs of the tammar wallaby...
  15. pmc Analysis of the platypus genome suggests a transposon origin for mammalian imprinting
    Andrew J Pask
    Department of Zoology, The University of Melbourne, Melbourne, Victoria, Australia
    Genome Biol 10:R1. 2009
    ..The recent release of the platypus genome has provided the first opportunity to perform comparisons between prototherian (monotreme; which appear to lack imprinting) and therian (marsupial and eutherian; which have imprinting) mammals...
  16. pmc Placental expression of pituitary hormones is an ancestral feature of therian mammals
    Brandon R Menzies
    Leibniz Institute for Zoo and Wildlife Research, Alfred Kowalke Str 17, 10315, Berlin, Germany
    Evodevo 2:16. 2011
    ..abstract:..
  17. pmc Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby
    Emily S W Wong
    Faculty of Veterinary Sciences, University of Sydney, Sydney, NSW 2006, Australia
    BMC Genomics 12:420. 2011
    ..Here, we used pyrosequencing to compare the transcriptomes of a cervical and thoracic thymus from a single 178 day old tammar wallaby...
  18. pmc Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting
    Shunsuke Suzuki
    ARC Centre of Excellence for Kangaroo Genomics, The University of Melbourne, Parkville, Victoria 3010, Australia
    BMC Evol Biol 11:244. 2011
    ..In mice, Phlda2 is a dose-sensitive negative regulator of placental growth, as Cdkn1c is for embryonic growth...
  19. pmc Evolution of the CDKN1C-KCNQ1 imprinted domain
    Eleanor I Ager
    Department of Zoology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
    BMC Evol Biol 8:163. 2008
    ..The CDKN1C and IGF2 genes are both imprinted and syntenic in the mouse and human, but in marsupials only IGF2 is imprinted. This study examines the evolution of features that, in eutherians, regulate CDKN1C imprinting...
  20. pmc Differential roles of TGIF family genes in mammalian reproduction
    Yanqiu Hu
    ARC Centre of Excellence for Kangaroo Genomics, Department of Zoology, The University of Melbourne, Vic, 3010, Australia
    BMC Dev Biol 11:58. 2011
    ..We therefore studied the TGIF family in the tammar wallaby (a marsupial mammal) to investigate their roles in reproduction and how and when these genes may have evolved their functions and chromosomal locations...
  21. pmc ATRX has a critical and conserved role in mammalian sexual differentiation
    Kim Huyhn
    ARC Centre of Excellence for Kangaroo Genomics, Australia
    BMC Dev Biol 11:39. 2011
    ..The disease is characterised by severe mental retardation, mild alpha-thalassemia, microcephaly, short stature, facial, skeletal, genital and gonadal abnormalities...
  22. pmc Oestrogen blocks the nuclear entry of SOX9 in the developing gonad of a marsupial mammal
    Andrew J Pask
    Department of Molecular and Cellular Biology, University of Connecticut, Storrs, CT 06260, USA
    BMC Biol 8:113. 2010
    ..Here we assess the effect of exogenous oestrogen on the molecular pathways of mammalian gonadal development...
  23. doi request reprint Wolffian duct differentiation by physiological concentrations of androgen delivered systemically
    Marilyn B Renfree
    Department of Zoology, The University of Melbourne, Victoria 3010, Australia
    Dev Biol 334:429-36. 2009
    ..Virilization of the Wolffian ducts occurred during an early but short-lived window of sensitivity. This study provides the first clear evidence that under physiological conditions virilization can be mediated by circulating androgen...
  24. doi request reprint Review: Marsupials: placental mammals with a difference
    M B Renfree
    Department of Zoology, The University of Melbourne, Victoria 3010, Australia
    Placenta 31:S21-6. 2010
    ..Marsupials are certainly placental mammals. However marsupials have an additional trick in their pouches, with the physiologically sophisticated and extended lactation that has allowed them to exchange the umbilical cord for the teat...
  25. doi request reprint Genomic imprinting in marsupial placentation
    Marilyn B Renfree
    Department of Zoology, ARC Centre of Excellence for Kangaroo Genomics, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Reproduction 136:523-31. 2008
    ..There is currently no evidence for genomic imprinting in the egg-laying monotreme mammals. However, since these mammals do have a short-lived placenta, imprinting appears to be correlated with viviparity but not placentation...
  26. ncbi request reprint The genome of a Gondwanan mammal
    Marilyn B Renfree
    ARC Centre of Excellence for Kangaroo Genomics, Department of Zoology, The University of Melbourne, Victoria 3010, Australia
    Bioessays 29:1073-6. 2007
    ..The opossum genome has turned up several surprises and provided critical new information on the evolution of mammalian genomes...
  27. ncbi request reprint Society for Reproductive Biology Founders' Lecture 2006 - life in the pouch: womb with a view
    Marilyn B Renfree
    Department of Zoology, The University of Melbourne, Vic, Australia
    Reprod Fertil Dev 18:721-34. 2006
    ....
  28. doi request reprint Reproductive and developmental manipulation of the marsupial, the tammar wallaby Macropus eugenii
    Marilyn B Renfree
    Department of Zoology, The University of Melbourne, Melbourne, VIC 3010, Australia
    Methods Mol Biol 770:457-73. 2011
    ..Standard molecular techniques can be used for most manipulations in marsupials. However, there are several special techniques for treating the young for experimental surgery and for organ culture that we detail below...
  29. pmc Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development
    Marilyn B Renfree
    The Australian Research Council Centre of Excellence in Kangaroo Genomics, Australia
    Genome Biol 12:R81. 2011
    ..Like other marsupials, it gives birth to highly altricial young, and has a small number of very large chromosomes, making it a valuable model for genomics, reproduction and development...
  30. doi request reprint Evolution of genomic imprinting: insights from marsupials and monotremes
    Marilyn B Renfree
    ARC Center of Excellence for Kangaroo Genomics, Melbourne, Victoria 3010, Australia
    Annu Rev Genomics Hum Genet 10:241-62. 2009
    ..Here we review the recent analyses of imprinted gene clusters in marsupials and monotremes, which have served to shed light on the origin and evolution of imprinting mechanisms in mammals...
  31. doi request reprint Eggs, embryos and the evolution of imprinting: insights from the platypus genome
    Marilyn B Renfree
    ARC Centre of Excellence for Kangaroo Genomics, Australia
    Reprod Fertil Dev 21:935-42. 2009
    ..Comparative platypus genome analyses of orthologous imprinted regions have provided strong support for the host defence hypothesis to explain the origin of imprinting...
  32. ncbi request reprint Estrogen-induced gonadal sex reversal in the tammar wallaby
    D Coveney
    Department of Zoology, The University of Melbourne, Victoria 3010, Australia
    Biol Reprod 65:613-21. 2001
    ..These results confirm that estrogen can inhibit early testicular development, and that testis determination occurs during a narrow window of time...
  33. ncbi request reprint Sex down under: the differentiation of sexual dimorphisms during marsupial development
    M B Renfree
    Department of Zoology, The University of Melbourne, Victoria, Australia
    Reprod Fertil Dev 13:679-90. 2001
    ..At birth, the marsupial neonate has a well-developed digestive, respiratory and circulatory system, but retains its fetal excretory system with a fully functional mesonephric kidney and undifferentiated gonads and genitalia...
  34. doi request reprint Marsupial WT1 has a novel isoform and is expressed in both somatic and germ cells in the developing ovary and testis
    A J Pask
    Department of Zoology, The University of Melbourne, Melbourne, Vic, Australia
    Sex Dev 1:169-80. 2007
    ..Our data suggest that WT1 has a conserved function in both the somatic and germ cell lineages of the gonads of marsupials...
  35. ncbi request reprint Contraceptive effects of levonorgestrel implants in a marsupial
    C D Nave
    Department of Zoology, The University of Melbourne, Victoria, Australia
    Reprod Fertil Dev 12:81-6. 2000
    ..This contraceptive system appears to offer a method of population control for the management of overabundant captive and selected wild populations of macropodid marsupials...
  36. ncbi request reprint Marsupial anti-Mullerian hormone gene structure, regulatory elements, and expression
    Andrew J Pask
    Department of Zoology, University of Melbourne, Victoria 3010, Australia
    Biol Reprod 70:160-7. 2004
    ..It is not detectable in atretic follicles. Collectively, these studies suggest that AMH expression has been conserved during mammalian evolution and is intimately linked to upstream sex determination mechanisms...
  37. ncbi request reprint Reactivating tammar wallaby blastocysts oxidize glucose
    R E Spindler
    Department of Zoology, University of Melbourne, Parkville, Victoria, Australia
    Biol Reprod 58:1425-31. 1998
    ..The increased oxidation results in greater ATP production, which plausibly fuels the increased energy requirements of wallaby blastocysts during the early stages of reactivation...
  38. ncbi request reprint Differential regulation of contractility and nitric oxide sensitivity in gravid and nongravid myometrium during late pregnancy in a marsupial
    J N Ingram
    Department of Zoology, University of Melbourne, Victoria, 3010, Australia
    Endocrinology 142:2244-51. 2001
    ....
  39. ncbi request reprint Changes in semen quality and morphology of the reproductive tract of the male tammar wallaby parallel seasonal breeding activity in the female
    D B B P Paris
    Department of Zoology, University of Melbourne, Victoria 3010, Australia
    Reproduction 130:367-78. 2005
    ..Semen quality may also improve in response to an increase in the number of available oestrous females...
  40. doi request reprint Formation of 5alpha-reduced androgens in the testes and urogenital tract of the grey short-tailed opossum, Monodelphis domestica
    Jean D Wilson
    Department of Zoology, University of Melbourne, VIC 3010, Australia
    Reprod Fertil Dev 21:649-54. 2009
    ....
  41. pmc The developing renal, reproductive, and respiratory systems of the African elephant suggest an aquatic ancestry
    A P Gaeth
    Department of Zoology, University of Melbourne, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 96:5555-8. 1999
    ..The evidence from our embryological study of the elephant also suggests that it evolved from an aquatic mammal...
  42. ncbi request reprint Mouse embryos used as a bioassay to determine control of marsupial embryonic diapause
    R E Spindler
    Department of Zoology, University of Melbourne, Parkville, Australia
    J Exp Zool 283:590-9. 1999
    ..It is possible that the quiescent tammar endometrial environment has an inhibitory factor necessary to maintain diapause in the tammar blastocyst...
  43. ncbi request reprint Influence of progesterone and oestradiol-17 beta on blastocysts of the tammar wallaby (Macropus eugenii) during seasonal diapause
    T P Fletcher
    Department of Anatomy, Monash University, Melbourne, Victoria, Australia
    J Reprod Fertil 83:193-200. 1988
    ..We conclude that oestrogen alone is not capable of stimulating normal growth of blastocysts, and its role during early pregnancy in tammars remains unclear...
  44. ncbi request reprint Virilization of the urogenital sinus of the tammar wallaby is not unique to 5alpha-androstane-3alpha,17beta-diol
    M W Leihy
    Department of Zoology, University of Melbourne, Victoria 3010, Parkville, Australia
    Mol Cell Endocrinol 181:111-5. 2001
    ....
  45. ncbi request reprint Sex determining genes and sexual differentiation in a marsupial
    A Pask
    Department of Zoology, The University of Melbourne, Victoria, 3010, Australia
    J Exp Zool 290:586-96. 2001
    ....
  46. ncbi request reprint The influence of estrogen on the developing male marsupial
    M B Renfree
    Department of Zoology, The University of Melbourne, Victoria, Australia
    Reprod Fertil Dev 13:231-40. 2001
    ..The ability of estradiol to cause testis-to-ovary sex reversal in marsupials provides a new way of studying the interactions between genes and hormones in testicular differentiation...
  47. ncbi request reprint Germ cells, gonads and sex reversal in marsupials
    M B Renfree
    Department of Zoology, The University of Melbourne, Victoria, Australia
    Int J Dev Biol 45:557-67. 2001
    ....
  48. ncbi request reprint Penile development is initiated in the tammar wallaby pouch young during the period when 5alpha-androstane-3alpha,17beta-diol is secreted by the testes
    Michael W Leihy
    Department of Zoology, University of Melbourne, Gate 12, Royal Parade, Victoria 3010, Australia
    Endocrinology 145:3346-52. 2004
    ....
  49. doi request reprint Physical map of two tammar wallaby chromosomes: a strategy for mapping in non-model mammals
    Janine E Deakin
    ARC Centre of Excellence for Kangaroo Genomics, Research School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia
    Chromosome Res 16:1159-75. 2008
    ..Frequent rearrangement of the X, along with the absence of a marsupial XIST gene, suggests that inactivation of the marsupial X chromosome does not depend on a whole-chromosome repression by a control locus...
  50. ncbi request reprint Reactivating tammar wallaby blastocysts oxidize fatty acids and amino acids
    R E Spindler
    Dept of Zoology, University of Melbourne, Parkville, Australia
    J Reprod Fertil 115:79-86. 1999
    ..4 +/- 0.3 pmol per embryo h-1). It is likely that metabolism of amino acids and fatty acids contributes to the energy supply during reactivation of tammar wallaby blastocysts after embryonic diapause...
  51. ncbi request reprint Placental function in two distantly related marsupials
    C Freyer
    Department of Zoology, The University of Melbourne, Victoria 3010, Australia
    Placenta 28:249-57. 2007
    ....
  52. ncbi request reprint Developmental expression of the androgen receptor during virilization of the urogenital system of a marsupial
    C M Butler
    Department of Zoology, University of Melbourne, Parkville, Victoria 3052, Australia
    Biol Reprod 59:725-32. 1998
    ..p. We conclude that the presence of AR is not the initiating signal for virilization of the UGS in this marsupial male...
  53. ncbi request reprint Effect of an anti-androgen on testicular descent and inguinal closure in a marsupial, the tammar wallaby (Macropus eugenii)
    D Coveney
    Department of Zoology, University of Melbourne, Victoria 3010, Australia
    Reproduction 124:865-74. 2002
    ....
  54. ncbi request reprint Monotreme and marsupial reproduction
    M B Renfree
    Department of Zoology, University of Melbourne, Parkville, Vic, Australia
    Reprod Fertil Dev 7:1003-20. 1995
    ..There is no doubt that future research will strengthen this contribution, but we are faced with serious conservation questions that must be solved if we are to maintain these wonderful animals as a resource for future generations...
  55. doi request reprint Fibroblast growth factor-9 in marsupial testicular development
    J W Chung
    Australian Research Council Centre of Excellence in Kangaroo Genomics, University of Melbourne, Vic, Australia
    Sex Dev 5:131-40. 2011
    ..These observations suggest that FGF9 promotes male fate in the early gonad of marsupials through an antagonistic relationship with WNT4 as it does in eutherian mammals...
  56. pmc The functional development of Leydig cells in a marsupial
    Christopher M Butler
    Department of Zoology, University of Melbourne, Victoria, Australia
    J Anat 212:55-66. 2008
    ....
  57. ncbi request reprint Fetal control of parturition in marsupials
    G Shaw
    Department of Zoology, The University of Melbourne, Victoria, Australia
    Reprod Fertil Dev 13:653-9. 2001
    ..There is thus a strong case that fetal adrenal cortisol plays a key role in the preparation for birth and the timing of it. Further studies are in progress to more clearly define the mechanisms behind these actions of cortisol...
  58. doi request reprint Development of the penile urethra in the tammar wallaby
    M W Leihy
    Department of Zoology, University of Melbourne, Melbourne, Vic, Australia
    Sex Dev 5:241-9. 2011
    ..This study suggests that there is an early window of time before day 60 when androgen imprinting must occur for normal penile development and closure of the urethral groove...
  59. ncbi request reprint Effects of oestrogen treatment on testicular descent, inguinal closure and prostatic development in a male marsupial, Macropus eugenii
    D Coveney
    Department of Zoology, The University of Melbourne, Victoria 3010, Australia
    Reproduction 124:73-83. 2002
    ..Therefore, the tammar wallaby may provide a useful experimental model animal in which to investigate the hormonal control of testicular migration and closure of the inguinal canal...
  60. pmc The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determination
    A Pask
    Department of Genetics and Evolution, La Trobe University, Melbourne 3083, Australia
    Proc Natl Acad Sci U S A 97:13198-202. 2000
    ..There is no evidence for a Y-borne ATRX homologue in mouse or human, implying that this gene has been lost in eutherians and its role supplanted by the evolution of SRY from SOX3 as the dominant determiner of male differentiation...
  61. ncbi request reprint SOX9 has both conserved and novel roles in marsupial sexual differentiation
    Andrew J Pask
    Department of Zoology, The University of Melbourne, Melbourne, Australia
    Genesis 33:131-9. 2002
    ..These previously undescribed locations of SOX9 expression suggest that SOX9 may play additional roles in the differentiation of the marsupial reproductive system...
  62. ncbi request reprint The marsupial placenta: a phylogenetic analysis
    Claudia Freyer
    Department of Zoology, The University of Melbourne, Victoria 3010, Australia
    J Exp Zool A Comp Exp Biol 299:59-77. 2003
    ....
  63. doi request reprint The mammalian yolk sac placenta
    Claudia Freyer
    Department of Zoology, The University of Melbourne, Melbourne, Victoria, Australia
    J Exp Zool B Mol Dev Evol 312:545-54. 2009
    ..Thus, the yolk sac of humans, like that of all viviparous mammals, is a true placenta crucial for early embryonic development and survival...
  64. ncbi request reprint Role of the alternate pathway of dihydrotestosterone formation in virilization of the Wolffian ducts of the tammar wallaby, Macropus eugenii
    Geoffrey Shaw
    Department of Zoology, The University of Melbourne, Victoria, Australia
    Endocrinology 147:2368-73. 2006
    ..We conclude that dihydrotestosterone, largely formed in the tissue by the oxidation of androstanediol derived from the testes and also the 5alpha-reduction of testosterone, is responsible for Wolffian duct virilization in this species...
  65. ncbi request reprint 3' RACE walking along a large cDNA employing tiered suppression PCR
    Daniel J Park
    Gate 12, Royal Parade, Dept Zoology, Melbourne University, VIC 3010, Australia
    Biotechniques 34:750-2, 754-6. 2003
    ..This robust approach represents a new tool for isolating unknown sequence under challenging cloning scenarios such as poor library representation, long coding regions, long 3' untranslated regions, and difficult template regions...
  66. doi request reprint Cross-fostering of the tammar wallaby (Macropus eugenii) pouch young accelerates fore-stomach maturation
    Joly H L Kwek
    Department of Zoology, The University of Melbourne, Vic, Australia
    Mech Dev 126:449-63. 2009
    ..We propose that milk from later stages of lactation and/or herbage consumed by the PY may play independent roles in regulating these two processes...
  67. pmc Comparative analysis of the mammalian WNT4 promoter
    Hongshi Yu
    ARC Centre of Excellence in Kangaroo Genomics, Department of Zoology, The University of Melbourne, Victoria 3010, Australia
    BMC Genomics 10:416. 2009
    ..This study uses comparative cross species sequence and functional analyses between humans and a marsupial (the tammar wallaby,Macropus eugenii) to refine the mammalian Wnt4 promoter...
  68. doi request reprint The evolution of class V POU domain transcription factors in vertebrates and their characterisation in a marsupial
    Stephen Frankenberg
    Department of Zoology, University of Melbourne, 3010 Victoria, Australia
    Dev Biol 337:162-70. 2010
    ..Thus, unlike POU5F1, the role of POU2 may not be restricted to pluripotent cell types but could have a related function such as maintaining multipotency in adult stem cells...
  69. ncbi request reprint Developmental profile of thyroid hormone distributor proteins in a marsupial, the tammar wallaby Macropus eugenii
    Samantha J Richardson
    Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia
    Gen Comp Endocrinol 125:92-103. 2002
    ....
  70. doi request reprint Ontogeny of the oestrogen receptors ESR1 and ESR2 during gonadal development in the tammar wallaby, Macropus eugenii
    Natalie E Calatayud
    Department of Zoology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Reproduction 139:599-611. 2010
    ..The receptors can respond to exogenous estrogen at this early stage and are capable of transducing signals in the early mammalian gonad. However, the selective forces that maintained conserved ER expression in this tissue remain unknown...
  71. ncbi request reprint The hormonal control of sexual development
    Marilyn B Renfree
    Department of Zoology, The University of Melbourne, Victoria, Australia
    Novartis Found Symp 244:136-52; discussion 152-6, 203-6, 253-7. 2002
    ..Collectively these studies have led to the development of new paradigms to explain the hormonal mechanisms mediating sexual differentiation...
  72. doi request reprint The effect of pregnant and oestrous females on male testosterone and behaviour in the tammar wallaby
    Nanette Y Schneider
    Department of Zoology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Horm Behav 58:378-84. 2010
    ..This confirms that the male's reproductive state is dependent on a signal from females and is not blocked through seasonal effects...
  73. pmc The development of the gubernaculum and inguinal closure in the marsupial Macropus eugenii
    Douglas Coveney
    Department of Zoology, The University of Melbourne, Victoria, Australia
    J Anat 201:239-56. 2002
    ..Tammars have a hopping mode of locomotion and, like humans, are essentially bipedal. We suggest that inguinal closure evolved in these two species because their upright posture may otherwise lead to a high incidence of inguinal hernias...
  74. ncbi request reprint Administration of 5alpha-androstane-3alpha,17beta-diol to female tammar wallaby pouch young causes development of a mature prostate and male urethra
    Michael W Leihy
    Department of Zoology, University of Melbourne, Victoria 3010, Australia
    Endocrinology 143:2643-51. 2002
    ..This further strengthens the hypothesis that 5alpha-adiol is the circulating androgen responsible in this species for virilization during development...
  75. pmc Ultrastructure of the placenta of the tammar wallaby, Macropus eugenii: comparison with the grey short-tailed opossum, Monodelphis domestica
    Claudia Freyer
    Department of Zoology, The University of Melbourne, Victoria, Australia
    J Anat 201:101-19. 2002
    ..The extended secretory phase of the tammar uterus and the maternal recognition of early pregnancy appear to be derived characters of macropodid marsupials...
  76. doi request reprint Exon 3 of the growth hormone receptor (GH-R) is specific to eutherian mammals
    Brandon R Menzies
    Department of Zoology, The University of Melbourne, Victoria, Australia
    Mol Cell Endocrinol 296:64-8. 2008
    ..These data show that exon 3 was inserted into the GH-R after the divergence of the marsupial and eutherian lineages at least 130 million years ago...
  77. ncbi request reprint Ontogeny and pathway of formation of 5alpha-androstane-3alpha,17beta-diol in the testes of the immature brushtail possum Trichosurus vulpecula
    Jean D Wilson
    Department of Zoology, University of Melbourne, Victoria, Australia
    Reprod Fertil Dev 17:603-9. 2005
    ....
  78. ncbi request reprint Effects of levonorgestrel on ovulation and oestrous behaviour in the female tammar wallaby
    Emily F Hynes
    Department of Zoology, The University of Melbourne, VIC 3010, Australia
    Reprod Fertil Dev 19:335-40. 2007
    ..These results suggest that levonorgestrel inhibits the preovulatory surge of luteinising hormone...
  79. pmc Reproduction in male swamp wallabies (Wallabia bicolor): puberty and the effects of season
    Justyna Zofia Paplinska
    Department of Zoology, The University of Melbourne, Australia
    J Anat 211:518-33. 2007
    ..Females in the area conceived year-round, suggesting that seasonal changes in the male reproductive tract did not prevent at least some males from breeding throughout the year...
  80. ncbi request reprint Reproduction in female swamp wallabies, Wallabia bicolor
    Justyna Zofia Paplinska
    Department of Zoology, The University of Melbourne, Vic, Australia
    Reprod Fertil Dev 18:735-43. 2006
    ..Females did not have a period of seasonal anoestrus and conceived throughout the year. Female swamp wallabies in South Gippsland bred continuously throughout the period of this study...
  81. ncbi request reprint Perturbed growth and development in marsupial young after reciprocal cross-fostering between species
    Brandon R Menzies
    Department of Zoology, University of Melbourne, VIC 3010, Australia
    Reprod Fertil Dev 19:976-83. 2007
    ....
  82. ncbi request reprint Universal fast walking applied to cDNA
    Daniel J Park
    Department of Zoology, Melbourne University, Victoria, Australia
    Prep Biochem Biotechnol 34:123-33. 2004
    ....
  83. pmc Differential expression of WNT4 in testicular and ovarian development in a marsupial
    Hongshi Yu
    Department of Zoology, The University of Melbourne, Victoria 3010, Australia
    BMC Dev Biol 6:44. 2006
    ....
  84. ncbi request reprint Intra-cytoplasmic sperm injection in a marsupial
    Nadine M Richings
    Department of Zoology, The University of Melbourne, Victoria, 3010, Australia
    Reproduction 128:595-605. 2004
    ..However, blastomeres were more closely apposed in embryos from tubal oocytes and cell-cell adhesion was more pronounced, indicating that the mucoid coat may be involved in maintaining the integrity of the conceptus during cleavage...
  85. pmc Expression and protein localisation of IGF2 in the marsupial placenta
    Eleanor I Ager
    Department of Zoology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
    BMC Dev Biol 8:17. 2008
    ..This study examines the role of IGF2 in the yolk sac placenta of the tammar wallaby, Macropus eugenii...
  86. ncbi request reprint Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish
    Samantha J Richardson
    Dept of Biochemistry and Molecular Biology, Univ of Melbourne, Parkville 3010, Victoria, Australia
    Am J Physiol Regul Integr Comp Physiol 288:R1264-72. 2005
    ..We propose an hypothesis that an augmented thyroid hormone distributor protein network contributes to the rise in total thyroid hormone levels in the blood during development...
  87. ncbi request reprint Characterisation of the marsupial-specific ATRY gene: implications for the evolution of male-specific function
    Daniel J Park
    Department of Zoology, The University of Melbourne, Melbourne VIC 3010, Australia
    Gene 362:29-36. 2005
    ..The conservation and loss of particular motifs identify those required for testicular function (ATRY) and function in other tissues (ATRX)...
  88. doi request reprint Early onset of ghrelin production in a marsupial
    Brandon R Menzies
    Department of Zoology, The University of Melbourne, Royal Parade, 3010 Victoria, Australia
    Mol Cell Endocrinol 299:266-73. 2009
    ..These results demonstrate an early onset of gastric ghrelin expression in the tammar in concert with a functional stomach at a relatively earlier stage than that of developmentally more mature eutherian young...
  89. ncbi request reprint Comparative analysis of ATRX, a chromatin remodeling protein
    Daniel J Park
    Department of Zoology, The University of Melbourne, Gate 12 Royal Parade, Melbourne 3010, Australia
    Gene 339:39-48. 2004
    ..Alignment of vertebrate ATRX sequences highlights other conserved elements, including a negatively charged mammalian sequence which we propose to be involved in binding of positively charged histone tails...
  90. ncbi request reprint Ultrastructural localization of relaxin in the corpus luteum of the pregnant and early lactating tammar wallaby, Macropus eugenii
    L J Parry
    Department of Zoology, University of Melbourne, Parkville, Victoria, 3052, Australia
    Cell Tissue Res 290:615-22. 1997
    ..Our data demonstrate that electron-dense granules in the luteal cell cytoplasm of a pregnant marsupial contain relaxin. The peptide is produced in greatest amounts at the end of pregnancy, consistent with a role in parturition...
  91. ncbi request reprint Sperm transport, size of the seminal plug and the timing of ovulation after natural mating in the female tammar wallaby Macropus eugenii
    Damien B B P Paris
    Department of Zoology, University of Melbourne, Vic, Australia
    Reprod Fertil Dev 16:811-22. 2004
    ..p.). In contrast with the polyovular dasyurid and didelphid marsupials, the tammar wallaby ejaculates large numbers of spermatozoa, but transport is relatively inefficient and sperm storage in the tract before ovulation is limited...
  92. pmc The vomeronasal organ of the tammar wallaby
    Nanette Y Schneider
    Department of Zoology, The University of Melbourne, Victoria, Australia, 3010
    J Anat 213:93-105. 2008
    ..The degree of vomeronasal organ development makes it likely that, as in other mammals, pheromones are important in the reproduction of the tammar...
  93. ncbi request reprint Insulin is imprinted in the placenta of the marsupial, Macropus eugenii
    Eleanor Ager
    Department of Zoology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
    Dev Biol 309:317-28. 2007
    ..The restriction of imprinting to the yolk sac suggests that imprinting of INS evolved in the chorio-vitelline placenta independently of other tissues in the therian ancestor of marsupials and eutherians...
  94. ncbi request reprint Absence of SOX3 in the developing marsupial gonad is not consistent with a conserved role in mammalian sex determination
    A J Pask
    Department of Zoology, The University of Melbourne, Victoria, Australia
    Genesis 27:145-52. 2000
    ..The absence of expression in the developing gonad strongly suggests that SOX3 does not have a conserved role in mammalian sexual determination or differentiation...
  95. ncbi request reprint Long-term fertility control in the kangaroo and the wallaby using levonorgestrel implants
    C D Nave
    Department of Zoology, The University of Melbourne, Victoria, Australia
    Reprod Suppl 60:71-80. 2002
    ..Thus, levonorgestrel implants provide a safe, highly effective and long-term method of fertility control for macropodid marsupials and should be applicable for the management of overabundant captive and selected wild populations...
  96. ncbi request reprint Functional analysis of the cooled rat testis
    Z Zhang
    Department of Zoology, University of Melbourne, Australia
    J Androl 25:57-68. 2004
    ..These data suggest that modifications to Sertoli cell function resulting from testicular cooling create an environment that is unable to support spermatogenesis by donor germ cells...
  97. ncbi request reprint Diapause
    M B Renfree
    Department of Zoology, University of Melbourne, Parkville, Victoria, Australia
    Annu Rev Physiol 62:353-75. 2000
    ....
  98. doi request reprint Levonorgestrel, not etonogestrel, provides contraception in free-ranging koalas
    E F Hynes
    The Department of Zoology, The University of Melbourne, Vic, Australia
    Reprod Fertil Dev 22:913-9. 2010
    ..Etonogestrel had absolutely no contraceptive effect at the two doses delivered and so is not suitable for controlling koala populations. In contrast, levonorgestrel was effective as a long-term, reversible contraceptive in wild koalas...
  99. ncbi request reprint 5alpha-androstane-3alpha,17beta-diol is formed in tammar wallaby pouch young testes by a pathway involving 5alpha-pregnane-3alpha,17alpha-diol-20-one as a key intermediate
    Jean D Wilson
    Department of Zoology, University of Melbourne, Victoria 3010, Australia
    Endocrinology 144:575-80. 2003
    ..We conclude that expression of steroid 5alpha-reductase in the developing wallaby testes allows formation of 5alpha-reduced androgens by a pathway that does not involve testosterone as an intermediate...
  100. ncbi request reprint Birth of pouch young after artificial insemination in the tammar wallaby (Macropus eugenii)
    Damien B B P Paris
    Department of Zoology, University of Melbourne, Victoria 3010, Australia
    Biol Reprod 72:451-9. 2005
    ..p.) but with highly motile spermatozoa. These young represent the first macropodids born by AI and the first marsupials conceived using epididymal spermatozoa...
  101. pmc In vitro culture of peri-gastrulation embryos of a macropodid marsupial
    Danielle Hickford
    Department of Zoology, The University of Melbourne, Victoria, Australia
    J Anat 212:180-91. 2008
    ..These results provide a basis for developing culture conditions for longer term development of marsupial embryos in vitro...