Christopher A Reid

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. pmc Multiple molecular mechanisms for a single GABAA mutation in epilepsy
    Christopher A Reid
    Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia
    Neurology 80:1003-8. 2013
  2. pmc HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications
    Christopher A Reid
    Florey Neuroscience Institute and The Centre for Neuroscience, The University of Melbourne, Parkville, Victoria, Australia
    Br J Pharmacol 165:49-56. 2012
  3. doi request reprint Spontaneous release from mossy fiber terminals inhibits Ni2+-sensitive T-type Ca2+ channels of CA3 pyramidal neurons in the rat organotypic hippocampal slice
    Christopher A Reid
    Department of Physiology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
    Hippocampus 18:623-30. 2008
  4. pmc Sub region-specific modulation of synchronous neuronal burst firing after a kainic acid insult in organotypic hippocampal cultures
    Christopher A Reid
    Department of Physiology, The University of Melbourne, Melbourne, Australia
    BMC Neurosci 9:59. 2008
  5. ncbi request reprint Presynaptic Ca2+ channels: a functional patchwork
    Christopher A Reid
    Department of Physiology, University of Melbourne, Grattan St, 3010, Parkville, Victoria, Australia
    Trends Neurosci 26:683-7. 2003
  6. doi request reprint Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1
    Brendan E L Adams
    Department of Physiology, The University of Melbourne, Australia
    Exp Neurol 219:249-57. 2009
  7. pmc Developmental impact of a familial GABAA receptor epilepsy mutation
    Cindy Chiu
    Howard Florey Institute, The University of Melbourne, Parkville, Melbourne, Australia
    Ann Neurol 64:284-93. 2008
  8. doi request reprint Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats
    Kim L Powell
    Department of Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Epilepsia 49:1686-95. 2008
  9. doi request reprint Seizure-like thalamocortical rhythms initiate in the deep layers of the cortex in a co-culture model
    Brendan E L Adams
    Department of Physiology, Centre for Neuroscience and Medicine RMH WH, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Exp Neurol 227:203-9. 2011
  10. pmc Axon initial segment dysfunction in epilepsy
    Verena C Wimmer
    Florey Neuroscience Institutes, University of Melbourne, Parkville 3010, Victoria, Australia
    J Physiol 588:1829-40. 2010

Collaborators

Detail Information

Publications39

  1. pmc Multiple molecular mechanisms for a single GABAA mutation in epilepsy
    Christopher A Reid
    Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia
    Neurology 80:1003-8. 2013
    ..To understand the molecular basis and differential penetrance of febrile seizures and absence seizures in patients with the γ2(R43Q) GABA receptor mutation...
  2. pmc HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications
    Christopher A Reid
    Florey Neuroscience Institute and The Centre for Neuroscience, The University of Melbourne, Parkville, Victoria, Australia
    Br J Pharmacol 165:49-56. 2012
    ..We also discuss what is known about the pharmacological manipulation of HCN channels in the context of epilepsy and how this may help future efforts in developing HCN-channel-based therapy...
  3. doi request reprint Spontaneous release from mossy fiber terminals inhibits Ni2+-sensitive T-type Ca2+ channels of CA3 pyramidal neurons in the rat organotypic hippocampal slice
    Christopher A Reid
    Department of Physiology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
    Hippocampus 18:623-30. 2008
    ..This change in AP firing was completely reversed by the addition of Ni(2+). This mechanism may reduce the impact of T-type Ca(2+) channels in a region where large synaptic events are common...
  4. pmc Sub region-specific modulation of synchronous neuronal burst firing after a kainic acid insult in organotypic hippocampal cultures
    Christopher A Reid
    Department of Physiology, The University of Melbourne, Melbourne, Australia
    BMC Neurosci 9:59. 2008
    ..The effect of an excitotoxic insult (kainic acid, KA) on Mg2+-free-induced synchronized neuronal firing was tested in organotypic hippocampal culture by measuring extracellular field activity in CA1 and CA3...
  5. ncbi request reprint Presynaptic Ca2+ channels: a functional patchwork
    Christopher A Reid
    Department of Physiology, University of Melbourne, Grattan St, 3010, Parkville, Victoria, Australia
    Trends Neurosci 26:683-7. 2003
    ..The patchwork distribution of Ca(2+) channel subtypes might therefore enable terminal-specific modulation of transmitter release, enhancing the power of synaptic processing...
  6. doi request reprint Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1
    Brendan E L Adams
    Department of Physiology, The University of Melbourne, Australia
    Exp Neurol 219:249-57. 2009
    ..Lamotrigine, known to increase Ih, reversed the impact of KA on burst duration in CA1 at both time-points linking a transcriptional reduction in HCN2 function to increased burst duration...
  7. pmc Developmental impact of a familial GABAA receptor epilepsy mutation
    Cindy Chiu
    Howard Florey Institute, The University of Melbourne, Parkville, Melbourne, Australia
    Ann Neurol 64:284-93. 2008
    ..Our objective was to determine whether developmental expression of the mutation alters seizure susceptibility later in life...
  8. doi request reprint Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats
    Kim L Powell
    Department of Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Epilepsia 49:1686-95. 2008
    ..Here HCN1 and HCN2 mRNA expression was quantitatively measured at different time points during epileptogenesis in two distinct animal models of TLE; the kainic acid (KA)-induced status epilepticus (SE) and amygdala kindling models...
  9. doi request reprint Seizure-like thalamocortical rhythms initiate in the deep layers of the cortex in a co-culture model
    Brendan E L Adams
    Department of Physiology, Centre for Neuroscience and Medicine RMH WH, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Exp Neurol 227:203-9. 2011
    ..We propose that thalamocortical oscillatory network activity initiates in deep layers of the cortex with reciprocal thalamic interconnections enabling sustained hyper-synchronization...
  10. pmc Axon initial segment dysfunction in epilepsy
    Verena C Wimmer
    Florey Neuroscience Institutes, University of Melbourne, Parkville 3010, Victoria, Australia
    J Physiol 588:1829-40. 2010
    ..This article highlights the molecular coincidence of epilepsy mutations at the AIS and reviews pathogenic mechanisms converging at the AIS...
  11. doi request reprint Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability
    Evan A Thomas
    Howard Florey Institute, Parkville, Victoria, Australia
    Epilepsia 51:136-45. 2010
    ..The purpose of this study was to use computational approaches to explore the interaction between changes in sodium channel availability caused by mutations and mossy fiber sprouting...
  12. doi request reprint Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizures
    Thomas Zheng
    Department of Medicine The University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia
    Epilepsia 50:83-7. 2009
    ..We examined whether structural analogs of CBZ, oxcarbazepine (OXC), and its active metabolite, monohydroxy derivative (MHD), also potentiate GABA(A) receptor current and aggravate seizures...
  13. doi request reprint Perturbations in cortical development and neuronal network excitability arising from prenatal exposure to benzodiazepines in mice
    Matilda Haas
    The Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia
    Eur J Neurosci 37:1584-93. 2013
    ..Therefore, exposure of the fetal brain to benzodiazepines has consequences for the positioning of neurons and cortical network excitability...
  14. doi request reprint A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy
    Kim L Powell
    Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia
    J Neurosci 29:371-80. 2009
    ..This gain-of-function mutation, the first reported in the GAERS polygenic animal model, has a novel mechanism of action, being dependent on exonic splicing for its functional consequences to be expressed...
  15. pmc Temperature elevation increases GABA(A) -mediated cortical inhibition in a mouse model of genetic epilepsy
    Elisa L Hill
    Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia
    Epilepsia 52:179-84. 2011
    ....
  16. doi request reprint Rhythmic neuronal activity in S2 somatosensory and insular cortices contribute to the initiation of absence-related spike-and-wave discharges
    Thomas W Zheng
    Departments of Medicine, Surgery and Neurology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia
    Epilepsia 53:1948-58. 2012
    ..Our goal was to characterize the interictal, preictal and ictal neuronal activity in the primary and secondary cortical regions (S1, S2) and in the adjacent insular cortex (IC) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS)...
  17. doi request reprint Early development of electrical excitability in the mouse enteric nervous system
    Marlene M Hao
    Department of Anatomy, University of Melbourne, and Florey Neuroscience Institutes, Melbourne, Victoria 3010, Australia
    J Neurosci 32:10949-60. 2012
    ..Spontaneous depolarizations resembling excitatory postsynaptic potentials were observed at E12.5. The ENS is one of the earliest parts of the developing nervous system to exhibit mature forms of electrical activity...
  18. doi request reprint Cocaine-mediated synaptic potentiation is absent in VTA neurons from mGlu5-deficient mice
    Michael K Bird
    Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
    Int J Neuropsychopharmacol 13:133-41. 2010
    ..In contrast, the mGlu5 receptor may not be essential for psychostimulant behavioural sensitization; although it probably impacts other aspects drug addiction, such as motivation to self-administer...
  19. pmc Increased thalamic inhibition in the absence seizure prone DBA/2J mouse
    Heneu O Tan
    Howard Florey Institute, The University of Melbourne, Parkville, Australia
    Epilepsia 49:921-5. 2008
    ..Increased susceptibility of the DBA2/J strain to develop SWDs and increase in the 6-12 Hz EEG power may be due to a hypersynchronous ventrobasal thalamus as a consequence of increased GABAergic input...
  20. doi request reprint Two lines of transgenic mice expressing cre-recombinase exhibit increased seizure susceptibility
    Tae Hwan Kim
    Florey Neuroscience Institutes, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
    Epilepsy Res 104:11-6. 2013
    ..These data highlight that appropriate control experiments that compare wild-type mice to those that carry the cre-transgene but not the loxP-flanked target are essential when using this method...
  21. pmc Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy
    Heneu O Tan
    Howard Florey Institute, University of Melbourne, Parkville 3010, Australia
    Proc Natl Acad Sci U S A 104:17536-41. 2007
    ..We hypothesize that a subtle reduction in cortical inhibition underlies childhood absence epilepsy seen in humans harboring the R43Q mutation...
  22. doi request reprint The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore
    Mastura Monif
    Department of Physiology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    J Neurosci 29:3781-91. 2009
    ..Collectively, and contrary to previous reports describing P2X(7)R as a "death receptor," we provide evidence for a novel trophic role for P2X(7)R pore in microglia...
  23. pmc Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus
    Verena C Wimmer
    Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia
    J Clin Invest 120:2661-71. 2010
    ..We therefore conclude that Na+ channel beta1 subunits modulate AIS excitability and that epilepsy can arise if this modulation is impaired...
  24. doi request reprint Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy
    Tae Hwan Kim
    The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
    Epilepsy Res 103:101-5. 2013
    ..In summary, triheptanoin may be an effective and well tolerated dietary therapy for generalized epilepsy...
  25. doi request reprint Low blood glucose precipitates spike-and-wave activity in genetically predisposed animals
    Christopher A Reid
    Florey Neuroscience Institute, The University of Melbourne, Parkville, Victoria, Australia
    Epilepsia 52:115-20. 2011
    ..Herein we investigate if lowering blood glucose increases spike-wave activity in mouse models with varying seizure susceptibility...
  26. pmc Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility
    Ernesto Vargas
    Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia
    J Physiol 591:57-65. 2013
    ..These results provide evidence that a human GABA(A) receptor epilepsy mutation exerts a developmental influence by modulating the number of GDPs. It also draws attention to the potential risk of early treatment with bumetanide...
  27. doi request reprint Acute effect of carbamazepine on corticothalamic 5-9-Hz and thalamocortical spindle (10-16-Hz) oscillations in the rat
    Thomas W Zheng
    Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie, INSERM U1114, Strasbourg, France Fédération de Médecine Translationnelle de Strasbourg FMTS, NeuroPole de Strasbourg, Faculte de Medecine, Universite de Strasbourg, INSERM U1114, 11 rue Humann, Strasbourg, 67085, France Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Vic, Australia
    Eur J Neurosci 39:788-99. 2014
    ..In conclusion, CBZ potentiates GABAA receptor-mediated TC spindle oscillations. Furthermore, we propose that CT 5-9-Hz waves can trigger TC spindles...
  28. doi request reprint Spike-and-wave discharge mediated reduction in hippocampal HCN1 channel function associates with learning deficits in a genetic mouse model of epilepsy
    A Marie Phillips
    Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville 3010, Australia Department of Genetics, University of Melbourne, Parkville 3010, Australia Electronic address
    Neurobiol Dis 64:30-5. 2014
    ..SWD-free mice harboring the R43Q mutation had no learning deficit. We conclude that SWDs reduce hippocampal HCN1 expression and function, and that the reduction associates with a spatial learning deficit. ..
  29. ncbi request reprint The mechanism of carbamazepine aggravation of absence seizures
    Lige Liu
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Royal Parade, Parkville 3050, Victoria, Australia
    J Pharmacol Exp Ther 319:790-8. 2006
    ..These data demonstrate that CBZ acts at the VB thalamus to aggravate absence seizures in GAERS and that activation of GABA(A) receptors is critical to this effect...
  30. doi request reprint Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout mice
    Graham L Barrett
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Hippocampus 20:145-52. 2010
    ....
  31. doi request reprint Mechanisms of human inherited epilepsies
    Christopher A Reid
    Howard Florey Institute, The University of Melbourne, Parkville, Melbourne, Australia
    Prog Neurobiol 87:41-57. 2009
    ..Piecing together this puzzle should allow us to understand the underlying pathology of epilepsy ultimately providing novel therapeutic strategies to complete the clinic-bench-clinic cycle...
  32. ncbi request reprint Null mutation of the alpha4 nicotinic receptor subunit increases the propensity of muscarinic-mediated neuronal bursting in mouse hippocampal slices
    Christopher A Reid
    Department of Medicine, Monash Medical Centre, Monash University, Melbourne, VIC 3800, Australia
    Neuropharmacology 51:587-96. 2006
    ....
  33. doi request reprint New therapeutic opportunities in epilepsy: a genetic perspective
    Christopher A Reid
    Florey Neuroscience Institutes, The University of Melbourne, Parkville, Melbourne, Australia
    Pharmacol Ther 128:274-80. 2010
    ..Here we discuss how we can use knowledge of genetic mechanisms to improve treatment strategies now and into the future...
  34. doi request reprint Low glycaemic index diet reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy
    Tae Hwan Kim
    Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, Melbourne, Australia
    Epilepsy Res 108:139-43. 2014
    ..Here we investigate if diets containing carbohydrates with varying glycaemic index (GI) can modulate seizure susceptibility in a mouse model of generalized epilepsy...
  35. doi request reprint Glutamate is associated with a higher risk of seizures in patients with gliomas
    Tanya I Yuen
    Departments of Surgery, Royal Melbourne Hospital, University of Melbourne, Victoria, Australia
    Neurology 79:883-9. 2012
    ..To investigate the relationship of glutamate and glutamate transporter expression in human gliomas and surrounding peritumoral brain to the presence of tumor-associated seizures (TAS)...
  36. ncbi request reprint The role of dendritic spines: comparing the complex with the simple
    Christopher A Reid
    Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
    Eur J Pharmacol 447:173-6. 2002
    ..We compare the similarities and differences displayed by these spines in compartmentalising Ca(2+) and discuss a potential role for the morphologically complex spines found on CA3 pyramidal neurons...
  37. pmc Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation
    Mark Denham
    Centre for Neuroscience, University of Melbourne, Parkville, Vic, Australia
    Front Cell Neurosci 6:11. 2012
    ..These findings illustrate the intrinsic capacity for neurons derived from human ES cells to integrate at a structural and functional level following transplantation...
  38. ncbi request reprint Optical quantal analysis indicates that long-term potentiation at single hippocampal mossy fiber synapses is expressed through increased release probability, recruitment of new release sites, and activation of silent synapses
    Christopher A Reid
    Division of Neurophysiology, National Institute for Medical Research, London NW7 1AA, United Kingdom
    J Neurosci 24:3618-26. 2004
    ....
  39. ncbi request reprint Optical quantal analysis reveals a presynaptic component of LTP at hippocampal Schaffer-associational synapses
    Nigel J Emptage
    Division of Neurophysiology, National Institute for Medical Research, Mill Hill, NW7 1AA, London, United Kingdom
    Neuron 38:797-804. 2003
    ..In most cases, the store-dependent evoked Ca(2+) transient in the spine was also increased after induction, a novel postsynaptic aspect of LTP...