Patrick C Reading
Affiliation: University of Melbourne
Londrigan S, Short K, Ma J, Gillespie L, Rockman S, Brooks A, et al
. Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle. J Virol. 2015;89:12319-29 pubmed publisher
..These studies represent an important step toward identifying host-encoded factors that block replication of seasonal IAV, but not HPAI, in macrophages. ..
Reading P, Pickett D, Tate M, Whitney P, Job E, Brooks A. Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice. Respir Res. 2009;10:117 pubmed publisher
..A point mutation in the gene encoding the HA of Beij/89 was shown to ablate a glycan attachment site. This was associated with resistance to collectins and increased virulence in mice. ..
Reading P, Whitney P, Pickett D, Tate M, Brooks A. Influenza viruses differ in ability to infect macrophages and to induce a local inflammatory response following intraperitoneal injection of mice. Immunol Cell Biol. 2010;88:641-50 pubmed publisher
..Together, these data suggest that the ability of influenza virus strains to infect MPhi and stimulate cytokine release is an important factor governing the nature of the acute inflammatory response. ..
Reading P, Whitney P, Barr D, Smyth M, Brooks A. NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection. Eur J Immunol. 2006;36:897-905 pubmed
Reading P, Whitney P, Barr D, Wojtasiak M, Mintern J, Waithman J, et al
. IL-18, but not IL-12, regulates NK cell activity following intranasal herpes simplex virus type 1 infection. J Immunol. 2007;179:3214-21 pubmed
..IL-18(-/-) mice. Together these studies demonstrate that IL-18, but not IL-12, plays a key role in the rapid activation of NK cells and therefore in control of early HSV-1 replication in the lung. ..
Reading P, Bozza S, Gilbertson B, Tate M, Moretti S, Job E, et al
. Antiviral activity of the long chain pentraxin PTX3 against influenza viruses. J Immunol. 2008;180:3391-8 pubmed
Upham J, Pickett D, Irimura T, Anders E, Reading P. Macrophage receptors for influenza A virus: role of the macrophage galactose-type lectin and mannose receptor in viral entry. J Virol. 2010;84:3730-7 pubmed publisher
Ng W, Londrigan S, Nasr N, Cunningham A, Turville S, Brooks A, et al
. The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus. J Virol. 2016;90:206-21 pubmed publisher
..As langerin represented the sole receptor for IAV infection in this system, we have defined the pathways and compartments involved in infectious entry of IAV into cells following recognition by langerin. ..
Job E, Pizzolla A, Nebl T, Short K, Deng Y, Carolan L, et al
. Neutralizing inhibitors in the airways of naïve ferrets do not play a major role in modulating the virulence of H3 subtype influenza A viruses. Virology. 2016;494:143-57 pubmed publisher
..These data have important implications for our understanding of pathogenesis and immunity to human IAV infections in these two widely used animal models of infection. ..