William Rawlinson

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. pmc Proficiency of nucleic acid tests for avian influenza viruses, Australasia
    Sacha Stelzer-Braid
    Prince of Wales Hospital, Randwick, New South Wales, Australia
    Emerg Infect Dis 14:1126-8. 2008
  2. pmc Human cytomegalovirus-induces cytokine changes in the placenta with implications for adverse pregnancy outcomes
    Stuart T Hamilton
    Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia
    PLoS ONE 7:e52899. 2012
  3. pmc A pilot study to determine the feasibility of collecting amniotic fluid samples from women during labour and measuring amniotic fluid lactate at point of care
    Beverley Hall
    University of Sydney, Darlington, NSW 2006, Australia
    BMC Res Notes 6:112. 2013
  4. ncbi request reprint Antiviral agents for influenza, hepatitis C and herpesvirus, enterovirus and rhinovirus infections
    W D Rawlinson
    Department of Microbiology SEALS, Prince of Wales Hospital, Sydney, NSW
    Med J Aust 175:112-6. 2001
  5. doi request reprint Viruses and other infections in stillbirth: what is the evidence and what should we be doing?
    W D Rawlinson
    Microbiology SEALS, Prince of Wales Hospital, Randwick, Australia
    Pathology 40:149-60. 2008
  6. ncbi request reprint New point of care test is highly specific but less sensitive for influenza virus A and B in children and adults
    William D Rawlinson
    Virology Division, Department of Microbiology, SEALS, The Prince of Wales Hospital, Randwick, and School of Medical Sciences, University of New South Wales, Kensington, Sydney, Australia
    J Med Virol 74:127-31. 2004
  7. ncbi request reprint Cytomegalovirus. A common virus causing serious disease
    William Rawlinson
    South Eastern Sydney Area Health Service, Prince of Wales Hospital, Sydney Children s Hospital, Royal Hospital for Women, Faculties of Medicine and Science, University of New South Wales
    Aust Fam Physician 32:789-93. 2003
  8. ncbi request reprint Asthma exacerbations in children associated with rhinovirus but not human metapneumovirus infection
    William D Rawlinson
    Virology Division, Department of Microbiology, South Eastern Area Laboratory Services, Prince of Wales Hospital, Randwick, New South Wales, Australia
    J Infect Dis 187:1314-8. 2003
  9. pmc Hepatitis C virus reinfection and superinfection among treated and untreated participants with recent infection
    Jason Grebely
    Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia
    Hepatology 55:1058-69. 2012
  10. pmc Factors associated with uptake of treatment for recent hepatitis C virus infection in a predominantly injecting drug user cohort: The ATAHC Study
    J Grebely
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 376 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Drug Alcohol Depend 107:244-9. 2010

Collaborators

Detail Information

Publications89

  1. pmc Proficiency of nucleic acid tests for avian influenza viruses, Australasia
    Sacha Stelzer-Braid
    Prince of Wales Hospital, Randwick, New South Wales, Australia
    Emerg Infect Dis 14:1126-8. 2008
    ..Most laboratories were able to correctly detect clinically relevant amounts of influenza virus (H5N1), and results improved as each subsequent panel was tested...
  2. pmc Human cytomegalovirus-induces cytokine changes in the placenta with implications for adverse pregnancy outcomes
    Stuart T Hamilton
    Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia
    PLoS ONE 7:e52899. 2012
    ....
  3. pmc A pilot study to determine the feasibility of collecting amniotic fluid samples from women during labour and measuring amniotic fluid lactate at point of care
    Beverley Hall
    University of Sydney, Darlington, NSW 2006, Australia
    BMC Res Notes 6:112. 2013
    ..We compared amniotic fluid lactate results obtained using the hand held Lactate Pro (Arkray) to results obtained using reference laboratory methods ABX Pentra 400 (Horiba)...
  4. ncbi request reprint Antiviral agents for influenza, hepatitis C and herpesvirus, enterovirus and rhinovirus infections
    W D Rawlinson
    Department of Microbiology SEALS, Prince of Wales Hospital, Sydney, NSW
    Med J Aust 175:112-6. 2001
    ..Hepatitis C treatment efficacy has improved dramatically with the introduction of combination interferon-ribavirin therapy, with sustained-response rates up to 60%...
  5. doi request reprint Viruses and other infections in stillbirth: what is the evidence and what should we be doing?
    W D Rawlinson
    Microbiology SEALS, Prince of Wales Hospital, Randwick, Australia
    Pathology 40:149-60. 2008
    ..Modern molecular techniques such as multiplex PCR, allow searches for multiple agents. Now that such testing is available, it is important to assess the clinical usefulness of such testing...
  6. ncbi request reprint New point of care test is highly specific but less sensitive for influenza virus A and B in children and adults
    William D Rawlinson
    Virology Division, Department of Microbiology, SEALS, The Prince of Wales Hospital, Randwick, and School of Medical Sciences, University of New South Wales, Kensington, Sydney, Australia
    J Med Virol 74:127-31. 2004
    ..A positive test is useful, for both directing initiation of therapy in the clinician's office, and making a positive diagnosis of influenza in patients with influenza-like clinical syndromes...
  7. ncbi request reprint Cytomegalovirus. A common virus causing serious disease
    William Rawlinson
    South Eastern Sydney Area Health Service, Prince of Wales Hospital, Sydney Children s Hospital, Royal Hospital for Women, Faculties of Medicine and Science, University of New South Wales
    Aust Fam Physician 32:789-93. 2003
    ....
  8. ncbi request reprint Asthma exacerbations in children associated with rhinovirus but not human metapneumovirus infection
    William D Rawlinson
    Virology Division, Department of Microbiology, South Eastern Area Laboratory Services, Prince of Wales Hospital, Randwick, New South Wales, Australia
    J Infect Dis 187:1314-8. 2003
    ..0001). Human metapneumovirus was also found in small numbers of children with URTI, but significantly less frequently in children with asthma...
  9. pmc Hepatitis C virus reinfection and superinfection among treated and untreated participants with recent infection
    Jason Grebely
    Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia
    Hepatology 55:1058-69. 2012
    ..Conclusion: Reinfection and superinfection can occur during treatment of recent HCV and are associated with poor social functioning and ongoing IDU. ALT levels may be a useful clinical marker of reexposure...
  10. pmc Factors associated with uptake of treatment for recent hepatitis C virus infection in a predominantly injecting drug user cohort: The ATAHC Study
    J Grebely
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, 376 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Drug Alcohol Depend 107:244-9. 2010
    ..Decisions about whether to initiate treatment for recently acquired HCV were mainly driven by clinical factors, rather than factors related to sociodemographics or injecting behaviors...
  11. ncbi request reprint Virological responses during treatment for recent hepatitis C virus: potential benefit for ribavirin use in HCV/HIV co-infection
    Jason Grebely
    The Kirby Institute for Infection and Immunity in Society, University of New South Wales UNSW, Sydney, Australia
    AIDS 26:1653-61. 2012
    ..This study evaluated early virological decline during recent HCV therapy in HIV-uninfected individuals receiving pegylated interferon (PEG-IFN) monotherapy and HIV-infected individuals receiving PEG-IFN/RBV...
  12. pmc Adherence to treatment for recently acquired hepatitis C virus (HCV) infection among injecting drug users
    Jason Grebely
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    J Hepatol 55:76-85. 2011
    ..We assessed 80/80 adherence (≥80% of PEG-IFN doses, ≥80% treatment), on-treatment adherence, and treatment completion in a study of treatment of recent HCV infection (ATAHC)...
  13. pmc Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection
    Jason Grebely
    National Centre in HIV Epidemiology and Clinical Research NCHECR, University of New South Wales UNSW, Sydney, Australia
    Hepatology 52:1216-24. 2010
    ..Early therapeutic intervention could be recommended for individuals with unfavorable IL28B genotypes...
  14. doi request reprint Effect of reassortment on the nucleotide and amino acid changes of human A/H3N2 RNP subunits during 1998-2009
    Karen Ka Yin Wong
    School of Medical Sciences, University of New South Wales, Sydney 2052, Australia
    J Clin Virol 51:270-5. 2011
    ..While reassortment plays an important role in the evolution and virulence of influenza viruses, limited studies have investigated the effect of reassortment on the evolution of the internal RNP subunits...
  15. doi request reprint Incidence and risk for acute hepatitis C infection during imprisonment in Australia
    Kate Dolan
    National Drug and Alcohol Research Centre, Univeristy of New South Wales, Sydney, NSW, 2052, Australia
    Eur J Epidemiol 25:143-8. 2010
    ..Prison inmates were at high risk of HCV infection, despite some reduction in high-risk behaviours and access to prevention services. To prevent HCV transmission in prisons, better prevention strategies are required...
  16. pmc Incidence of primary hepatitis C infection and risk factors for transmission in an Australian prisoner cohort
    Suzy Teutsch
    School of Medical Sciences, The University of New South Wales, Sydney, New South Wales, Australia
    BMC Public Health 10:633. 2010
    ..Previous studies of HCV incidence have been based on small case numbers and have not distinguished risk events in prison from those in the community...
  17. pmc Effective treatment of injecting drug users with recently acquired hepatitis C virus infection
    Gregory J Dore
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    Gastroenterology 138:123-35.e1-2. 2010
    ..We evaluated the efficacy of treatment of recent HCV infection in IDUs with acute and early chronic HCV...
  18. ncbi request reprint Utility of newborn screening cards for detecting CMV infection in cases of stillbirth
    Jonathan Howard
    Department of Microbiology, SEALS, Prince of Wales Hospital, Randwick, Australia
    J Clin Virol 44:215-8. 2009
    ..In 2005, there were 1979 stillbirths in Australia, which is almost double the number of deaths reported for all children between 1 and 14 years age...
  19. pmc Patterns and characteristics of hepatitis C transmission clusters among HIV-positive and HIV-negative individuals in the Australian trial in acute hepatitis C
    G V Matthews
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Australia
    Clin Infect Dis 52:803-11. 2011
    ..The extent to which these separate epidemics overlap is unknown...
  20. doi request reprint Detecting human papillomavirus in ocular surface diseases
    Mark Woods
    School of Medical Sciences, University of New South Wales, Sydney, Australia
    Invest Ophthalmol Vis Sci 54:8069-78. 2013
    ..The aim of this study was to determine the prevalence of HPV in pterygia and OSSN and to devise a standardized approach for detecting viral DNA in ocular tissue samples...
  21. doi request reprint Laboratory diagnosis, molecular characteristics, epidemiological and clinical features of an outbreak of measles in a low incidence population in Australia
    Jude Jayamaha
    Virology Division, Department of Microbiology, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, Australia
    J Clin Virol 54:168-73. 2012
    ..Several disease markers are employed for diagnosis and are important to determine epidemiological and molecular characteristics for future control measures...
  22. doi request reprint Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome
    Barbara Cameron
    Center for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    J Med Virol 82:1684-8. 2010
    ..EBV and HHV6 DNA levels were at control levels in a minority of samples, and CMV was undetectable in all samples. These data do not support the hypothesis of ongoing or reactivated EBV, HHV-6, or CMV infection in the pathogenesis of CFS...
  23. ncbi request reprint Sexual behaviour and human herpesvirus 8 infection in homosexual men in Australia
    Andrew E Grulich
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Level 2, 376 Victoria Street, Sydney, NSW 2010 Australia
    Sex Health 2:13-8. 2005
    ..Human herpesvirus 8 (HHV-8) is a common sexually transmitted agent among homosexual men, but there are few Australian data. We aimed to describe the prevalence and risk factors for seropositivity to HHV-8 in Australian homosexual men...
  24. doi request reprint Comparison of influenza virus replication fidelity in vitro using selection pressure with monoclonal antibodies
    Karen Ka Yin Wong
    Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    J Med Virol 85:1090-4. 2013
    ..This higher fidelity may contribute to the lack of major antigenic changes in the pandemic virus since the emergence in 2009...
  25. doi request reprint Presence of hepatitis C virus in syringes confiscated in prisons in Australia
    Kate Dolan
    National Drug and Alcohol Research Center, University of New South Wales, Sydney, NSW 2052, Australia
    J Gastroenterol Hepatol 24:1655-7. 2009
    ..Needlestick injuries are an occupational hazard for prison officers. This study aimed to assess the presence of hepatitis C virus (HCV) in syringes found in prisons...
  26. pmc Stability of hepatitis C virus, HIV, and hepatitis B virus nucleic acids in plasma samples after long-term storage at -20°C and -70°C
    Cristina Baleriola
    Virology Division, SEALS, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    J Clin Microbiol 49:3163-7. 2011
    ..Hence, the loss was considered of minimal clinical impact and adequate for the detection of HCV, HIV-1, and HBV nucleic acids using nucleic acid assays for the assessment of the infectious risk of cell, blood, and tissue donors...
  27. pmc Characteristics and treatment outcomes among HIV-infected individuals in the Australian Trial in Acute Hepatitis C
    G V Matthews
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia
    Clin Infect Dis 48:650-8. 2009
    ..Enrollment is open to both human immunodeficiency virus (HIV)-infected and -uninfected individuals. The aim of this article was to evaluate characteristics and virological outcomes among HIV-infected individuals enrolled in ATAHC...
  28. doi request reprint Acute hepatitis C infection with evidence of heterosexual transmission
    Oanh Nguyen
    Centre for Population Health, Sydney West Area Health Service, Sydney, Australia
    J Clin Virol 49:65-8. 2010
    ..Phylogenetic analysis confirmed the case and index were infected with identical genotype 3a strains, consistent with heterosexual transmission in the absence of specific risk factors...
  29. ncbi request reprint Human enterovirus isolates from an outbreak typed using heteroduplex mobility analysis
    Leighton E Clancy
    Virology Division, Department of Microbiology, SEALS, The Prince of Wales Hospital, Randwick, Sydney, NSW, Australia
    J Med Virol 76:215-22. 2005
    ..HMA can be used to accurately distinguish identical and variant isolates derived from sporadic cases and clustered infections with enteroviruses, including those causing serious infections...
  30. doi request reprint Frequent multiple hepatitis C virus infections among injection drug users in a prison setting
    Son T Pham
    School of Biotechnology and Biomolecular Sciences, Faculty of Science, Sydney, Australia
    Hepatology 52:1564-72. 2010
    ..Spontaneous clearance of viruses from one subtype and persistence of the other subtype after mixed infection was observed in eight subjects. In these subjects, the virus with higher HCV RNA levels superseded the other...
  31. pmc The effect of hepatitis C virus infection on health-related quality of life in prisoners
    Hla Hla Thein
    National Centre in HIV Epidemiology and Clincal Research, The University of New South Wales, Sydney, NSW, Australia
    J Urban Health 83:275-88. 2006
    ..Non-HCV factors may override HCV-specific HRQOL impairment in this population. Targeted management strategies are required to improve HRQOL of prisoners...
  32. pmc CD127+CCR5+CD38+++ CD4+ Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2+ memory CD4+ T cells
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    J Virol 80:10151-61. 2006
    ..The current study provides important information on the differentiation of IL-2+ vaccinia virus-specific memory cells, allowing further study of antiviral effector CD4+ T cells in healthy adults and their dysfunction in HIV-1 infection...
  33. doi request reprint Mouse mammary tumor virus-like sequences in human breast cancer
    James S Lawson
    Faculty of Science and School of Medical Sciences, School of Biotechnology and Biomolecular Sciences, University of New South Wales, UNSW Sydney, Australia
    Cancer Res 70:3576-85. 2010
    ..Our findings extend the evidence that MMTV sequences found in naturally occurring mouse mammary tumors can be found in some human breast cancers, prompting further evaluation of causal roles in these settings...
  34. ncbi request reprint Mouse mammary tumor virus-like RNA transcripts and DNA are found in affected cells of human breast cancer
    Caroline E Ford
    Virology Division, Department of Microbiology, South Eastern Sydney Area Laboratory Services, Prince of Wales Hospital, Randwick, Australia
    Clin Cancer Res 10:7284-9. 2004
    ..The association with gynecomastia, a benign, possibly premalignant condition suggests hormonal influences, rather than cancer per se, may be the dominant factor in determining viral presence and replication...
  35. ncbi request reprint Prevalence of mouse mammary tumor virus (MMTV) in wild house mice (Mus musculis) in southeastern Australia
    Margaret Faedo
    Virology Division, Department of Microbiology, South Eastern and Illawarra Arca Laboratory Services, The Prince of Wales Hospital, Barker St, Randwick, NSW 2031, Australia
    J Wildl Dis 43:668-74. 2007
    ..Phylogenetic analysis, based upon env and LTR sequence data, indicated minor variation among all isolates. This represents the first report on the prevalence of MMTV in mouse populations in Australia...
  36. ncbi request reprint Host and viral factors in the immunopathogenesis of primary hepatitis C virus infection
    Andrew R Lloyd
    Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Immunol Cell Biol 85:24-32. 2007
    ..A growing body of evidence has implicated polymorphisms in both innate and adaptive immune response genes as determinants of viral clearance in individuals infected with HCV...
  37. ncbi request reprint Elevated expression of the tumor suppressing protein p53 is associated with the presence of mouse mammary tumor-like env gene sequences (MMTV-like) in human breast cancer
    James S Lawson
    Faculty of Medicine, University of New South Wales, Australia
    Breast Cancer Res Treat 87:13-7. 2004
    ..Although these observations do not provide evidence of causality, they are consistent with a role for MMTV-like viruses in some human breast cancers...
  38. ncbi request reprint Reduced frequency of HLA DRB1*03-DQB1*02 in children with type 1 diabetes associated with enterovirus RNA
    Maria E Craig
    Institute of Endocrinology, The Children s Hospital at Westmead, Sydney, Australia
    J Infect Dis 187:1562-70. 2003
    ..1) tested positive for enterovirus RNA (P=.04). These results suggest that there is a subgroup of patients with T1DM, who are at low genetic risk, in whom enteroviruses contribute to diabetes onset...
  39. ncbi request reprint Prevalence of production of virus-specific interferon-gamma among seronegative hepatitis C-resistant subjects reporting injection drug use
    Anthony J Freeman
    Department of Pathology, School of Medical Sciences, The University of New South Wales, Sydney, New South Wales, Australia
    J Infect Dis 190:1093-7. 2004
    ..Vaccine strategies to mimic this response may provide protection against persistent HCV infection...
  40. pmc Diagnosis of enterovirus infection by genus-specific PCR and enzyme-linked immunosorbent assays
    Maria E Craig
    The Children s Hospital at Westmead, Sydney, Australia
    J Clin Microbiol 41:841-4. 2003
    ..The ELISAs were less sensitive than the PCR, and only the ELISA for IgM was highly specific. When retrospective diagnosis is important or when specimens are unsuitable for PCR, the ELISA has a limited role if PCR is not available...
  41. ncbi request reprint Clearance of hepatitis C viremia associated with cellular immunity in the absence of seroconversion in the hepatitis C incidence and transmission in prisons study cohort
    Jeffrey J Post
    Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    J Infect Dis 189:1846-55. 2004
    ..These cases highlight the potential for cellular immune responses against HCV to facilitate viral clearance, responses that may model those required for effective HCV vaccination...
  42. ncbi request reprint Comparison of two rapid influenza A/B test kits with reference methods showing high specificity and sensitivity for influenza A infection
    Susanne Booth
    Virology Division, Department of Microbiology, South Eastern Area Laboratory Services, Prince of Wales Hospital, Randwick, New South Wales, Australia
    J Med Virol 78:619-22. 2006
    ..Overall results were very similar for both testing devices with the advantage of ImmunoCard STAT! Flu A and B Plus test detecting influenza A and B with sharp and easy to read results...
  43. pmc Quantification of hepatitis C virus in human liver and serum samples by using LightCycler reverse transcriptase PCR
    Peter A White
    Virology Division, Department of Microbiology, SEALS, Prince of Wales Hospital, Sydney, New South Wales 2031, Australia
    J Clin Microbiol 40:4346-8. 2002
    ..There was a strong correlation between hepatic and serum viral load measurements (r = 0.689, P = 0.004, n = 15), indicating that the level of viremia reflected the amount of virus present in the liver...
  44. doi request reprint Correlation of polymerase replication fidelity with genetic evolution of influenza A/Fujian/411/02(H3N2) viruses
    Karen Ka Yin Wong
    Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, Australia
    J Med Virol 83:510-6. 2011
    ..This correlation implicates changes in the polymerase replication fidelity as contributing to altered genetic evolution of influenza viruses...
  45. doi request reprint Comparison of a novel HPV test with the Hybrid Capture II (hcII) and a reference PCR method shows high specificity and positive predictive value for 13 high-risk human papillomavirus infections
    Cristina Baleriola
    Virology Division, Department of Microbiology, South Eastern Area Laboratory Services, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    J Clin Virol 42:22-6. 2008
    ..The hcII has moderate sensitivity (64.7%) and is dependent on the cellular content of samples, rendering occasionally false positive and false negative results...
  46. pmc Emergence of a new norovirus genotype II.4 variant associated with global outbreaks of gastroenteritis
    Rowena A Bull
    School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney 2052, Australia
    J Clin Microbiol 44:327-33. 2006
    ..The Hunter virus was subsequently identified as the etiological agent in large epidemics of gastroenteritis in The Netherlands, Japan, and Taiwan in 2004 and 2005...
  47. ncbi request reprint The presence of an intrahepatic cytotoxic T lymphocyte response is associated with low viral load in patients with chronic hepatitis C virus infection
    Anthony J Freeman
    Viral Hepatitis Research, Gastrointestinal and Liver Unit, The Prince of Wales Hospital, Barker Street, Randwick, Sydney, NSW 2031, Australia
    J Hepatol 38:349-56. 2003
    ..The role of cytotoxic T lymphocytes (CTL) in limiting viral replication and producing hepatocellular injury in patients with chronic hepatitis C virus (HCV) infection is controversial...
  48. ncbi request reprint Progression from normal breast pathology to breast cancer is associated with increasing prevalence of mouse mammary tumor virus-like sequences in men and women
    Caroline E Ford
    Virology Division, Department of Microbiology, South Eastern Area Laboratory Services, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia
    Cancer Res 64:4755-9. 2004
    ..These results support the association of MMTV-like sequences with development of breast tumors in men and women and suggest association of MMTV with increasing severity of cancer...
  49. doi request reprint Mouse mammary tumor like virus sequences in breast milk from healthy lactating women
    Harpreet Johal
    Prince of Wales Hospital, Randwick, NSW, Australia
    Breast Cancer Res Treat 129:149-55. 2011
    ..As MMTV is transmitted via milk from mouse mothers to their newborn pups to cause mammary tumors when they become adults, this indicates a means of transmission of this virus in humans...
  50. ncbi request reprint Risk factors for an intensive care unit admission in children with asthma
    Yvonne Belessis
    Department of Respiratory Medicine, Sydney Children s Hospital, Randwick, New South Wales, Australia
    Pediatr Pulmonol 37:201-9. 2004
    ..Specialist referral of children with multiple ED presentations may improve asthma control and reduce the risk of an ICU admission. Background asthma management remains suboptimal in children needing hospitalization...
  51. pmc Norovirus recombination in ORF1/ORF2 overlap
    Rowena A Bull
    School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, New South Wales, Australia
    Emerg Infect Dis 11:1079-85. 2005
    ..We provide evidence to support the theory of the role of subgenomic RNA promoters as recombination hotspots and describe a simple mechanism of how recombination might occur in NoV...
  52. pmc Influenza outbreaks during World Youth Day 2008 mass gathering
    Christopher C Blyth
    Westmead Hospital, Sydney, New South Wales, Australia
    Emerg Infect Dis 16:809-15. 2010
    ..Greater flexibility by public health authorities and hospitals is required to appropriately manage and contain these outbreaks...
  53. doi request reprint Mouse mammary tumour virus-like virus (MMTV-LV) is present within the liver in a wide range of hepatic disorders and unrelated to nuclear p53 expression or hepatocarcinogenesis
    Harpreet Johal
    Virology Division, Department of Microbiology, South Eastern Area Health Services SEALS, Prince of Wales Hospital, Randwick, NSW, Australia
    J Hepatol 50:548-54. 2009
    ..We investigated MMTV-LV prevalence in patients with liver disease of diverse aetiology and associations with hepatic expression of hormonal receptors, p53 protein and complicating hepatocarcinogenesis...
  54. pmc Rapid evolution of pandemic noroviruses of the GII.4 lineage
    Rowena A Bull
    School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, New South Wales, Australia
    PLoS Pathog 6:e1000831. 2010
    ..This study supports the hypothesis that the ability of the virus to generate genetic diversity is vital for viral fitness...
  55. ncbi request reprint Highly sensitive detection and localization of maternally acquired human cytomegalovirus in placental tissue by in situ polymerase chain reaction
    Daniel E Trincado
    Virology Division, Department of Microbiology, South Eastern Area Laboratory Services, The Prince of Wales Hospital, Randwick, and the School of Medical Sciences, University of New South Wales, Kensington, Australia
    J Infect Dis 192:650-7. 2005
    ..Placental villi are involved in the transfer of blood from maternal to fetal circulation. Infection and replication of CMV within placental trophoblasts suggests that these structures may be involved in the transmission of CMV...
  56. doi request reprint Epidemics of gastroenteritis during 2006 were associated with the spread of norovirus GII.4 variants 2006a and 2006b
    Elise T V Tu
    School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, Australia
    Clin Infect Dis 46:413-20. 2008
    ..Norovirus GII has 17 classified genotypes (GII.1-GII.17), but only 1 norovirus genotype (GII.4) is associated with global epidemics of gastroenteritis. In 2006, an increase in global norovirus activity was observed...
  57. doi request reprint A new method for sampling and detection of exhaled respiratory virus aerosols
    Kerrianne N Huynh
    Faculty of Medicine, University of Sydney, Sydney, NSW, Australia
    Clin Infect Dis 46:93-5. 2008
    ....
  58. ncbi request reprint Transmission of hepatitis C virus by needle-stick injury in community settings
    Paul S Haber
    Royal Prince Alfred Hospital and Discipline of Medicine, University of Sydney, Sydney, New South Wales, Australia
    J Gastroenterol Hepatol 22:1882-5. 2007
    ..Hepatitis C virus (HCV) is predominantly transmitted by blood-to-blood contact, typically by sharing of needles by injecting drug users. Discarded needles could act as a vector for transmission of this infection...
  59. ncbi request reprint Characterisation of transcripts from the human cytomegalovirus genes TRL7, UL20a, UL36, UL65, UL94, US3 and US34
    Gillian M Scott
    Virology Division, Department of Microbiology SEALS, Prince of Wales Hospital, Randwick NSW, Australia
    Virus Genes 24:39-48. 2002
    ..These findings show the variation between predicted and actual transcription and indicate the complex nature of transcription from HCMV ORFs...
  60. ncbi request reprint Multicentric Castleman's disease treated with antivirals and immunosuppressants
    Sanjaya Senanayake
    Department of Infectious Diseases, Prince of Wales Hospital, Barker Street, Randwick, New South Wales 2031, Australia
    J Med Virol 71:399-403. 2003
    ..Despite the implication of HHV-8 as a cause of MCD, few studies have correlated HHV-8 levels with clinical response...
  61. ncbi request reprint Clearance of hepatitis C virus after newly acquired infection in injection drug users
    Marianne Jauncey
    New South Wales Public Health Officer Training Program, New South Wales Department of Health, Kirketon Road Centre, South Eastern Sydney Area Health Service, Sydney, New South Wales, Australia
    J Infect Dis 190:1270-4. 2004
    ..Viral clearance occurred in 24 (42%) cases, with Kaplan-Meier estimated probabilities of 23%, 38%, and 40% at 6, 12, and 24 months, respectively...
  62. ncbi request reprint Mouse mammary tumor-like virus is associated with p53 nuclear accumulation and progesterone receptor positivity but not estrogen positivity in human female breast cancer
    Margaret Faedo
    Virology Division, Department of Microbiology, South Eastern Area Laboratory Services, The Prince of Wales Hospital, Randwick, Australia
    Clin Cancer Res 10:4417-9. 2004
    ....
  63. ncbi request reprint Mouse mammary tumor virus-like gene sequences in breast tumors of Australian and Vietnamese women
    Caroline E Ford
    Virology Division, Department of Microbiology, South Eastern Sydney Area Laboratory Services, The Prince of Wales Hospital, Randwick, NSW 2031, Australia
    Clin Cancer Res 9:1118-20. 2003
    ..Previous studies have found MMTV-like gene sequences in 38% of breast cancer tissue from United States women. The prevalence of these sequences in Australian and Vietnamese women has never been reported...
  64. doi request reprint DNA of mouse mammary tumor virus-like virus is present in human tumors influenced by hormones
    Harpreet Johal
    Virology Division, SEALS Microbiology, The Prince of Wales Hospital, Randwick, NSW, Australia
    J Med Virol 82:1044-50. 2010
    ....
  65. ncbi request reprint Concurrent summer influenza and pertussis outbreaks in a nursing home in Sydney, Australia
    Mark J Ferson
    South Eastern Sydney Public Health Unit, Randwick, New South Wales, Australia
    Infect Control Hosp Epidemiol 25:962-6. 2004
    ..To report on the investigation of a summer outbreak of acute respiratory illness among residents of a Sydney nursing home...
  66. pmc High-affinity aptamers to subtype 3a hepatitis C virus polymerase display genotypic specificity
    Louisa A Jones
    Department of Microbiology, Prince Wales Hospital, Randwick, Sydney, NSW 2031, Australia
    Antimicrob Agents Chemother 50:3019-27. 2006
    ..Neither r10/43 nor r10/47 was able to inhibit the RdRp activity of HCV genotype 1a and 1b polymerases. This study is the first description of an inhibitor specific to the HCV subtype 3a polymerase...
  67. ncbi request reprint Bilateral benign lymphoid hyperplasia of the conjunctiva in a paediatric patient
    Peter Kim
    Department of Ophthalmology, Liverpool Hospital, New South Wales, Australia
    Clin Experiment Ophthalmol 33:285-7. 2005
    ..Benign lymphoid hyperplasia of the conjunctiva with bilateral involvement is extremely rare in children. Only a few case reports have been documented in the literature...
  68. ncbi request reprint Congenital cytomegalovirus--time to diagnosis, management and clinical sequelae in Australia: opportunities for earlier identification
    Brendan J McMullan
    St Vincent s Hospital, Sydney, NSW, Australia
    Med J Aust 194:625-9. 2011
    ..To report on the burden of disease in Australian infants with congenital cytomegalovirus (cCMV) infection in the era of neonatal hearing screening and improved diagnostic techniques...
  69. ncbi request reprint Polymerase chain reaction screening for integrons can be used to complement resistance surveillance programs
    Louisa A Jones
    Virology Division, Department of Microbiology, SEALS, Prince of Wales Hospital, Randwick, New South Wales
    Commun Dis Intell 27:S103-10. 2003
    ..Such screening could assist in guiding treatment regimens and complement existing antibiotic resistance surveillance programs by providing information on molecular mechanisms of both resistance and resistance dissemination...
  70. ncbi request reprint Identification of putative functional motifs in viral proteins essential for human cytomegalovirus DNA replication
    Heng Giap Woon
    Virology Division, Department of Microbiology, SEALS, POWH and UNSW Research Laboratories, Prince of Wales Hospital, Randwick, NSW, Australia
    Virus Genes 37:193-202. 2008
    ....
  71. ncbi request reprint Symptomatic infant characteristics of congenital cytomegalovirus disease in Australia
    Sian C Munro
    Virology Division, Department of Microbiology, SEALS, Prince of Wales Hospital, New South Wales, Australia
    J Paediatr Child Health 41:449-52. 2005
    ..Human cytomegalovirus (CMV) is the most common cause of viral intrauterine infection. In utero transmission can occur during primary maternal infection, reactivation or reinfection of seropositive mothers...
  72. pmc Norovirus excretion in an aged-care setting
    Elise T V Tu
    School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney 2052, Australia
    J Clin Microbiol 46:2119-21. 2008
    ..Viral shedding peaked in the acute stage of illness and continued for an average of 28.7 days. The viral decay rate was 0.76 per day, which corresponds to a viral half-life of 2.5 days...
  73. pmc Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates
    Gillian M Scott
    Virology Research, POWH and UNSW Research Laboratories, Level 3 Clinical Sciences Building, Prince of Wales Hospital, Avoca Street, Randwick, NSW 2031, Australia
    Antimicrob Agents Chemother 51:89-94. 2007
    ..The additive effect of multiple mutations on antiviral susceptibility suggests that increasing antiviral-resistant phenotypes can result from different virus-antiviral interactions...
  74. doi request reprint A commercial ELISA detects high levels of human H5 antibody but cross-reacts with influenza A antibodies
    Sacha Stelzer-Braid
    Virology Research, Department of Microbiology, South Eastern Area Laboratory Service, Prince of Wales Hospital, Randwick, NSW 2031, Australia
    J Clin Virol 43:241-3. 2008
    ..This study aimed to assess the validity of a commercial ELISA H5 hemagglutinin (HA) antibody kit...
  75. doi request reprint Differences in amniotic fluid and maternal serum cytokine levels in early midtrimester women without evidence of infection
    Sharon S W Chow
    School of Medical Sciences, University of New South Wales, 2052 NSW, Australia
    Cytokine 44:78-84. 2008
    ..This study provides new normative data for multiple cytokine levels in amniotic fluid and maternal sera at 14-16 weeks gestation, and is a valuable tool for future diagnostic and comparative studies...
  76. pmc The aadB gene cassette is associated with blaSHV genes in Klebsiella species producing extended-spectrum beta-lactamases
    Louisa A Jones
    School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney 2052, Australia
    Antimicrob Agents Chemother 49:794-7. 2005
    ..aadB was associated with a class 1 integron on a 28-kb plasmid, pES1, that also contained bla(SHV-12) and IS26...
  77. ncbi request reprint Exhalation of respiratory viruses by breathing, coughing, and talking
    Sacha Stelzer-Braid
    Faculty of Science, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW, Australia
    J Med Virol 81:1674-9. 2009
    ..In the subset of exhaled samples from 10 subjects examined by culture, infective rhinovirus was detected in 2. These data provide further evidence that breathing may be a source of respirable particles carrying infectious virus...
  78. ncbi request reprint Trichomonas vaginalis: underdiagnosis in urban Australia could facilitate re-emergence
    M Josephine Lusk
    Short Street Clinic, St George Hospital, Kogarah, New South Wales, Australia
    Sex Transm Infect 86:227-30. 2010
    ..The objective of this study was to determine the true prevalence of TV in an Australian urban sexual health setting using sensitive molecular diagnostic techniques...
  79. pmc Epidemic strains of Shigella sonnei biotype g carrying integrons
    Christopher J McIver
    Virology Division, Department of Microbiology, SEALS, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia
    J Clin Microbiol 40:1538-40. 2002
    ..A class 1 integron was also found in two epidemic strains. Gene cassettes within these integrons account for resistance to commonly used therapeutic agents...
  80. ncbi request reprint Enhanced diagnosis of pandemic (H1N1) 2009 influenza infection using molecular and serological testing in intensive care unit patients with suspected influenza
    Jenna M Iwasenko
    Department of Microbiology, South Eastern Area Laboratory Services, Prince of Wales Hospital, Randwick, New South Wales, Australia
    Clin Infect Dis 51:70-2. 2010
    ..These results indicate that up to one-third of pH1N1 cases may not have laboratory confirmation of infection unless serological testing is included for suspected cases...
  81. pmc Multiplex PCR testing detection of higher-than-expected rates of cervical mycoplasma, ureaplasma, and trichomonas and viral agent infections in sexually active australian women
    Christopher J McIver
    Microbiology Department SEALS, Virology Division, Prince of Wales Hospital, Randwick, NSW, Australia
    J Clin Microbiol 47:1358-63. 2009
    ..pallidum were not detected. These assays are adaptable for routine diagnostic laboratories and provide an opportunity to measure the true prevalence of microorganisms potentially associated with cervicitis and other genital infections...
  82. pmc Norovirus GII.4 strains and outbreaks, Australia
    Elise T V Tu
    Emerg Infect Dis 13:1128-30. 2007
  83. pmc Genetic diversity of Sapovirus in children, Australia
    Grant S Hansman
    National Institute of Infectious Diseases, Tokyo, Japan
    Emerg Infect Dis 12:141-3. 2006
    ..Sequence analysis of the N-terminal capsid region showed all human sapovirus genogroups...
  84. ncbi request reprint The interplay between host and viral factors in shaping the outcome of cytomegalovirus infection
    Anthony A Scalzo
    Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Nedlands, Western Australia, Australia
    Immunol Cell Biol 85:46-54. 2007
    ..We also discuss recent studies of genetic responses to antiviral therapy, particularly changes in DNA polymerase and protein kinase genes of MCMV and HCMV...
  85. doi request reprint Identification of Australian human respiratory syncytial virus strains containing a 60-nucleotide duplication within the G glycoprotein gene
    Sarah Tozer
    Pathology 40:632-5. 2008
  86. pmc Genotypic analysis of two hypervariable human cytomegalovirus genes
    Amanda J Bradley
    MRC Virology Unit, Institute of Virology, University of Glasgow, Glasgow, United Kingdom
    J Med Virol 80:1615-23. 2008
    ..The emerging scenario is that the HCMV genotypes developed in early human populations (or even earlier), becoming established via founder or bottleneck effects, and have spread, recombined and mixed worldwide in more recent times...
  87. ncbi request reprint Emergence and persistence of multiple antiviral-resistant CMV strains in a highly immunocompromised child
    Jenna M Iwasenko
    Virology Research, POWH and UNSW Research Laboratories, Prince of Wales Hospital, Randwick, NSW, Australia
    J Clin Virol 40:152-5. 2007
    ..The emergence of human cytomegalovirus (CMV) antiviral resistance plays a significant role in disease progression in immunocompromised patients who have received antiviral therapy...
  88. ncbi request reprint Norwalk-like virus 95/96-US strain is a major cause of gastroenteritis outbreaks in Australia
    Peter A White
    Virology Division, Department of Microbiology, SEALS, Prince of Wales Hospital, Randwick, Sydney, Australia
    J Med Virol 68:113-8. 2002
    ..This study demonstrates the usefulness of targeting primers for NLVs to the predominant circulating genotype(s) and confirms the spread of this subtype globally, including the Southern Hemisphere...
  89. ncbi request reprint Limiting potential infectious risks of transplanting insulin-producing pig cells into humans
    Ganesh Kumar
    Diabetes Transplant Unit, Prince of Wales Hospital, Randwick, NSW, Australia
    Pathology 34:178-84. 2002
    ..Prior to commencing a study of grafting foetal/neonatal pig islet-like cell clusters into type I diabetic human subjects, the microbiological risks of transplanting porcine pancreatic tissue were assessed...