Patrick C Reading

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. pmc The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice
    Michelle D Tate
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010, Victoria, Australia
    Respir Res 9:57. 2008
  2. pmc The role of neutrophils during mild and severe influenza virus infections of mice
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 6:e17618. 2011
  3. pmc Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses
    Emma R Job
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 8:e59623. 2013
  4. ncbi request reprint Antiviral activity of the long chain pentraxin PTX3 against influenza viruses
    Patrick C Reading
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 180:3391-8. 2008
  5. doi request reprint Influenza viruses differ in ability to infect macrophages and to induce a local inflammatory response following intraperitoneal injection of mice
    Patrick C Reading
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 88:641-50. 2010
  6. pmc Macrophage receptors for influenza A virus: role of the macrophage galactose-type lectin and mannose receptor in viral entry
    Jacqueline P Upham
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
    J Virol 84:3730-7. 2010
  7. pmc Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice
    Patrick C Reading
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010, Victoria, Australia
    Respir Res 10:117. 2009
  8. ncbi request reprint IL-18, but not IL-12, regulates NK cell activity following intranasal herpes simplex virus type 1 infection
    Patrick C Reading
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Immunol 179:3214-21. 2007
  9. ncbi request reprint NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection
    Patrick C Reading
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia
    Eur J Immunol 36:897-905. 2006
  10. doi request reprint Depletion of Gr-1+, but not Ly6G+, immune cells exacerbates virus replication and disease in an intranasal model of herpes simplex virus type 1 infection
    Magdalena Wojtasiak
    Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia
    J Gen Virol 91:2158-66. 2010

Collaborators

Detail Information

Publications50

  1. pmc The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice
    Michelle D Tate
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010, Victoria, Australia
    Respir Res 9:57. 2008
    ....
  2. pmc The role of neutrophils during mild and severe influenza virus infections of mice
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 6:e17618. 2011
    ....
  3. pmc Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses
    Emma R Job
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 8:e59623. 2013
    ..Given the widespread expression of α(2,6)-linked sialic acid in the human respiratory tract, we propose that SAP may act as an effective receptor mimic to limit IAV infection of airway epithelial cells...
  4. ncbi request reprint Antiviral activity of the long chain pentraxin PTX3 against influenza viruses
    Patrick C Reading
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 180:3391-8. 2008
    ....
  5. doi request reprint Influenza viruses differ in ability to infect macrophages and to induce a local inflammatory response following intraperitoneal injection of mice
    Patrick C Reading
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 88:641-50. 2010
    ..Together, these data suggest that the ability of influenza virus strains to infect MPhi and stimulate cytokine release is an important factor governing the nature of the acute inflammatory response...
  6. pmc Macrophage receptors for influenza A virus: role of the macrophage galactose-type lectin and mannose receptor in viral entry
    Jacqueline P Upham
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
    J Virol 84:3730-7. 2010
    ....
  7. pmc Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice
    Patrick C Reading
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010, Victoria, Australia
    Respir Res 10:117. 2009
    ..This, in turn, modulates the virulence of different viruses for mice. The role of particular oligosaccharide attachments on the HA in determining sensitivity to collectins has yet to be fully elucidated...
  8. ncbi request reprint IL-18, but not IL-12, regulates NK cell activity following intranasal herpes simplex virus type 1 infection
    Patrick C Reading
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Immunol 179:3214-21. 2007
    ..IL-18(-/-) mice. Together these studies demonstrate that IL-18, but not IL-12, plays a key role in the rapid activation of NK cells and therefore in control of early HSV-1 replication in the lung...
  9. ncbi request reprint NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection
    Patrick C Reading
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia
    Eur J Immunol 36:897-905. 2006
    ....
  10. doi request reprint Depletion of Gr-1+, but not Ly6G+, immune cells exacerbates virus replication and disease in an intranasal model of herpes simplex virus type 1 infection
    Magdalena Wojtasiak
    Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia
    J Gen Virol 91:2158-66. 2010
    ..Furthermore, we use mAb 1A8 to demonstrate that specific depletion of neutrophils does not modulate disease or alter virus replication following intranasal infection with HSV-1...
  11. doi request reprint Pandemic H1N1 influenza A viruses are resistant to the antiviral activities of innate immune proteins of the collectin and pentraxin superfamilies
    Emma R Job
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    J Immunol 185:4284-91. 2010
    ..Thus, unlike recent seasonal H1N1 strains of influenza virus, A(H1N1) pandemic viruses are resistant to the antiviral activities of innate immune proteins of the collectin superfamily...
  12. pmc The macrophage galactose-type lectin can function as an attachment and entry receptor for influenza virus
    Wy Ching Ng
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    J Virol 88:1659-72. 2014
    ..Together, these studies identify MGL1 as a cell surface glycoprotein that can act as an authentic receptor for both attachment and infectious entry of IAV. ..
  13. doi request reprint Gr-1+ cells, but not neutrophils, limit virus replication and lesion development following flank infection of mice with herpes simplex virus type-1
    Magdalena Wojtasiak
    Department of Microbiology and Immunology, University of Melbourne, Victoria, 3010, Australia
    Virology 407:143-51. 2010
    ..In contrast, Gr-1(+) cells limit both virus replication and lesion development in the zosteriform model...
  14. pmc A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection
    Daniel P Barr
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia
    Eur J Immunol 37:1334-42. 2007
    ..These data identify IL-18 as a crucial factor for pDC-mediated NK cell regulation...
  15. ncbi request reprint Glycosylation as a target for recognition of influenza viruses by the innate immune system
    Patrick C Reading
    The University of Melbourne, Department of Microbiology and Immunology, Victoria, Australia 3010
    Adv Exp Med Biol 598:279-92. 2007
    ....
  16. pmc Influenza-induced inflammation drives pneumococcal otitis media
    Kirsty R Short
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria, Australia
    Infect Immun 81:645-52. 2013
    ..This study thus provides the first evidence that inflammation drives pneumococcal replication in the middle ear cavity, which may have important implications for the treatment of pneumococcal OM...
  17. doi request reprint A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice
    Emma R Job
    Department of Microbiology and Immunology, University of Melbourne, Melbourne 3010, Victoria, Australia
    J Immunol 192:271-81. 2014
    ..Together, these studies identify determinants in the viral HA that can be associated with sensitivity to the antiviral activities of PTX3 and highlight its importance in the control of IAV infection. ..
  18. pmc Influenza A virus induced bacterial otitis media is independent of virus tropism for α2,6-linked sialic acid
    Kirsty R Short
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Vic, 3010, Australia
    Virol J 10:128. 2013
    ..We have previously shown that H3 IAV strains (such as Udorn/72) induced a higher rate of bacterial OM than H1 strains (such as PR8/34). This was associated with more efficient replication of H3 strains in the middle ear...
  19. pmc Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Virol 84:7569-80. 2010
    ..Furthermore, the inability of PR8 to infect airway macrophages may be a critical factor contributing to its virulence for mice...
  20. pmc Antibodies mediate formation of neutrophil extracellular traps in the middle ear and facilitate secondary pneumococcal otitis media
    Kirsty R Short
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Australia
    Infect Immun 82:364-70. 2014
    ..Taken together, these data provide novel insight into how pneumococci are able to replicate in the middle ear cavity and induce disease. ..
  21. ncbi request reprint Addition of glycosylation to influenza A virus hemagglutinin modulates antibody-mediated recognition of H1N1 2009 pandemic viruses
    Emma R Job
    Department of Microbiology and Immunology, University of Melbourne, Melbourne 3010, Victoria, Australia
    J Immunol 190:2169-77. 2013
    ..Thus, a fine balance exists regarding the optimal pattern of HA glycosylation to facilitate evasion of Ab-mediated immunity while maintaining resistance to lectin-mediated defenses of the innate immune system...
  22. doi request reprint Neutrophils sustain effective CD8(+) T-cell responses in the respiratory tract following influenza infection
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    Immunol Cell Biol 90:197-205. 2012
    ..Therefore, neutrophils are important participants in anti-viral mechanisms that sustain effective CD8(+) T-cell responses in the respiratory tract of influenza virus-infected mice...
  23. doi request reprint Receptor specificity of the influenza virus hemagglutinin modulates sensitivity to soluble collectins of the innate immune system and virulence in mice
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia
    Virology 413:128-38. 2011
    ..Together, these studies confirm that residue 186 of H3 subtype viruses is a critical determinant of virulence in a mouse model of influenza infection...
  24. doi request reprint Responses of mouse airway epithelial cells and alveolar macrophages to virulent and avirulent strains of influenza A virus
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    Viral Immunol 24:77-88. 2011
    ..These findings provide insight into the mechanisms underlying disease severity in the mouse model of influenza infection...
  25. doi request reprint The fate of influenza A virus after infection of human macrophages and dendritic cells
    Kirsty R Short
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Gen Virol 93:2315-25. 2012
    ..Insights regarding the consequences and outcomes of IAV infection of airway MΦ and DC are discussed in order to gain a better understanding of the pathogenesis of influenza virus...
  26. doi request reprint Inhibition of lectin-mediated innate host defences in vivo modulates disease severity during influenza virus infection
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 89:482-91. 2011
    ..Moreover, soluble and cell-associated lectins coordinate to modulate disease severity following influenza virus infection of mice...
  27. doi request reprint Glycosylation of the hemagglutinin modulates the sensitivity of H3N2 influenza viruses to innate proteins in airway secretions and virulence in mice
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
    Virology 413:84-92. 2011
    ..These studies define the importance of particular glycans on H3 HA in determining sensitivity to airway collectins and virulence in mice...
  28. doi request reprint Cell-surface receptors on macrophages and dendritic cells for attachment and entry of influenza virus
    Sarah L Londrigan
    The Department of Microbiology and Immunology, The University of Melbourne, Victoria, Australia
    J Leukoc Biol 92:97-106. 2012
    ..Herein, we review the early stages of infection of MΦ and DC by IAV. Specifically, we examine the potential role of CLRs expressed on MΦ and DC to act as attachment and/or entry receptors for IAV...
  29. pmc N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN
    Sarah L Londrigan
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia
    J Virol 85:2990-3000. 2011
    ..Together, these data indicate that human C-type lectins (DC-SIGN and L-SIGN) can mediate attachment and entry of influenza viruses independently of cell surface SA...
  30. doi request reprint Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
    Thomas Gebhardt
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne Victoria, Australia
    Nat Immunol 10:524-30. 2009
    ..Thus, these cells represent an example of tissue-resident memory T cells that can provide protective immunity at points of pathogen entry...
  31. doi request reprint Neutrophils ameliorate lung injury and the development of severe disease during influenza infection
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia
    J Immunol 183:7441-50. 2009
    ..Thus, while it is well established that neutrophils contribute to lung injury in a range of pathological conditions, reduced numbers or impaired neutrophil function can facilitate progression of mild influenza to severe clinical disease...
  32. pmc Soluble host defense lectins in innate immunity to influenza virus
    Wy Ching Ng
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, VIC 3010, Australia
    J Biomed Biotechnol 2012:732191. 2012
    ....
  33. doi request reprint Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity antibodies in the absence of neutralizing antibodies
    Sinthujan Jegaskanda
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
    J Immunol 190:1837-48. 2013
    ..We conclude that there is a remarkable degree of cross-reactivity of influenza-specific ADCC Abs in seropositive humans. Targeting cross-reactive influenza-specific ADCC epitopes by vaccination could lead to improved influenza vaccines...
  34. doi request reprint Age-associated cross-reactive antibody-dependent cellular cytotoxicity toward 2009 pandemic influenza A virus subtype H1N1
    Sinthujan Jegaskanda
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Infect Dis 208:1051-61. 2013
    ..It is not known whether preexisting antibodies with effector functions such as antibody-dependent cellular cytotoxicity (ADCC) contributed to the immunity observed...
  35. doi request reprint Specific sites of N-linked glycosylation on the hemagglutinin of H1N1 subtype influenza A virus determine sensitivity to inhibitors of the innate immune system and virulence in mice
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia
    J Immunol 187:1884-94. 2011
    ..These studies provide insight regarding the mechanisms by which IAV can induce disease in mice. Moreover, reduced glycosylation of HA is likely to be an important factor associated with adaptation of human IAV to growth in mouse lung...
  36. doi request reprint Correlation between sialic acid expression and infection of murine macrophages by different strains of influenza virus
    Michelle D Tate
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia
    Microbes Infect 13:202-7. 2011
    ..Thus, during adaptation of human influenza viruses to growth in mice, a switch in receptor specificity from α(2,6)-linked SA to α(2,3)-linked SA is likely to favour evasion of attachment, entry and destruction by airway macrophages...
  37. pmc Standard trivalent influenza virus protein vaccination does not prime antibody-dependent cellular cytotoxicity in macaques
    Sinthujan Jegaskanda
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    J Virol 87:13706-18. 2013
    ..There was a marked difference in the ability of infection compared to that of vaccination to induce cross-reactive ADCC and CTL responses. Improved vaccination strategies are needed to induce broad-based ADCC immunity to influenza. ..
  38. pmc Playing hide and seek: how glycosylation of the influenza virus hemagglutinin can modulate the immune response to infection
    Michelle D Tate
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, 3168, Australia
    Viruses 6:1294-316. 2014
    ....
  39. doi request reprint Bacterial lipopolysaccharide inhibits influenza virus infection of human macrophages and the consequent induction of CD8+ T cell immunity
    Kirsty R Short
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Vic, Australia
    J Innate Immun 6:129-39. 2014
    ....
  40. pmc Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model
    Teagan Guarnaccia
    WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia
    PLoS Pathog 9:e1003354. 2013
    ..Furthermore, the potential changes in receptor binding properties that accompany antigenic changes highlight the importance of routine characterization of clinical samples in human A(H1N1)pdm09 influenza surveillance...
  41. pmc Influenza virus induces bacterial and nonbacterial otitis media
    Kirsty R Short
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria, Australia
    J Infect Dis 204:1857-65. 2011
    ..Moreover, we provide, to our knowledge, the first evidence that influenza virus alone causes middle ear inflammation in infant mice. This inflammation may then play an important role in the development of bacterial OM...
  42. ncbi request reprint Influenza in the Pacific
    Anne Kelso
    World Health Organization Collaborating Centre for Reference and Research on Influenza, Victoria, Australia
    P N G Med J 53:180-90. 2010
    ..Such systems will improve the understanding, detection and control of seasonal influenza while also providing early warning of the emergence of potential pandemic viruses...
  43. pmc Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence
    Julianne Stack
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 201:1007-18. 2005
    ..Importantly, VV lacking the A46R gene was attenuated in a murine intranasal model, demonstrating the importance of A46R for VV virulence...
  44. pmc Steroid hormone synthesis by vaccinia virus suppresses the inflammatory response to infection
    Patrick C Reading
    Department of Virology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    J Exp Med 197:1269-78. 2003
    ..These data suggest that steroid production by v3beta-HSD contributes to virus virulence by inhibiting an effective inflammatory response to infection...
  45. ncbi request reprint A soluble chemokine-binding protein from vaccinia virus reduces virus virulence and the inflammatory response to infection
    Patrick C Reading
    Department of Virology, Faculty of Medicine, Imperial College, London, United Kingdom
    J Immunol 170:1435-42. 2003
    ..These observations suggest that vCCI plays an important role in regulating leukocyte trafficking to the lungs during VV infection by binding to CC chemokines and blocking their chemotactic activities...
  46. ncbi request reprint The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model
    Julian A Symons
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, UK
    J Gen Virol 83:2833-44. 2002
    ..However, infection of BALB/c mice by the intranasal route showed that the deletion mutant was attenuated and induced lower weight loss and signs of illness compared to controls...
  47. ncbi request reprint A kinetic analysis of immune mediators in the lungs of mice infected with vaccinia virus and comparison with intradermal infection
    Patrick C Reading
    Department of Virology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    J Gen Virol 84:1973-83. 2003
    ..Together these findings highlight differences in the pathogenesis and in the cellular inflammatory response to WR following intranasal and intradermal inoculation of mice...
  48. ncbi request reprint The vaccinia virus kelch-like protein C2L affects calcium-independent adhesion to the extracellular matrix and inflammation in a murine intradermal model
    Marta Pires de Miranda
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    J Gen Virol 84:2459-71. 2003
    ..In summary, we found that C2L is not required for virus replication in vitro but contributes to aspects of VV-induced CPE and reduces immunopathology in vivo...
  49. pmc Vaccinia virus interleukin-18-binding protein promotes virulence by reducing gamma interferon production and natural killer and T-cell activity
    Patrick C Reading
    Department of Virology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, United Kingdom
    J Virol 77:9960-8. 2003
    ....
  50. ncbi request reprint Dermal infection with vaccinia virus reveals roles for virus proteins not seen using other inoculation routes
    David C Tscharke
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Gen Virol 83:1977-86. 2002
    ..Thus, the intranasal and intradermal models are complementary tools for dissecting the genetic basis of VV virulence...